IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Adrian Egli, Jyotshna Mandal, Desiree M. Schumann, Michael Roth, Brad Thomas, D. Lorne Tyrrell, Francesco Blasi, Kostantinos Kostikas, Wim Boersma, Branislava Milenkovic, Alicia Lacoma, Katharina Rentsch, Gernot G. U. Rohde, Renaud Louis, Joachim G. Aerts, Tobias Welte, Antoni Torres, Michael Tamm, Daiana Stolz

ABSTRACT

BACKGROUND: Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations? METHODS: Five hundred twenty eight patients were recruited in a prospective observational multicentre cohort (PROMISE) study. The genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and circulating levels of IFNL3 in COPD patients were determined and associated with disease activity and outcome during a median follow-up of 24 months. RESULTS: The GG genotype significantly influenced severe exacerbation rate (42 vs. 23%; p = 0.032) and time to severe exacerbation (HR = 2.260; p = 0.012). Compared to the TT or TG genotypes, the GG genotype was associated with severe dyspnoea (modified medical research council score ≥ median 3; 22 vs 42%, p = 0.030). The CC genotype of the rs12979860 SNP was associated with a poorer prognosis (body mass index, airflow obstruction, dyspnea and exercise capacity index ≥ median 4; 46 vs. 36% TC vs. 20.5% TT; p = 0.031). Patients with stable COPD and at exacerbation had significantly lower circulating IFNL3 compared to healthy controls (p < 0.001 and p < 0.001, respectively). Circulating IFNL3 correlated to post-bronchodilator FEV1%predicted and the tissue maturation biomarker Pro-collagen 3. CONCLUSION: IFNL3/4 polymorphisms and circulating IFNL3 may be associated with disease activity and outcomes in COPD. TRIAL REGISTRATION: Clinical Trial registration http://www.isrctn.com/ identifier ISRCTN99586989 on 16 April 2008. More... »

PAGES

51

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12890-018-0616-6

DOI

http://dx.doi.org/10.1186/s12890-018-0616-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101676743

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29562888


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenomedullin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atrial Natriuretic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dyspnea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Forced Expiratory Volume", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycopeptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Procalcitonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proportional Hazards Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Precursors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Disease, Chronic Obstructive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospital of Basel", 
          "id": "https://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Applied Microbiology Research, Department of Medicine, University of Basel, Basel, Switzerland", 
            "Clinical Microbiology, University Hospital Basel, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Egli", 
        "givenName": "Adrian", 
        "id": "sg:person.01311225705.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311225705.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Basel", 
          "id": "https://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mandal", 
        "givenName": "Jyotshna", 
        "id": "sg:person.01336440444.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336440444.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Basel", 
          "id": "https://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schumann", 
        "givenName": "Desiree M.", 
        "id": "sg:person.01172332651.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172332651.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Basel", 
          "id": "https://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roth", 
        "givenName": "Michael", 
        "id": "sg:person.014257130740.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014257130740.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alberta", 
          "id": "https://www.grid.ac/institutes/grid.17089.37", 
          "name": [
            "Li Ka Shing Institute for Virology, University of Alberta, Edmonton, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "Brad", 
        "id": "sg:person.01105571050.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105571050.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alberta", 
          "id": "https://www.grid.ac/institutes/grid.17089.37", 
          "name": [
            "Li Ka Shing Institute for Virology, University of Alberta, Edmonton, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lorne Tyrrell", 
        "givenName": "D.", 
        "id": "sg:person.013176364002.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013176364002.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Milan", 
          "id": "https://www.grid.ac/institutes/grid.4708.b", 
          "name": [
            "Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blasi", 
        "givenName": "Francesco", 
        "id": "sg:person.01355420747.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355420747.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Basel", 
          "id": "https://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kostikas", 
        "givenName": "Kostantinos", 
        "id": "sg:person.01364374656.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364374656.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medisch Centrum Alkmaar", 
          "id": "https://www.grid.ac/institutes/grid.414828.3", 
          "name": [
            "Department of Pneumology, Medisch Centrum Alkmaar, Alkmaar, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boersma", 
