Korean childhood asthma study (KAS): a prospective, observational cohort of Korean asthmatic children View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03-15

AUTHORS

Dong In Suh, Dae Jin Song, Hey-Sung Baek, Meeyong Shin, Young Yoo, Ji-Won Kwon, Gwang Cheon Jang, Hyeon-Jong Yang, Eun Lee, Hwan Soo Kim, Ju-Hee Seo, Sung-Il Woo, Hyung Young Kim, Youn Ho Shin, Ju Suk Lee, Jisun Yoon, Sungsu Jung, Minkyu Han, Eunjin Eom, Jinho Yu, Woo Kyung Kim, Dae Hyun Lim, Jin Tack Kim, Woo-Sung Chang, Jeom-Kyu Lee

ABSTRACT

BACKGROUND: Asthma is a syndrome composed of heterogeneous disease entities. Although it is agreed that proper asthma endo-typing and appropriate type-specific interventions are crucial in the management of asthma, little data are available regarding pediatric asthma. METHODS: We designed a cluster-based, prospective, observational cohort study of asthmatic children in Korea (Korean childhood Asthma Study [KAS]). A total of 1000 Korean asthmatic children, aged from 5 to 15 years, will be enrolled at the allergy clinics of the 19 regional tertiary hospitals from August 2016 to December 2018. Physicians will verify the relevant histories of asthma and comorbid diseases, as well as airway lability from the results of spirometry and bronchial provocation tests. Questionnaires regarding subjects' baseline characteristics and their environment, self-rating of asthma control, and laboratory tests for allergy and airway inflammation will be collected at the time of enrollment. Follow-up data regarding asthma control, lung function, and environmental questionnaires will be collected at least every 6 months to assess outcome and exacerbation-related aggravating factors. In a subgroup of subjects, peak expiratory flow rate will be monitored by communication through a mobile application during the overall study period. Cluster analysis of the initial data will be used to classify Korean pediatric asthma patients into several clusters; the exacerbation and progression of asthma will be assessed and compared among these clusters. In a subgroup of patients, big data-based deep learning analysis will be applied to predict asthma exacerbation. DISCUSSION: Based on the assumption that asthma is heterogeneous and each subject exhibits a different subset of risk factors for asthma exacerbation, as well as a different disease progression, the KAS aims to identify several asthma clusters and their essential determinants, which are more suitable for Korean asthmatic children. Thereafter we may suggest cluster-specific strategies by focusing on subjects' personalized aggravating factors during each exacerbation episode and by focusing on disease progression. The KAS will provide a good academic background with respect to each interventional strategy to achieve better asthma control and prognosis. More... »

PAGES

64

Journal

TITLE

BMC Pulmonary Medicine

ISSUE

1

VOLUME

19

Author Affiliations

  • Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea
  • Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea
  • Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Seoul, South Korea
  • Department of Pediatrics, Soonchunhyang University School of Medicine, Bucheon, South Korea
  • Department of Pediatrics, Korea University Anam Hospital, Seoul, South Korea
  • Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea
  • Department of Pediatrics, National Health Insurance Service Ilsan Hospital, Ilsan, South Korea
  • Department of Pediatrics, Pediatric Allergy and Respiratory Center, Soonchunhyang University College of Medicine, Seoul, South Korea
  • Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea
  • Department of Pediatrics, School of Medicine, The Catholic University of Korea, Bucheon St. Mary’s Hospital, Bucheon, South Korea
  • Department of Pediatrics, Dankook University Hospital, Cheonan, South Korea
  • Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, South Korea
  • Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, South Korea
  • Department of Pediatrics, Gangnam CHA Medical Center CHA University School of Medicine, Seoul, South Korea
  • Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea
  • Department of Pediatrics, Mediplex Sejong hospital, Incheon, South Korea
  • Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
  • Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, Seoul, South Korea
  • Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, South Korea
  • Department of Pediatrics, Inje University Seoul Paik Hospital, Seoul, South Korea
  • Department of Pediatrics, School of Medicine, Inha University, Incheon, South Korea
  • Department of Pediatrics, School of Medicine, The Catholic University of Korea, Uijeongbu St. Mary’s hospital, Uijeongbu, South Korea
  • Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, South Korea
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12890-019-0829-3

    DOI

    http://dx.doi.org/10.1186/s12890-019-0829-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112775118

