Solid part size is an important predictor of nodal metastasis in lung cancer with a subsolid tumor View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Jun Yeun Cho, Cho Sun Leem, Youlim Kim, Eun Sun Kim, Sang Hoon Lee, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Jae Ho Lee, Choon-Taek Lee, Ho Il Yoon

ABSTRACT

BACKGROUND: Candidates for preoperative or intraoperative nodal assessment among patients with non-small cell lung cancer (NSCLC) manifesting as a subsolid tumor are not established. The present study was conducted to demonstrate the distribution of nodal metastasis rate according to newly proposed T categories for subsolid tumors, and we further aimed to identify radiologic parameters that can be predictive of nodal metastasis. METHODS: We retrospectively reviewed cases of NSCLC manifesting as a subsolid tumor in computed tomography scans in a university-affiliated tertiary hospital between April 2013 and August 2016. All patients underwent mediastinal lymph node dissection during resection surgery. Multivariate analysis was performed among clinical and radiologic parameters. RESULTS: Of the 269 eligible patients, T-categories were classified as cTis (n = 23, 8.6%), cT1 (n = 203, 75.5%), and cT2 (n = 43, 16.0%). Ten patients (3.7%) had nodal metastasis: pN1 (n = 5, 1.9%), pN2 (n = 5, 1.9%). Nodal metastasis was not observed in tumors with a solid part ≤1.0 cm (cT1mi and cT1a) or in nonsolid tumors ≤3.0 cm (cTis). The nodal metastasis rate in cT1b, cT1c, and cT2 tumors was 6.1% (4/65), 8.3% (1/12), and 11.7% (5/43), respectively. Multivariate analysis showed that a solid part size > 1.5 cm [odds ratio, 5.89; 95% confidence interval, 1.25-27.68, p = 0.025] was significantly associated with nodal metastasis. CONCLUSIONS: We observed nodal metastasis from cT1b tumors (solid part size > 1 cm) among proposed T categories for subsolid tumors and a solid part size is an important radiologic parameter predictive of nodal metastasis in NSCLC manifesting as a subsolid tumor. Considering the low rate of nodal metastasis, pathologic nodal assessment may be unnecessary in early T category tumors with a small solid part size. More... »

PAGES

151

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12890-018-0709-2

DOI

http://dx.doi.org/10.1186/s12890-018-0709-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106905792

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30200917


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Jun Yeun", 
        "id": "sg:person.010770146370.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010770146370.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Bundang Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leem", 
        "givenName": "Cho Sun", 
        "id": "sg:person.01112345222.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112345222.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Youlim", 
        "id": "sg:person.012604612513.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012604612513.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Eun Sun", 
        "id": "sg:person.0612420327.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612420327.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Sang Hoon", 
        "id": "sg:person.01153520571.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153520571.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Yeon Joo", 
        "id": "sg:person.01145052716.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145052716.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Jong Sun", 
        "id": "sg:person.0726712374.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726712374.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Young-Jae", 
        "id": "sg:person.0607300751.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607300751.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jae Ho", 
        "id": "sg:person.01352730316.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352730316.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Choon-Taek", 
        "id": "sg:person.01072170577.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072170577.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoon", 
        "givenName": "Ho Il", 
        "id": "sg:person.01271336470.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271336470.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ejcts.2006.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001725012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0000000000001802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003199033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0000000000001802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003199033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2012.03.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014225125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ejcts/ezr272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014238793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2014.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023746195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00126714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027508126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00126714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027508126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00126714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027508126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-012-2395-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030875797", 
          "https://doi.org/10.1007/s00330-012-2395-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e31825871de", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036735477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2005.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036792789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2005.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036792789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.14-1355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038588175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e3181a0d82e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039022570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2007.03.081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039783721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jtho.2016.03.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040864192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jtho.2016.03.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040864192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.12120628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041317307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1513/pats.201107-042st", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045498380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1513/pats.201107-042st", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045498380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2013.03.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049187497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejcts.2004.12.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051498361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cllc.2011.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053284310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2017.0050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084819289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2017.0050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084819289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lungcan.2017.04.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085206278"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Candidates for preoperative or intraoperative nodal assessment among patients with non-small cell lung cancer (NSCLC) manifesting as a subsolid tumor are not established. The present study was conducted to demonstrate the distribution of nodal metastasis rate according to newly proposed T categories for subsolid tumors, and we further aimed to identify radiologic parameters that can be predictive of nodal metastasis.\nMETHODS: We retrospectively reviewed cases of NSCLC manifesting as a subsolid tumor in computed tomography scans in a university-affiliated tertiary hospital between April 2013 and August 2016. All patients underwent mediastinal lymph node dissection during resection surgery. Multivariate analysis was performed among clinical and radiologic parameters.\nRESULTS: Of the 269 eligible patients, T-categories were classified as cTis (n\u2009=\u200923, 8.6%), cT1 (n\u2009=\u2009203, 75.5%), and cT2 (n\u2009=\u200943, 16.0%). Ten patients (3.7%) had nodal metastasis: pN1 (n\u2009=\u20095, 1.9%), pN2 (n\u2009=\u20095, 1.9%). Nodal metastasis was not observed in tumors with a solid part \u22641.0\u00a0cm (cT1mi and cT1a) or in nonsolid tumors \u22643.0\u00a0cm (cTis). The nodal metastasis rate in cT1b, cT1c, and cT2 tumors was 6.1% (4/65), 8.3% (1/12), and 11.7% (5/43), respectively. Multivariate analysis showed that a solid part size >\u20091.5\u00a0cm [odds ratio, 5.89; 95% confidence interval, 1.25-27.68, p\u2009=\u20090.025] was significantly associated with nodal metastasis.\nCONCLUSIONS: We observed nodal metastasis from cT1b tumors (solid part size >\u20091\u00a0cm) among proposed T categories for subsolid tumors and a solid part size is an important radiologic parameter predictive of nodal metastasis in NSCLC manifesting as a subsolid tumor. Considering the low rate of nodal metastasis, pathologic nodal assessment may be unnecessary in early T category tumors with a small solid part size.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12890-018-0709-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024955", 
        "issn": [
          "1471-2466"
        ], 
        "name": "BMC Pulmonary Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Solid part size is an important predictor of nodal metastasis in lung cancer with a subsolid tumor", 
    "pagination": "151", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "474f815b86b4da848b191fef4bfb3088a62a0903f743b79cf49f35b07dcfaa91"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30200917"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968563"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12890-018-0709-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106905792"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12890-018-0709-2", 
      "https://app.dimensions.ai/details/publication/pub.1106905792"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000528.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12890-018-0709-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0709-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0709-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0709-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0709-2'


