Ontology type: schema:ScholarlyArticle Open Access: True
2016-06-08
AUTHORSKeishi Oda, Kazuhiro Yatera, Yoshihisa Fujino, Hiroshi Ishimoto, Hiroyuki Nakao, Tetsuya Hanaka, Takaaki Ogoshi, Takashi Kido, Kiyohide Fushimi, Shinya Matsuda, Hiroshi Mukae
ABSTRACTBackgroundSome IPF patients show a rapid progression of respiratory failure. Most patients are treated with high-dose corticosteroids. However, no large clinical studies have investigated the prognosis or efficacy of combined treatments including high-dose corticosteroids in IPF patients with a rapid progression of respiratory failure.MethodsWe enrolled IPF patients who received mechanical ventilation and high-dose corticosteroids between April 2010 and March 2013. Records were extracted from a Japanese nationwide inpatient database. We conducted a retrospective epidemiologic and prognostic analysis.ResultsTwo hundred nine patients receiving an average of 12.8 days of ventilatory support were enrolled. There were 138 (66 %) fatal cases; the median survival was 21 days. The short-term (within 30 days) and long-term (within 90 days) survival rates were 44.6 and 24.6 %, respectively. The average monthly admission rate among the IPF patients with the rapid progression of respiratory failure in the winter was significantly higher than that in spring (p = 0.018). Survival did not differ to a statistically significant extent in the different geographic areas of Japan. Survivors were significantly younger (p = 0.002) with higher rates of mild dyspnea on admission (p = 0.012), they more frequently underwent bronchoscopy (p < 0.001), and received anticoagulants (p = 0.027), co-trimoxazole (p < 0.001) and macrolide (p = 0.02) more frequently than non-survivors. A multivariate logistic analysis demonstrated that two factors were significantly associated with a poor prognosis: >80 years of age (OR = 2.94, 95 % Cl 1.044–8.303; p = 0.041) and the intravenous administration of high-dose cyclophosphamide (OR = 3.17, 95 % Cl 1.101–9.148; p = 0.033). Undergoing bronchoscopy during intubation (OR = 0.25, 95 % Cl 0.079–0.798; p = 0.019) and the administration of co-trimoxazole (OR = 0.28, 95 % Cl 0.132–0.607; p = 0.001) and macrolides (OR = 0.37, 95 % Cl 0.155–0.867; p = 0.033) were significantly associated with a good prognosis. The dosage of co-trimoxazole significantly correlated with survival.ConclusionsCo-trimoxazole and macrolides may be a good addition to high-dose corticosteroids in the treatment of IPF patients with a rapid progression of respiratory failure. More... »
PAGES91
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DOIhttp://dx.doi.org/10.1186/s12890-016-0253-x
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"description": "BackgroundSome IPF patients show a rapid progression of respiratory failure. Most patients are treated with high-dose corticosteroids. However, no large clinical studies have investigated the prognosis or efficacy of combined treatments including high-dose corticosteroids in IPF patients with a rapid progression of respiratory failure.MethodsWe enrolled IPF patients who received mechanical ventilation and high-dose corticosteroids between April 2010 and March 2013. Records were extracted from a Japanese nationwide inpatient database. We conducted a retrospective epidemiologic and prognostic analysis.ResultsTwo hundred nine patients receiving an average of 12.8\u00a0days of ventilatory support were enrolled. There were 138 (66\u00a0%) fatal cases; the median survival was 21\u00a0days. The short-term (within 30\u00a0days) and long-term (within 90\u00a0days) survival rates were 44.6 and 24.6\u00a0%, respectively. The average monthly admission rate among the IPF patients with the rapid progression of respiratory failure in the winter was significantly higher than that in spring (p\u2009=\u20090.018). Survival did not differ to a statistically significant extent in the different geographic areas of Japan. Survivors were significantly younger (p\u2009=\u20090.002) with higher rates of mild dyspnea on admission (p\u2009=\u20090.012), they more frequently underwent bronchoscopy (p\u2009<\u20090.001), and received anticoagulants (p\u2009=\u20090.027), co-trimoxazole (p\u2009<\u20090.001) and macrolide (p\u2009=\u20090.02) more frequently than non-survivors. A multivariate logistic analysis demonstrated that two factors were significantly associated with a poor prognosis: >80\u00a0years of age (OR\u2009=\u20092.94, 95\u00a0% Cl 1.044\u20138.303; p\u2009=\u20090.041) and the intravenous administration of high-dose cyclophosphamide (OR\u2009=\u20093.17, 95\u00a0% Cl 1.101\u20139.148; p\u2009=\u20090.033). Undergoing bronchoscopy during intubation (OR\u2009=\u20090.25, 95\u00a0% Cl 0.079\u20130.798; p\u2009=\u20090.019) and the administration of co-trimoxazole (OR\u2009=\u20090.28, 95\u00a0% Cl 0.132\u20130.607; p\u2009=\u20090.001) and macrolides (OR\u2009=\u20090.37, 95\u00a0% Cl 0.155\u20130.867; p\u2009=\u20090.033) were significantly associated with a good prognosis. The dosage of co-trimoxazole significantly correlated with survival.ConclusionsCo-trimoxazole and macrolides may be a good addition to high-dose corticosteroids in the treatment of IPF patients with a rapid progression of respiratory failure.",
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