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30876418


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Asthma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bronchial Provocation Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child, Preschool", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cluster Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multicenter Studies as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Observational Studies as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Peak Expiratory Flow Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Republic of Korea", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spirometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Surveys and Questionnaires", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.31501.36", 
              "name": [
                "Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suh", 
            "givenName": "Dong In", 
            "id": "sg:person.01254457462.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254457462.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.222754.4", 
              "name": [
                "Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Song", 
            "givenName": "Dae Jin", 
            "id": "sg:person.016142467257.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016142467257.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.488451.4", 
              "name": [
                "Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baek", 
            "givenName": "Hey-Sung", 
            "id": "sg:person.01211217657.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211217657.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Soonchunhyang University School of Medicine, Bucheon, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.412674.2", 
              "name": [
                "Department of Pediatrics, Soonchunhyang University School of Medicine, Bucheon, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shin", 
            "givenName": "Meeyong", 
            "id": "sg:person.01344404066.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344404066.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Korea University Anam Hospital, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.411134.2", 
              "name": [
                "Department of Pediatrics, Korea University Anam Hospital, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoo", 
            "givenName": "Young", 
            "id": "sg:person.0702274057.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702274057.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.412480.b", 
              "name": [
                "Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kwon", 
            "givenName": "Ji-Won", 
            "id": "sg:person.01127221072.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127221072.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, National Health Insurance Service Ilsan Hospital, Ilsan, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.416665.6", 
              "name": [
                "Department of Pediatrics, National Health Insurance Service Ilsan Hospital, Ilsan, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jang", 
            "givenName": "Gwang Cheon", 
            "id": "sg:person.01366012171.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366012171.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Pediatric Allergy and Respiratory Center, Soonchunhyang University College of Medicine, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.412674.2", 
              "name": [
                "Department of Pediatrics, Pediatric Allergy and Respiratory Center, Soonchunhyang University College of Medicine, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Hyeon-Jong", 
            "id": "sg:person.0640757073.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640757073.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.14005.30", 
              "name": [
                "Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Eun", 
            "id": "sg:person.01210355177.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210355177.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, School of Medicine, The Catholic University of Korea, Bucheon St. Mary\u2019s Hospital, Bucheon, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.414678.8", 
              "name": [
                "Department of Pediatrics, School of Medicine, The Catholic University of Korea, Bucheon St. Mary\u2019s Hospital, Bucheon, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Hwan Soo", 
            "id": "sg:person.0702325111.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702325111.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Dankook University Hospital, Cheonan, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.411983.6", 
              "name": [
                "Department of Pediatrics, Dankook University Hospital, Cheonan, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Seo", 
            "givenName": "Ju-Hee", 
            "id": "sg:person.0676544072.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676544072.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.254229.a", 
              "name": [
                "Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Woo", 
            "givenName": "Sung-Il", 
            "id": "sg:person.01074473637.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074473637.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.412591.a", 
              "name": [
                "Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Hyung Young", 
            "id": "sg:person.01324603112.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324603112.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Gangnam CHA Medical Center CHA University School of Medicine, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.410886.3", 
              "name": [
                "Department of Pediatrics, Gangnam CHA Medical Center CHA University School of Medicine, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shin", 
            "givenName": "Youn Ho", 
            "id": "sg:person.01037000621.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037000621.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.264381.a", 
