Heterogeneous pattern of differences in respiratory parameters between elderly with either good or poor FEV1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02-06

AUTHORS

Stefan Karrasch, Jürgen Behr, Rudolf M. Huber, Dennis Nowak, Annette Peters, Stefan Peters, Rolf Holle, Rudolf A. Jörres, Holger Schulz, KORA Study Group

ABSTRACT

BackgroundThe relationship of spirometric values to other respiratory and functional parameters in advanced age is not well studied. We assessed this relationship in elderly subjects with either good or poor spirometric parameters to reveal whether different domains of lung function show comparable differences between the two groups.MethodsAmong subjects of the population-based KORA-Age cohort (n = 935, 65-90y; 51% male) two groups were selected from either the lower (LED; n = 51) or the upper (UED; n = 72) end of the FEV1 distribution. All subjects did not have a history of lung disease and were non-smokers at the time of the study. Measurements included spirometry, body plethysmography, diffusing capacity for NO and CO, respiratory pump function and exhaled NO (FeNO). In addition, 6-min walking distance as a functional overall measure, as well as telomere length of blood leukocytes and serum 8-hydroxydeoxyguanosine (8-OHdG) as potential markers of overall biological ageing and stress were determined.ResultsIn the majority of parameters, LED subjects showed significantly impaired values compared to UED subjects. Differences in spirometric parameters, airway resistance and respiratory pump function ranged between 10% and more than 90% in terms of predicted values. In contrast, volume-related CO and NO diffusing capacity showed differences between groups of lower than 5%, while telomere length, 8-OHdG and FeNO were similar. This was reflected in the differences in “functional age” as derived from prediction equations.ConclusionsIn elderly subjects without a history of lung disease differences in spirometric parameters were associated with differences in other lung-mechanical parameters including body plethysmography but not with differences in volume-corrected gas exchange measures. Thus, the concept of a general “lung age” as suggested by the widespread use of this term in connection with spirometry should be considered with caution. More... »

PAGES

27

References to SciGraph publications

  • 2011-12-14. Multimorbidität und erfolgreiches Altern in ZEITSCHRIFT FÜR GERONTOLOGIE UND GERIATRIE
  • Journal

    TITLE

    BMC Pulmonary Medicine

    ISSUE

    1

    VOLUME

    18

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12890-018-0582-z

    DOI

    http://dx.doi.org/10.1186/s12890-018-0582-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100864601

