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    "description": "BackgroundThe purpose of this study was to compare the serum inflammatory indicators and radiographic results of conventional manual total knee arthroplasty (CM-TKA) with those of MAKO-robotic assisted total knee arthroplasty (MA-TKA).MethodsWe retrospectively analysed 65 patients with knee osteoarthritis who underwent unilateral TKA from December 2020 to November 2021 in our department, which included 34 patients who underwent MA-TKA and 31 patients who underwent CM-TKA. The tourniquet time and estimated blood loss (EBL) were compared between the two groups. Knee function was evaluated using range of motion (ROM), functional score and pain score. Leukocytes, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), creatine kinase (CK), and neutrophil-to-lymphocyte ratio (NLR) were recorded at 3 time points (preoperative, and on the first and third postoperative days). The hip-knee-ankle angle (HKA) and the femoral and tibial component angles in the coronal and sagittal planes were used for postoperative radiographic evaluation.ResultsThe postoperative MA-TKA group had less EBL (496.9\u2009\u00b1\u2009257.8 vs. 773.0\u2009\u00b1\u2009301.3\u2009ml, p\u2009<\u20090.001). There was no significant difference in knee function scores at 6\u2009weeks postoperatively (p\u2009>\u20090.05). IL-6 levels were significantly lower in the MA-TKA group on the 1st postoperative day (11.4 (5.2, 21.0) vs. 24.6 (86.3, 170.8), p\u2009=\u20090.031). This difference in inflammatory indices became more pronounced at 72\u2009hours after the operation because CRP, ESR, IL-6, and CK values were significantly lower in the MA-TKA group on the 3rd postoperative day (72\u2009h) (p\u2009<\u20090.05). Postoperative radiographic examinations performed 2\u2009days after the MA-TKA group suggested that only 2 cases of HKA had outlier values, which was remarkably better than the 12 cases found in the CM-TKA group (5.9% vs. 38.7%, p\u2009<\u20090.001). The frontal femoral component was significantly closer to the expected value of 90\u00b0 in the MA-TKA group (90.9 (90.5, 92.3) vs. 92.4 (91.3, 93.7), p\u2009=\u20090.031). The remaining imaging evaluation parameters were not significantly different between the two groups (p\u2009>\u20090.05).ConclusionsIn Chinese patients with OA, there was a milder systemic inflammatory response in the early postoperative period after MA-TKA compared to that of CM-TKA, as well as better radiographic outcomes. However, the tourniquet time was prolonged, and no advantages were observed in terms of functional score or pain score in the short-term follow-up.", 
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