              "name": [
                "Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Ju Suk", 
            "id": "sg:person.013352327355.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013352327355.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Mediplex Sejong hospital, Incheon, South Korea", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Pediatrics, Mediplex Sejong hospital, Incheon, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoon", 
            "givenName": "Jisun", 
            "id": "sg:person.011055234615.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011055234615.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.413967.e", 
              "name": [
                "Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jung", 
            "givenName": "Sungsu", 
            "id": "sg:person.012060504754.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012060504754.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.413967.e", 
              "name": [
                "Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Han", 
            "givenName": "Minkyu", 
            "id": "sg:person.01177744113.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177744113.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.413967.e", 
              "name": [
                "Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eom", 
            "givenName": "Eunjin", 
            "id": "sg:person.012640510051.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012640510051.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.413967.e", 
              "name": [
                "Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yu", 
            "givenName": "Jinho", 
            "id": "sg:person.0715563752.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715563752.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Inje University Seoul Paik Hospital, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.411635.4", 
              "name": [
                "Department of Pediatrics, Inje University Seoul Paik Hospital, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Woo Kyung", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, School of Medicine, Inha University, Incheon, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.202119.9", 
              "name": [
                "Department of Pediatrics, School of Medicine, Inha University, Incheon, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lim", 
            "givenName": "Dae Hyun", 
            "id": "sg:person.01164202324.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164202324.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, School of Medicine, The Catholic University of Korea, Uijeongbu St. Mary\u2019s hospital, Uijeongbu, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.416981.3", 
              "name": [
                "Department of Pediatrics, School of Medicine, The Catholic University of Korea, Uijeongbu St. Mary\u2019s hospital, Uijeongbu, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Jin Tack", 
            "id": "sg:person.01216105737.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216105737.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, South Korea", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chang", 
            "givenName": "Woo-Sung", 
            "id": "sg:person.0756526516.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756526516.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, South Korea", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Jeom-Kyu", 
            "id": "sg:person.013752460137.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013752460137.14"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nri3786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014629794", 
              "https://doi.org/10.1038/nri3786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s41030-016-0017-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005399818", 
              "https://doi.org/10.1007/s41030-016-0017-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1465-9921-6-144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024121562", 
              "https://doi.org/10.1186/1465-9921-6-144"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03-15", 
        "datePublishedReg": "2019-03-15", 
        "description": "BACKGROUND: Asthma is a syndrome composed of heterogeneous disease entities. Although it is agreed that proper asthma endo-typing and appropriate type-specific interventions are crucial in the management of asthma, little data are available regarding pediatric asthma.\nMETHODS: We designed a cluster-based, prospective, observational cohort study of asthmatic children in Korea (Korean childhood Asthma Study [KAS]). A total of 1000 Korean asthmatic children, aged from 5 to 15\u2009years, will be enrolled at the allergy clinics of the 19 regional tertiary hospitals from August 2016 to December 2018. Physicians will verify the relevant histories of asthma and comorbid diseases, as well as airway lability from the results of spirometry and bronchial provocation tests. Questionnaires regarding subjects' baseline characteristics and their environment, self-rating of asthma control, and laboratory tests for allergy and airway inflammation will be collected at the time of enrollment. Follow-up data regarding asthma control, lung function, and environmental questionnaires will be collected at least every 6\u2009months to assess outcome and exacerbation-related aggravating factors. In a subgroup of subjects, peak expiratory flow rate will be monitored by communication through a mobile application during the overall study period. Cluster analysis of the initial data will be used to classify Korean pediatric asthma patients into several clusters; the exacerbation and progression of asthma will be assessed and compared among these clusters. In a subgroup of patients, big data-based deep learning analysis will be applied to predict asthma exacerbation.\nDISCUSSION: Based on the assumption that asthma is heterogeneous and each subject exhibits a different subset of risk factors for asthma exacerbation, as well as a different disease progression, the KAS aims to identify several asthma clusters and their essential determinants, which are more suitable for Korean asthmatic children. Thereafter we may suggest cluster-specific strategies by focusing on subjects' personalized aggravating factors during each exacerbation episode and by focusing on disease progression. The KAS will provide a good academic background with respect to each interventional strategy to achieve better asthma control and prognosis.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12890-019-0829-3", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1024955", 
