The relationship between high-dose corticosteroid treatment and mortality in acute respiratory distress syndrome: a retrospective and observational study using a ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02-07

AUTHORS

Takashi Kido, Keiji Muramatsu, Takeshi Asakawa, Hiroki Otsubo, Takaaki Ogoshi, Keishi Oda, Tatsuhiko Kubo, Yoshihisa Fujino, Shinya Matsuda, Toshihiko Mayumi, Hiroshi Mukae, Kazuhiro Yatera

ABSTRACT

BackgroundIn the 1980s, randomized-controlled trials showed that high-dose corticosteroid treatment did not improve the mortality of acute respiratory distress syndrome (ARDS). However, while the diagnostic criteria for ARDS have since changed, and supportive therapies have been improved, no randomized-controlled trials have revisited this issue since 1987; thus, the effect of high-dose corticosteroid treatment may be different in this era. We evaluated the effect of high-dose corticosteroid treatment in patients with ARDS using a nationwide administrative database in Japan in a retrospective and observational study.MethodsThis study was performed with a large population using the 2012 Japanese nationwide administrative database (diagnostic procedure combination). We evaluated the mortality of ARDS patients receiving or not receiving high-dose corticosteroid treatment within 7 days of hospital admission. We employed propensity score weighting with a Cox proportional hazards model in order to minimize the bias associated with the retrospective collection of data on baseline characteristics and compared the mortality between the high-dose and non-high-dose corticosteroid groups.ResultsData from 2707 patients were used; 927 patients were treated with high-dose corticosteroid and 1780 patients were treated without high-dose corticosteroid, within 7 days of admission. After adjusting for confounds, mortality rates within 3 months were significantly higher in the high-dose corticosteroid group compared to the non-high-dose corticosteroid group (weighted hazard ratio: 1.59; 95% CI: 1.37-1.84; P < 0.001).ConclusionsOur results suggest that high-dose corticosteroid treatment does not improve the prognosis of patients with ARDS, even in this era. However, this study has limitations owing to its retrospective and observational design. More... »

PAGES

28

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12890-018-0597-5

DOI

http://dx.doi.org/10.1186/s12890-018-0597-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100861533

