Diagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome View Full Text


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Article Info

DATE

2019-06-25

AUTHORS

Jee-min Kim, Jung-Kyu Lee, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sang-Min Lee

ABSTRACT

BackgroundWe aimed to evaluate whether serum activin-A levels are elevated and have any value in predicting severity and prognosis in acute respiratory distress syndrome (ARDS).MethodsRetrospective cohort study was performed with patients who were admitted to MICU with diagnosis of ARDS and have serum samples stored within 48 h of Intensive care unit (ICU) admission between March 2013 and December 2016 at a single tertiary referral hospital. Serum activin-A levels were measured with ELISA kit, and were compared with those of normal healthy control and non-ARDS sepsis patients.ResultsTotal 97 ARDS patients were included for the study. Levels of Activin-A were elevated in ARDS patients compared to those of healthy controls (Log-transformed activin-A levels 2.89 ± 0.36 vs. 2.34 ± 0.11, p < 0.001, absolute activin-A levels 1525.6 ± 1060.98 vs. 225.9 ± 30.1, p = 0.016) and non-ARDS sepsis patients (Log-transformed activin-A levels 2.89 ± 0.36 vs. 2.73 ± 0.34, p = 0.002, Absolute activin-A levels 1525.6 ± 1060.98 vs. 754.8 ± 123.5 pg/mL, p = 0.036). When excluding five outliers with extremely high activin-A levels, activin-A showed statistically significant correlation with in-hospital mortalities (In-hospital survivors 676.2 ± 407 vs. non-survivors 897.9 ± 561.9 pg/mL, p = 0.047). In predicting in-hospital mortality, serum activin-A concentrations showed superior area under curve compared to that of Acute physiologic and chronic health evaluation II scores (0.653; 95% CI [0541, 0.765] vs. 0.591, 95% CI [0.471, 0.710]). With cut-off level of 708 pg/mL, those with high serum activin-A levels had more than twofold increased risk of in-hospital mortalities. However, those relations were missing when outliers were in.ConclusionsSerum activin-A levels in ARDS patients are elevated. However, its levels are weakly associated with ARDS outcomes. More... »

PAGES

115

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12890-019-0879-6

DOI

http://dx.doi.org/10.1186/s12890-019-0879-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1117494619

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31238942


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    "description": "BackgroundWe aimed to evaluate whether serum activin-A levels are elevated and have any value in predicting severity and prognosis in acute respiratory distress syndrome (ARDS).MethodsRetrospective cohort study was performed with patients who were admitted to MICU with diagnosis of ARDS and have serum samples stored within 48\u2009h of Intensive care unit (ICU) admission between March 2013 and December 2016 at a single tertiary referral hospital. Serum activin-A levels were measured with ELISA kit, and were compared with those of normal healthy control and non-ARDS sepsis patients.ResultsTotal 97 ARDS patients were included for the study. Levels of Activin-A were elevated in ARDS patients compared to those of healthy controls (Log-transformed activin-A levels 2.89\u2009\u00b1\u20090.36 vs. 2.34\u2009\u00b1\u20090.11, p\u2009<\u20090.001, absolute activin-A levels 1525.6\u2009\u00b1\u20091060.98 vs. 225.9\u2009\u00b1\u200930.1, p\u2009=\u20090.016) and non-ARDS sepsis patients (Log-transformed activin-A levels 2.89\u2009\u00b1\u20090.36 vs. 2.73\u2009\u00b1\u20090.34, p\u2009=\u20090.002, Absolute activin-A levels 1525.6\u2009\u00b1\u20091060.98 vs. 754.8\u2009\u00b1\u2009123.5\u2009pg/mL, p\u2009=\u20090.036). When excluding five outliers with extremely high activin-A levels, activin-A showed statistically significant correlation with in-hospital mortalities (In-hospital survivors 676.2\u2009\u00b1\u2009407 vs. non-survivors 897.9\u2009\u00b1\u2009561.9\u2009pg/mL, p\u2009=\u20090.047). In predicting in-hospital mortality, serum activin-A concentrations showed superior area under curve compared to that of Acute physiologic and chronic health evaluation II scores (0.653; 95% CI [0541, 0.765] vs. 0.591, 95% CI [0.471, 0.710]). With cut-off level of 708\u2009pg/mL, those with high serum activin-A levels had more than twofold increased risk of in-hospital mortalities. However, those relations were missing when outliers were in.ConclusionsSerum activin-A levels in ARDS patients are elevated. However, its levels are weakly associated with ARDS outcomes.", 
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26 schema:description BackgroundWe aimed to evaluate whether serum activin-A levels are elevated and have any value in predicting severity and prognosis in acute respiratory distress syndrome (ARDS).MethodsRetrospective cohort study was performed with patients who were admitted to MICU with diagnosis of ARDS and have serum samples stored within 48 h of Intensive care unit (ICU) admission between March 2013 and December 2016 at a single tertiary referral hospital. Serum activin-A levels were measured with ELISA kit, and were compared with those of normal healthy control and non-ARDS sepsis patients.ResultsTotal 97 ARDS patients were included for the study. Levels of Activin-A were elevated in ARDS patients compared to those of healthy controls (Log-transformed activin-A levels 2.89 ± 0.36 vs. 2.34 ± 0.11, p < 0.001, absolute activin-A levels 1525.6 ± 1060.98 vs. 225.9 ± 30.1, p = 0.016) and non-ARDS sepsis patients (Log-transformed activin-A levels 2.89 ± 0.36 vs. 2.73 ± 0.34, p = 0.002, Absolute activin-A levels 1525.6 ± 1060.98 vs. 754.8 ± 123.5 pg/mL, p = 0.036). When excluding five outliers with extremely high activin-A levels, activin-A showed statistically significant correlation with in-hospital mortalities (In-hospital survivors 676.2 ± 407 vs. non-survivors 897.9 ± 561.9 pg/mL, p = 0.047). In predicting in-hospital mortality, serum activin-A concentrations showed superior area under curve compared to that of Acute physiologic and chronic health evaluation II scores (0.653; 95% CI [0541, 0.765] vs. 0.591, 95% CI [0.471, 0.710]). With cut-off level of 708 pg/mL, those with high serum activin-A levels had more than twofold increased risk of in-hospital mortalities. However, those relations were missing when outliers were in.ConclusionsSerum activin-A levels in ARDS patients are elevated. However, its levels are weakly associated with ARDS outcomes.
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32 schema:keywords ARDS outcome
33 ARDS patients
34 Acute Physiologic
35 BackgroundWe
36 Chronic Health Evaluation II score
37 ELISA kit
38 II score
39 MICU
40 MethodsRetrospective cohort study
41 activin
42 activin A concentrations
43 acute respiratory distress syndrome
44 admission
45 area
46 care unit admission
47 cohort study
48 concentration
49 control
50 correlation
51 curves
52 diagnosis
53 diagnosis of ARDS
54 distress syndrome
55 healthy controls
56 high activin
57 hospital
58 hospital mortality
59 intensive care unit admission
60 kit
61 levels
62 levels of activin
63 mL
64 mortality
65 non-ARDS sepsis patients
66 normal healthy controls
67 outcomes
68 outliers
69 patients
70 pg/mL
71 physiologic
72 prognosis
73 prognostic value
74 referral hospital
75 relation
76 respiratory distress syndrome
77 risk
78 samples
79 scores
80 sepsis patients
81 serum activin
82 serum activin-A concentrations
83 serum samples
84 severity
85 significant correlation
86 single tertiary referral hospital
87 study
88 superior area
89 syndrome
90 tertiary referral hospital
91 unit admission
92 values
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