            "issn": [
              "1471-2466"
            ], 
            "name": "BMC Pulmonary Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "keywords": [
          "Korean asthmatic children", 
          "asthmatic children", 
          "asthma control", 
          "asthma exacerbations", 
          "baseline characteristics", 
          "disease progression", 
          "peak expiratory flow rate", 
          "regional tertiary hospital", 
          "subjects' baseline characteristics", 
          "observational cohort study", 
          "better asthma control", 
          "management of asthma", 
          "results of spirometry", 
          "bronchial provocation test", 
          "pediatric asthma patients", 
          "progression of asthma", 
          "subgroup of patients", 
          "heterogeneous disease entity", 
          "time of enrollment", 
          "expiratory flow rate", 
          "Childhood Asthma Study", 
          "different disease progression", 
          "subgroup of subjects", 
          "overall study period", 
          "airway lability", 
          "airway inflammation", 
          "allergy clinic", 
          "exacerbation episodes", 
          "pediatric asthma", 
          "cohort study", 
          "comorbid diseases", 
          "provocation test", 
          "lung function", 
          "asthma patients", 
          "observational cohort", 
          "tertiary hospital", 
          "asthma clusters", 
          "risk factors", 
          "disease entity", 
          "interventional strategies", 
          "Asthma Study", 
          "asthma", 
          "exacerbation", 
          "study period", 
          "relevant history", 
          "little data", 
          "progression", 
          "patients", 
          "environmental questionnaire", 
          "children", 
          "subjects", 
          "subgroups", 
          "laboratory tests", 
          "questionnaire", 
          "different subsets", 
          "spirometry", 
          "allergy", 
          "inflammation", 
          "prognosis", 
          "syndrome", 
          "clinic", 
          "hospital", 
          "cohort", 
          "factors", 
          "disease", 
          "physicians", 
          "essential determinant", 
          "control", 
          "months", 
          "intervention", 
          "outcomes", 
          "episodes", 
          "total", 
          "enrollment", 
          "study", 
          "deep learning analysis", 
          "test", 
          "years", 
          "data", 
          "subset", 
          "determinants", 
          "management", 
          "period", 
          "history", 
          "strategies", 
          "entities", 
          "learning analysis", 
          "background", 
          "rate", 
          "analysis", 
          "lability", 
          "function", 
          "time", 
          "cluster analysis", 
          "Korea", 
          "results", 
          "characteristics", 
          "flow rate", 
          "clusters", 
          "respect", 
          "communication", 
          "good academic background", 
          "academic background", 
          "mobile applications", 
          "initial data", 
          "environment", 
          "applications", 
          "assumption", 
          "proper asthma", 
          "appropriate type-specific interventions", 
          "type-specific interventions", 
          "Korean pediatric asthma patients", 
          "big data-based deep learning analysis", 
          "data-based deep learning analysis", 
          "KAS", 
          "cluster-specific strategies"
        ], 
        "name": "Korean childhood asthma study (KAS): a prospective, observational cohort of Korean asthmatic children", 
        "pagination": "64", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112775118"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12890-019-0829-3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30876418"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12890-019-0829-3", 
          "https://app.dimensions.ai/details/publication/pub.1112775118"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_825.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12890-019-0829-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12890-019-0829-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12890-019-0829-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12890-019-0829-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12890-019-0829-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    494 TRIPLES      22 PREDICATES      164 URIs      152 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12890-019-0829-3 schema:about N150c8321b240423ea2b8fb393ce4ba29
    2 N187c5ddb1da640c69876bbfb920493b0
    3 N3362fe60359444c8993b7ee2b825a8a7
    4 N3d86db7746564f97bcadd62c49804c55
    5 N49e812ec99344ba0bdce5fa80363da42
    6 N4f36b4b4bc4f4a178f71a6a88d9d2fc7
    7 N70477f39e96547adbbc82a6fa98c75c9
    8 N7140ae8798f84d92b5fa3a218ae771fc
    9 N7941fa80f39647bfa60a73faec7cea1b
    10 N7e73df99d5a041b8939f653cab28f4d9
    11 N977d2e008a2e416aaa4af667f0bdccdf
    12 Naaef245eff34498d8b9a0f04c4a415d9
    13 Nbf5853989e8b444a81d0bbed39edf34b
    14 Nc06bddc205bc487283ce940aea3cd498
    15 Nc25be5a232af4d93885f28f501cf6f07
    16 Ne77f5eab7bd94582ad54b2859d0ae053
    17 Ne8e846580c544b429ad9ef2aa3fc9aa8
    18 Nea64c81f298e4d52bc0fcf1c6334e9ca
    19 anzsrc-for:11
    20 anzsrc-for:1102
    21 anzsrc-for:1117
    22 schema:author N42efffb0cfec4e499bf318e691078f07
    23 schema:citation sg:pub.10.1007/s41030-016-0017-z
    24 sg:pub.10.1038/nri3786
    25 sg:pub.10.1186/1465-9921-6-144
    26 schema:datePublished 2019-03-15
    27 schema:datePublishedReg 2019-03-15
