Ontology type: schema:ScholarlyArticle Open Access: True
2019-12-30
AUTHORSTetsuya Hanaka, Takashi Kido, Shingo Noguchi, Sohsuke Yamada, Hirotsugu Noguchi, Xin Guo, Aya Nawata, Ke-Yong Wang, Keishi Oda, Tsutomu Takaki, Hiroto Izumi, Hiroshi Ishimoto, Kazuhiro Yatera, Hiroshi Mukae
ABSTRACTBackgroundAcute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is life-threatening. Several serum biomarkers, such as Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D), are clinically used for evaluating AE-IPF, but these biomarkers are not adequate for establishing an early and accurate diagnosis of AE-IPF. Recently, the protective roles of the members of the peroxiredoxin (PRDX) family have been reported in IPF; however, the role of PRDX4 in AE-IPF is unclear.MethodsSerum levels of PRDX4 protein, KL-6, SP-D and lactate dehydrogenase (LDH) in 51 patients with stable IPF (S-IPF), 38 patients with AE-IPF and 15 healthy volunteers were retrospectively assessed using enzyme-linked immunosorbent assay. Moreover, as an animal model of pulmonary fibrosis, wild-type (WT) and PRDX4-transgenic (Tg) mice were intratracheally administered with bleomycin (BLM, 2 mg/kg), and fibrotic and inflammatory changes in lungs were evaluated 3 weeks after the intratracheal administration.ResultsSerum levels of PRDX4 protein, KL-6, SP-D and LDH in patients with S-IPF and AE-IPF were significantly higher than those in healthy volunteers, and those in AE-IPF patients were the highest among the three groups. Using receiver operating characteristic curves, area under the curve values of serum PRDX4 protein, KL-6, SP-D, and LDH for detecting AE-IPF were 0.873, 0.698, 0.675, and 0.906, respectively. BLM-treated Tg mice demonstrated aggravated histopathological findings and poor prognosis compared with BLM-treated WT mice. Moreover, PRDX4 expression was observed in alveolar macrophages and lung epithelial cells of BLM-treated Tg mice.ConclusionsPRDX4 is associated with the aggravation of inflammatory changes and fibrosis in the pathogenesis of IPF, and serum PRDX4 may be useful in clinical practice of IPF patients. More... »
PAGES265
http://scigraph.springernature.com/pub.10.1186/s12890-019-1032-2
DOIhttp://dx.doi.org/10.1186/s12890-019-1032-2
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1123732001
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/31888585
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease Models, Animal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease Progression",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Idiopathic Pulmonary Fibrosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Peroxiredoxins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Hanaka",
"givenName": "Tetsuya",
"id": "sg:person.0731742444.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731742444.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Kido",
"givenName": "Takashi",
"id": "sg:person.01211346734.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211346734.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Noguchi",
"givenName": "Shingo",
"id": "sg:person.01347347515.79",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347347515.79"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, 920-0293, Kahoku, Ishikawa, Japan",
"id": "http://www.grid.ac/institutes/grid.411998.c",
"name": [
"Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, 920-0293, Kahoku, Ishikawa, Japan"
],
"type": "Organization"
},
"familyName": "Yamada",
"givenName": "Sohsuke",
"id": "sg:person.01103750361.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103750361.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan",
"id": "http://www.grid.ac/institutes/grid.258333.c",
"name": [
"Department of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan"
],
"type": "Organization"
},
"familyName": "Noguchi",
"givenName": "Hirotsugu",
"id": "sg:person.01340765141.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340765141.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, 920-0293, Kahoku, Ishikawa, Japan",
"id": "http://www.grid.ac/institutes/grid.411998.c",
"name": [
"Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, 920-0293, Kahoku, Ishikawa, Japan"
],
"type": "Organization"
},
"familyName": "Guo",
"givenName": "Xin",
"id": "sg:person.01161712014.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161712014.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Nawata",
"givenName": "Aya",
"id": "sg:person.01327362126.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327362126.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shared-Use Research Center, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Shared-Use Research Center, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Wang",
"givenName": "Ke-Yong",
"id": "sg:person.0616131554.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616131554.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Oda",
"givenName": "Keishi",
"id": "sg:person.01146120052.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146120052.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Takaki",
"givenName": "Tsutomu",
"id": "sg:person.01036021177.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036021177.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Izumi",
"givenName": "Hiroto",
"id": "sg:person.01007122017.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007122017.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.174567.6",
"name": [
"Department of Respiratory Medicine, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Ishimoto",
"givenName": "Hiroshi",