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29409487


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "8-Hydroxy-2'-Deoxyguanosine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breath Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carbon Monoxide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Deoxyguanosine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Forced Expiratory Volume", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nitric Oxide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plethysmography, Whole Body", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pulmonary Diffusing Capacity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Telomere", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Walk Test", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.452624.3", 
              "name": [
                "Institute of Epidemiology I, Helmholtz Zentrum M\u00fcnchen - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764, Neuherberg, Germany", 
                "Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universit\u00e4t, Ziemssenstrasse 1, 80336, Munich, Germany", 
                "Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karrasch", 
            "givenName": "Stefan", 
            "id": "sg:person.0721677441.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721677441.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.452624.3", 
              "name": [
                "Department of Internal Medicine V, Comprehensive Pneumology Center Munich, Ludwig-Maximilians-Universit\u00e4t, Ziemssenstrasse 1, 80336, Munich, Germany", 
                "Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Behr", 
            "givenName": "J\u00fcrgen", 
            "id": "sg:person.0776277206.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776277206.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Respiratory Medicine and Thoracic Oncology, Department of Medicine, Innenstadt, Ludwig-Maximilians-University, Ziemssenstrasse 1, 80336, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany", 
                "Division of Respiratory Medicine and Thoracic Oncology, Department of Medicine, Innenstadt, Ludwig-Maximilians-University, Ziemssenstrasse 1, 80336, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huber", 
            "givenName": "Rudolf M.", 
            "id": "sg:person.01230464277.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230464277.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.452624.3", 
              "name": [
                "Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universit\u00e4t, Ziemssenstrasse 1, 80336, Munich, Germany", 
                "Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nowak", 
            "givenName": "Dennis", 
            "id": "sg:person.01334554665.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334554665.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peters", 
            "givenName": "Annette", 
            "id": "sg:person.01117072553.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117072553.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universit\u00e4t, Ziemssenstrasse 1, 80336, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universit\u00e4t, Ziemssenstrasse 1, 80336, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peters", 
            "givenName": "Stefan", 
            "id": "sg:person.011556175221.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011556175221.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Health Economics and Health Care Management, Helmholtz Zentrum M\u00fcnchen - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "Institute of Health Economics and Health Care Management, Helmholtz Zentrum M\u00fcnchen - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holle", 
            "givenName": "Rolf", 
            "id": "sg:person.01215630466.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215630466.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.452624.3", 
              "name": [
                "Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universit\u00e4t, Ziemssenstrasse 1, 80336, Munich, Germany", 
                "Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "J\u00f6rres", 
            "givenName": "Rudolf A.", 
            "id": "sg:person.016104551234.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016104551234.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.452624.3", 
              "name": [
                "Institute of Epidemiology I, Helmholtz Zentrum M\u00fcnchen - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764, Neuherberg, Germany", 
                "Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schulz", 
            "givenName": "Holger", 
            "id": "sg:person.0637527306.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637527306.80"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "KORA Study Group", 
            "id": "sg:person.015446242737.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015446242737.55"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00391-011-0245-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018513081", 