 

This table displays all metadata directly associated to this object as RDF triples.

203 TRIPLES      21 PREDICATES      49 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12890-018-0709-2 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Ndee9b1a7943947cbb9aaea2a0a957c6a
4 schema:citation sg:pub.10.1007/s00330-012-2395-4
5 https://doi.org/10.1016/j.athoracsur.2005.02.005
6 https://doi.org/10.1016/j.athoracsur.2007.03.081
7 https://doi.org/10.1016/j.athoracsur.2012.03.033
8 https://doi.org/10.1016/j.athoracsur.2013.03.050
9 https://doi.org/10.1016/j.athoracsur.2014.03.005
10 https://doi.org/10.1016/j.cllc.2011.08.002
11 https://doi.org/10.1016/j.ejcts.2004.12.035
12 https://doi.org/10.1016/j.ejcts.2006.08.008
13 https://doi.org/10.1016/j.jtho.2016.03.025
14 https://doi.org/10.1016/j.lungcan.2017.04.018
15 https://doi.org/10.1093/ejcts/ezr272
16 https://doi.org/10.1097/jto.0b013e3181a0d82e
17 https://doi.org/10.1097/jto.0b013e31825871de
18 https://doi.org/10.1097/sla.0000000000001802
19 https://doi.org/10.1148/radiol.12120628
20 https://doi.org/10.1183/09031936.00126714
21 https://doi.org/10.1378/chest.14-1355
22 https://doi.org/10.1513/pats.201107-042st
23 https://doi.org/10.6004/jnccn.2017.0050
24 schema:datePublished 2018-12
25 schema:datePublishedReg 2018-12-01
26 schema:description BACKGROUND: Candidates for preoperative or intraoperative nodal assessment among patients with non-small cell lung cancer (NSCLC) manifesting as a subsolid tumor are not established. The present study was conducted to demonstrate the distribution of nodal metastasis rate according to newly proposed T categories for subsolid tumors, and we further aimed to identify radiologic parameters that can be predictive of nodal metastasis. METHODS: We retrospectively reviewed cases of NSCLC manifesting as a subsolid tumor in computed tomography scans in a university-affiliated tertiary hospital between April 2013 and August 2016. All patients underwent mediastinal lymph node dissection during resection surgery. Multivariate analysis was performed among clinical and radiologic parameters. RESULTS: Of the 269 eligible patients, T-categories were classified as cTis (n = 23, 8.6%), cT1 (n = 203, 75.5%), and cT2 (n = 43, 16.0%). Ten patients (3.7%) had nodal metastasis: pN1 (n = 5, 1.9%), pN2 (n = 5, 1.9%). Nodal metastasis was not observed in tumors with a solid part ≤1.0 cm (cT1mi and cT1a) or in nonsolid tumors ≤3.0 cm (cTis). The nodal metastasis rate in cT1b, cT1c, and cT2 tumors was 6.1% (4/65), 8.3% (1/12), and 11.7% (5/43), respectively. Multivariate analysis showed that a solid part size > 1.5 cm [odds ratio, 5.89; 95% confidence interval, 1.25-27.68, p = 0.025] was significantly associated with nodal metastasis. CONCLUSIONS: We observed nodal metastasis from cT1b tumors (solid part size > 1 cm) among proposed T categories for subsolid tumors and a solid part size is an important radiologic parameter predictive of nodal metastasis in NSCLC manifesting as a subsolid tumor. Considering the low rate of nodal metastasis, pathologic nodal assessment may be unnecessary in early T category tumors with a small solid part size.
27 schema:genre research_article
28 schema:inLanguage en
29 schema:isAccessibleForFree true
30 schema:isPartOf N5b54c851382549ad87c72755633cce45
31 N96d4fe9d3a9c40bea2496ea1127d8286
32 sg:journal.1024955
33 schema:name Solid part size is an important predictor of nodal metastasis in lung cancer with a subsolid tumor
34 schema:pagination 151
35 schema:productId N0c043b58d8374807aa2b24b764a31c5e
36 N191f1934ae994bfaa248104183f49626
37 N395ef91ee5f24dbcb71a2b2cf784cc5c
38 Nb36fdc98bc274721978cb2e8d4075357
39 Nb8cd8f4a955c43d596f04276e791fc7e
40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106905792
41 https://doi.org/10.1186/s12890-018-0709-2
42 schema:sdDatePublished 2019-04-11T01:10
43 schema:sdLicense https://scigraph.springernature.com/explorer/license/
44 schema:sdPublisher N4f75960867c34cf1ac38486e100525fe
45 schema:url http://link.springer.com/10.1186%2Fs12890-018-0709-2
46 sgo:license sg:explorer/license/
47 sgo:sdDataset articles
48 rdf:type schema:ScholarlyArticle
49 N0c043b58d8374807aa2b24b764a31c5e schema:name doi
