The efficacy of local continuous chemotherapy and postural drainage in combination with one-stage posterior surgery for the treatment of lumbar ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-02-09

AUTHORS

Yongchun Zhou, Zongrang Song, Jing Luo, Jijun Liu, Yunfei Huang, Yibin Meng, Wentao Wang, Dingjun Hao

ABSTRACT

BACKGROUND: The objective of this study was to compare the outcomes of one-stage posterior surgery involving debridement, bone grafting, and instrumentation with and without local continuous chemotherapy and postural drainage for the treatment of lumbar spinal tuberculosis. METHODS: From January 2009 to January 2013, 109 patients with lumbar spinal tuberculosis were treated in our center using a posterior surgical approach. Patients underwent one-stage posterior debridement, bone grafting, and instrumentation, without (group A) and with (group B) local continuous chemotherapy and postural drainage. Clinical and radiographic results for the two groups were analyzed and compared. Clinical efficacy was evaluated based on surgery duration and blood loss. The Frankel scale was used to evaluate neurological function. A visual analog scale was used to assess low back pain. Bone graft fusion and instrumentation failure were monitored by radiography, and tuberculosis activity was monitored by erythrocyte sedimentation rate (ESR) and C-reactive protein testing. RESULTS: Groups A and B contained 52 and 57 patients, respectively. Patients were followed for 18-36 (mean, 26.64 ± 4.2) months. All bone grafts ultimately fused, but the fusion rate was significantly more rapid in group B [6.4 ± 0.5 (range, 5-10) months] than in group A [8.9 ± 0.6 (range, 6-12) months; P < 0.05]. At 6 weeks postoperatively, ESR levels differed significantly between groups A and B (24.6 ± 1.5 vs. 16.3 ± 1.1 mm/h; P < 0.05). ESR levels normalized in both groups at 16 weeks. CONCLUSIONS: Local continuous chemotherapy and postural drainage effectively eliminated infection foci caused by abscess remnants and accelerated interbody bone fusion in patients with lumbar spinal tuberculosis undergoing one-stage posterior surgery involving debridement, bone grafting, and instrumentation. More... »

PAGES

66

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12891-016-0921-2

DOI

http://dx.doi.org/10.1186/s12891-016-0921-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030773874