              "https://doi.org/10.1007/s00391-011-0245-7"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-02-06", 
        "datePublishedReg": "2018-02-06", 
        "description": "BackgroundThe relationship of spirometric values to other respiratory and functional parameters in advanced age is not well studied. We assessed this relationship in elderly subjects with either good or poor spirometric parameters to reveal whether different domains of lung function show comparable differences between the two groups.MethodsAmong subjects of the population-based KORA-Age cohort (n\u2009=\u2009935, 65-90y; 51% male) two groups were selected from either the lower (LED; n\u2009=\u200951) or the upper (UED; n\u2009=\u200972) end of the FEV1 distribution. All subjects did not have a history of lung disease and were non-smokers at the time of the study. Measurements included spirometry, body plethysmography, diffusing capacity for NO and CO, respiratory pump function and exhaled NO (FeNO). In addition, 6-min walking distance as a functional overall measure, as well as telomere length of blood leukocytes and serum 8-hydroxydeoxyguanosine (8-OHdG) as potential markers of overall biological ageing and stress were determined.ResultsIn the majority of parameters, LED subjects showed significantly impaired values compared to UED subjects. Differences in spirometric parameters, airway resistance and respiratory pump function ranged between 10% and more than 90% in terms of predicted values. In contrast, volume-related CO and NO diffusing capacity showed differences between groups of lower than 5%, while telomere length, 8-OHdG and FeNO were similar. This was reflected in the differences in \u201cfunctional age\u201d as derived from prediction equations.ConclusionsIn elderly subjects without a history of lung disease differences in spirometric parameters were associated with differences in other lung-mechanical parameters including body plethysmography but not with differences in volume-corrected gas exchange measures. Thus, the concept of a general \u201clung age\u201d as suggested by the widespread use of this term in connection with spirometry should be considered with caution.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12890-018-0582-z", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7937039", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7937011", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7940112", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1024955", 
            "issn": [
              "1471-2466"
            ], 
            "name": "BMC Pulmonary Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "keywords": [
          "respiratory pump function", 
          "spirometric parameters", 
          "body plethysmography", 
          "elderly subjects", 
          "pump function", 
          "telomere length", 
          "lung mechanical parameters", 
          "poorer FEV1", 
          "lung age", 
          "lung function", 
          "gas exchange measures", 
          "airway resistance", 
          "lung disease", 
          "spirometric values", 
          "advanced age", 
          "blood leukocytes", 
          "walking distance", 
          "respiratory parameters", 
          "potential marker", 
          "disease differences", 
          "functional age", 
          "functional parameters", 
          "spirometry", 
          "plethysmography", 
          "two-group", 
          "age", 
          "biological aging", 
          "subjects", 
          "comparable differences", 
          "majority of parameters", 
          "heterogeneous pattern", 
          "group", 
          "FEV1", 
          "differences", 
          "FeNO", 
          "widespread use", 
          "leukocytes", 
          "disease", 
          "ResultsIn", 
          "overall measure", 
          "history", 
          "markers", 
          "measures", 
          "upper end", 
          "caution", 
          "function", 
          "majority", 
          "aging", 
          "relationship", 
          "study", 
          "NO", 
          "prediction equations", 
          "contrast", 
          "resistance", 
          "length", 
          "values", 
          "capacity", 
          "use", 
          "patterns", 
          "stress", 
          "addition", 
          "end", 
          "time", 
          "parameters", 
          "terms", 
          "different domains", 
          "measurements", 
          "domain", 
          "connection", 
          "distribution", 
          "concept", 
          "distance", 
          "CO", 
          "equations"
        ], 
        "name": "Heterogeneous pattern of differences in respiratory parameters between elderly with either good or poor FEV1", 
        "pagination": "27", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1100864601"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12890-018-0582-z"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29409487"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12890-018-0582-z", 