        "givenName": "Wim", 
        "id": "sg:person.011063000114.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011063000114.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pneumology, Institute for Pulmonary Diseases, Belgrade, Serbia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milenkovic", 
        "givenName": "Branislava", 
        "id": "sg:person.01304136556.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304136556.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitari Germans Trias i Pujol", 
          "id": "https://www.grid.ac/institutes/grid.411438.b", 
          "name": [
            "Department of Microbiology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lacoma", 
        "givenName": "Alicia", 
        "id": "sg:person.01314562321.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314562321.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Basel", 
          "id": "https://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Laboratory Medicine, University Hospital Basel, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rentsch", 
        "givenName": "Katharina", 
        "id": "sg:person.01143003154.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143003154.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Maastricht University Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.412966.e", 
          "name": [
            "Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rohde", 
        "givenName": "Gernot G. U.", 
        "id": "sg:person.01053063160.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053063160.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pneumology, CHU Liege, University of Liege, GIGAI Research Group, Liege, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Louis", 
        "givenName": "Renaud", 
        "id": "sg:person.0757320177.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757320177.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pneumology, Amphia Hospital/Erasmus MC, Breda, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aerts", 
        "givenName": "Joachim G.", 
        "id": "sg:person.016645000412.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016645000412.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Pneumology, Medizinische Hochschule Hannover, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Welte", 
        "givenName": "Tobias", 
        "id": "sg:person.01200122325.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200122325.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Clinic of Barcelona", 
          "id": "https://www.grid.ac/institutes/grid.410458.c", 
          "name": [
            "Department of Pneumology, Hospital Clinic, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Torres", 
        "givenName": "Antoni", 
        "id": "sg:person.013605501140.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013605501140.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Basel", 
          "id": "https://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tamm", 
        "givenName": "Michael", 
        "id": "sg:person.01112036134.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112036134.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Basel", 
          "id": "https://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stolz", 
        "givenName": "Daiana", 
        "id": "sg:person.0600221261.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600221261.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/liv.12700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001643145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12931-015-0225-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002472442", 
          "https://doi.org/10.1186/s12931-015-0225-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12931-015-0225-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002472442", 
          "https://doi.org/10.1186/s12931-015-0225-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.09-2225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005552514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000369459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007082451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000439228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007152389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007717765", 
          "https://doi.org/10.1038/nri3787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2015.01.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008425568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/imj.13213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009027906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humimm.2016.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009175818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.2005.02244.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010905988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.2005.02244.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010905988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2006-0199tr", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011897391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000430993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013477093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.inf.0000188164.33856.f9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015874690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.inf.0000188164.33856.f9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015874690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.inf.0000188164.33856.f9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015874690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019337542", 
