Gut microbiota, short chain fatty acids, and obesity across the epidemiologic transition: the METS-Microbiome study protocol View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Lara R. Dugas, Louise Lie, Jacob Plange-Rhule, Kweku Bedu-Addo, Pascal Bovet, Estelle V. Lambert, Terrence E. Forrester, Amy Luke, Jack A. Gilbert, Brian T. Layden

ABSTRACT

BACKGROUND: While some of the variance observed in adiposity and weight change within populations can be accounted for by traditional risk factors, a new factor, the gut microbiota, has recently been associated with obesity. However, the causal mechanisms through which the gut microbiota and its metabolites, short chain fatty acids (SCFAs) influence obesity are unknown, as are the individual obesogenic effects of the individual SCFAs (butyrate, acetate and propionate). This study, METS-Microbiome, proposes to examine the influence of novel risk factors, the gut microbiota and SCFAs, on obesity, adiposity and weight change in an international established cohort spanning the epidemiologic transition. METHODS: The parent study; Modeling the Epidemiologic Transition Study (METS) is a well-established and ongoing prospective cohort study designed to assess the association between body composition, physical activity, and relative weight, weight gain and cardiometabolic disease risk in five diverse population-based samples in 2500 people of African descent. The cohort has been prospectively followed since 2009. Annual measures of obesity risk factors, including body composition, objectively measured physical activity and dietary intake, components which vary across the spectrum of social and economic development. In our new study; METS-Microbiome, in addition to continuing yearly measures of obesity risk, we will also measure gut microbiota and stool SCFAs in all contactable participants, and follow participants for a further 3 years, thus providing one of the largest gut microbiota population-based studies to date. DISCUSSION: This new study capitalizes upon an existing, extensively well described cohort of adults of African-origin, with significant variability as a result of the widespread geographic distributions, and therefore variation in the environmental covariate exposures. The METS-Microbiome study will substantially advance the understanding of the role gut microbiota and SCFAs play in the development of obesity and provide novel obesity therapeutic targets targeting SCFAs producing features of the gut microbiota. TRIAL REGISTRATION: Registered NCT03378765 Date first posted: December 20, 2017. More... »

PAGES

978

References to SciGraph publications

  • 2006-12. An obesity-associated gut microbiome with increased capacity for energy harvest in NATURE
  • 2014-12. Comparisons of intensity-duration patterns of physical activity in the US, Jamaica and 3 African countries in BMC PUBLIC HEALTH
  • 2015-07. The Epidemiology of Obesity: A Big Picture in PHARMACOECONOMICS
  • 2015-12. Association of car ownership and physical activity across the spectrum of human development: Modeling the Epidemiologic Transition Study (METS) in BMC PUBLIC HEALTH
  • 2015-01. Fast and sensitive protein alignment using DIAMOND in NATURE METHODS
  • 2016-12. The obese gut microbiome across the epidemiologic transition in EMERGING THEMES IN EPIDEMIOLOGY
  • 2015-12. A comparison of indices of glucose metabolism in five black populations: data from modeling the epidemiologic transition study (METS) in BMC PUBLIC HEALTH
  • 2016-07. Microbiome-wide association studies link dynamic microbial consortia to disease in NATURE
  • 2009. The Elements of Statistical Learning, Data Mining, Inference, and Prediction in NONE
  • 2013-09. Prediction of fat-free mass using bioelectrical impedance analysis in young adults from five populations of African origin in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2014-12. Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats in BMC GENOMICS
  • 2011-12. Protocol for the modeling the epidemiologic transition study: a longitudinal observational study of energy balance and change in body weight, diabetes and cardiovascular disease risk in BMC PUBLIC HEALTH
  • 2006-12. Microbial ecology: Human gut microbes associated with obesity in NATURE
  • 2014-12. A mixed ecologic-cohort comparison of physical activity & weight among young adults from five populations of African origin in BMC PUBLIC HEALTH
  • 2012-09. Functional interactions between the gut microbiota and host metabolism in NATURE
  • 2014-12. Association between smoking and total energy expenditure in a multi-country study in NUTRITION & METABOLISM
  • 2012-09. Molecular analysis of gut microbiota in obesity among Indian individuals in JOURNAL OF BIOSCIENCES
  • 2014-12. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2013-12. Human gut microbiota community structures in urban and rural populations in Russia in NATURE COMMUNICATIONS
  • 2014-12. Distribution of metals exposure and associations with cardiometabolic risk factors in the “Modeling the Epidemiologic Transition Study” in ENVIRONMENTAL HEALTH
  • 2011-05-12. Enterotypes of the human gut microbiome in NATURE
  • 2013-02. Nutrition transition in a middle-income country: 22-year trends in the Seychelles in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2008-12. The RAST Server: Rapid Annotations using Subsystems Technology in BMC GENOMICS
  • 2010-05. QIIME allows analysis of high-throughput community sequencing data in NATURE METHODS
  • 2011-03. Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway in AMINO ACIDS
  • 2013-12. A comprehensive evaluation of multicategory classification methods for microbiomic data in MICROBIOME
  • 2012-08. Metagenomic microbial community profiling using unique clade-specific marker genes in NATURE METHODS
  • 2011-02. Dominant and diet-responsive groups of bacteria within the human colonic microbiota in THE ISME JOURNAL
  • 2003-12. Body weight gain in free-living Pima Indians: effect of energy intake vs expenditure in INTERNATIONAL JOURNAL OF OBESITY
  • 2012-06. Missing values in mass spectrometry based metabolomics: an undervalued step in the data processing pipeline in METABOLOMICS
  • 2005-12. An international comparative study of blood pressure in populations of European vs. African descent in BMC MEDICINE
  • 2017-11. A communal catalogue reveals Earth’s multiscale microbial diversity in NATURE
  • 2013-12. The metabolic signature associated with the Western dietary pattern: a cross-sectional study in NUTRITION JOURNAL
  • 2006-04. Development of the World Health Organization Global Physical Activity Questionnaire (GPAQ) in JOURNAL OF PUBLIC HEALTH
  • 2011-12. Predicted Relative Metabolomic Turnover (PRMT): determining metabolic turnover from a coastal marine metagenomic dataset in MICROBIAL INFORMATICS AND EXPERIMENTATION
  • 2001-07. Heritability of obesity-related traits among Nigerians, Jamaicans and US black people in INTERNATIONAL JOURNAL OF OBESITY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12889-018-5879-6

