Effects of mesenchymal stromal cells versus serum on tendon healing in a controlled experimental trial in an equine model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-07-18

AUTHORS

A. B. Ahrberg, C. Horstmeier, D. Berner, W. Brehm, C. Gittel, A. Hillmann, C. Josten, G. Rossi, S. Schubert, K. Winter, J. Burk

ABSTRACT

BackgroundMesenchymal stromal cells (MSC) have shown promising results in the treatment of tendinopathy in equine medicine, making this therapeutic approach seem favorable for translation to human medicine. Having demonstrated that MSC engraft within the tendon lesions after local injection in an equine model, we hypothesized that they would improve tendon healing superior to serum injection alone.MethodsQuadrilateral tendon lesions were induced in six horses by mechanical tissue disruption combined with collagenase application 3 weeks before treatment. Adipose-derived MSC suspended in serum or serum alone were then injected intralesionally. Clinical examinations, ultrasound and magnetic resonance imaging were performed over 24 weeks. Tendon biopsies for histological assessment were taken from the hindlimbs 3 weeks after treatment. Horses were sacrificed after 24 weeks and forelimb tendons were subjected to macroscopic and histological examination as well as analysis of musculoskeletal marker expression.ResultsTendons injected with MSC showed a transient increase in inflammation and lesion size, as indicated by clinical and imaging parameters between week 3 and 6 (p < 0.05). Thereafter, symptoms decreased in both groups and, except that in MSC-treated tendons, mean lesion signal intensity as seen in T2w magnetic resonance imaging and cellularity as seen in the histology (p < 0.05) were lower, no major differences could be found at week 24.ConclusionsThese data suggest that MSC have influenced the inflammatory reaction in a way not described in tendinopathy studies before. However, at the endpoint of the current study, 24 weeks after treatment, no distinct improvement was observed in MSC-treated tendons compared to the serum-injected controls. Future studies are necessary to elucidate whether and under which conditions MSC are beneficial for tendon healing before translation into human medicine. More... »

PAGES

230

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12891-018-2163-y

DOI

http://dx.doi.org/10.1186/s12891-018-2163-y

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https://app.dimensions.ai/details/publication/pub.1105679275

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30021608


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51 engraft
52 equine medicine
53 equine model
54 examination
55 experimental trials
56 expression
57 forelimb tendons
58 future studies
59 group
60 healing
61 histological assessment
62 histological examination
63 histology
64 horses
65 human medicine
66 imaging
67 improvement
68 increase
69 inflammation
70 inflammatory reaction
71 injection
72 intensity
73 lesion signal intensity
74 lesion size
75 lesions
76 local injection
77 magnetic resonance imaging
78 major differences
79 marker expression
80 mechanical tissue disruption
81 medicine
82 mesenchymal stromal cells
83 model
84 parameters
85 promising results
86 reaction
87 resonance imaging
88 results
89 serum
90 serum injection
91 signal intensity
92 size
93 stromal cells
94 study
95 symptoms
96 tendinopathy
97 tendon
98 tendon biopsies
99 tendon healing
100 tendon lesions
101 therapeutic approaches
102 tissue disruption
103 transient increase
104 translation
105 treatment
106 treatment of tendinopathy
107 trials
108 ultrasound
109 way
110 week 3
111 weeks
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