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29415701


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Databases, Factual", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucocorticoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospital Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intensive Care Units", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Length of Stay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Logistic Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methylprednisolone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Propensity Score", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proportional Hazards Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiration, Artificial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Distress Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Emergency Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan", 
            "Department of Emergency Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kido", 
        "givenName": "Takashi", 
        "id": "sg:person.01211346734.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211346734.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muramatsu", 
        "givenName": "Keiji", 
        "id": "sg:person.01051644222.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051644222.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Information Systems Center, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Information Systems Center, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asakawa", 
        "givenName": "Takeshi", 
        "id": "sg:person.014111064035.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014111064035.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Emergency Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Emergency Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Otsubo", 
        "givenName": "Hiroki", 
        "id": "sg:person.01245571254.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245571254.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogoshi", 
        "givenName": "Takaaki", 
        "id": "sg:person.01143343732.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143343732.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oda", 
        "givenName": "Keishi", 
        "id": "sg:person.01146120052.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146120052.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kubo", 
        "givenName": "Tatsuhiko", 
        "id": "sg:person.012144422162.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012144422162.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujino", 
        "givenName": "Yoshihisa", 
        "id": "sg:person.01171406332.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171406332.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuda", 
        "givenName": "Shinya", 
        "id": "sg:person.0755324561.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755324561.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Emergency Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Emergency Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayumi", 
        "givenName": "Toshihiko", 
        "id": "sg:person.0652144310.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652144310.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411873.8", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan", 
            "Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukae", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01143125277.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yatera", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.01032646234.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032646234.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/srep17654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029279445", 
          "https://doi.org/10.1038/srep17654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-017-1723-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085919715", 
          "https://doi.org/10.1186/s13054-017-1723-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc13029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005015506", 
          "https://doi.org/10.1186/cc13029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6963-12-129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027837036", 
          "https://doi.org/10.1186/1472-6963-12-129"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-02-07", 
    "datePublishedReg": "2018-02-07", 
    "description": "BackgroundIn the 1980s, randomized-controlled trials showed that high-dose corticosteroid treatment did not improve the mortality of acute respiratory distress syndrome (ARDS). However, while the diagnostic criteria for ARDS have since changed, and supportive therapies have been improved, no randomized-controlled trials have revisited this issue since 1987; thus, the effect of high-dose corticosteroid treatment may be different in this era. We evaluated the effect of high-dose corticosteroid treatment in patients with ARDS using a nationwide administrative database in Japan in a retrospective and observational study.MethodsThis study was performed with a large population using the 2012 Japanese nationwide administrative database (diagnostic procedure combination). We evaluated the mortality of ARDS patients receiving or not receiving high-dose corticosteroid treatment within 7\u00a0days of hospital admission. We employed propensity score weighting with a Cox proportional hazards model in order to minimize the bias associated with the retrospective collection of data on baseline characteristics and compared the mortality between the high-dose and non-high-dose corticosteroid groups.ResultsData from 2707 patients were used; 927 patients were treated with high-dose corticosteroid and 1780 patients were treated without high-dose corticosteroid, within 7\u00a0days of admission. After adjusting for confounds, mortality rates within 3\u00a0months were significantly higher in the high-dose corticosteroid group compared to the non-high-dose corticosteroid group (weighted hazard ratio: 1.59; 95% CI: 1.37-1.84; P\u2009<\u2009\u00a00.001).ConclusionsOur results suggest that high-dose corticosteroid treatment does not improve the prognosis of patients with ARDS, even in this era. However, this study has limitations owing to its retrospective and observational design.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12890-018-0597-5", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024955", 
        "issn": [
          "1471-2466"
        ], 
        "name": "BMC Pulmonary Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "high-dose corticosteroid treatment", 
      "acute respiratory distress syndrome", 
      "nationwide administrative database", 
      "high-dose corticosteroids", 
      "corticosteroid treatment", 
      "respiratory distress syndrome", 
      "randomized-controlled trial", 
      "corticosteroid group", 
      "administrative databases", 
      "distress syndrome", 
      "observational study", 
      "Japanese nationwide administrative database", 
      "high-dose corticosteroid group", 
      "day of admission", 
      "prognosis of patients", 
      "Cox proportional hazards", 
      "baseline characteristics", 
      "ARDS patients", 
      "hospital admission", 
      "supportive therapy", 
      "MethodsThis study", 
      "diagnostic criteria", 
      "patients", 
      "retrospective collection", 
      "mortality rate", 
      "proportional hazards", 
      "observational design", 
      "propensity score", 
      "mortality", 
      "ConclusionsOur results", 
      "corticosteroids", 
      "treatment", 
      "admission", 
      "syndrome", 
      "trials", 
      "group", 
      "large population", 
      "days", 
      "prognosis", 
      "ResultsData", 
      "therapy", 
      "study", 
      "database", 
      "months", 
      "BackgroundIn", 
      "scores", 
      "effect", 
      "population", 
      "confounds", 
      "criteria", 
      "rate", 
      "Japan", 
      "hazards", 
      "era", 
      "data", 
      "relationship", 
      "bias", 
      "results", 
      "limitations", 
      "characteristics", 
      "collection", 
      "issues", 
      "design", 
      "order"
    ], 
    "name": "The relationship between high-dose corticosteroid treatment and mortality in acute respiratory distress syndrome: a retrospective and observational study using a nationwide administrative database in Japan", 
    "pagination": "28", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100861533"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12890-018-0597-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29415701"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12890-018-0597-5", 
      "https://app.dimensions.ai/details/publication/pub.1100861533"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_772.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12890-018-0597-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0597-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0597-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0597-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0597-5'


 

This table displays all metadata directly associated to this object as RDF triples.

