Ontology type: schema:ScholarlyArticle Open Access: True
2016-06-08
AUTHORSKeishi Oda, Kazuhiro Yatera, Yoshihisa Fujino, Hiroshi Ishimoto, Hiroyuki Nakao, Tetsuya Hanaka, Takaaki Ogoshi, Takashi Kido, Kiyohide Fushimi, Shinya Matsuda, Hiroshi Mukae
ABSTRACTBackgroundSome IPF patients show a rapid progression of respiratory failure. Most patients are treated with high-dose corticosteroids. However, no large clinical studies have investigated the prognosis or efficacy of combined treatments including high-dose corticosteroids in IPF patients with a rapid progression of respiratory failure.MethodsWe enrolled IPF patients who received mechanical ventilation and high-dose corticosteroids between April 2010 and March 2013. Records were extracted from a Japanese nationwide inpatient database. We conducted a retrospective epidemiologic and prognostic analysis.ResultsTwo hundred nine patients receiving an average of 12.8 days of ventilatory support were enrolled. There were 138 (66 %) fatal cases; the median survival was 21 days. The short-term (within 30 days) and long-term (within 90 days) survival rates were 44.6 and 24.6 %, respectively. The average monthly admission rate among the IPF patients with the rapid progression of respiratory failure in the winter was significantly higher than that in spring (p = 0.018). Survival did not differ to a statistically significant extent in the different geographic areas of Japan. Survivors were significantly younger (p = 0.002) with higher rates of mild dyspnea on admission (p = 0.012), they more frequently underwent bronchoscopy (p < 0.001), and received anticoagulants (p = 0.027), co-trimoxazole (p < 0.001) and macrolide (p = 0.02) more frequently than non-survivors. A multivariate logistic analysis demonstrated that two factors were significantly associated with a poor prognosis: >80 years of age (OR = 2.94, 95 % Cl 1.044–8.303; p = 0.041) and the intravenous administration of high-dose cyclophosphamide (OR = 3.17, 95 % Cl 1.101–9.148; p = 0.033). Undergoing bronchoscopy during intubation (OR = 0.25, 95 % Cl 0.079–0.798; p = 0.019) and the administration of co-trimoxazole (OR = 0.28, 95 % Cl 0.132–0.607; p = 0.001) and macrolides (OR = 0.37, 95 % Cl 0.155–0.867; p = 0.033) were significantly associated with a good prognosis. The dosage of co-trimoxazole significantly correlated with survival.ConclusionsCo-trimoxazole and macrolides may be a good addition to high-dose corticosteroids in the treatment of IPF patients with a rapid progression of respiratory failure. More... »
PAGES91
http://scigraph.springernature.com/pub.10.1186/s12890-016-0253-x
DOIhttp://dx.doi.org/10.1186/s12890-016-0253-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1004735654
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/27278093
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adrenal Cortex Hormones",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bronchoscopy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Databases, Factual",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease Progression",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Idiopathic Pulmonary Fibrosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Intensive Care Units",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Japan",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kaplan-Meier Estimate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Logistic Models",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Macrolides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Multivariate Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Respiration, Artificial",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Respiratory Insufficiency",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Trimethoprim, Sulfamethoxazole Drug Combination",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Oda",
"givenName": "Keishi",
"id": "sg:person.01146120052.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146120052.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Yatera",
"givenName": "Kazuhiro",
"id": "sg:person.01032646234.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032646234.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Fujino",
"givenName": "Yoshihisa",
"id": "sg:person.01171406332.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171406332.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.174567.6",
"name": [
"Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan",
"Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Ishimoto",
"givenName": "Hiroshi",
"id": "sg:person.01342450607.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342450607.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Miyazaki Prefectural Nursing University, 3-5-1 Manabino, 880-0929, Miyazaki city, Miyazaki, Japan",
"id": "http://www.grid.ac/institutes/grid.444304.3",
"name": [
"Miyazaki Prefectural Nursing University, 3-5-1 Manabino, 880-0929, Miyazaki city, Miyazaki, Japan"
],
"type": "Organization"
},
"familyName": "Nakao",
"givenName": "Hiroyuki",
"id": "sg:person.0732154756.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732154756.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Hanaka",
"givenName": "Tetsuya",
"id": "sg:person.0731742444.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731742444.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Ogoshi",
"givenName": "Takaaki",
"id": "sg:person.01143343732.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143343732.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Kido",
"givenName": "Takashi",
"id": "sg:person.01211346734.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211346734.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Health Care Informatics, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyoku, 113-8510, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.265073.5",
"name": [
"Department of Health Care Informatics, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyoku, 113-8510, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Fushimi",
"givenName": "Kiyohide",
"id": "sg:person.0704273470.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704273470.86"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Matsuda",
"givenName": "Shinya",
"id": "sg:person.0755324561.79",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755324561.79"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.174567.6",