50 schema:value 10.1186/s12890-018-0709-2
51 rdf:type schema:PropertyValue
52 N191f1934ae994bfaa248104183f49626 schema:name readcube_id
53 schema:value 474f815b86b4da848b191fef4bfb3088a62a0903f743b79cf49f35b07dcfaa91
54 rdf:type schema:PropertyValue
55 N22c6ca05259e4c87b0dfe3b723779fbb rdf:first sg:person.01153520571.58
56 rdf:rest Nf6e109609eb04ed69f1dbd26e00e7cfd
57 N3512624ec5d0427889b4bd09543c07ed rdf:first sg:person.012604612513.32
58 rdf:rest Nebff0eff5d224f749c05e19acbba2343
59 N395ef91ee5f24dbcb71a2b2cf784cc5c schema:name dimensions_id
60 schema:value pub.1106905792
61 rdf:type schema:PropertyValue
62 N4f75960867c34cf1ac38486e100525fe schema:name Springer Nature - SN SciGraph project
63 rdf:type schema:Organization
64 N4fd246dc4eea4e4eaf80da73acd669c2 rdf:first sg:person.01352730316.43
65 rdf:rest N7e28ff346dd54c3c9797a0aa4fbdde08
66 N5b54c851382549ad87c72755633cce45 schema:volumeNumber 18
67 rdf:type schema:PublicationVolume
68 N7e28ff346dd54c3c9797a0aa4fbdde08 rdf:first sg:person.01072170577.31
69 rdf:rest N8b492660fd4447b8b72b2c6168bd2287
70 N7f46c071975b461eb1d7709f968bcce3 rdf:first sg:person.01112345222.20
71 rdf:rest N3512624ec5d0427889b4bd09543c07ed
72 N8b492660fd4447b8b72b2c6168bd2287 rdf:first sg:person.01271336470.66
73 rdf:rest rdf:nil
74 N96d4fe9d3a9c40bea2496ea1127d8286 schema:issueNumber 1
75 rdf:type schema:PublicationIssue
76 Nb36fdc98bc274721978cb2e8d4075357 schema:name nlm_unique_id
77 schema:value 100968563
78 rdf:type schema:PropertyValue
79 Nb5295f6c4bf6446487cf776f6a300a09 rdf:first sg:person.0726712374.46
80 rdf:rest Nf24da11023084573a0e769b9436ff009
81 Nb8cd8f4a955c43d596f04276e791fc7e schema:name pubmed_id
82 schema:value 30200917
83 rdf:type schema:PropertyValue
84 Ndee9b1a7943947cbb9aaea2a0a957c6a rdf:first sg:person.010770146370.62
85 rdf:rest N7f46c071975b461eb1d7709f968bcce3
86 Nebff0eff5d224f749c05e19acbba2343 rdf:first sg:person.0612420327.90
87 rdf:rest N22c6ca05259e4c87b0dfe3b723779fbb
88 Nf24da11023084573a0e769b9436ff009 rdf:first sg:person.0607300751.61
89 rdf:rest N4fd246dc4eea4e4eaf80da73acd669c2
90 Nf6e109609eb04ed69f1dbd26e00e7cfd rdf:first sg:person.01145052716.49
91 rdf:rest Nb5295f6c4bf6446487cf776f6a300a09
92 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
93 schema:name Medical and Health Sciences
94 rdf:type schema:DefinedTerm
95 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
96 schema:name Oncology and Carcinogenesis
97 rdf:type schema:DefinedTerm
98 sg:journal.1024955 schema:issn 1471-2466
99 schema:name BMC Pulmonary Medicine
100 rdf:type schema:Periodical
101 sg:person.01072170577.31 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
102 schema:familyName Lee
103 schema:givenName Choon-Taek
104 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072170577.31
105 rdf:type schema:Person
106 sg:person.010770146370.62 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
107 schema:familyName Cho
108 schema:givenName Jun Yeun
109 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010770146370.62
110 rdf:type schema:Person
111 sg:person.01112345222.20 schema:affiliation https://www.grid.ac/institutes/grid.412480.b
112 schema:familyName Leem
113 schema:givenName Cho Sun
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112345222.20
115 rdf:type schema:Person
116 sg:person.01145052716.49 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
117 schema:familyName Lee
118 schema:givenName Yeon Joo
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145052716.49
120 rdf:type schema:Person
121 sg:person.01153520571.58 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
122 schema:familyName Lee
123 schema:givenName Sang Hoon
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153520571.58
125 rdf:type schema:Person
126 sg:person.012604612513.32 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
127 schema:familyName Kim
128 schema:givenName Youlim
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012604612513.32
130 rdf:type schema:Person
131 sg:person.01271336470.66 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
132 schema:familyName Yoon
133 schema:givenName Ho Il
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271336470.66
135 rdf:type schema:Person