    28 schema:description BACKGROUND: Asthma is a syndrome composed of heterogeneous disease entities. Although it is agreed that proper asthma endo-typing and appropriate type-specific interventions are crucial in the management of asthma, little data are available regarding pediatric asthma. METHODS: We designed a cluster-based, prospective, observational cohort study of asthmatic children in Korea (Korean childhood Asthma Study [KAS]). A total of 1000 Korean asthmatic children, aged from 5 to 15 years, will be enrolled at the allergy clinics of the 19 regional tertiary hospitals from August 2016 to December 2018. Physicians will verify the relevant histories of asthma and comorbid diseases, as well as airway lability from the results of spirometry and bronchial provocation tests. Questionnaires regarding subjects' baseline characteristics and their environment, self-rating of asthma control, and laboratory tests for allergy and airway inflammation will be collected at the time of enrollment. Follow-up data regarding asthma control, lung function, and environmental questionnaires will be collected at least every 6 months to assess outcome and exacerbation-related aggravating factors. In a subgroup of subjects, peak expiratory flow rate will be monitored by communication through a mobile application during the overall study period. Cluster analysis of the initial data will be used to classify Korean pediatric asthma patients into several clusters; the exacerbation and progression of asthma will be assessed and compared among these clusters. In a subgroup of patients, big data-based deep learning analysis will be applied to predict asthma exacerbation. DISCUSSION: Based on the assumption that asthma is heterogeneous and each subject exhibits a different subset of risk factors for asthma exacerbation, as well as a different disease progression, the KAS aims to identify several asthma clusters and their essential determinants, which are more suitable for Korean asthmatic children. Thereafter we may suggest cluster-specific strategies by focusing on subjects' personalized aggravating factors during each exacerbation episode and by focusing on disease progression. The KAS will provide a good academic background with respect to each interventional strategy to achieve better asthma control and prognosis.
    29 schema:genre article
    30 schema:inLanguage en
    31 schema:isAccessibleForFree true
    32 schema:isPartOf N62faa1447bcb451183e697a8c4de15f9
    33 Ndb1906d7af7b4aa090b723ac8e859168
    34 sg:journal.1024955
    35 schema:keywords Asthma Study
    36 Childhood Asthma Study
    37 KAS
    38 Korea
    39 Korean asthmatic children
    40 Korean pediatric asthma patients
    41 academic background
    42 airway inflammation
    43 airway lability
    44 allergy
    45 allergy clinic
    46 analysis
    47 applications
    48 appropriate type-specific interventions
    49 assumption
    50 asthma
    51 asthma clusters
    52 asthma control
    53 asthma exacerbations
    54 asthma patients
    55 asthmatic children
    56 background
    57 baseline characteristics
    58 better asthma control
    59 big data-based deep learning analysis
    60 bronchial provocation test
    61 characteristics
    62 children
    63 clinic
    64 cluster analysis
    65 cluster-specific strategies
    66 clusters
    67 cohort
    68 cohort study
    69 communication
    70 comorbid diseases
    71 control
    72 data
    73 data-based deep learning analysis
    74 deep learning analysis
    75 determinants
    76 different disease progression
    77 different subsets
    78 disease
    79 disease entity
    80 disease progression
    81 enrollment
    82 entities
    83 environment
    84 environmental questionnaire
    85 episodes
    86 essential determinant
    87 exacerbation
    88 exacerbation episodes
    89 expiratory flow rate
    90 factors
    91 flow rate
    92 function
    93 good academic background
    94 heterogeneous disease entity
    95 history
    96 hospital
    97 inflammation
    98 initial data
    99 intervention
    100 interventional strategies
    101 lability
    102 laboratory tests
    103 learning analysis
    104 little data
    105 lung function
    106 management
    107 management of asthma
    108 mobile applications
    109 months
    110 observational cohort
    111 observational cohort study
    112 outcomes
    113 overall study period
    114 patients
    115 peak expiratory flow rate
    116 pediatric asthma
    117 pediatric asthma patients
    118 period
    119 physicians
    120 prognosis
    121 progression
    122 progression of asthma
    123 proper asthma
    124 provocation test
    125 questionnaire
    126 rate
    127 regional tertiary hospital
    128 relevant history
    129 respect
    130 results
    131 results of spirometry
    132 risk factors
    133 spirometry
    134 strategies
    135 study
    136 study period
    137 subgroup of patients
    138 subgroup of subjects
    139 subgroups
    140 subjects
    141 subjects' baseline characteristics
    142 subset
    143 syndrome
    144 tertiary hospital
    145 test
    146 time
    147 time of enrollment
    148 total
    149 type-specific interventions
    150 years
    151 schema:name Korean childhood asthma study (KAS): a prospective, observational cohort of Korean asthmatic children
    152 schema:pagination 64
    153 schema:productId N624f8e292cc5426db660c491fb9a08c2
    154 N66a477e2c5624d5884df0f2e3418a813
    155 Nc7c162b757df4a67b989e8b3c1ce2a84
    156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112775118
    157 https://doi.org/10.1186/s12890-019-0829-3
    158 schema:sdDatePublished 2021-12-01T19:45
    159 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    160 schema:sdPublisher N9a71adbb366949c2beff73cd7d341f6f
    161 schema:url https://doi.org/10.1186/s12890-019-0829-3
    162 sgo:license sg:explorer/license/
    163 sgo:sdDataset articles
    164 rdf:type schema:ScholarlyArticle
    165 N150c8321b240423ea2b8fb393ce4ba29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Republic of Korea
    167 rdf:type schema:DefinedTerm
    168 N1745a9e1fa6744a2ab907dc1de59bdda rdf:first sg:person.01210355177.15
    169 rdf:rest N798717725999448390d94de26b581f69
    170 N187c5ddb1da640c69876bbfb920493b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Bronchial Provocation Tests
    172 rdf:type schema:DefinedTerm
    173 N1b87a35530fc430d8df07fef08a451f1 rdf:first sg:person.012640510051.40
    174 rdf:rest N1eceb651dcdd457fab4013fb84969b5f
    175 N1eceb651dcdd457fab4013fb84969b5f rdf:first sg:person.0715563752.60