          "https://doi.org/10.1038/nature08309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019337542", 
          "https://doi.org/10.1038/nature08309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01485-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020376787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01485-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020376787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01485-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020376787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00272-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020472904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1751-2980.12202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021616648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00705-016-3095-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022593942", 
          "https://doi.org/10.1007/s00705-016-3095-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00705-016-3095-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022593942", 
          "https://doi.org/10.1007/s00705-016-3095-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026235932", 
          "https://doi.org/10.1038/ng.447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026235932", 
          "https://doi.org/10.1038/ng.447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-319-15774-0_1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026816246", 
          "https://doi.org/10.1007/978-3-319-15774-0_1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.2008.03045.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028926960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-013-0858-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031379658", 
          "https://doi.org/10.1007/s00535-013-0858-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033513354", 
          "https://doi.org/10.1038/nri1684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033513354", 
          "https://doi.org/10.1038/nri1684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2010.11.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034193910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chest.2016.08.1440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034401469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2010.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035517326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036823458", 
          "https://doi.org/10.1038/nm1462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036823458", 
          "https://doi.org/10.1038/nm1462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11882-016-0661-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037013337", 
          "https://doi.org/10.1007/s11882-016-0661-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11882-016-0661-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037013337", 
          "https://doi.org/10.1007/s11882-016-0661-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2011.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037134822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkr598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037877775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.06-2336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039501677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2010.04.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040232481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/emmm.201100142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041415525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jiu144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047579563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2009.12.056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048073263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08820139.2016.1208215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048720999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2013.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048848276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049900143", 
          "https://doi.org/10.1038/ng.449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049900143", 
          "https://doi.org/10.1038/ng.449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1741-7015-10-27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050155314", 
          "https://doi.org/10.1186/1741-7015-10-27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/emi.2014.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051120986", 
          "https://doi.org/10.1038/emi.2014.51"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201006-0833oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053649664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2011.0354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059226420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00430-017-0497-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083848435", 
          "https://doi.org/10.1007/s00430-017-0497-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00430-017-0497-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083848435", 