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26862044


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antitubercular Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Loss, Surgical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Screws", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Debridement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drainage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lumbar Vertebrae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Operative Time", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Orthopedic Procedures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osseointegration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patient Positioning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, X-Ray Computed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tuberculosis, Spinal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.452452.0", 
          "name": [
            "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Yongchun", 
        "id": "sg:person.0700133504.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700133504.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.452452.0", 
          "name": [
            "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Zongrang", 
        "id": "sg:person.0773656013.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773656013.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.452452.0", 
          "name": [
            "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luo", 
        "givenName": "Jing", 
        "id": "sg:person.01041771213.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041771213.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.452452.0", 
          "name": [
            "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Jijun", 
        "id": "sg:person.01000740361.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000740361.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.452452.0", 
          "name": [
            "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Yunfei", 
        "id": "sg:person.012217575711.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012217575711.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.452452.0", 
          "name": [
            "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meng", 
        "givenName": "Yibin", 
        "id": "sg:person.015444243515.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015444243515.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.452452.0", 
          "name": [
            "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Wentao", 
        "id": "sg:person.01272446213.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272446213.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/grid.452452.0", 
          "name": [
            "Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hao", 
        "givenName": "Dingjun", 
        "id": "sg:person.012777353465.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012777353465.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00402-012-1473-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042220216", 
          "https://doi.org/10.1007/s00402-012-1473-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00402-013-1751-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013183640", 
          "https://doi.org/10.1007/s00402-013-1751-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00264-009-0758-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037945568", 
          "https://doi.org/10.1007/s00264-009-0758-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00264-011-1390-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012043045", 
          "https://doi.org/10.1007/s00264-011-1390-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00586-002-0403-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075274255", 
          "https://doi.org/10.1007/s00586-002-0403-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00402-013-1722-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022773136", 
          "https://doi.org/10.1007/s00402-013-1722-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00586-011-2049-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039809081", 
          "https://doi.org/10.1007/s00586-011-2049-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-02-09", 
    "datePublishedReg": "2016-02-09", 