          "https://app.dimensions.ai/details/publication/pub.1100864601"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:02", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_760.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12890-018-0582-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0582-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0582-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0582-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12890-018-0582-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    291 TRIPLES      21 PREDICATES      118 URIs      109 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12890-018-0582-z schema:about N04a366a4348c45a283249a2843f044e4
    2 N061d7b332f4f496682139399f25b1161
    3 N16fa2c031ae8413583c6d2bf8ae57245
    4 N2c088782e8da4ddcb7c9cfa9e4706c66
    5 N49a672f9c85d403db12d0151e4fb6205
    6 N898aa5dbc5334c2baef7448da1691ea6
    7 N927d9260db3e4a798dce377c8bf164c5
    8 N97024c440559460daf3d30891bf3b246
    9 N984f49474ebf41d8951a10484841357d
    10 Na6280c6e24d443c8a7cf5d41d807f780
    11 Naa91612e8fd644f38d6356526fb41709
    12 Nba402336f15b4b8bad040957ef54300d
    13 Nc5c08c3c463541d2a88b6e32a5604f13
    14 Nc968cadf41874cda841e4d05c9c9d29b
    15 Nce904418a7c443e597f7586ec338ce97
    16 Nd8ba8e94f8454c65a64d44e46af2fdff
    17 Ne352d9366dce4bc0bd8a034c92c58f8b
    18 Ne45e6be2c3ec48faaf33bb048c2f24ea
    19 anzsrc-for:11
    20 anzsrc-for:1102
    21 schema:author Ncd3d1fe213544a2c956e60389dedbec1
    22 schema:citation sg:pub.10.1007/s00391-011-0245-7
    23 schema:datePublished 2018-02-06
    24 schema:datePublishedReg 2018-02-06
    25 schema:description BackgroundThe relationship of spirometric values to other respiratory and functional parameters in advanced age is not well studied. We assessed this relationship in elderly subjects with either good or poor spirometric parameters to reveal whether different domains of lung function show comparable differences between the two groups.MethodsAmong subjects of the population-based KORA-Age cohort (n = 935, 65-90y; 51% male) two groups were selected from either the lower (LED; n = 51) or the upper (UED; n = 72) end of the FEV1 distribution. All subjects did not have a history of lung disease and were non-smokers at the time of the study. Measurements included spirometry, body plethysmography, diffusing capacity for NO and CO, respiratory pump function and exhaled NO (FeNO). In addition, 6-min walking distance as a functional overall measure, as well as telomere length of blood leukocytes and serum 8-hydroxydeoxyguanosine (8-OHdG) as potential markers of overall biological ageing and stress were determined.ResultsIn the majority of parameters, LED subjects showed significantly impaired values compared to UED subjects. Differences in spirometric parameters, airway resistance and respiratory pump function ranged between 10% and more than 90% in terms of predicted values. In contrast, volume-related CO and NO diffusing capacity showed differences between groups of lower than 5%, while telomere length, 8-OHdG and FeNO were similar. This was reflected in the differences in “functional age” as derived from prediction equations.ConclusionsIn elderly subjects without a history of lung disease differences in spirometric parameters were associated with differences in other lung-mechanical parameters including body plethysmography but not with differences in volume-corrected gas exchange measures. Thus, the concept of a general “lung age” as suggested by the widespread use of this term in connection with spirometry should be considered with caution.
    26 schema:genre article
    27 schema:isAccessibleForFree true
    28 schema:isPartOf Ncae233a15a32428a93d2283c1b2b39b0
    29 Nf78768a8af6f40c5b2980563d98af612
    30 sg:journal.1024955
    31 schema:keywords CO
    32 FEV1
    33 FeNO
    34 NO
    35 ResultsIn
    36 addition
    37 advanced age
    38 age
    39 aging
    40 airway resistance
    41 biological aging
    42 blood leukocytes
    43 body plethysmography
    44 capacity
    45 caution
    46 comparable differences
    47 concept
    48 connection
    49 contrast
    50 differences
    51 different domains
    52 disease
    53 disease differences
    54 distance
    55 distribution
    56 domain
    57 elderly subjects
    58 end
    59 equations
    60 function
    61 functional age
    62 functional parameters
    63 gas exchange measures
    64 group
    65 heterogeneous pattern
    66 history
    67 length
    68 leukocytes
    69 lung age
    70 lung disease
    71 lung function
    72 lung mechanical parameters
    73 majority
    74 majority of parameters
    75 markers
    76 measurements
    77 measures
    78 overall measure
    79 parameters
    80 patterns
    81 plethysmography
    82 poorer FEV1
    83 potential marker
    84 prediction equations
    85 pump function
    86 relationship
    87 resistance
    88 respiratory parameters
    89 respiratory pump function
    90 spirometric parameters
    91 spirometric values
    92 spirometry
    93 stress
    94 study
    95 subjects
    96 telomere length
    97 terms
    98 time
    99 two-group
    100 upper end
    101 use
    102 values
    103 walking distance
    104 widespread use
    105 schema:name Heterogeneous pattern of differences in respiratory parameters between elderly with either good or poor FEV1