"id": "sg:person.01342450607.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342450607.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Respiratory Medicine, School of Medicine, University of Occupational and Environment Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, 807-8555, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Yatera",
"givenName": "Kazuhiro",
"id": "sg:person.01032646234.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032646234.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.174567.6",
"name": [
"Department of Respiratory Medicine, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Mukae",
"givenName": "Hiroshi",
"id": "sg:person.01143125277.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s12192-013-0411-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022407849",
"https://doi.org/10.1007/s12192-013-0411-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.2749",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007752887",
"https://doi.org/10.1038/nm.2749"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12931-014-0092-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010895859",
"https://doi.org/10.1186/s12931-014-0092-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12890-016-0253-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004735654",
"https://doi.org/10.1186/s12890-016-0253-x"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12-30",
"datePublishedReg": "2019-12-30",
"description": "BackgroundAcute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is life-threatening. Several serum biomarkers, such as Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D), are clinically used for evaluating AE-IPF, but these biomarkers are not adequate for establishing an early and accurate diagnosis of AE-IPF. Recently, the protective roles of the members of the peroxiredoxin (PRDX) family have been reported in IPF; however, the role of PRDX4 in AE-IPF is unclear.MethodsSerum levels of PRDX4 protein, KL-6, SP-D and lactate dehydrogenase (LDH) in 51 patients with stable IPF (S-IPF), 38 patients with AE-IPF and 15 healthy volunteers were retrospectively assessed using enzyme-linked immunosorbent assay. Moreover, as an animal model of pulmonary fibrosis, wild-type (WT) and PRDX4-transgenic (Tg) mice were intratracheally administered with bleomycin (BLM, 2\u2009mg/kg), and fibrotic and inflammatory changes in lungs were evaluated 3\u2009weeks after the intratracheal administration.ResultsSerum levels of PRDX4 protein, KL-6, SP-D and LDH in patients with S-IPF and AE-IPF were significantly higher than those in healthy volunteers, and those in AE-IPF patients were the highest among the three groups. Using receiver operating characteristic curves, area under the curve values of serum PRDX4 protein, KL-6, SP-D, and LDH for detecting AE-IPF were 0.873, 0.698, 0.675, and 0.906, respectively. BLM-treated Tg mice demonstrated aggravated histopathological findings and poor prognosis compared with BLM-treated WT mice. Moreover, PRDX4 expression was observed in alveolar macrophages and lung epithelial cells of BLM-treated Tg mice.ConclusionsPRDX4 is associated with the aggravation of inflammatory changes and fibrosis in the pathogenesis of IPF, and serum PRDX4 may be useful in clinical practice of IPF patients.",
"genre": "article",
"id": "sg:pub.10.1186/s12890-019-1032-2",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.6835125",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1024955",
"issn": [
"1471-2466"
],
"name": "BMC Pulmonary Medicine",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "19"
}
],
"keywords": [
"Krebs von den Lungen-6",
"AE-IPF",
"idiopathic pulmonary fibrosis",
"pulmonary fibrosis",
"inflammatory changes",
"Tg mice",
"lactate dehydrogenase",
"healthy volunteers",
"AE-IPF patients",
"pathogenesis of IPF",
"enzyme-linked immunosorbent",
"surfactant protein D",
"lung epithelial cells",
"BackgroundAcute exacerbations",
"stable IPF",
"ResultsSerum levels",
"S-IPF",
"IPF patients",
"Lungen-6",
"MethodsSerum levels",
"histopathological findings",
"WT mice",
"poor prognosis",
"intratracheal administration",
"serum biomarkers",
"animal models",
"patients",
"PRDX4 expression",
"clinical practice",
"protective role",
"alveolar macrophages",
"accurate diagnosis",
"fibrosis",
"mice",
"protein D",
"epithelial cells",
"curve values",
"IPF",
"characteristic curve",
"peroxiredoxin 4",
"biomarkers",
"volunteers",
"peroxiredoxin family",
"PRDX4",
"exacerbation",
"prognosis",
"lung",
"pathogenesis",
"immunosorbent",
"bleomycin",
"diagnosis",
"macrophages",
"administration",
"BLM",
"protein",
"progression",
"weeks",
"aggravation",
"levels",
"role",
"overexpression",
"cells",
"group",
"changes",
"expression",
"findings",
"dehydrogenase",
"family",
"practice",
"members",
"receiver",
"curves",
"area",
"values",
"sp",
"model"
],
"name": "The overexpression of peroxiredoxin-4 affects the progression of idiopathic pulmonary fibrosis",
"pagination": "265",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1123732001"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12890-019-1032-2"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"31888585"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12890-019-1032-2",
"https://app.dimensions.ai/details/publication/pub.1123732001"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:09",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_815.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/s12890-019-1032-2"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12890-019-1032-2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12890-019-1032-2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12890-019-1032-2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12890-019-1032-2'
This table displays all metadata directly associated to this object as RDF triples.
316 TRIPLES
21 PREDICATES
119 URIs
107 LITERALS
21 BLANK NODES