Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSStephen Okoboi, Barbara Castelnuovo, David M. Moore, Joseph Musaazi, Andrew Kambugu, Josephine Birungi, Mastula Nanfuka, Annelies Van Rie
ABSTRACTBACKGROUND: HIV immunosuppression increases susceptibility to other STIs and STIs can enhance HIV transmission, reduce CD4 cell count and increase viral load. Co-infections of HIV and STIs may thus reduce the preventive benefits of ART. Little is known about the incidence rate of STIs among long-term patients on ART. METHOD: We conducted a secondary data analysis of all patients enrolled in a rural and an urban longitudinal cohort studies who initiated ART between April 2003 and July 2007 followed up to 2016. Patients were screened for STI every three months using "a syndromic and case management approaches". STI incidence rate, was defined as the number of new cases per population at risk over the follow-up review period. We performed a time-to-event and Kaplan Meier analysis. We used a multivariable Cox proportional hazards regression model to assess for factors associated with STI incidence. RESULT: Of 1012 participants, 402 (39.8%) were urban and 610 (60.2%) rural residents. Mean age was 42.8 years (SD 8.5). The total number of follow up time was 44,304 person years. We observed STI incidence rate of 2.1 per 1000 person-years after follow-up. Rural residence (adjusted hazard ratio [aHR] 3.53, 95% CI: 1.95-6.39), younger age (aHR 2.05, 95% CI: 1.02-4.12 for 18-34 years and aHR 1.65, 95% CI: 1.00-2.72 for 35-44 years) were factors associated with higher incidence of STIs. Being male (aHR 0.51, 95% CI: 0.27-0.93) was associated with a lower incidence of STIs. CONCLUSION: We found STIs incidence rate of approximately 3 per 1000 person-years among patients on long-term (≥ 4 years) ART followed up-to 3.5 years. Rural and younger persons on ART should be routinely screened for STIs because high incidence of STIs may undo the preventative effects of ART for all. More... »
PAGES87
http://scigraph.springernature.com/pub.10.1186/s12889-019-6417-x
DOIhttp://dx.doi.org/10.1186/s12889-019-6417-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1111504743
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30658611
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Public Health and Health Services",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Anti-Retroviral Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HIV Infections",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Incidence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Longitudinal Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rural Health Services",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sexually Transmitted Diseases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Uganda",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Urban Health Services",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Young Adult",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Antwerp",
"id": "https://www.grid.ac/institutes/grid.5284.b",
"name": [
"Infectious Diseases Institute; College of Health Sciences, Makerere University, P.O BOX 22418, Kampala, Uganda",
"Global Health Institute; University of Antwerp, Antwerp, Belgium",
"Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium"
],
"type": "Organization"
},
"familyName": "Okoboi",
"givenName": "Stephen",
"id": "sg:person.0705524057.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705524057.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Makerere University",
"id": "https://www.grid.ac/institutes/grid.11194.3c",
"name": [
"Infectious Diseases Institute; College of Health Sciences, Makerere University, P.O BOX 22418, Kampala, Uganda"
],
"type": "Organization"
},
"familyName": "Castelnuovo",
"givenName": "Barbara",
"id": "sg:person.01120312242.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120312242.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada",
"University of British Columbia, Vancouver, Canada"
],
"type": "Organization"
},
"familyName": "Moore",
"givenName": "David M.",
"id": "sg:person.011507471272.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011507471272.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Makerere University",
"id": "https://www.grid.ac/institutes/grid.11194.3c",
"name": [
"Infectious Diseases Institute; College of Health Sciences, Makerere University, P.O BOX 22418, Kampala, Uganda"
],
"type": "Organization"
},
"familyName": "Musaazi",
"givenName": "Joseph",
"id": "sg:person.01071046126.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071046126.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Makerere University",
"id": "https://www.grid.ac/institutes/grid.11194.3c",
"name": [
"Infectious Diseases Institute; College of Health Sciences, Makerere University, P.O BOX 22418, Kampala, Uganda"
],
"type": "Organization"
},
"familyName": "Kambugu",
"givenName": "Andrew",
"id": "sg:person.01302654042.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302654042.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The AIDS Support Organization",
"id": "https://www.grid.ac/institutes/grid.422943.a",
"name": [
"The AIDS Support Organization, Kampala, Uganda"
],
"type": "Organization"
},
"familyName": "Birungi",
"givenName": "Josephine",
"id": "sg:person.0613320011.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613320011.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The AIDS Support Organization",
"id": "https://www.grid.ac/institutes/grid.422943.a",
"name": [
"The AIDS Support Organization, Kampala, Uganda"
],
"type": "Organization"
},
"familyName": "Nanfuka",
"givenName": "Mastula",
"id": "sg:person.01153332153.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153332153.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Antwerp",
"id": "https://www.grid.ac/institutes/grid.5284.b",
"name": [
"Global Health Institute; University of Antwerp, Antwerp, Belgium",
"Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium"
],
"type": "Organization"
},
"familyName": "Van Rie",
"givenName": "Annelies",
"id": "sg:person.01150514637.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150514637.42"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1136/sti.73.3.228-a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000394069"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/sti.73.3.228-a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000394069"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-3156.2002.00963.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005596603"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1742-4755-6-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007751435",
"https://doi.org/10.1186/1742-4755-6-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1258/0956462961918211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009537811"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1258/0956462961918211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009537811"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/592303",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013621183"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12981-015-0077-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018774816",
"https://doi.org/10.1186/s12981-015-0077-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1742-6405-11-31",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020489714",