    106 schema:pagination 27
    107 schema:productId N4d853943b5bf49349afc0284c98e768d
    108 Nbb26bcd50a3048caadd279c39aaa0c08
    109 Ncdd4a9466939424c89abcdedc0b3dd5d
    110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100864601
    111 https://doi.org/10.1186/s12890-018-0582-z
    112 schema:sdDatePublished 2022-09-02T16:02
    113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    114 schema:sdPublisher N6f25b571d3b944c29853f236779acc59
    115 schema:url https://doi.org/10.1186/s12890-018-0582-z
    116 sgo:license sg:explorer/license/
    117 sgo:sdDataset articles
    118 rdf:type schema:ScholarlyArticle
    119 N04a366a4348c45a283249a2843f044e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Walk Test
    121 rdf:type schema:DefinedTerm
    122 N061d7b332f4f496682139399f25b1161 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Female
    124 rdf:type schema:DefinedTerm
    125 N16fa2c031ae8413583c6d2bf8ae57245 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Humans
    127 rdf:type schema:DefinedTerm
    128 N213115d335e04b3a9712b4fc19e42a09 rdf:first sg:person.015446242737.55
    129 rdf:rest rdf:nil
    130 N2b803a7ee046476290e30d571506ca28 rdf:first sg:person.01215630466.46
    131 rdf:rest N5763e2964ec14d77a06f71ff25e09c30
    132 N2c088782e8da4ddcb7c9cfa9e4706c66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Plethysmography, Whole Body
    134 rdf:type schema:DefinedTerm
    135 N4317fffef57842c980d425d81ca30112 rdf:first sg:person.01117072553.44
    136 rdf:rest Nc7397f06b1de4c86a6c0f5da070b70fa
    137 N49a672f9c85d403db12d0151e4fb6205 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Nitric Oxide
    139 rdf:type schema:DefinedTerm
    140 N4d853943b5bf49349afc0284c98e768d schema:name pubmed_id
    141 schema:value 29409487
    142 rdf:type schema:PropertyValue
    143 N5763e2964ec14d77a06f71ff25e09c30 rdf:first sg:person.016104551234.34
    144 rdf:rest N86bb9ed91dee4190b5f445a6d8968e83
    145 N64620d2a0b36466a8c0256065cc66c64 rdf:first sg:person.01230464277.15
    146 rdf:rest N6b832fed21644e429bcd30d03b80154f
    147 N6b832fed21644e429bcd30d03b80154f rdf:first sg:person.01334554665.45
    148 rdf:rest N4317fffef57842c980d425d81ca30112
    149 N6f25b571d3b944c29853f236779acc59 schema:name Springer Nature - SN SciGraph project
    150 rdf:type schema:Organization
    151 N86bb9ed91dee4190b5f445a6d8968e83 rdf:first sg:person.0637527306.80
    152 rdf:rest N213115d335e04b3a9712b4fc19e42a09
    153 N898aa5dbc5334c2baef7448da1691ea6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Carbon Monoxide
    155 rdf:type schema:DefinedTerm
    156 N927d9260db3e4a798dce377c8bf164c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Aged, 80 and over
    158 rdf:type schema:DefinedTerm
    159 N97024c440559460daf3d30891bf3b246 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Pulmonary Diffusing Capacity
    161 rdf:type schema:DefinedTerm
    162 N984f49474ebf41d8951a10484841357d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Male
    164 rdf:type schema:DefinedTerm
    165 Na6280c6e24d443c8a7cf5d41d807f780 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Forced Expiratory Volume
    167 rdf:type schema:DefinedTerm
    168 Naa91612e8fd644f38d6356526fb41709 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Aged
    170 rdf:type schema:DefinedTerm
    171 Nb4b6f6a4e5574a319dc8519d2bbf06b5 rdf:first sg:person.0776277206.39
    172 rdf:rest N64620d2a0b36466a8c0256065cc66c64
    173 Nba402336f15b4b8bad040957ef54300d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Breath Tests
    175 rdf:type schema:DefinedTerm
    176 Nbb26bcd50a3048caadd279c39aaa0c08 schema:name doi
    177 schema:value 10.1186/s12890-018-0582-z
    178 rdf:type schema:PropertyValue
    179 Nc5c08c3c463541d2a88b6e32a5604f13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name 8-Hydroxy-2'-Deoxyguanosine
    181 rdf:type schema:DefinedTerm
    182 Nc7397f06b1de4c86a6c0f5da070b70fa rdf:first sg:person.011556175221.67
    183 rdf:rest N2b803a7ee046476290e30d571506ca28
    184 Nc968cadf41874cda841e4d05c9c9d29b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Aging
    186 rdf:type schema:DefinedTerm
    187 Ncae233a15a32428a93d2283c1b2b39b0 schema:issueNumber 1
    188 rdf:type schema:PublicationIssue
    189 Ncd3d1fe213544a2c956e60389dedbec1 rdf:first sg:person.0721677441.98
    190 rdf:rest Nb4b6f6a4e5574a319dc8519d2bbf06b5
    191 Ncdd4a9466939424c89abcdedc0b3dd5d schema:name dimensions_id
    192 schema:value pub.1100864601
    193 rdf:type schema:PropertyValue
    194 Nce904418a7c443e597f7586ec338ce97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Telomere
    196 rdf:type schema:DefinedTerm
    197 Nd8ba8e94f8454c65a64d44e46af2fdff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Deoxyguanosine
    199 rdf:type schema:DefinedTerm
    200 Ne352d9366dce4bc0bd8a034c92c58f8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Lung
    202 rdf:type schema:DefinedTerm
    203 Ne45e6be2c3ec48faaf33bb048c2f24ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Leukocytes
    205 rdf:type schema:DefinedTerm
    206 Nf78768a8af6f40c5b2980563d98af612 schema:volumeNumber 18
    207 rdf:type schema:PublicationVolume