    "description": "BACKGROUND: The objective of this study was to compare the outcomes of one-stage posterior surgery involving debridement, bone grafting, and instrumentation with and without local continuous chemotherapy and postural drainage for the treatment of lumbar spinal tuberculosis.\nMETHODS: From January 2009 to January 2013, 109 patients with lumbar spinal tuberculosis were treated in our center using a posterior surgical approach. Patients underwent one-stage posterior debridement, bone grafting, and instrumentation, without (group A) and with (group B) local continuous chemotherapy and postural drainage. Clinical and radiographic results for the two groups were analyzed and compared. Clinical efficacy was evaluated based on surgery duration and blood loss. The Frankel scale was used to evaluate neurological function. A visual analog scale was used to assess low back pain. Bone graft fusion and instrumentation failure were monitored by radiography, and tuberculosis activity was monitored by erythrocyte sedimentation rate (ESR) and C-reactive protein testing.\nRESULTS: Groups A and B contained 52 and 57 patients, respectively. Patients were followed for 18-36 (mean, 26.64\u2009\u00b1\u20094.2) months. All bone grafts ultimately fused, but the fusion rate was significantly more rapid in group B [6.4\u2009\u00b1\u20090.5 (range, 5-10) months] than in group A [8.9\u2009\u00b1\u20090.6 (range, 6-12) months; P\u2009<\u20090.05]. At 6\u00a0weeks postoperatively, ESR levels differed significantly between groups A and B (24.6\u2009\u00b1\u20091.5 vs. 16.3\u2009\u00b1\u20091.1\u00a0mm/h; P\u2009<\u20090.05). ESR levels normalized in both groups at 16\u00a0weeks.\nCONCLUSIONS: Local continuous chemotherapy and postural drainage effectively eliminated infection foci caused by abscess remnants and accelerated interbody bone fusion in patients with lumbar spinal tuberculosis undergoing one-stage posterior surgery involving debridement, bone grafting, and instrumentation.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12891-016-0921-2", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024957", 
        "issn": [
          "1471-2474"
        ], 
        "name": "BMC Musculoskeletal Disorders", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "keywords": [
      "one-stage posterior surgery", 
      "lumbar spinal tuberculosis", 
      "erythrocyte sedimentation rate", 
      "spinal tuberculosis", 
      "postural drainage", 
      "continuous chemotherapy", 
      "posterior surgery", 
      "bone grafting", 
      "group A", 
      "ESR levels", 
      "one-stage posterior debridement", 
      "posterior surgical approach", 
      "low back pain", 
      "visual analog scale", 
      "reactive protein testing", 
      "bone graft fusion", 
      "Frankel scale", 
      "posterior debridement", 
      "blood loss", 
      "radiographic results", 
      "back pain", 
      "clinical efficacy", 
      "neurological function", 
      "analog scale", 
      "surgical approach", 
      "graft fusion", 
      "instrumentation failure", 
      "group B", 
      "bone fusion", 
      "surgery duration", 
      "patients", 
      "chemotherapy", 
      "bone graft", 
      "fusion rate", 
      "protein testing", 
      "debridement", 
      "tuberculosis activity", 
      "surgery", 
      "tuberculosis", 
      "infection foci", 
      "weeks", 
      "efficacy", 
      "sedimentation rate", 
      "drainage", 
      "treatment", 
      "grafting", 
      "pain", 
      "group", 
      "graft", 
      "months", 
      "outcomes", 
      "radiography", 
      "levels", 
      "duration", 
      "rate", 
      "failure", 
      "fusion", 
      "testing", 
      "activity", 
      "study", 
      "center", 
      "instrumentation", 
      "loss", 
      "scale", 
      "objective", 
      "combination", 
      "function", 
      "remnants", 
      "focus", 
      "results", 
      "approach", 
      "local continuous chemotherapy", 
      "abscess remnants", 
      "interbody bone fusion"
    ], 
    "name": "The efficacy of local continuous chemotherapy and postural drainage in combination with one-stage posterior surgery for the treatment of lumbar spinal tuberculosis", 
    "pagination": "66", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030773874"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12891-016-0921-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26862044"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12891-016-0921-2", 
      "https://app.dimensions.ai/details/publication/pub.1030773874"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_700.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12891-016-0921-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12891-016-0921-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12891-016-0921-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12891-016-0921-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12891-016-0921-2'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      22 PREDICATES      131 URIs      116 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12891-016-0921-2 schema:about N0e0c224396304eefb65d43281dd02ab5