307 TRIPLES      21 PREDICATES      113 URIs      101 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12890-018-0597-5 schema:about N0e57864f90e249e18e77ab8dea2a4fd7
2 N263fff3c7b0a4f7896ade7547cc1bc3b
3 N2f3ad6d762ba4e26aed146c8d9a1e5d6
4 N31688798704e4e5ea8d5b7c401bf6405
5 N574ba9ba08cd43c7847ae4fe33a16aa2
6 N65c470b4f8dc4ecaa2b1f7ae7548ce06
7 N75062d1620aa4ef8bf4cb8dc17677270
8 N7de33b5f86b04bd496d83a7845fbb115
9 N8785474a18bd48d790a3607ee5513a2d
10 N9d7c13cf59f94118a9d57ff3676ff554
11 N9e4ea6a879e34b52877fbf39a40cf18b
12 Na0c419a5473b4a198f477229da9070f0
13 Na5abe1b0fdf4419e831d53b73e671881
14 Na5b9d38bd9624e51bd1e8434b4b20b4d
15 Na9874e56d9d74ab9bd70131f0425e070
16 Nba34ace3a89343f6a21c09f82a07d523
17 Nc31f8075cac841d88b0e1399afd1c12a
18 Nc5464db84ddf4d838ea1ef78fb40a2b6
19 Nc5f269f5c5f64bd1a9005c738ab370fa
20 Ne0c6889d26b64db3931ccd7c84e9c784
21 anzsrc-for:11
22 anzsrc-for:1103
23 schema:author Nbacb8ef92d0a482d9e19a4ca09e67cce
24 schema:citation sg:pub.10.1038/srep17654
25 sg:pub.10.1186/1472-6963-12-129
26 sg:pub.10.1186/cc13029
27 sg:pub.10.1186/s13054-017-1723-0
28 schema:datePublished 2018-02-07
29 schema:datePublishedReg 2018-02-07
30 schema:description BackgroundIn the 1980s, randomized-controlled trials showed that high-dose corticosteroid treatment did not improve the mortality of acute respiratory distress syndrome (ARDS). However, while the diagnostic criteria for ARDS have since changed, and supportive therapies have been improved, no randomized-controlled trials have revisited this issue since 1987; thus, the effect of high-dose corticosteroid treatment may be different in this era. We evaluated the effect of high-dose corticosteroid treatment in patients with ARDS using a nationwide administrative database in Japan in a retrospective and observational study.MethodsThis study was performed with a large population using the 2012 Japanese nationwide administrative database (diagnostic procedure combination). We evaluated the mortality of ARDS patients receiving or not receiving high-dose corticosteroid treatment within 7 days of hospital admission. We employed propensity score weighting with a Cox proportional hazards model in order to minimize the bias associated with the retrospective collection of data on baseline characteristics and compared the mortality between the high-dose and non-high-dose corticosteroid groups.ResultsData from 2707 patients were used; 927 patients were treated with high-dose corticosteroid and 1780 patients were treated without high-dose corticosteroid, within 7 days of admission. After adjusting for confounds, mortality rates within 3 months were significantly higher in the high-dose corticosteroid group compared to the non-high-dose corticosteroid group (weighted hazard ratio: 1.59; 95% CI: 1.37-1.84; P <  0.001).ConclusionsOur results suggest that high-dose corticosteroid treatment does not improve the prognosis of patients with ARDS, even in this era. However, this study has limitations owing to its retrospective and observational design.
31 schema:genre article
32 schema:isAccessibleForFree true
33 schema:isPartOf N36638587aad14860a903b9f0c16e21c4
34 Ncb7f932d73684030818f84fc559bd17a
35 sg:journal.1024955
36 schema:keywords ARDS patients
37 BackgroundIn
38 ConclusionsOur results
39 Cox proportional hazards
40 Japan
41 Japanese nationwide administrative database
42 MethodsThis study
43 ResultsData
44 acute respiratory distress syndrome
45 administrative databases
46 admission
47 baseline characteristics
48 bias
49 characteristics
50 collection
51 confounds
52 corticosteroid group
53 corticosteroid treatment
54 corticosteroids
55 criteria
56 data
57 database
58 day of admission
59 days
60 design
61 diagnostic criteria
62 distress syndrome
63 effect
64 era
65 group
66 hazards
67 high-dose corticosteroid group
68 high-dose corticosteroid treatment
69 high-dose corticosteroids
70 hospital admission
71 issues
72 large population
73 limitations
74 months
75 mortality
76 mortality rate
77 nationwide administrative database
78 observational design
79 observational study
80 order
81 patients
82 population
83 prognosis
84 prognosis of patients
85 propensity score
86 proportional hazards
87 randomized-controlled trial
88 rate
89 relationship
90 respiratory distress syndrome
91 results
92 retrospective collection
93 scores
94 study
95 supportive therapy
96 syndrome
97 therapy
98 treatment
99 trials
100 schema:name The relationship between high-dose corticosteroid treatment and mortality in acute respiratory distress syndrome: a retrospective and observational study using a nationwide administrative database in Japan
101 schema:pagination 28
102 schema:productId N02eb0bfcdde14fceaa66594f9dee06df
103 N9b6eb5fcaabc488ab0e9216459636cd8
104 Nb9c741a1224545e38d057bab771ccfb1
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100861533
106 https://doi.org/10.1186/s12890-018-0597-5