    208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    209 schema:name Medical and Health Sciences
    210 rdf:type schema:DefinedTerm
    211 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    212 schema:name Cardiorespiratory Medicine and Haematology
    213 rdf:type schema:DefinedTerm
    214 sg:grant.7937011 http://pending.schema.org/fundedItem sg:pub.10.1186/s12890-018-0582-z
    215 rdf:type schema:MonetaryGrant
    216 sg:grant.7937039 http://pending.schema.org/fundedItem sg:pub.10.1186/s12890-018-0582-z
    217 rdf:type schema:MonetaryGrant
    218 sg:grant.7940112 http://pending.schema.org/fundedItem sg:pub.10.1186/s12890-018-0582-z
    219 rdf:type schema:MonetaryGrant
    220 sg:journal.1024955 schema:issn 1471-2466
    221 schema:name BMC Pulmonary Medicine
    222 schema:publisher Springer Nature
    223 rdf:type schema:Periodical
    224 sg:person.01117072553.44 schema:affiliation grid-institutes:grid.4567.0
    225 schema:familyName Peters
    226 schema:givenName Annette
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117072553.44
    228 rdf:type schema:Person
    229 sg:person.011556175221.67 schema:affiliation grid-institutes:grid.5252.0
    230 schema:familyName Peters
    231 schema:givenName Stefan
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011556175221.67
    233 rdf:type schema:Person
    234 sg:person.01215630466.46 schema:affiliation grid-institutes:grid.4567.0
    235 schema:familyName Holle
    236 schema:givenName Rolf
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215630466.46
    238 rdf:type schema:Person
    239 sg:person.01230464277.15 schema:affiliation grid-institutes:grid.5252.0
    240 schema:familyName Huber
    241 schema:givenName Rudolf M.
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230464277.15
    243 rdf:type schema:Person
    244 sg:person.01334554665.45 schema:affiliation grid-institutes:grid.452624.3
    245 schema:familyName Nowak
    246 schema:givenName Dennis
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334554665.45
    248 rdf:type schema:Person
    249 sg:person.015446242737.55 schema:familyName KORA Study Group
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015446242737.55
    251 rdf:type schema:Person
    252 sg:person.016104551234.34 schema:affiliation grid-institutes:grid.452624.3
    253 schema:familyName Jörres
    254 schema:givenName Rudolf A.
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016104551234.34
    256 rdf:type schema:Person
    257 sg:person.0637527306.80 schema:affiliation grid-institutes:grid.452624.3
    258 schema:familyName Schulz
    259 schema:givenName Holger
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637527306.80
    261 rdf:type schema:Person
    262 sg:person.0721677441.98 schema:affiliation grid-institutes:grid.452624.3
    263 schema:familyName Karrasch
    264 schema:givenName Stefan
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721677441.98
    266 rdf:type schema:Person
    267 sg:person.0776277206.39 schema:affiliation grid-institutes:grid.452624.3
    268 schema:familyName Behr
    269 schema:givenName Jürgen
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776277206.39
    271 rdf:type schema:Person
    272 sg:pub.10.1007/s00391-011-0245-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018513081
    273 https://doi.org/10.1007/s00391-011-0245-7
    274 rdf:type schema:CreativeWork
    275 grid-institutes:grid.452624.3 schema:alternateName Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany
    276 schema:name Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany
    277 Department of Internal Medicine V, Comprehensive Pneumology Center Munich, Ludwig-Maximilians-Universität, Ziemssenstrasse 1, 80336, Munich, Germany
    278 Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Ziemssenstrasse 1, 80336, Munich, Germany
    279 Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764, Neuherberg, Germany
    280 rdf:type schema:Organization
    281 grid-institutes:grid.4567.0 schema:alternateName Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany
    282 Institute of Health Economics and Health Care Management, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany
    283 schema:name Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany
    284 Institute of Health Economics and Health Care Management, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany
    285 rdf:type schema:Organization
    286 grid-institutes:grid.5252.0 schema:alternateName Division of Respiratory Medicine and Thoracic Oncology, Department of Medicine, Innenstadt, Ludwig-Maximilians-University, Ziemssenstrasse 1, 80336, Munich, Germany
    287 Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Ziemssenstrasse 1, 80336, Munich, Germany
    288 schema:name Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377, Munich, Germany
    289 Division of Respiratory Medicine and Thoracic Oncology, Department of Medicine, Innenstadt, Ludwig-Maximilians-University, Ziemssenstrasse 1, 80336, Munich, Germany
    290 Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Ziemssenstrasse 1, 80336, Munich, Germany
    291 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...