Supervised pulmonary hypertension exercise rehabilitation (SPHERe): study protocol for a multi-centre randomised controlled trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-05-19

AUTHORS

Gordon McGregor, Julie Bruce, Stuart Ennis, James Mason, Ranjit Lall, Chen Ji, Harbinder Sandhu, Kate Seers, Prithwish Banerjee, Alastair Canaway, Katie Booth, Stephanie J. C. Taylor, Elizabeth Robertson, Tamar Pincus, Sally Singh, David Fitzmaurice, Sarah Bowater, Paul Clift, Martin Underwood

ABSTRACT

BackgroundSupervised cardio-pulmonary rehabilitation may be safe and beneficial for people with pulmonary hypertension (PH) in groups 1 (pulmonary arterial hypertension) and 4 (chronic thromboembolic disease), particularly as a hospital in-patient. It has not been tested in the most common PH groups; 2 (left heart disease), 3 (lung disease), or 5 (other disorders). Further it has not been evaluated in the UK National Health Service (NHS) out-patient setting, or with long-term follow-up. The aim of this randomised controlled trial (RCT) is to test the clinical and cost-effectiveness of a supervised exercise rehabilitation intervention with psychosocial support compared to best practice usual care for people with PH in the community/outpatient setting.MethodsThis multi-centre, pragmatic, two-arm RCT with embedded process evaluation aims to recruit 352 clinically stable adults with PH (groups 1–5) and WHO functional class II-IV. Participants will be randomised to either the Supervised Pulmonary Hypertension Exercise Rehabilitation (SPHERe) intervention or control. The SPHERe intervention consists of 1) individual assessment and familiarisation sessions; 2) 8-week, twice-weekly, supervised out-patient exercise training; 3) psychosocial/motivational support and education; 4) guided home exercise plan. The control intervention consists of best practice usual care with a single one-to-one practitioner appointment, and general advice on physical activity. Outcomes will be measured at baseline, 4 months (post-intervention) and 12 months by researchers blinded to treatment allocation. The primary outcome is the incremental shuttle walk test at 4 months. Secondary outcomes include health-related quality of life (HRQoL), time to clinical worsening and health and social care use. A purposive sample of participants (n = 20 intervention and n = 20 control) and practitioners (n = 20) will be interviewed to explore experiences of the trial, outcomes and interventions.DiscussionThe SPHERe study is the first multi-centre clinical RCT to assess the clinical and cost effectiveness of a supervised exercise rehabilitation intervention compared to usual care, delivered in the UK NHS, for people in all PH groups. Results will inform clinicians and commissioners as to whether or not supervised exercise rehabilitation is effective and should be routinely provided for people with PH.Trial registrationISRCTN no. 10608766, prospectively registered on 18th March 2019. More... »

PAGES

143

Journal

TITLE

BMC Pulmonary Medicine

ISSUE

1

VOLUME

20

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12890-020-01182-y

DOI

http://dx.doi.org/10.1186/s12890-020-01182-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1127694604

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32429969


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374 rdf:type schema:Organization
375 grid-institutes:grid.4970.a schema:alternateName Department of Psychology, Royal Holloway University of London, London, UK
376 schema:name Department of Psychology, Royal Holloway University of London, London, UK
377 rdf:type schema:Organization
378 grid-institutes:grid.7372.1 schema:alternateName Centre for Health Economics at Warwick, Warwick Medical School, University of Warwick, Coventry, UK
379 Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
380 Warwick Research in Nursing, Warwick Medical School, University of Warwick, Coventry, UK
381 schema:name Centre for Health Economics at Warwick, Warwick Medical School, University of Warwick, Coventry, UK
382 Department of Cardiopulmonary Rehabilitation, Centre for Exercise & Health, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK
383 Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
384 Warwick Research in Nursing, Warwick Medical School, University of Warwick, Coventry, UK
385 rdf:type schema:Organization
386 grid-institutes:grid.8096.7 schema:alternateName Centre for Sport Exercise & Life Sciences, Coventry University, Coventry, UK
387 schema:name Centre for Sport Exercise & Life Sciences, Coventry University, Coventry, UK
388 Department of Cardiopulmonary Rehabilitation, Centre for Exercise & Health, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK
389 Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
390 rdf:type schema:Organization
 




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