JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscular Atrophy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peripheral Nerve Injuries", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, 329-0498, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Center for Molecular Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, 329-0498, Tochigi, Japan", 
            "Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, 329-0498, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimada", 
        "givenName": "Nobuhiro", 
        "id": "sg:person.01071174402.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071174402.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Nara Medical University, 840, Shijocho, Kashihara, 634-0813, Nara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Center for Molecular Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, 329-0498, Tochigi, Japan", 
            "Department of Pediatrics, Nara Medical University, 840, Shijocho, Kashihara, 634-0813, Nara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakata", 
        "givenName": "Asuka", 
        "id": "sg:person.01252654620.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252654620.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, 329-0498, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, 329-0498, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Igarashi", 
        "givenName": "Takashi", 
        "id": "sg:person.01122132700.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122132700.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, 329-0498, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, 329-0498, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeuchi", 
        "givenName": "Mamoru", 
        "id": "sg:person.01274434546.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274434546.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Molecular Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, 329-0498, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Center for Molecular Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, 329-0498, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishimura", 
        "givenName": "Satoshi", 
        "id": "sg:person.07504546042.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07504546042.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s002239900547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006016573", 
          "https://doi.org/10.1007/s002239900547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sc.1977.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050616460", 
          "https://doi.org/10.1038/sc.1977.20"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-01-20", 
    "datePublishedReg": "2020-01-20", 
    "description": "BackgroundPeripheral nerve injury causes limb muscle/bone atrophy, leading to chronic pain. However, the mechanisms underlying muscle/bone atrophy after peripheral nerve injury remain unknown. It was recently reported that M1 macrophages are the main factors responsible for neurogenic inflammation after peripheral nerve injury. We hypothesized that M1 macrophages are important in muscle/bone atrophy after nerve injury. Therefore, we investigated the influence of M1 macrophages on muscle/bone atrophy after nerve injury in mice to prevent muscle/bone atrophy by suppressing M1 macrophages.MethodsHindlimb muscle weight and total bone density were measured in a chronic constriction injury (CCI) mouse model. Immunohistochemical analysis and intravital microscopy were performed to visualize hindlimb muscles/bones, and cells were quantified using flow cytometry. We compared M1 macrophage infiltration into muscles/bones and muscle/bone atrophy between macrophage depletion and untreated groups. We also investigated muscle/bone atrophy using administration models for anti-inflammatory and neuropathic pain drugs.ResultsPeripheral nerve injury caused significant reduction in muscle weight and total bone density at 1 and 3\u2009weeks after CCI, respectively, compared with that in controls. Osteoclast numbers were significantly higher at 1\u2009week after CCI in the CCI group than in the control group. M1 macrophage infiltration into muscles was observed from 2\u2009h after CCI via intravital microscopy and 1\u2009week after CCI, and it was significantly higher 1\u2009week after CCI than in the control group. In the macrophage depletion group, dexamethasone, pregabalin, and loxoprofen groups, M1 macrophage infiltration into muscles/bones was significantly lower and muscle weight and total bone density were significantly higher than in the untreated group.ConclusionsM1 macrophage infiltration exacerbates muscle/bone atrophy after peripheral nerve injury. By suppressing M1 macrophages at the neural injury local site, muscle/bone atrophy could be avoided.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12891-020-3069-z", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024957", 
        "issn": [
          "1471-2474"
        ], 
        "name": "BMC Musculoskeletal Disorders", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "keywords": [
      "M1 macrophage infiltration", 
      "peripheral nerve injury", 
      "total bone density", 
      "nerve injury", 
      "macrophage infiltration", 
      "M1 macrophages", 
      "bone atrophy", 
      "bone density", 
      "muscle/bone", 
      "muscle weight", 
      "untreated group", 
      "chronic constriction injury (CCI) mouse model", 
      "control group", 
      "intravital microscopy", 
      "injury mouse model", 
      "neuropathic pain drugs", 
      "loxoprofen group", 
      "neurogenic inflammation", 
      "CCI group", 
      "chronic pain", 
      "macrophage depletion", 
      "osteoclast number", 
      "pain drugs", 
      "mouse model", 
      "immunohistochemical analysis", 
      "atrophy", 
      "injury", 
      "flow cytometry", 
      "macrophages", 
      "depletion group", 
      "weeks", 
      "infiltration", 
      "significant reduction", 
      "CCI", 
      "bone", 
      "group", 
      "pain", 
      "inflammation", 
      "pregabalin", 
      "dexamethasone", 
      "mice", 
      "weight", 
      "cytometry", 
      "drugs", 
      "muscle", 
      "local sites", 
      "administration model", 
      "cells", 
      "depletion", 
      "factors", 
      "control", 
      "reduction", 
      "mechanism", 
      "sites", 
      "number", 
      "main factors", 
      "analysis", 
      "model", 
      "microscopy", 
      "density", 
      "influence"
    ], 
    "name": "M1 macrophage infiltration exacerbate muscle/bone atrophy after peripheral nerve injury", 
    "pagination": "44", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1124199708"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12891-020-3069-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31959156"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12891-020-3069-z", 
      "https://app.dimensions.ai/details/publication/pub.1124199708"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_845.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12891-020-3069-z"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

200 TRIPLES      22 PREDICATES      98 URIs      87 LITERALS      15 BLANK NODES