136 sg:person.01352730316.43 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
137 schema:familyName Lee
138 schema:givenName Jae Ho
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352730316.43
140 rdf:type schema:Person
141 sg:person.0607300751.61 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
142 schema:familyName Cho
143 schema:givenName Young-Jae
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607300751.61
145 rdf:type schema:Person
146 sg:person.0612420327.90 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
147 schema:familyName Kim
148 schema:givenName Eun Sun
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612420327.90
150 rdf:type schema:Person
151 sg:person.0726712374.46 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
152 schema:familyName Park
153 schema:givenName Jong Sun
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726712374.46
155 rdf:type schema:Person
156 sg:pub.10.1007/s00330-012-2395-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030875797
157 https://doi.org/10.1007/s00330-012-2395-4
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/j.athoracsur.2005.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036792789
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/j.athoracsur.2007.03.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039783721
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/j.athoracsur.2012.03.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014225125
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/j.athoracsur.2013.03.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049187497
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.athoracsur.2014.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023746195
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/j.cllc.2011.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053284310
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.ejcts.2004.12.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051498361
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.ejcts.2006.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001725012
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.jtho.2016.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040864192
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.lungcan.2017.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085206278
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1093/ejcts/ezr272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014238793
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1097/jto.0b013e3181a0d82e schema:sameAs https://app.dimensions.ai/details/publication/pub.1039022570
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1097/jto.0b013e31825871de schema:sameAs https://app.dimensions.ai/details/publication/pub.1036735477
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1097/sla.0000000000001802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003199033
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1148/radiol.12120628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041317307
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1183/09031936.00126714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027508126
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1378/chest.14-1355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038588175
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1513/pats.201107-042st schema:sameAs https://app.dimensions.ai/details/publication/pub.1045498380
194 rdf:type schema:CreativeWork
195 https://doi.org/10.6004/jnccn.2017.0050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084819289
196 rdf:type schema:CreativeWork
197 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
198 schema:name Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
199 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea
200 rdf:type schema:Organization
201 https://www.grid.ac/institutes/grid.412480.b schema:alternateName Seoul National University Bundang Hospital
202 schema:name Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 13620, Seongnam-si, Gyeonggi-do, Republic of Korea
203 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...