2 N23ed385a0023435b8c35c4162999db04
3 N24f06f8e84a0418c932b39cb4e85c033
4 N32cedbe2a0fb43209afb5e18e65f6ca3
5 N4a1cb77f7443430fa71477f14473280f
6 N5201c547f72447b2a5034d6581b5ae75
7 N5b79bfa693b04198acc30657fd68702a
8 N5f7f25f6958c4a0394e11509283490cf
9 N75e14349eb774a5390652d49c15d63e7
10 N772b66bac5be41c291317ec0f1ac2b19
11 N862175ad4d444dd9a20bcd3661166b95
12 N9f540b77529b42e6bbf19a4f9feb4bec
13 Na32a909010074b798439d9869b447735
14 Na840af92c363461f80d9c15dc40e60de
15 Nbbeb6a54c8fb4a58aa4b32a468c7358c
16 Nc804e7d4ffa94606809c07c9aa493432
17 Nce7cea6b9bc04e61b462600f9a66e70a
18 Ndd804fc88a544c6e9115d5887cb8b1b2
19 Ndfe723c5413a4b8a824fa14f9f54a805
20 Ne8eba6b6427040f7b19dc6c00008edcd
21 Nea84de9ee6e249e1afc6656fec99d60c
22 Neacba1c077f645a7bcff408014d11a91
23 Neb5d564b7a0d4c3fb619ab90f7bc4029
24 Nfe72fa62b14a4441ac63413af5cbbc5f
25 anzsrc-for:11
26 anzsrc-for:1103
27 schema:author Na8cc2dad3f1841d7a6d84508f850bf00
28 schema:citation sg:pub.10.1007/s00264-009-0758-5
29 sg:pub.10.1007/s00264-011-1390-8
30 sg:pub.10.1007/s00402-012-1473-z
31 sg:pub.10.1007/s00402-013-1722-9
32 sg:pub.10.1007/s00402-013-1751-4
33 sg:pub.10.1007/s00586-002-0403-0
34 sg:pub.10.1007/s00586-011-2049-2
35 schema:datePublished 2016-02-09
36 schema:datePublishedReg 2016-02-09
37 schema:description BACKGROUND: The objective of this study was to compare the outcomes of one-stage posterior surgery involving debridement, bone grafting, and instrumentation with and without local continuous chemotherapy and postural drainage for the treatment of lumbar spinal tuberculosis. METHODS: From January 2009 to January 2013, 109 patients with lumbar spinal tuberculosis were treated in our center using a posterior surgical approach. Patients underwent one-stage posterior debridement, bone grafting, and instrumentation, without (group A) and with (group B) local continuous chemotherapy and postural drainage. Clinical and radiographic results for the two groups were analyzed and compared. Clinical efficacy was evaluated based on surgery duration and blood loss. The Frankel scale was used to evaluate neurological function. A visual analog scale was used to assess low back pain. Bone graft fusion and instrumentation failure were monitored by radiography, and tuberculosis activity was monitored by erythrocyte sedimentation rate (ESR) and C-reactive protein testing. RESULTS: Groups A and B contained 52 and 57 patients, respectively. Patients were followed for 18-36 (mean, 26.64 ± 4.2) months. All bone grafts ultimately fused, but the fusion rate was significantly more rapid in group B [6.4 ± 0.5 (range, 5-10) months] than in group A [8.9 ± 0.6 (range, 6-12) months; P < 0.05]. At 6 weeks postoperatively, ESR levels differed significantly between groups A and B (24.6 ± 1.5 vs. 16.3 ± 1.1 mm/h; P < 0.05). ESR levels normalized in both groups at 16 weeks. CONCLUSIONS: Local continuous chemotherapy and postural drainage effectively eliminated infection foci caused by abscess remnants and accelerated interbody bone fusion in patients with lumbar spinal tuberculosis undergoing one-stage posterior surgery involving debridement, bone grafting, and instrumentation.
38 schema:genre article
39 schema:inLanguage en
40 schema:isAccessibleForFree true
41 schema:isPartOf N578f4741e37b4ef996478470e7acd926
42 Nb9f80a506a3b4a16a5531c6d6d007ca2
43 sg:journal.1024957
44 schema:keywords ESR levels
45 Frankel scale
46 abscess remnants
47 activity
48 analog scale
49 approach
50 back pain
51 blood loss
52 bone fusion
53 bone graft
54 bone graft fusion
55 bone grafting
56 center
57 chemotherapy
58 clinical efficacy
59 combination
60 continuous chemotherapy
61 debridement
62 drainage
63 duration
64 efficacy
65 erythrocyte sedimentation rate
66 failure
67 focus
68 function
69 fusion
70 fusion rate
71 graft
72 graft fusion
73 grafting
74 group
75 group A
76 group B
77 infection foci
78 instrumentation
79 instrumentation failure
80 interbody bone fusion
81 levels
82 local continuous chemotherapy
83 loss
84 low back pain
85 lumbar spinal tuberculosis
86 months
87 neurological function
88 objective
89 one-stage posterior debridement
90 one-stage posterior surgery
91 outcomes
92 pain
93 patients
94 posterior debridement
95 posterior surgery
96 posterior surgical approach
97 postural drainage
98 protein testing
99 radiographic results
100 radiography
101 rate
102 reactive protein testing
103 remnants
104 results
105 scale
106 sedimentation rate
107 spinal tuberculosis
108 study
109 surgery
110 surgery duration
111 surgical approach
112 testing
113 treatment
114 tuberculosis
115 tuberculosis activity