          "https://doi.org/10.1007/s00430-017-0497-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2017.00119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084432956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4135/9781412952453.n413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1088072834"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations?\nMETHODS: Five hundred twenty eight patients were recruited in a prospective observational multicentre cohort (PROMISE) study. The genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and circulating levels of IFNL3 in COPD patients were determined and associated with disease activity and outcome during a median follow-up of 24 months.\nRESULTS: The GG genotype significantly influenced severe exacerbation rate (42 vs. 23%; p = 0.032) and time to severe exacerbation (HR = 2.260; p = 0.012). Compared to the TT or TG genotypes, the GG genotype was associated with severe dyspnoea (modified medical research council score \u2265 median 3; 22 vs 42%, p = 0.030). The CC genotype of the rs12979860 SNP was associated with a poorer prognosis (body mass index, airflow obstruction, dyspnea and exercise capacity index \u2265 median 4; 46 vs. 36% TC vs. 20.5% TT; p = 0.031). Patients with stable COPD and at exacerbation had significantly lower circulating IFNL3 compared to healthy controls (p < 0.001 and p < 0.001, respectively). Circulating IFNL3 correlated to post-bronchodilator FEV1%predicted and the tissue maturation biomarker Pro-collagen 3.\nCONCLUSION: IFNL3/4 polymorphisms and circulating IFNL3 may be associated with disease activity and outcomes in COPD.\nTRIAL REGISTRATION: Clinical Trial registration http://www.isrctn.com/ identifier ISRCTN99586989 on 16 April 2008.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12890-018-0616-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5225886", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5236978", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024955", 
        "issn": [
          "1471-2466"
        ], 
        "name": "BMC Pulmonary Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "IFN\u039b3/4 locus polymorphisms and IFN\u039b3 circulating levels are associated with COPD severity and outcomes", 
    "pagination": "51", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b4daa03c6d78dc6c5a8863138bca8eca36af8fd6a1ead05f3cae85b9990d13e3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29562888"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968563"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12890-018-0616-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101676743"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12890-018-0616-6", 
      "https://app.dimensions.ai/details/publication/pub.1101676743"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000366_0000000366/records_112045_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12890-018-0616-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0616-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0616-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0616-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0616-6'


 

This table displays all metadata directly associated to this object as RDF triples.

469 TRIPLES      21 PREDICATES      97 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12890-018-0616-6 schema:about N0e05babfee284252963a5909591a3a81
2 N0fd7c33473654475a86b55d3548a5ef9
3 N1df2ae49ea8e4aef9ed5c3c7a6027661
4 N2d7ce310719c4ab1a3048ec80725ca66
5 N2df609e140ca42e0b327da41af958ef9
6 N3efddd6e47344dbca6cc8f150924bc9d
7 N419069514ae040e9af9515168fca626c
8 N64fe83b6c1274a1380106ba9b4dd8c0d
9 N78a312556b684c7983a2eb2e24fec247
10 N7f57c66c2d11425b9d235093ea232ea7
11 N80eb5f4a47194e70abaf499f69b7cf5e
12 Na91fbb4ce7b945b38eb46815efa8d4eb
13 Nc17202ecf43d474fb4bafb5982945bea
14 Nc2392963d3f347beb55f3ab60593fa75
15 Nc8d998f65b564954895cf2228c6bbb29
16 Ndb03d1efd55343fbb21fd4f3a4bae71f
17 Ne05affbff1364709bdbab470170df0b6
18 Ne12fac7519714238b5212a77c5021d0f
19 Ne2e60bb88d014685abcbec497f440e36
20 Ne3efc9fe63294826a0b695a9887a1d57
21 Ne6e4b90750164c28872f1507ae648c9d
22 Ned87d70573f94f16bbdb4d7f9b157760
23 Nf22e667470c640d98740d79c138a8b66
24 anzsrc-for:11
25 anzsrc-for:1102
26 schema:author N57c94fbbb9414dbd9b6d3ceb70b9656d
27 schema:citation sg:pub.10.1007/978-3-319-15774-0_1
28 sg:pub.10.1007/s00430-017-0497-y
29 sg:pub.10.1007/s00535-013-0858-2
30 sg:pub.10.1007/s00705-016-3095-1
31 sg:pub.10.1007/s11882-016-0661-2
32 sg:pub.10.1038/emi.2014.51
33 sg:pub.10.1038/nature08309
34 sg:pub.10.1038/ng.447
35 sg:pub.10.1038/ng.449
36 sg:pub.10.1038/nm1462
37 sg:pub.10.1038/nri1684
38 sg:pub.10.1038/nri3787
39 sg:pub.10.1186/1741-7015-10-27
40 sg:pub.10.1186/s12931-015-0225-3
41 https://doi.org/10.1002/emmm.201100142
42 https://doi.org/10.1016/j.chest.2016.08.1440
43 https://doi.org/10.1016/j.humimm.2016.09.007
44 https://doi.org/10.1016/j.jaci.2015.01.038
45 https://doi.org/10.1016/j.jhep.2010.08.020
46 https://doi.org/10.1016/j.jhep.2011.03.015
47 https://doi.org/10.1016/j.virol.2013.06.025
48 https://doi.org/10.1053/j.gastro.2009.12.056
49 https://doi.org/10.1053/j.gastro.2010.04.049
50 https://doi.org/10.1053/j.gastro.2010.11.039
51 https://doi.org/10.1080/08820139.2016.1208215
52 https://doi.org/10.1089/aid.2011.0354
53 https://doi.org/10.1093/infdis/jiu144
54 https://doi.org/10.1093/jac/dkr598
55 https://doi.org/10.1097/01.inf.0000188164.33856.f9
56 https://doi.org/10.1111/1751-2980.12202
57 https://doi.org/10.1111/imj.13213
58 https://doi.org/10.1111/j.1365-2222.2005.02244.x
59 https://doi.org/10.1111/j.1365-2222.2008.03045.x
60 https://doi.org/10.1111/liv.12700
61 https://doi.org/10.1128/jvi.00272-10
62 https://doi.org/10.1159/000369459
63 https://doi.org/10.1159/000430993
64 https://doi.org/10.1159/000439228
65 https://doi.org/10.1164/rccm.201006-0833oc
66 https://doi.org/10.1165/rcmb.2006-0199tr
67 https://doi.org/10.1183/13993003.01485-2015
68 https://doi.org/10.1378/chest.06-2336
69 https://doi.org/10.1378/chest.09-2225
70 https://doi.org/10.3389/fimmu.2017.00119