107 schema:sdDatePublished 2022-09-02T16:02
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher N96b95573dc564639a992762623d9a920
110 schema:url https://doi.org/10.1186/s12890-018-0597-5
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N02eb0bfcdde14fceaa66594f9dee06df schema:name doi
115 schema:value 10.1186/s12890-018-0597-5
116 rdf:type schema:PropertyValue
117 N0e57864f90e249e18e77ab8dea2a4fd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Female
119 rdf:type schema:DefinedTerm
120 N12b593d6beb74c7897fa6171fd5d3462 rdf:first sg:person.012144422162.95
121 rdf:rest N9434b129c9364c86b38073ee835ef150
122 N263fff3c7b0a4f7896ade7547cc1bc3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Retrospective Studies
124 rdf:type schema:DefinedTerm
125 N2f3ad6d762ba4e26aed146c8d9a1e5d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N31688798704e4e5ea8d5b7c401bf6405 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Propensity Score
130 rdf:type schema:DefinedTerm
131 N339f4d0c28904ab8a869dce99f17d424 rdf:first sg:person.01245571254.09
132 rdf:rest Nf45d1424d55d489cba46624b893a0e70
133 N36638587aad14860a903b9f0c16e21c4 schema:issueNumber 1
134 rdf:type schema:PublicationIssue
135 N3d8e1d18be814aa28c9a1a42ec9b5aa7 rdf:first sg:person.014111064035.23
136 rdf:rest N339f4d0c28904ab8a869dce99f17d424
137 N574ba9ba08cd43c7847ae4fe33a16aa2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Male
139 rdf:type schema:DefinedTerm
140 N65c470b4f8dc4ecaa2b1f7ae7548ce06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Proportional Hazards Models
142 rdf:type schema:DefinedTerm
143 N75062d1620aa4ef8bf4cb8dc17677270 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Respiratory Distress Syndrome
145 rdf:type schema:DefinedTerm
146 N7de33b5f86b04bd496d83a7845fbb115 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Mortality
148 rdf:type schema:DefinedTerm
149 N8785474a18bd48d790a3607ee5513a2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Intensive Care Units
151 rdf:type schema:DefinedTerm
152 N9434b129c9364c86b38073ee835ef150 rdf:first sg:person.01171406332.78
153 rdf:rest Na432621980094203813a20f70d6913c2
154 N96b95573dc564639a992762623d9a920 schema:name Springer Nature - SN SciGraph project
155 rdf:type schema:Organization
156 N9b6eb5fcaabc488ab0e9216459636cd8 schema:name dimensions_id
157 schema:value pub.1100861533
158 rdf:type schema:PropertyValue
159 N9d7c13cf59f94118a9d57ff3676ff554 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Japan
161 rdf:type schema:DefinedTerm
162 N9e4ea6a879e34b52877fbf39a40cf18b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Hospital Mortality
164 rdf:type schema:DefinedTerm
165 Na0c419a5473b4a198f477229da9070f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Respiration, Artificial
167 rdf:type schema:DefinedTerm
168 Na432621980094203813a20f70d6913c2 rdf:first sg:person.0755324561.79
169 rdf:rest Nf90ae3683c2a4fb48f3ef4b9b3350e91
170 Na5abe1b0fdf4419e831d53b73e671881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Databases, Factual
172 rdf:type schema:DefinedTerm
173 Na5b9d38bd9624e51bd1e8434b4b20b4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Methylprednisolone
175 rdf:type schema:DefinedTerm
176 Na9874e56d9d74ab9bd70131f0425e070 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Case-Control Studies
178 rdf:type schema:DefinedTerm
179 Nb9c741a1224545e38d057bab771ccfb1 schema:name pubmed_id
180 schema:value 29415701
181 rdf:type schema:PropertyValue
182 Nba34ace3a89343f6a21c09f82a07d523 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Glucocorticoids
184 rdf:type schema:DefinedTerm
185 Nbacb8ef92d0a482d9e19a4ca09e67cce rdf:first sg:person.01211346734.05
186 rdf:rest Nbbfcca14c2814616917526d41f274048
187 Nbbfcca14c2814616917526d41f274048 rdf:first sg:person.01051644222.46
188 rdf:rest N3d8e1d18be814aa28c9a1a42ec9b5aa7
189 Nc31f8075cac841d88b0e1399afd1c12a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Prognosis
191 rdf:type schema:DefinedTerm
192 Nc5464db84ddf4d838ea1ef78fb40a2b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Length of Stay
194 rdf:type schema:DefinedTerm
195 Nc5f269f5c5f64bd1a9005c738ab370fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Logistic Models
197 rdf:type schema:DefinedTerm
198 Ncb7f932d73684030818f84fc559bd17a schema:volumeNumber 18
199 rdf:type schema:PublicationVolume
200 Ne0c6889d26b64db3931ccd7c84e9c784 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Aged
202 rdf:type schema:DefinedTerm
203 Ne46336b2fda1487cbb9cb8d5d860cfe8 rdf:first sg:person.01143125277.28
204 rdf:rest Ne9e2dd6c377f4bb5b22354be635e8cef
205 Ne9e2dd6c377f4bb5b22354be635e8cef rdf:first sg:person.01032646234.50
206 rdf:rest rdf:nil
207 Nf45d1424d55d489cba46624b893a0e70 rdf:first sg:person.01143343732.14
208 rdf:rest Nf5ded10c8c3446578dc4570295e54cc9
209 Nf5ded10c8c3446578dc4570295e54cc9 rdf:first sg:person.01146120052.08