116 visual analog scale
117 weeks
118 schema:name The efficacy of local continuous chemotherapy and postural drainage in combination with one-stage posterior surgery for the treatment of lumbar spinal tuberculosis
119 schema:pagination 66
120 schema:productId N5010a3fd2ad54cdda4c415acfefb0d8f
121 N5aae7021aa5e46abb6f9ac090046dfde
122 Nc3cd06ca980c4e129aa8bfad3cfd210f
123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030773874
124 https://doi.org/10.1186/s12891-016-0921-2
125 schema:sdDatePublished 2022-01-01T18:40
126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
127 schema:sdPublisher N8025af8b74024180a0232dd3bd8268af
128 schema:url https://doi.org/10.1186/s12891-016-0921-2
129 sgo:license sg:explorer/license/
130 sgo:sdDataset articles
131 rdf:type schema:ScholarlyArticle
132 N0e0c224396304eefb65d43281dd02ab5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Middle Aged
134 rdf:type schema:DefinedTerm
135 N128a59cf4d4849658b62ef9eb8cf7c48 rdf:first sg:person.012217575711.34
136 rdf:rest N96c1fdf6035b47c6bc8c3cfb17e453aa
137 N23ed385a0023435b8c35c4162999db04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Combined Modality Therapy
139 rdf:type schema:DefinedTerm
140 N24f06f8e84a0418c932b39cb4e85c033 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Young Adult
142 rdf:type schema:DefinedTerm
143 N302a32b148bc485c9a60c00433df5dab rdf:first sg:person.01272446213.08
144 rdf:rest Na9385d10f450491b9a341e2e2f84ec65
145 N32cedbe2a0fb43209afb5e18e65f6ca3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Adult
147 rdf:type schema:DefinedTerm
148 N444d31ac234545ad909e86b931949e34 rdf:first sg:person.0773656013.23
149 rdf:rest Nfc5b0294326e4cd68c0dbabd2d205224
150 N4a1cb77f7443430fa71477f14473280f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Drainage
152 rdf:type schema:DefinedTerm
153 N5010a3fd2ad54cdda4c415acfefb0d8f schema:name doi
154 schema:value 10.1186/s12891-016-0921-2
155 rdf:type schema:PropertyValue
156 N5201c547f72447b2a5034d6581b5ae75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Patient Positioning
158 rdf:type schema:DefinedTerm
159 N578f4741e37b4ef996478470e7acd926 schema:issueNumber 1
160 rdf:type schema:PublicationIssue
161 N5aae7021aa5e46abb6f9ac090046dfde schema:name pubmed_id
162 schema:value 26862044
163 rdf:type schema:PropertyValue
164 N5b79bfa693b04198acc30657fd68702a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Aged
166 rdf:type schema:DefinedTerm
167 N5f7f25f6958c4a0394e11509283490cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Antitubercular Agents
169 rdf:type schema:DefinedTerm
170 N75e14349eb774a5390652d49c15d63e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Magnetic Resonance Imaging
172 rdf:type schema:DefinedTerm
173 N772b66bac5be41c291317ec0f1ac2b19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Tomography, X-Ray Computed
175 rdf:type schema:DefinedTerm
176 N8025af8b74024180a0232dd3bd8268af schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 N862175ad4d444dd9a20bcd3661166b95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Blood Loss, Surgical
180 rdf:type schema:DefinedTerm
181 N96c1fdf6035b47c6bc8c3cfb17e453aa rdf:first sg:person.015444243515.82
182 rdf:rest N302a32b148bc485c9a60c00433df5dab
183 N9f540b77529b42e6bbf19a4f9feb4bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Treatment Outcome
185 rdf:type schema:DefinedTerm
186 Na32a909010074b798439d9869b447735 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Orthopedic Procedures
188 rdf:type schema:DefinedTerm
189 Na840af92c363461f80d9c15dc40e60de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Humans
191 rdf:type schema:DefinedTerm
192 Na8cc2dad3f1841d7a6d84508f850bf00 rdf:first sg:person.0700133504.72
193 rdf:rest N444d31ac234545ad909e86b931949e34
194 Na9385d10f450491b9a341e2e2f84ec65 rdf:first sg:person.012777353465.36
195 rdf:rest rdf:nil
196 Nb9f80a506a3b4a16a5531c6d6d007ca2 schema:volumeNumber 17
197 rdf:type schema:PublicationVolume
198 Nbbeb6a54c8fb4a58aa4b32a468c7358c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Operative Time
200 rdf:type schema:DefinedTerm
201 Nc3cd06ca980c4e129aa8bfad3cfd210f schema:name dimensions_id
202 schema:value pub.1030773874
203 rdf:type schema:PropertyValue
204 Nc804e7d4ffa94606809c07c9aa493432 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Bone Screws
206 rdf:type schema:DefinedTerm
207 Nce7cea6b9bc04e61b462600f9a66e70a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Debridement
209 rdf:type schema:DefinedTerm
210 Ncec0c6bd2b944295aae9e592be46f0e7 rdf:first sg:person.01000740361.37
211 rdf:rest N128a59cf4d4849658b62ef9eb8cf7c48
212 Ndd804fc88a544c6e9115d5887cb8b1b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Lumbar Vertebrae
214 rdf:type schema:DefinedTerm