71 https://doi.org/10.4135/9781412952453.n413
72 schema:datePublished 2018-12
73 schema:datePublishedReg 2018-12-01
74 schema:description BACKGROUND: Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations? METHODS: Five hundred twenty eight patients were recruited in a prospective observational multicentre cohort (PROMISE) study. The genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and circulating levels of IFNL3 in COPD patients were determined and associated with disease activity and outcome during a median follow-up of 24 months. RESULTS: The GG genotype significantly influenced severe exacerbation rate (42 vs. 23%; p = 0.032) and time to severe exacerbation (HR = 2.260; p = 0.012). Compared to the TT or TG genotypes, the GG genotype was associated with severe dyspnoea (modified medical research council score ≥ median 3; 22 vs 42%, p = 0.030). The CC genotype of the rs12979860 SNP was associated with a poorer prognosis (body mass index, airflow obstruction, dyspnea and exercise capacity index ≥ median 4; 46 vs. 36% TC vs. 20.5% TT; p = 0.031). Patients with stable COPD and at exacerbation had significantly lower circulating IFNL3 compared to healthy controls (p < 0.001 and p < 0.001, respectively). Circulating IFNL3 correlated to post-bronchodilator FEV1%predicted and the tissue maturation biomarker Pro-collagen 3. CONCLUSION: IFNL3/4 polymorphisms and circulating IFNL3 may be associated with disease activity and outcomes in COPD. TRIAL REGISTRATION: Clinical Trial registration http://www.isrctn.com/ identifier ISRCTN99586989 on 16 April 2008.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N11db075867dc42dcbac98dffdeb5aded
79 N85084058f4194fb780cd58f18f757f06
80 sg:journal.1024955
81 schema:name IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes
82 schema:pagination 51
83 schema:productId N573f74bfe0514471a58f6657e59a8db0
84 N5c6b7d1113dc492c866bafd5bd26da7e
85 N6b829c3989e54882a48698d8c4e597fd
86 N7dca95348dde44f886a00a3ed323b412
87 Nc46d28b5e5014095b1eea6a636fc689b
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101676743
89 https://doi.org/10.1186/s12890-018-0616-6
90 schema:sdDatePublished 2019-04-11T13:04
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N7d343041679a43589fe3d50c059d9eeb
93 schema:url https://link.springer.com/10.1186%2Fs12890-018-0616-6
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N007c503df20b444ca15e3aeda3ae6e43 rdf:first sg:person.013176364002.53
98 rdf:rest N066f3da7597e4b32a94c12491737e5a5
99 N066f3da7597e4b32a94c12491737e5a5 rdf:first sg:person.01355420747.67
100 rdf:rest N49a826f71a494c128f7f5e6d44ed37b2
101 N080de834a86741b9b60c260dc277e61f rdf:first sg:person.01053063160.74
102 rdf:rest Ndd050bda079749c284b4de060196a2e7
103 N0e05babfee284252963a5909591a3a81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Aged
105 rdf:type schema:DefinedTerm
106 N0fd7c33473654475a86b55d3548a5ef9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Male
108 rdf:type schema:DefinedTerm
109 N11db075867dc42dcbac98dffdeb5aded schema:volumeNumber 18
110 rdf:type schema:PublicationVolume
111 N12b9e1e7d12d4cefa0e8000a505e06ee rdf:first sg:person.01200122325.47
112 rdf:rest N9ced0fcc961042d4bb709905bddbca6d
113 N14ce87c051a8438da7f42695f2301326 rdf:first sg:person.0600221261.07
114 rdf:rest rdf:nil
115 N19003669714149788633482de79fc287 rdf:first sg:person.014257130740.79
116 rdf:rest Nc20c5a420f934e428983f67b637b6903
117 N1df2ae49ea8e4aef9ed5c3c7a6027661 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Pulmonary Disease, Chronic Obstructive
119 rdf:type schema:DefinedTerm
120 N262f0631f43b4c3fa45cbae92e86aae6 rdf:first sg:person.01336440444.83
121 rdf:rest N6ae6a3aca942409e8c139e4d60da5ebf
122 N2ae843e9eb374eeda9b63e767de44fd8 rdf:first sg:person.01112036134.17
123 rdf:rest N14ce87c051a8438da7f42695f2301326
124 N2d7ce310719c4ab1a3048ec80725ca66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Disease Progression
126 rdf:type schema:DefinedTerm
127 N2df609e140ca42e0b327da41af958ef9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Glycopeptides
129 rdf:type schema:DefinedTerm
130 N32e7ed56bc1e4d8c816607d421e7ebb4 schema:name Department of Pneumology, Amphia Hospital/Erasmus MC, Breda, The Netherlands
131 rdf:type schema:Organization
132 N3efddd6e47344dbca6cc8f150924bc9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Severity of Illness Index
134 rdf:type schema:DefinedTerm
135 N419069514ae040e9af9515168fca626c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Procalcitonin
137 rdf:type schema:DefinedTerm
138 N49a826f71a494c128f7f5e6d44ed37b2 rdf:first sg:person.01364374656.12
139 rdf:rest N755b16e07f934f7e8c3ecbec24aa761e
140 N56229493aa794e36a5f82cb370c2cf79 rdf:first sg:person.01304136556.81
141 rdf:rest N6b0a32face634d94b5977c0f57b870af
142 N566a56aacfa349288fa81c73539abfc4 schema:name Department of Pneumology, CHU Liege, University of Liege, GIGAI Research Group, Liege, Belgium
143 rdf:type schema:Organization
144 N573f74bfe0514471a58f6657e59a8db0 schema:name nlm_unique_id
145 schema:value 100968563
146 rdf:type schema:PropertyValue
147 N57c94fbbb9414dbd9b6d3ceb70b9656d rdf:first sg:person.01311225705.71
148 rdf:rest N262f0631f43b4c3fa45cbae92e86aae6
149 N5c6b7d1113dc492c866bafd5bd26da7e schema:name pubmed_id
150 schema:value 29562888
151 rdf:type schema:PropertyValue
152 N64fe83b6c1274a1380106ba9b4dd8c0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Prognosis
154 rdf:type schema:DefinedTerm
155 N6ae6a3aca942409e8c139e4d60da5ebf rdf:first sg:person.01172332651.74
156 rdf:rest N19003669714149788633482de79fc287
157 N6b0a32face634d94b5977c0f57b870af rdf:first sg:person.01314562321.96
158 rdf:rest Nd874ca3cdfc6481e9b74a965ffa2ecd0
159 N6b829c3989e54882a48698d8c4e597fd schema:name dimensions_id