210 rdf:rest N12b593d6beb74c7897fa6171fd5d3462
211 Nf90ae3683c2a4fb48f3ef4b9b3350e91 rdf:first sg:person.0652144310.40
212 rdf:rest Ne46336b2fda1487cbb9cb8d5d860cfe8
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
217 schema:name Clinical Sciences
218 rdf:type schema:DefinedTerm
219 sg:journal.1024955 schema:issn 1471-2466
220 schema:name BMC Pulmonary Medicine
221 schema:publisher Springer Nature
222 rdf:type schema:Periodical
223 sg:person.01032646234.50 schema:affiliation grid-institutes:grid.271052.3
224 schema:familyName Yatera
225 schema:givenName Kazuhiro
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032646234.50
227 rdf:type schema:Person
228 sg:person.01051644222.46 schema:affiliation grid-institutes:grid.271052.3
229 schema:familyName Muramatsu
230 schema:givenName Keiji
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051644222.46
232 rdf:type schema:Person
233 sg:person.01143125277.28 schema:affiliation grid-institutes:grid.411873.8
234 schema:familyName Mukae
235 schema:givenName Hiroshi
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28
237 rdf:type schema:Person
238 sg:person.01143343732.14 schema:affiliation grid-institutes:grid.271052.3
239 schema:familyName Ogoshi
240 schema:givenName Takaaki
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143343732.14
242 rdf:type schema:Person
243 sg:person.01146120052.08 schema:affiliation grid-institutes:grid.271052.3
244 schema:familyName Oda
245 schema:givenName Keishi
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146120052.08
247 rdf:type schema:Person
248 sg:person.01171406332.78 schema:affiliation grid-institutes:grid.271052.3
249 schema:familyName Fujino
250 schema:givenName Yoshihisa
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171406332.78
252 rdf:type schema:Person
253 sg:person.01211346734.05 schema:affiliation grid-institutes:grid.271052.3
254 schema:familyName Kido
255 schema:givenName Takashi
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211346734.05
257 rdf:type schema:Person
258 sg:person.012144422162.95 schema:affiliation grid-institutes:grid.271052.3
259 schema:familyName Kubo
260 schema:givenName Tatsuhiko
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012144422162.95
262 rdf:type schema:Person
263 sg:person.01245571254.09 schema:affiliation grid-institutes:grid.271052.3
264 schema:familyName Otsubo
265 schema:givenName Hiroki
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245571254.09
267 rdf:type schema:Person
268 sg:person.014111064035.23 schema:affiliation grid-institutes:grid.271052.3
269 schema:familyName Asakawa
270 schema:givenName Takeshi
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014111064035.23
272 rdf:type schema:Person
273 sg:person.0652144310.40 schema:affiliation grid-institutes:grid.271052.3
274 schema:familyName Mayumi
275 schema:givenName Toshihiko
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652144310.40
277 rdf:type schema:Person
278 sg:person.0755324561.79 schema:affiliation grid-institutes:grid.271052.3
279 schema:familyName Matsuda
280 schema:givenName Shinya
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755324561.79
282 rdf:type schema:Person
283 sg:pub.10.1038/srep17654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029279445
284 https://doi.org/10.1038/srep17654
285 rdf:type schema:CreativeWork
286 sg:pub.10.1186/1472-6963-12-129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027837036
287 https://doi.org/10.1186/1472-6963-12-129
288 rdf:type schema:CreativeWork
289 sg:pub.10.1186/cc13029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005015506
290 https://doi.org/10.1186/cc13029
291 rdf:type schema:CreativeWork
292 sg:pub.10.1186/s13054-017-1723-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085919715
293 https://doi.org/10.1186/s13054-017-1723-0
294 rdf:type schema:CreativeWork
295 grid-institutes:grid.271052.3 schema:alternateName Department of Emergency Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
296 Department of Information Systems Center, University of Occupational and Environmental Health, Kitakyushu, Japan
297 Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan
298 Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan
299 schema:name Department of Emergency Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
300 Department of Information Systems Center, University of Occupational and Environmental Health, Kitakyushu, Japan
301 Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan
302 Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan
303 rdf:type schema:Organization
304 grid-institutes:grid.411873.8 schema:alternateName Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan
305 schema:name Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan
306 Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan
307 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...