    176 rdf:rest Ned663b4fa8854cd9ab18575e39f8e0df
    177 N31fdda91d9504d648eaedc36d40177b5 rdf:first sg:person.01216105737.11
    178 rdf:rest N6033e5fdfab04115b27eec644a5bd1da
    179 N3362fe60359444c8993b7ee2b825a8a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Asthma
    181 rdf:type schema:DefinedTerm
    182 N3d31f58baa344ac480d495d1cf081a00 rdf:first sg:person.01324603112.37
    183 rdf:rest N95bdfff0141e46a9965fc4637cbc2e9b
    184 N3d86db7746564f97bcadd62c49804c55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Female
    186 rdf:type schema:DefinedTerm
    187 N42efffb0cfec4e499bf318e691078f07 rdf:first sg:person.01254457462.39
    188 rdf:rest N7fbd3e0479c5420bb4906d4867cdb008
    189 N49e812ec99344ba0bdce5fa80363da42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Risk Factors
    191 rdf:type schema:DefinedTerm
    192 N4ba10504fd514c7b87971a0494896f98 rdf:first sg:person.0640757073.69
    193 rdf:rest N1745a9e1fa6744a2ab907dc1de59bdda
    194 N4c00c235008b4683af365ad742c97243 rdf:first sg:person.011055234615.12
    195 rdf:rest N6ee72e2a2193451cbb1f3829f3548dd6
    196 N4f36b4b4bc4f4a178f71a6a88d9d2fc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Surveys and Questionnaires
    198 rdf:type schema:DefinedTerm
    199 N5f999770074a4e4980e86a6015ee0108 rdf:first sg:person.01344404066.83
    200 rdf:rest N95163171a3dc4c14a83c267e275631a1
    201 N6033e5fdfab04115b27eec644a5bd1da rdf:first sg:person.0756526516.64
    202 rdf:rest Nba8b887ee0124ce696be848958171df6
    203 N618d2b3bc01b4a18a63f2697f20afc48 rdf:first sg:person.01211217657.80
    204 rdf:rest N5f999770074a4e4980e86a6015ee0108
    205 N624f8e292cc5426db660c491fb9a08c2 schema:name dimensions_id
    206 schema:value pub.1112775118
    207 rdf:type schema:PropertyValue
    208 N62faa1447bcb451183e697a8c4de15f9 schema:issueNumber 1
    209 rdf:type schema:PublicationIssue
    210 N66a477e2c5624d5884df0f2e3418a813 schema:name pubmed_id
    211 schema:value 30876418
    212 rdf:type schema:PropertyValue
    213 N6c6ea1ea0f2342c8b0e31a7be93632da rdf:first sg:person.01177744113.84
    214 rdf:rest N1b87a35530fc430d8df07fef08a451f1
    215 N6d968f2bdc074cf4bd7f0c628eadd560 schema:affiliation grid-institutes:grid.411635.4
    216 schema:familyName Kim
    217 schema:givenName Woo Kyung
    218 rdf:type schema:Person
    219 N6ee72e2a2193451cbb1f3829f3548dd6 rdf:first sg:person.012060504754.87
    220 rdf:rest N6c6ea1ea0f2342c8b0e31a7be93632da
    221 N70477f39e96547adbbc82a6fa98c75c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Peak Expiratory Flow Rate
    223 rdf:type schema:DefinedTerm
    224 N7140ae8798f84d92b5fa3a218ae771fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Humans
    226 rdf:type schema:DefinedTerm
    227 N7941fa80f39647bfa60a73faec7cea1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    228 schema:name Spirometry
    229 rdf:type schema:DefinedTerm
    230 N798717725999448390d94de26b581f69 rdf:first sg:person.0702325111.20
    231 rdf:rest N88b2c49636cf42aa9d8f0eec1bf2d165
    232 N7e73df99d5a041b8939f653cab28f4d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    233 schema:name Multicenter Studies as Topic
    234 rdf:type schema:DefinedTerm
    235 N7fbd3e0479c5420bb4906d4867cdb008 rdf:first sg:person.016142467257.07
    236 rdf:rest N618d2b3bc01b4a18a63f2697f20afc48
    237 N88b2c49636cf42aa9d8f0eec1bf2d165 rdf:first sg:person.0676544072.47
    238 rdf:rest Nbc149b5f8e8444d2ae7f583e5a684977
    239 N95163171a3dc4c14a83c267e275631a1 rdf:first sg:person.0702274057.63
    240 rdf:rest Nf4d86ed389d34228bb4cadeb1a55d792
    241 N95bdfff0141e46a9965fc4637cbc2e9b rdf:first sg:person.01037000621.29
    242 rdf:rest Nc25e088f9490428d97346e2cf148cc1a
    243 N977d2e008a2e416aaa4af667f0bdccdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    244 schema:name Adolescent
    245 rdf:type schema:DefinedTerm
    246 N9a71adbb366949c2beff73cd7d341f6f schema:name Springer Nature - SN SciGraph project
    247 rdf:type schema:Organization
    248 Na62b834ba90041ec9034ff572014a7d4 rdf:first sg:person.01164202324.99
    249 rdf:rest N31fdda91d9504d648eaedc36d40177b5
    250 Naaef245eff34498d8b9a0f04c4a415d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    251 schema:name Child, Preschool
    252 rdf:type schema:DefinedTerm
    253 Nba8b887ee0124ce696be848958171df6 rdf:first sg:person.013752460137.14
    254 rdf:rest rdf:nil
    255 Nbc149b5f8e8444d2ae7f583e5a684977 rdf:first sg:person.01074473637.22
    256 rdf:rest N3d31f58baa344ac480d495d1cf081a00
    257 Nbf5853989e8b444a81d0bbed39edf34b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    258 schema:name Observational Studies as Topic
    259 rdf:type schema:DefinedTerm
    260 Nc06bddc205bc487283ce940aea3cd498 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    261 schema:name Disease Progression
    262 rdf:type schema:DefinedTerm
    263 Nc25be5a232af4d93885f28f501cf6f07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    264 schema:name Cluster Analysis
    265 rdf:type schema:DefinedTerm
    266 Nc25e088f9490428d97346e2cf148cc1a rdf:first sg:person.013352327355.17
    267 rdf:rest N4c00c235008b4683af365ad742c97243
    268 Nc7c162b757df4a67b989e8b3c1ce2a84 schema:name doi
    269 schema:value 10.1186/s12890-019-0829-3
    270 rdf:type schema:PropertyValue
    271 Ndb1906d7af7b4aa090b723ac8e859168 schema:volumeNumber 19
    272 rdf:type schema:PublicationVolume
    273 Ne77f5eab7bd94582ad54b2859d0ae053 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    274 schema:name Prospective Studies
    275 rdf:type schema:DefinedTerm
    276 Ne8e846580c544b429ad9ef2aa3fc9aa8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    277 schema:name Child
    278 rdf:type schema:DefinedTerm
    279 Nea64c81f298e4d52bc0fcf1c6334e9ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    280 schema:name Male
    281 rdf:type schema:DefinedTerm
    282 Ned663b4fa8854cd9ab18575e39f8e0df rdf:first N6d968f2bdc074cf4bd7f0c628eadd560
    283 rdf:rest Na62b834ba90041ec9034ff572014a7d4
    284 Nf34ca75cfab144ebbd62d2b59793a3ac rdf:first sg:person.01366012171.28
    285 rdf:rest N4ba10504fd514c7b87971a0494896f98
    286 Nf4d86ed389d34228bb4cadeb1a55d792 rdf:first sg:person.01127221072.59
    287 rdf:rest Nf34ca75cfab144ebbd62d2b59793a3ac
    288 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    289 schema:name Medical and Health Sciences