215 Ndfe723c5413a4b8a824fa14f9f54a805 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Bone Transplantation
217 rdf:type schema:DefinedTerm
218 Ne8eba6b6427040f7b19dc6c00008edcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Osseointegration
220 rdf:type schema:DefinedTerm
221 Nea84de9ee6e249e1afc6656fec99d60c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Female
223 rdf:type schema:DefinedTerm
224 Neacba1c077f645a7bcff408014d11a91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Tuberculosis, Spinal
226 rdf:type schema:DefinedTerm
227 Neb5d564b7a0d4c3fb619ab90f7bc4029 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
228 schema:name Time Factors
229 rdf:type schema:DefinedTerm
230 Nfc5b0294326e4cd68c0dbabd2d205224 rdf:first sg:person.01041771213.13
231 rdf:rest Ncec0c6bd2b944295aae9e592be46f0e7
232 Nfe72fa62b14a4441ac63413af5cbbc5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Male
234 rdf:type schema:DefinedTerm
235 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
236 schema:name Medical and Health Sciences
237 rdf:type schema:DefinedTerm
238 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
239 schema:name Clinical Sciences
240 rdf:type schema:DefinedTerm
241 sg:journal.1024957 schema:issn 1471-2474
242 schema:name BMC Musculoskeletal Disorders
243 schema:publisher Springer Nature
244 rdf:type schema:Periodical
245 sg:person.01000740361.37 schema:affiliation grid-institutes:grid.452452.0
246 schema:familyName Liu
247 schema:givenName Jijun
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000740361.37
249 rdf:type schema:Person
250 sg:person.01041771213.13 schema:affiliation grid-institutes:grid.452452.0
251 schema:familyName Luo
252 schema:givenName Jing
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041771213.13
254 rdf:type schema:Person
255 sg:person.012217575711.34 schema:affiliation grid-institutes:grid.452452.0
256 schema:familyName Huang
257 schema:givenName Yunfei
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012217575711.34
259 rdf:type schema:Person
260 sg:person.01272446213.08 schema:affiliation grid-institutes:grid.452452.0
261 schema:familyName Wang
262 schema:givenName Wentao
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272446213.08
264 rdf:type schema:Person
265 sg:person.012777353465.36 schema:affiliation grid-institutes:grid.452452.0
266 schema:familyName Hao
267 schema:givenName Dingjun
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012777353465.36
269 rdf:type schema:Person
270 sg:person.015444243515.82 schema:affiliation grid-institutes:grid.452452.0
271 schema:familyName Meng
272 schema:givenName Yibin
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015444243515.82
274 rdf:type schema:Person
275 sg:person.0700133504.72 schema:affiliation grid-institutes:grid.452452.0
276 schema:familyName Zhou
277 schema:givenName Yongchun
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700133504.72
279 rdf:type schema:Person
280 sg:person.0773656013.23 schema:affiliation grid-institutes:grid.452452.0
281 schema:familyName Song
282 schema:givenName Zongrang
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773656013.23
284 rdf:type schema:Person
285 sg:pub.10.1007/s00264-009-0758-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037945568
286 https://doi.org/10.1007/s00264-009-0758-5
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/s00264-011-1390-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012043045
289 https://doi.org/10.1007/s00264-011-1390-8
290 rdf:type schema:CreativeWork
291 sg:pub.10.1007/s00402-012-1473-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1042220216
292 https://doi.org/10.1007/s00402-012-1473-z
293 rdf:type schema:CreativeWork
294 sg:pub.10.1007/s00402-013-1722-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022773136
295 https://doi.org/10.1007/s00402-013-1722-9
296 rdf:type schema:CreativeWork
297 sg:pub.10.1007/s00402-013-1751-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013183640
298 https://doi.org/10.1007/s00402-013-1751-4
299 rdf:type schema:CreativeWork
300 sg:pub.10.1007/s00586-002-0403-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075274255
301 https://doi.org/10.1007/s00586-002-0403-0
302 rdf:type schema:CreativeWork
303 sg:pub.10.1007/s00586-011-2049-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039809081
304 https://doi.org/10.1007/s00586-011-2049-2
305 rdf:type schema:CreativeWork
306 grid-institutes:grid.452452.0 schema:alternateName Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University College of Medicine, Xi’an, People’s Republic of China
307 schema:name Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University College of Medicine, Xi’an, People’s Republic of China
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...