160 schema:value pub.1101676743
161 rdf:type schema:PropertyValue
162 N755b16e07f934f7e8c3ecbec24aa761e rdf:first sg:person.011063000114.56
163 rdf:rest N56229493aa794e36a5f82cb370c2cf79
164 N78a312556b684c7983a2eb2e24fec247 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Middle Aged
166 rdf:type schema:DefinedTerm
167 N7d343041679a43589fe3d50c059d9eeb schema:name Springer Nature - SN SciGraph project
168 rdf:type schema:Organization
169 N7dca95348dde44f886a00a3ed323b412 schema:name readcube_id
170 schema:value b4daa03c6d78dc6c5a8863138bca8eca36af8fd6a1ead05f3cae85b9990d13e3
171 rdf:type schema:PropertyValue
172 N7f57c66c2d11425b9d235093ea232ea7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Dyspnea
174 rdf:type schema:DefinedTerm
175 N80eb5f4a47194e70abaf499f69b7cf5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Protein Precursors
177 rdf:type schema:DefinedTerm
178 N85084058f4194fb780cd58f18f757f06 schema:issueNumber 1
179 rdf:type schema:PublicationIssue
180 N9ced0fcc961042d4bb709905bddbca6d rdf:first sg:person.013605501140.89
181 rdf:rest N2ae843e9eb374eeda9b63e767de44fd8
182 Na09eaf4e480043c4a0e647426962ed18 schema:name Department of Pneumology, Institute for Pulmonary Diseases, Belgrade, Serbia
183 rdf:type schema:Organization
184 Na91fbb4ce7b945b38eb46815efa8d4eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Forced Expiratory Volume
186 rdf:type schema:DefinedTerm
187 Nbeed719fcbef45febd036dc8746d5b09 rdf:first sg:person.016645000412.35
188 rdf:rest N12b9e1e7d12d4cefa0e8000a505e06ee
189 Nc17202ecf43d474fb4bafb5982945bea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Female
191 rdf:type schema:DefinedTerm
192 Nc20c5a420f934e428983f67b637b6903 rdf:first sg:person.01105571050.06
193 rdf:rest N007c503df20b444ca15e3aeda3ae6e43
194 Nc2392963d3f347beb55f3ab60593fa75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Adrenomedullin
196 rdf:type schema:DefinedTerm
197 Nc46d28b5e5014095b1eea6a636fc689b schema:name doi
198 schema:value 10.1186/s12890-018-0616-6
199 rdf:type schema:PropertyValue
200 Nc8d998f65b564954895cf2228c6bbb29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Proportional Hazards Models
202 rdf:type schema:DefinedTerm
203 Nd874ca3cdfc6481e9b74a965ffa2ecd0 rdf:first sg:person.01143003154.94
204 rdf:rest N080de834a86741b9b60c260dc277e61f
205 Ndb03d1efd55343fbb21fd4f3a4bae71f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Atrial Natriuretic Factor
207 rdf:type schema:DefinedTerm
208 Ndd050bda079749c284b4de060196a2e7 rdf:first sg:person.0757320177.87
209 rdf:rest Nbeed719fcbef45febd036dc8746d5b09
210 Ne05affbff1364709bdbab470170df0b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Humans
212 rdf:type schema:DefinedTerm
213 Ne12fac7519714238b5212a77c5021d0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Polymorphism, Single Nucleotide
215 rdf:type schema:DefinedTerm
216 Ne2e60bb88d014685abcbec497f440e36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Cohort Studies
218 rdf:type schema:DefinedTerm
219 Ne3efc9fe63294826a0b695a9887a1d57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Polymorphism, Genetic
221 rdf:type schema:DefinedTerm
222 Ne6e4b90750164c28872f1507ae648c9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Case-Control Studies
224 rdf:type schema:DefinedTerm
225 Ned87d70573f94f16bbdb4d7f9b157760 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Interleukins
227 rdf:type schema:DefinedTerm
228 Nf22e667470c640d98740d79c138a8b66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Prospective Studies
230 rdf:type schema:DefinedTerm
231 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
232 schema:name Medical and Health Sciences
233 rdf:type schema:DefinedTerm
234 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
235 schema:name Cardiorespiratory Medicine and Haematology
236 rdf:type schema:DefinedTerm
237 sg:grant.5225886 http://pending.schema.org/fundedItem sg:pub.10.1186/s12890-018-0616-6
238 rdf:type schema:MonetaryGrant
239 sg:grant.5236978 http://pending.schema.org/fundedItem sg:pub.10.1186/s12890-018-0616-6
240 rdf:type schema:MonetaryGrant
241 sg:journal.1024955 schema:issn 1471-2466
242 schema:name BMC Pulmonary Medicine
243 rdf:type schema:Periodical
244 sg:person.01053063160.74 schema:affiliation https://www.grid.ac/institutes/grid.412966.e
245 schema:familyName Rohde
246 schema:givenName Gernot G. U.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053063160.74
248 rdf:type schema:Person
249 sg:person.01105571050.06 schema:affiliation https://www.grid.ac/institutes/grid.17089.37
250 schema:familyName Thomas
251 schema:givenName Brad
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105571050.06
253 rdf:type schema:Person
254 sg:person.011063000114.56 schema:affiliation https://www.grid.ac/institutes/grid.414828.3
255 schema:familyName Boersma
256 schema:givenName Wim
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011063000114.56
258 rdf:type schema:Person
259 sg:person.01112036134.17 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
260 schema:familyName Tamm
261 schema:givenName Michael
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112036134.17
263 rdf:type schema:Person
264 sg:person.01143003154.94 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
265 schema:familyName Rentsch
266 schema:givenName Katharina
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143003154.94
268 rdf:type schema:Person
269 sg:person.01172332651.74 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
270 schema:familyName Schumann
271 schema:givenName Desiree M.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172332651.74
273 rdf:type schema:Person
274 sg:person.01200122325.47 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
275 schema:familyName Welte