    290 rdf:type schema:DefinedTerm
    291 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    292 schema:name Cardiorespiratory Medicine and Haematology
    293 rdf:type schema:DefinedTerm
    294 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    295 schema:name Public Health and Health Services
    296 rdf:type schema:DefinedTerm
    297 sg:journal.1024955 schema:issn 1471-2466
    298 schema:name BMC Pulmonary Medicine
    299 schema:publisher Springer Nature
    300 rdf:type schema:Periodical
    301 sg:person.01037000621.29 schema:affiliation grid-institutes:grid.410886.3
    302 schema:familyName Shin
    303 schema:givenName Youn Ho
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037000621.29
    305 rdf:type schema:Person
    306 sg:person.01074473637.22 schema:affiliation grid-institutes:grid.254229.a
    307 schema:familyName Woo
    308 schema:givenName Sung-Il
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074473637.22
    310 rdf:type schema:Person
    311 sg:person.011055234615.12 schema:affiliation grid-institutes:None
    312 schema:familyName Yoon
    313 schema:givenName Jisun
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011055234615.12
    315 rdf:type schema:Person
    316 sg:person.01127221072.59 schema:affiliation grid-institutes:grid.412480.b
    317 schema:familyName Kwon
    318 schema:givenName Ji-Won
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127221072.59
    320 rdf:type schema:Person
    321 sg:person.01164202324.99 schema:affiliation grid-institutes:grid.202119.9
    322 schema:familyName Lim
    323 schema:givenName Dae Hyun
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164202324.99
    325 rdf:type schema:Person
    326 sg:person.01177744113.84 schema:affiliation grid-institutes:grid.413967.e
    327 schema:familyName Han
    328 schema:givenName Minkyu
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177744113.84
    330 rdf:type schema:Person
    331 sg:person.012060504754.87 schema:affiliation grid-institutes:grid.413967.e
    332 schema:familyName Jung
    333 schema:givenName Sungsu
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012060504754.87
    335 rdf:type schema:Person
    336 sg:person.01210355177.15 schema:affiliation grid-institutes:grid.14005.30
    337 schema:familyName Lee
    338 schema:givenName Eun
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210355177.15
    340 rdf:type schema:Person
    341 sg:person.01211217657.80 schema:affiliation grid-institutes:grid.488451.4
    342 schema:familyName Baek
    343 schema:givenName Hey-Sung
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211217657.80
    345 rdf:type schema:Person
    346 sg:person.01216105737.11 schema:affiliation grid-institutes:grid.416981.3
    347 schema:familyName Kim
    348 schema:givenName Jin Tack
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216105737.11
    350 rdf:type schema:Person
    351 sg:person.01254457462.39 schema:affiliation grid-institutes:grid.31501.36
    352 schema:familyName Suh
    353 schema:givenName Dong In
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254457462.39
    355 rdf:type schema:Person
    356 sg:person.012640510051.40 schema:affiliation grid-institutes:grid.413967.e
    357 schema:familyName Eom
    358 schema:givenName Eunjin
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012640510051.40
    360 rdf:type schema:Person
    361 sg:person.01324603112.37 schema:affiliation grid-institutes:grid.412591.a
    362 schema:familyName Kim
    363 schema:givenName Hyung Young
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324603112.37
    365 rdf:type schema:Person
    366 sg:person.013352327355.17 schema:affiliation grid-institutes:grid.264381.a
    367 schema:familyName Lee
    368 schema:givenName Ju Suk
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013352327355.17
    370 rdf:type schema:Person
    371 sg:person.01344404066.83 schema:affiliation grid-institutes:grid.412674.2
    372 schema:familyName Shin
    373 schema:givenName Meeyong
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344404066.83
    375 rdf:type schema:Person
    376 sg:person.01366012171.28 schema:affiliation grid-institutes:grid.416665.6
    377 schema:familyName Jang
    378 schema:givenName Gwang Cheon
    379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366012171.28
    380 rdf:type schema:Person
    381 sg:person.013752460137.14 schema:affiliation grid-institutes:None
    382 schema:familyName Lee
    383 schema:givenName Jeom-Kyu
    384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013752460137.14
    385 rdf:type schema:Person
    386 sg:person.016142467257.07 schema:affiliation grid-institutes:grid.222754.4
    387 schema:familyName Song
    388 schema:givenName Dae Jin
    389 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016142467257.07
    390 rdf:type schema:Person
    391 sg:person.0640757073.69 schema:affiliation grid-institutes:grid.412674.2
    392 schema:familyName Yang
    393 schema:givenName Hyeon-Jong
    394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640757073.69
    395 rdf:type schema:Person
    396 sg:person.0676544072.47 schema:affiliation grid-institutes:grid.411983.6
    397 schema:familyName Seo
    398 schema:givenName Ju-Hee
    399 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676544072.47
    400 rdf:type schema:Person
    401 sg:person.0702274057.63 schema:affiliation grid-institutes:grid.411134.2
    402 schema:familyName Yoo
    403 schema:givenName Young
    404 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702274057.63
    405 rdf:type schema:Person
    406 sg:person.0702325111.20 schema:affiliation grid-institutes:grid.414678.8
    407 schema:familyName Kim
    408 schema:givenName Hwan Soo
    409 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702325111.20
    410 rdf:type schema:Person
    411 sg:person.0715563752.60 schema:affiliation grid-institutes:grid.413967.e
    412 schema:familyName Yu
    413 schema:givenName Jinho
    414 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715563752.60
    415 rdf:type schema:Person
    416 sg:person.0756526516.64 schema:affiliation grid-institutes:None
    417 schema:familyName Chang
    418 schema:givenName Woo-Sung
    419 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756526516.64
    420 rdf:type schema:Person
