The significance of oral streptococci in patients with pneumonia with risk factors for aspiration: the bacterial floral analysis of 16S ... View Full Text


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Article Info

DATE

2016-05-11

AUTHORS

Kentaro Akata, Kazuhiro Yatera, Kei Yamasaki, Toshinori Kawanami, Keisuke Naito, Shingo Noguchi, Kazumasa Fukuda, Hiroshi Ishimoto, Hatsumi Taniguchi, Hiroshi Mukae

ABSTRACT

BackgroundAspiration pneumonia has been a growing interest in an aging population. Anaerobes are important pathogens, however, the etiology of aspiration pneumonia is not fully understood. In addition, the relationship between the patient clinical characteristics and the causative pathogens in pneumonia patients with aspiration risk factors are unclear. To evaluate the relationship between the patient clinical characteristics with risk factors for aspiration and bacterial flora in bronchoalveolar lavage fluid (BALF) in pneumonia patients, the bacterial floral analysis of 16S ribosomal RNA gene was applied in addition to cultivation methods in BALF samples.MethodsFrom April 2010 to February 2014, BALF samples were obtained from the affected lesions of pneumonia via bronchoscopy, and were evaluated by the bacterial floral analysis of 16S rRNA gene in addition to cultivation methods in patients with community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP). Factors associated with aspiration risks in these patients were analyzed.ResultsA total of 177 (CAP 83, HCAP 94) patients were enrolled. According to the results of the bacterial floral analysis, detection rate of oral streptococci as the most detected bacterial phylotypes in BALF was significantly higher in patients with aspiration risks (31.0 %) than in patients without aspiration risks (14.7 %) (P = 0.009). In addition, the percentages of oral streptococci in each BALF sample were significantly higher in patients with aspiration risks (26.6 ± 32.0 %) than in patients without aspiration risks (13.8 ± 25.3 %) (P = 0.002). A multiple linear regression analysis showed that an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of ≥3, the presence of comorbidities, and a history of pneumonia within a previous year were significantly associated with a detection of oral streptococci in BALF.ConclusionsThe bacterial floral analysis of 16S rRNA gene revealed that oral streptococci were mostly detected as the most detected bacterial phylotypes in BALF samples in CAP and HCAP patients with aspiration risks, especially in those with a poor ECOG-PS or a history of pneumonia. More... »

PAGES

79

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http://scigraph.springernature.com/pub.10.1186/s12890-016-0235-z

DOI

http://dx.doi.org/10.1186/s12890-016-0235-z

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https://app.dimensions.ai/details/publication/pub.1034830793

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27169775


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42 aspiration risk factors
43 bacterial flora
44 bacterial phylotypes
45 bronchoalveolar lavage fluid
46 bronchoscopy
47 causative pathogen
48 characteristics
49 clinical characteristics
50 community-acquired pneumonia
51 comorbidities
52 cultivation methods
53 detection
54 detection rate
55 etiology
56 factors
57 flora
58 floral analysis
59 fluid
60 genes
61 healthcare-associated pneumonia
62 history
63 history of pneumonia
64 important pathogen
65 interest
66 lavage fluid
67 lesions
68 lesions of pneumonia
69 linear regression analysis
70 method
71 multiple linear regression analysis
72 oral streptococci
73 pathogens
74 patients
75 patients' clinical characteristics
76 percentage
77 performance status
78 phylotypes
79 pneumonia
80 pneumonia patients
81 poor ECOG PS
82 population
83 presence
84 presence of comorbidities
85 previous year
86 rRNA gene
87 rate
88 regression analysis
89 relationship
90 results
91 ribosomal RNA genes
92 risk
93 risk factors
94 samples
95 significance
96 status
97 streptococci
98 total
99 years
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