"name": [
"Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1, Iseigaoka, Yahatanishiku, 807-8555, Kitakyushu City, Fukuoka, Japan",
"Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
],
"type": "Organization"
},
"familyName": "Mukae",
"givenName": "Hiroshi",
"id": "sg:person.01143125277.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/s12931-014-0109-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046516287",
"https://doi.org/10.1186/s12931-014-0109-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2334-9-47",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000295532",
"https://doi.org/10.1186/1471-2334-9-47"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1465-9921-14-73",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019536721",
"https://doi.org/10.1186/1465-9921-14-73"
],
"type": "CreativeWork"
}
],
"datePublished": "2016-06-08",
"datePublishedReg": "2016-06-08",
"description": "BackgroundSome IPF patients show a rapid progression of respiratory failure. Most patients are treated with high-dose corticosteroids. However, no large clinical studies have investigated the prognosis or efficacy of combined treatments including high-dose corticosteroids in IPF patients with a rapid progression of respiratory failure.MethodsWe enrolled IPF patients who received mechanical ventilation and high-dose corticosteroids between April 2010 and March 2013. Records were extracted from a Japanese nationwide inpatient database. We conducted a retrospective epidemiologic and prognostic analysis.ResultsTwo hundred nine patients receiving an average of 12.8\u00a0days of ventilatory support were enrolled. There were 138 (66\u00a0%) fatal cases; the median survival was 21\u00a0days. The short-term (within 30\u00a0days) and long-term (within 90\u00a0days) survival rates were 44.6 and 24.6\u00a0%, respectively. The average monthly admission rate among the IPF patients with the rapid progression of respiratory failure in the winter was significantly higher than that in spring (p\u2009=\u20090.018). Survival did not differ to a statistically significant extent in the different geographic areas of Japan. Survivors were significantly younger (p\u2009=\u20090.002) with higher rates of mild dyspnea on admission (p\u2009=\u20090.012), they more frequently underwent bronchoscopy (p\u2009<\u20090.001), and received anticoagulants (p\u2009=\u20090.027), co-trimoxazole (p\u2009<\u20090.001) and macrolide (p\u2009=\u20090.02) more frequently than non-survivors. A multivariate logistic analysis demonstrated that two factors were significantly associated with a poor prognosis: >80\u00a0years of age (OR\u2009=\u20092.94, 95\u00a0% Cl 1.044\u20138.303; p\u2009=\u20090.041) and the intravenous administration of high-dose cyclophosphamide (OR\u2009=\u20093.17, 95\u00a0% Cl 1.101\u20139.148; p\u2009=\u20090.033). Undergoing bronchoscopy during intubation (OR\u2009=\u20090.25, 95\u00a0% Cl 0.079\u20130.798; p\u2009=\u20090.019) and the administration of co-trimoxazole (OR\u2009=\u20090.28, 95\u00a0% Cl 0.132\u20130.607; p\u2009=\u20090.001) and macrolides (OR\u2009=\u20090.37, 95\u00a0% Cl 0.155\u20130.867; p\u2009=\u20090.033) were significantly associated with a good prognosis. The dosage of co-trimoxazole significantly correlated with survival.ConclusionsCo-trimoxazole and macrolides may be a good addition to high-dose corticosteroids in the treatment of IPF patients with a rapid progression of respiratory failure.",
"genre": "article",
"id": "sg:pub.10.1186/s12890-016-0253-x",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.6130473",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1024955",
"issn": [
"1471-2466"
],
"name": "BMC Pulmonary Medicine",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "16"
}
],
"keywords": [
"high-dose corticosteroids",
"IPF patients",
"respiratory failure",
"rapid progression",
"Japanese nationwide inpatient database",
"idiopathic pulmonary fibrosis patients",
"long-term survival rates",
"high-dose cyclophosphamide",
"nationwide inpatient database",
"pulmonary fibrosis patients",
"multivariate logistic analysis",
"national administrative database",
"large clinical studies",
"years of age",
"monthly admission rates",
"nine patients",
"ventilatory support",
"median survival",
"most patients",
"underwent bronchoscopy",
"better prognosis",
"mechanical ventilation",
"Inpatient Database",
"poor prognosis",
"fatal cases",
"mild dyspnea",
"admission rates",
"concurrent treatment",
"administrative databases",
"clinical studies",
"intravenous administration",
"logistic analysis",
"patients",
"corticosteroids",
"prognostic analysis",
"survival rate",
"fibrosis patients",
"Combined treatment",
"prognosis",
"progression",
"bronchoscopy",
"survival",
"high rate",
"treatment",
"administration",
"different geographic areas",
"efficacy",
"failure",
"days",
"dyspnea",
"cyclophosphamide",
"intubation",
"anticoagulants",
"admission",
"geographic areas",
"MethodsWe",
"survivors",
"ventilation",
"age",
"rate",
"good addition",
"database",
"macrolides",
"significant extent",
"dosage",
"years",
"factors",
"records",
"cases",
"analysis",
"study",
"Japan",
"average",
"extent",
"support",
"addition",
"area",
"winter",
"spring"
],
"name": "Efficacy of concurrent treatments in idiopathic pulmonary fibrosis patients with a rapid progression of respiratory failure: an analysis of a national administrative database in Japan",
"pagination": "91",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1004735654"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12890-016-0253-x"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"27278093"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12890-016-0253-x",
"https://app.dimensions.ai/details/publication/pub.1004735654"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:04",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_717.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/s12890-016-0253-x"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12890-016-0253-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12890-016-0253-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12890-016-0253-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12890-016-0253-x'
This table displays all metadata directly associated to this object as RDF triples.
331 TRIPLES
21 PREDICATES
131 URIs
120 LITERALS
31 BLANK NODES