Risk of acute exacerbations in chronic obstructive pulmonary disease associated with biomass smoke compared with tobacco smoke View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03-22

AUTHORS

Jaeyoung Cho, Chang-Hoon Lee, Seung-sik Hwang, Ki Uk Kim, Sang Haak Lee, Hye Yun Park, Seoung Ju Park, Kyung Hoon Min, Yeon-Mok Oh, Kwang Ha Yoo, Ki-Suck Jung

ABSTRACT

BackgroundRisk of exacerbations in chronic obstructive pulmonary disease (COPD) associated with biomass smoke has not been well addressed, although biomass smoke is similar in composition to tobacco smoke.MethodsTo investigate whether the risk of exacerbations in COPD associated with biomass smoke differs from that in COPD associated with tobacco smoke, we recruited patients with COPD from two Korean multicenter prospective cohorts. In a multiple linear regression model, the standardized regression coefficient (β) of biomass smoke exposure ≥25 years was most similar to that (β′) of tobacco smoke exposure ≥10 pack-years (β = − 0.13 and β′ = − 0.14). We grouped patients with COPD into four categories based on the above cut-offs: Less Tobacco-Less Biomass, Less Tobacco-More Biomass, More Tobacco-Less Biomass, and More Tobacco-More Biomass. The main outcome was the incidence of moderate or severe exacerbations.ResultsAmong 1033 patients with COPD, 107 were included in Less Tobacco-Less Biomass (mean age: 67 years, men: 67%), 40 in Less Tobacco-More Biomass (mean age: 70 years, men: 35%), 631 in More Tobacco-Less Biomass (mean age: 68 years, men: 98%), and 255 in More Tobacco-More Biomass (mean age: 69 years, men: 97%). The incidence rates of exacerbations were not significantly different between Less Tobacco-More Biomass and More Tobacco-Less Biomass (adjusted incidence rate ratio, 1.03; 95% confidence interval, 0.56–1.89; P = 0.921). No interaction between sex and tobacco and biomass smoke was observed. When propensity score matching with available covariates including age and sex was applied, a similar result was observed.ConclusionsPatients with COPD associated with biomass smoke and those with COPD associated with tobacco smoke had a similar risk of exacerbations. This suggests that patients with COPD associated with biomass smoke should be treated actively. More... »

PAGES

68

Journal

TITLE

BMC Pulmonary Medicine

ISSUE

1

VOLUME

19

Author Affiliations

  • Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea
  • Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea
  • Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea
  • Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, St. Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  • Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea
  • Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea
  • Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
  • Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea
  • Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12890-019-0833-7

    DOI

    http://dx.doi.org/10.1186/s12890-019-0833-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112946215

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30902075


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        "description": "BackgroundRisk of exacerbations in chronic obstructive pulmonary disease (COPD) associated with biomass smoke has not been well addressed, although biomass smoke is similar in composition to tobacco smoke.MethodsTo investigate whether the risk of exacerbations in COPD associated with biomass smoke differs from that in COPD associated with tobacco smoke, we recruited patients with COPD from two Korean multicenter prospective cohorts. In a multiple linear regression model, the standardized regression coefficient (\u03b2) of biomass smoke exposure \u226525\u2009years was most similar to that (\u03b2\u2032) of tobacco smoke exposure \u226510 pack-years (\u03b2\u2009=\u2009\u2212\u20090.13 and \u03b2\u2032 = \u2212\u20090.14). We grouped patients with COPD into four categories based on the above cut-offs: Less Tobacco-Less Biomass, Less Tobacco-More Biomass, More Tobacco-Less Biomass, and More Tobacco-More Biomass. The main outcome was the incidence of moderate or severe exacerbations.ResultsAmong 1033 patients with COPD, 107 were included in Less Tobacco-Less Biomass (mean age: 67\u2009years, men: 67%), 40 in Less Tobacco-More Biomass (mean age: 70\u2009years, men: 35%), 631 in More Tobacco-Less Biomass (mean age: 68\u2009years, men: 98%), and 255 in More Tobacco-More Biomass (mean age: 69\u2009years, men: 97%). The incidence rates of exacerbations were not significantly different between Less Tobacco-More Biomass and More Tobacco-Less Biomass (adjusted incidence rate ratio, 1.03; 95% confidence interval, 0.56\u20131.89; P\u2009=\u20090.921). No interaction between sex and tobacco and biomass smoke was observed. When propensity score matching with available covariates including age and sex was applied, a similar result was observed.ConclusionsPatients with COPD associated with biomass smoke and those with COPD associated with tobacco smoke had a similar risk of exacerbations. This suggests that patients with COPD associated with biomass smoke should be treated actively.", 
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