276 schema:givenName Tobias
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200122325.47
278 rdf:type schema:Person
279 sg:person.01304136556.81 schema:affiliation Na09eaf4e480043c4a0e647426962ed18
280 schema:familyName Milenkovic
281 schema:givenName Branislava
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304136556.81
283 rdf:type schema:Person
284 sg:person.01311225705.71 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
285 schema:familyName Egli
286 schema:givenName Adrian
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311225705.71
288 rdf:type schema:Person
289 sg:person.01314562321.96 schema:affiliation https://www.grid.ac/institutes/grid.411438.b
290 schema:familyName Lacoma
291 schema:givenName Alicia
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314562321.96
293 rdf:type schema:Person
294 sg:person.013176364002.53 schema:affiliation https://www.grid.ac/institutes/grid.17089.37
295 schema:familyName Lorne Tyrrell
296 schema:givenName D.
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013176364002.53
298 rdf:type schema:Person
299 sg:person.01336440444.83 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
300 schema:familyName Mandal
301 schema:givenName Jyotshna
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336440444.83
303 rdf:type schema:Person
304 sg:person.01355420747.67 schema:affiliation https://www.grid.ac/institutes/grid.4708.b
305 schema:familyName Blasi
306 schema:givenName Francesco
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355420747.67
308 rdf:type schema:Person
309 sg:person.013605501140.89 schema:affiliation https://www.grid.ac/institutes/grid.410458.c
310 schema:familyName Torres
311 schema:givenName Antoni
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013605501140.89
313 rdf:type schema:Person
314 sg:person.01364374656.12 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
315 schema:familyName Kostikas
316 schema:givenName Kostantinos
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364374656.12
318 rdf:type schema:Person
319 sg:person.014257130740.79 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
320 schema:familyName Roth
321 schema:givenName Michael
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014257130740.79
323 rdf:type schema:Person
324 sg:person.016645000412.35 schema:affiliation N32e7ed56bc1e4d8c816607d421e7ebb4
325 schema:familyName Aerts
326 schema:givenName Joachim G.
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016645000412.35
328 rdf:type schema:Person
329 sg:person.0600221261.07 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
330 schema:familyName Stolz
331 schema:givenName Daiana
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600221261.07
333 rdf:type schema:Person
334 sg:person.0757320177.87 schema:affiliation N566a56aacfa349288fa81c73539abfc4
335 schema:familyName Louis
336 schema:givenName Renaud
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757320177.87
338 rdf:type schema:Person
339 sg:pub.10.1007/978-3-319-15774-0_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026816246
340 https://doi.org/10.1007/978-3-319-15774-0_1
341 rdf:type schema:CreativeWork
342 sg:pub.10.1007/s00430-017-0497-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1083848435
343 https://doi.org/10.1007/s00430-017-0497-y
344 rdf:type schema:CreativeWork
345 sg:pub.10.1007/s00535-013-0858-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031379658
346 https://doi.org/10.1007/s00535-013-0858-2
347 rdf:type schema:CreativeWork
348 sg:pub.10.1007/s00705-016-3095-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022593942
349 https://doi.org/10.1007/s00705-016-3095-1
350 rdf:type schema:CreativeWork
351 sg:pub.10.1007/s11882-016-0661-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037013337
352 https://doi.org/10.1007/s11882-016-0661-2
353 rdf:type schema:CreativeWork
354 sg:pub.10.1038/emi.2014.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051120986
355 https://doi.org/10.1038/emi.2014.51
356 rdf:type schema:CreativeWork
357 sg:pub.10.1038/nature08309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019337542
358 https://doi.org/10.1038/nature08309
359 rdf:type schema:CreativeWork
360 sg:pub.10.1038/ng.447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026235932
361 https://doi.org/10.1038/ng.447
362 rdf:type schema:CreativeWork
363 sg:pub.10.1038/ng.449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049900143
364 https://doi.org/10.1038/ng.449
365 rdf:type schema:CreativeWork
366 sg:pub.10.1038/nm1462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036823458
367 https://doi.org/10.1038/nm1462
368 rdf:type schema:CreativeWork
369 sg:pub.10.1038/nri1684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033513354
370 https://doi.org/10.1038/nri1684
371 rdf:type schema:CreativeWork
372 sg:pub.10.1038/nri3787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007717765
373 https://doi.org/10.1038/nri3787
374 rdf:type schema:CreativeWork
375 sg:pub.10.1186/1741-7015-10-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050155314
376 https://doi.org/10.1186/1741-7015-10-27
377 rdf:type schema:CreativeWork
378 sg:pub.10.1186/s12931-015-0225-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002472442
379 https://doi.org/10.1186/s12931-015-0225-3
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1002/emmm.201100142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041415525
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1016/j.chest.2016.08.1440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034401469
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1016/j.humimm.2016.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009175818