    421 sg:pub.10.1007/s41030-016-0017-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1005399818
    422 https://doi.org/10.1007/s41030-016-0017-z
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1038/nri3786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014629794
    425 https://doi.org/10.1038/nri3786
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1186/1465-9921-6-144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024121562
    428 https://doi.org/10.1186/1465-9921-6-144
    429 rdf:type schema:CreativeWork
    430 grid-institutes:None schema:alternateName Department of Pediatrics, Mediplex Sejong hospital, Incheon, South Korea
    431 Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, South Korea
    432 schema:name Department of Pediatrics, Mediplex Sejong hospital, Incheon, South Korea
    433 Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, South Korea
    434 rdf:type schema:Organization
    435 grid-institutes:grid.14005.30 schema:alternateName Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea
    436 schema:name Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea
    437 rdf:type schema:Organization
    438 grid-institutes:grid.202119.9 schema:alternateName Department of Pediatrics, School of Medicine, Inha University, Incheon, South Korea
    439 schema:name Department of Pediatrics, School of Medicine, Inha University, Incheon, South Korea
    440 rdf:type schema:Organization
    441 grid-institutes:grid.222754.4 schema:alternateName Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea
    442 schema:name Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea
    443 rdf:type schema:Organization
    444 grid-institutes:grid.254229.a schema:alternateName Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, South Korea
    445 schema:name Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, South Korea
    446 rdf:type schema:Organization
    447 grid-institutes:grid.264381.a schema:alternateName Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea
    448 schema:name Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea
    449 rdf:type schema:Organization
    450 grid-institutes:grid.31501.36 schema:alternateName Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea
    451 schema:name Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea
    452 rdf:type schema:Organization
    453 grid-institutes:grid.410886.3 schema:alternateName Department of Pediatrics, Gangnam CHA Medical Center CHA University School of Medicine, Seoul, South Korea
    454 schema:name Department of Pediatrics, Gangnam CHA Medical Center CHA University School of Medicine, Seoul, South Korea
    455 rdf:type schema:Organization
    456 grid-institutes:grid.411134.2 schema:alternateName Department of Pediatrics, Korea University Anam Hospital, Seoul, South Korea
    457 schema:name Department of Pediatrics, Korea University Anam Hospital, Seoul, South Korea
    458 rdf:type schema:Organization
    459 grid-institutes:grid.411635.4 schema:alternateName Department of Pediatrics, Inje University Seoul Paik Hospital, Seoul, South Korea
    460 schema:name Department of Pediatrics, Inje University Seoul Paik Hospital, Seoul, South Korea
    461 rdf:type schema:Organization
    462 grid-institutes:grid.411983.6 schema:alternateName Department of Pediatrics, Dankook University Hospital, Cheonan, South Korea
    463 schema:name Department of Pediatrics, Dankook University Hospital, Cheonan, South Korea
    464 rdf:type schema:Organization
    465 grid-institutes:grid.412480.b schema:alternateName Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea
    466 schema:name Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea
    467 rdf:type schema:Organization
    468 grid-institutes:grid.412591.a schema:alternateName Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, South Korea
    469 schema:name Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, South Korea
    470 rdf:type schema:Organization
    471 grid-institutes:grid.412674.2 schema:alternateName Department of Pediatrics, Pediatric Allergy and Respiratory Center, Soonchunhyang University College of Medicine, Seoul, South Korea
    472 Department of Pediatrics, Soonchunhyang University School of Medicine, Bucheon, South Korea
    473 schema:name Department of Pediatrics, Pediatric Allergy and Respiratory Center, Soonchunhyang University College of Medicine, Seoul, South Korea
    474 Department of Pediatrics, Soonchunhyang University School of Medicine, Bucheon, South Korea
    475 rdf:type schema:Organization
    476 grid-institutes:grid.413967.e schema:alternateName Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, South Korea
    477 Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, Seoul, South Korea
    478 Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    479 schema:name Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, South Korea
    480 Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, Seoul, South Korea
    481 Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    482 rdf:type schema:Organization
    483 grid-institutes:grid.414678.8 schema:alternateName Department of Pediatrics, School of Medicine, The Catholic University of Korea, Bucheon St. Mary’s Hospital, Bucheon, South Korea
    484 schema:name Department of Pediatrics, School of Medicine, The Catholic University of Korea, Bucheon St. Mary’s Hospital, Bucheon, South Korea
    485 rdf:type schema:Organization
    486 grid-institutes:grid.416665.6 schema:alternateName Department of Pediatrics, National Health Insurance Service Ilsan Hospital, Ilsan, South Korea
    487 schema:name Department of Pediatrics, National Health Insurance Service Ilsan Hospital, Ilsan, South Korea
    488 rdf:type schema:Organization
    489 grid-institutes:grid.416981.3 schema:alternateName Department of Pediatrics, School of Medicine, The Catholic University of Korea, Uijeongbu St. Mary’s hospital, Uijeongbu, South Korea
    490 schema:name Department of Pediatrics, School of Medicine, The Catholic University of Korea, Uijeongbu St. Mary’s hospital, Uijeongbu, South Korea
    491 rdf:type schema:Organization
    492 grid-institutes:grid.488451.4 schema:alternateName Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Seoul, South Korea
    493 schema:name Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Seoul, South Korea
    494 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...