"https://doi.org/10.1186/1742-6405-11-31"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/sti.73.3.229",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026748899"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/sti.73.3.229",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026748899"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.srhc.2010.03.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027225772"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1468-1293.2009.00818.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028686621"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-0897.2010.00942.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028882538"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/427262",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029677840"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4236/wja.2012.23022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030368737"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0122400",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031661662"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0122400",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031661662"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/olq.0b013e3181812d15",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034081325"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/olq.0b013e3181812d15",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034081325"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/sti.72.2.83",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036319129"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/sti.72.2.83",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036319129"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/sextrans-2013-051446",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036333378"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/sextrans-2013-051446",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036333378"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/qad.0b013e328341fb18",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036740320"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/qad.0b013e328341fb18",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036740320"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/sti.2010.047514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037494115"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/sti.2010.047514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037494115"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0132182",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039193800"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1472-698x-12-11",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044768173",
"https://doi.org/10.1186/1472-698x-12-11"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7448/ias.19.1.20773",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048006173"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007435-199219020-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052916215"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007435-199219020-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052916215"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1258/ijsa.2007.007273",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053636570"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1258/ijsa.2007.007273",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053636570"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2105/ajph.2009.184796",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068844884"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4103/0253-7184.74998",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072237558"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077409715",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pmed.1002485",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100303558"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "BACKGROUND: HIV immunosuppression increases susceptibility to other STIs and STIs can enhance HIV transmission, reduce CD4 cell count and increase viral load. Co-infections of HIV and STIs may thus reduce the preventive benefits of ART. Little is known about the incidence rate of STIs among long-term patients on ART.\nMETHOD: We conducted a secondary data analysis of all patients enrolled in a rural and an urban longitudinal cohort studies who initiated ART between April 2003 and July 2007 followed up to 2016. Patients were screened for STI every three months using \"a syndromic and case management approaches\". STI incidence rate, was defined as the number of new cases per population at risk over the follow-up review period. We performed a time-to-event and Kaplan Meier analysis. We used a multivariable Cox proportional hazards regression model to assess for factors associated with STI incidence.\nRESULT: Of 1012 participants, 402 (39.8%) were urban and 610 (60.2%) rural residents. Mean age was 42.8\u2009years (SD 8.5). The total number of follow up time was 44,304 person years. We observed STI incidence rate of 2.1 per 1000 person-years after follow-up. Rural residence (adjusted hazard ratio [aHR] 3.53, 95% CI: 1.95-6.39), younger age (aHR 2.05, 95% CI: 1.02-4.12 for 18-34\u2009years and aHR 1.65, 95% CI: 1.00-2.72 for 35-44\u2009years) were factors associated with higher incidence of STIs. Being male (aHR 0.51, 95% CI: 0.27-0.93) was associated with a lower incidence of STIs.\nCONCLUSION: We found STIs incidence rate of approximately 3 per 1000 person-years among patients on long-term (\u2265 4\u2009years) ART followed up-to 3.5\u2009years. Rural and younger persons on ART should be routinely screened for STIs because high incidence of STIs may undo the preventative effects of ART for all.",
"genre": "research_article",
"id": "sg:pub.10.1186/s12889-019-6417-x",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1024954",
"issn": [
"1471-2458"
],
"name": "BMC Public Health",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "19"
}
],
"name": "Incidence rate of sexually transmitted infections among HIV infected patients on long-term ART in an urban and a rural clinic in Uganda",
"pagination": "87",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12889-019-6417-x"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"04f7e57218c6b0eddd5b7831e3980fa00b65d7051ab125071efd81ff3669f2aa"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1111504743"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100968562"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30658611"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12889-019-6417-x",
"https://app.dimensions.ai/details/publication/pub.1111504743"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-15T09:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56176_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs12889-019-6417-x"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12889-019-6417-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12889-019-6417-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12889-019-6417-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12889-019-6417-x'
This table displays all metadata directly associated to this object as RDF triples.
276 TRIPLES
21 PREDICATES
72 URIs
36 LITERALS
24 BLANK NODES