Triweekly administration of parathyroid hormone (1–34) accelerates bone healing in a rat refractory fracture model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12-21

AUTHORS

Yohei Kumabe, Sang Yang Lee, Takahiro Waki, Takashi Iwakura, Shunsuke Takahara, Michio Arakura, Yu Kuroiwa, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda, Takahiro Niikura

ABSTRACT

BACKGROUND: Some reports have shown that intermittent parathyroid hormone (PTH) (1-34) treatment for patients with delayed union or nonunion have led to successful healing. In this study, we investigated whether systemic intermittent administration of PTH (1-34) has a beneficial effect on bone healing in a rat refractory fracture model. METHODS: We created a refractory femoral fracture model in 32 rats with periosteal cauterization that leads to atrophic nonunion at 8 weeks after surgery. Half the rats received subcutaneous intermittent human PTH (1-34) injections at a dosage of 100 μg/kg, thrice a week for 8 weeks. The other half received the vehicle only. At 8 weeks after fracture, radiographic, histological and mechanical assessments were performed. RESULTS: Radiographic assessments showed that the union rate was significantly higher in the PTH group than in the control group (P < 0.05). The degree of fracture repair as scored using the Allen grading system in histological assessment was significantly greater in the PTH group than in the control group (P < 0.05). The ultimate stress and stiffness measurements were significantly greater in the PTH group than in the control group (p < 0.05). CONCLUSIONS: We demonstrated that triweekly administration of PTH (1-34) increased union rate and accelerated bone healing in a rat refractory fracture model, suggesting that systemic administration of PTH (1-34) could become a novel and useful therapy for accelerating fracture healing in patients at high risk of delayed union or nonunion. More... »

PAGES

545

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12891-017-1917-2

DOI

http://dx.doi.org/10.1186/s12891-017-1917-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099730024

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29268728


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22 schema:description BACKGROUND: Some reports have shown that intermittent parathyroid hormone (PTH) (1-34) treatment for patients with delayed union or nonunion have led to successful healing. In this study, we investigated whether systemic intermittent administration of PTH (1-34) has a beneficial effect on bone healing in a rat refractory fracture model. METHODS: We created a refractory femoral fracture model in 32 rats with periosteal cauterization that leads to atrophic nonunion at 8 weeks after surgery. Half the rats received subcutaneous intermittent human PTH (1-34) injections at a dosage of 100 μg/kg, thrice a week for 8 weeks. The other half received the vehicle only. At 8 weeks after fracture, radiographic, histological and mechanical assessments were performed. RESULTS: Radiographic assessments showed that the union rate was significantly higher in the PTH group than in the control group (P < 0.05). The degree of fracture repair as scored using the Allen grading system in histological assessment was significantly greater in the PTH group than in the control group (P < 0.05). The ultimate stress and stiffness measurements were significantly greater in the PTH group than in the control group (p < 0.05). CONCLUSIONS: We demonstrated that triweekly administration of PTH (1-34) increased union rate and accelerated bone healing in a rat refractory fracture model, suggesting that systemic administration of PTH (1-34) could become a novel and useful therapy for accelerating fracture healing in patients at high risk of delayed union or nonunion.
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29 schema:keywords Allen grading system
30 PTH
31 PTH group
32 PTH injection
33 Union
34 administration
35 assessment
36 atrophic nonunion
37 beneficial effects
38 bone healing
39 cauterization
40 control group
41 degree
42 dosage
43 effect
44 femoral fracture model
45 fracture healing
46 fracture model
47 fracture repair
48 fractures
49 grading system
50 group
51 half
52 healing
53 high risk
54 histological assessment
55 hormone
56 hormone treatment
57 human PTH (1-34) injections
58 injection
59 intermittent administration
60 intermittent human PTH (1-34) injections
61 intermittent parathyroid hormone treatment
62 measurements
63 mechanical assessment
64 model
65 nonunion
66 parathyroid hormone
67 parathyroid hormone treatment
68 patients
69 periosteal cauterization
70 radiographic assessment
71 rat refractory fracture model
72 rate
73 rats
74 refractory femoral fracture model
75 refractory fracture model
76 repair
77 report
78 risk
79 stiffness measurement
80 stress
81 study
82 subcutaneous intermittent human PTH (1-34) injections
83 successful healing
84 surgery
85 system
86 systemic administration
87 systemic intermittent administration
88 therapy
89 thrice
90 treatment
91 triweekly administration
92 ultimate stress
93 union rate
94 useful therapy
95 vehicles
96 weeks
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