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1016/j.jaci.2015.01.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008425568
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1016/j.jhep.2010.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035517326
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1016/j.jhep.2011.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037134822
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1016/j.virol.2013.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048848276
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1053/j.gastro.2009.12.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048073263
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1053/j.gastro.2010.04.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040232481
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1053/j.gastro.2010.11.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034193910
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1080/08820139.2016.1208215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048720999
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1089/aid.2011.0354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059226420
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1093/infdis/jiu144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047579563
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1093/jac/dkr598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037877775
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1097/01.inf.0000188164.33856.f9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015874690
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1111/1751-2980.12202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021616648
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1111/imj.13213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009027906
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1111/j.1365-2222.2005.02244.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010905988
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1111/j.1365-2222.2008.03045.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028926960
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1111/liv.12700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001643145
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1128/jvi.00272-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020472904
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1159/000369459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007082451
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1159/000430993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013477093
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1159/000439228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007152389
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1164/rccm.201006-0833oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1053649664
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1165/rcmb.2006-0199tr schema:sameAs https://app.dimensions.ai/details/publication/pub.1011897391
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1183/13993003.01485-2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020376787
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1378/chest.06-2336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039501677
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1378/chest.09-2225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005552514
438 rdf:type schema:CreativeWork
439 https://doi.org/10.3389/fimmu.2017.00119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084432956
440 rdf:type schema:CreativeWork
441 https://doi.org/10.4135/9781412952453.n413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1088072834
442 rdf:type schema:CreativeWork
443 https://www.grid.ac/institutes/grid.10423.34 schema:alternateName Hannover Medical School
444 schema:name Department of Pneumology, Medizinische Hochschule Hannover, Hannover, Germany
445 rdf:type schema:Organization
446 https://www.grid.ac/institutes/grid.17089.37 schema:alternateName University of Alberta
447 schema:name Li Ka Shing Institute for Virology, University of Alberta, Edmonton, Canada
448 rdf:type schema:Organization
449 https://www.grid.ac/institutes/grid.410458.c schema:alternateName Hospital Clinic of Barcelona
450 schema:name Department of Pneumology, Hospital Clinic, Barcelona, Spain
451 rdf:type schema:Organization
452 https://www.grid.ac/institutes/grid.410567.1 schema:alternateName University Hospital of Basel
453 schema:name Applied Microbiology Research, Department of Medicine, University of Basel, Basel, Switzerland
454 Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
455 Clinical Microbiology, University Hospital Basel, Basel, Switzerland
456 Laboratory Medicine, University Hospital Basel, Basel, Switzerland
457 rdf:type schema:Organization
458 https://www.grid.ac/institutes/grid.411438.b schema:alternateName Hospital Universitari Germans Trias i Pujol
459 schema:name Department of Microbiology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
460 rdf:type schema:Organization
461 https://www.grid.ac/institutes/grid.412966.e schema:alternateName Maastricht University Medical Centre
462 schema:name Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
463 rdf:type schema:Organization
464 https://www.grid.ac/institutes/grid.414828.3 schema:alternateName Medisch Centrum Alkmaar
465 schema:name Department of Pneumology, Medisch Centrum Alkmaar, Alkmaar, The Netherlands
466 rdf:type schema:Organization
467 https://www.grid.ac/institutes/grid.4708.b schema:alternateName University of Milan
468 schema:name Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
469 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...