    DOI

    http://dx.doi.org/10.1186/s12889-018-5879-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106018893

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30081857


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Loyola University Chicago", 
              "id": "https://www.grid.ac/institutes/grid.164971.c", 
              "name": [
                "Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, 2160 S. 1st Avenue, 60153, Maywood, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dugas", 
            "givenName": "Lara R.", 
            "id": "sg:person.01347453053.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347453053.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Loyola University Chicago", 
              "id": "https://www.grid.ac/institutes/grid.164971.c", 
              "name": [
                "Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, 2160 S. 1st Avenue, 60153, Maywood, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lie", 
            "givenName": "Louise", 
            "id": "sg:person.013341020266.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013341020266.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kwame Nkrumah University of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.9829.a", 
              "name": [
                "Department of Physiology, SMS, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Plange-Rhule", 
            "givenName": "Jacob", 
            "id": "sg:person.01275605144.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275605144.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kwame Nkrumah University of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.9829.a", 
              "name": [
                "Department of Physiology, SMS, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bedu-Addo", 
            "givenName": "Kweku", 
            "id": "sg:person.0753126627.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753126627.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Social and Preventive Medicine", 
              "id": "https://www.grid.ac/institutes/grid.482968.9", 
              "name": [
                "Institute of Social & Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland", 
                "Ministry of Health, Republic of Seychelles, Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bovet", 
            "givenName": "Pascal", 
            "id": "sg:person.01117020021.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117020021.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cape Town", 
              "id": "https://www.grid.ac/institutes/grid.7836.a", 
              "name": [
                "Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lambert", 
            "givenName": "Estelle V.", 
            "id": "sg:person.013454700177.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013454700177.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of the West Indies", 
              "id": "https://www.grid.ac/institutes/grid.12916.3d", 
              "name": [
                "Solutions for Developing Countries, University of the West Indies, Mona, Kingston, Jamaica"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Forrester", 
            "givenName": "Terrence E.", 
            "id": "sg:person.012567461417.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012567461417.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Loyola University Chicago", 
              "id": "https://www.grid.ac/institutes/grid.164971.c", 
              "name": [
                "Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, 2160 S. 1st Avenue, 60153, Maywood, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Luke", 
            "givenName": "Amy", 
            "id": "sg:person.01024436530.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024436530.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Microbiome Center, Department of Surgery, University of Chicago, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gilbert", 
            "givenName": "Jack A.", 
            "id": "sg:person.0727626545.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727626545.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jesse Brown VA Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.280892.9", 
              "name": [
                "Division of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL, USA", 
                "Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Layden", 
            "givenName": "Brian T.", 
            "id": "sg:person.0630770706.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630770706.32"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1155/2014/651895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000605957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3945/ajcn.2008.26630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000845916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1472-765x.1989.tb00278.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001500077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mib.2016.03.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002907891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1047-2797(96)00107-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003599567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004952443", 
              "https://doi.org/10.1038/nature11552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.05.052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005962197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2458-14-882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006955503", 
              "https://doi.org/10.1186/1471-2458-14-882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkm882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007077161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001648-199607000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007205236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001648-199607000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007205236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001648-199607000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007205236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejcn.2013.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007792312", 
              "https://doi.org/10.1038/ejcn.2013.123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40273-014-0243-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008014634", 
              "https://doi.org/10.1007/s40273-014-0243-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3945/ajcn.113.066605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008717334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.f.303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009032055", 
              "https://doi.org/10.1038/nmeth.f.303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.f.303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009032055", 
              "https://doi.org/10.1038/nmeth.f.303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11306-011-0366-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009770929", 
              "https://doi.org/10.1007/s11306-011-0366-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2008.330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010399753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010611135", 
              "https://doi.org/10.1038/nmeth.2066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mco.0b013e32832e6776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010696798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mco.0b013e32832e6776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010696798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mco.0b013e32832e6776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010696798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mco.0b013e32832e6776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010696798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4137/ehi.s13130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011225353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.aje.a008708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012474469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature18850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013019120", 
              "https://doi.org/10.1038/nature18850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jhep.2013.11.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013244622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-9-75", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013431920", 
              "https://doi.org/10.1186/1471-2164-9-75"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)61728-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013705877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mog.0b013e328333d751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013759152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mog.0b013e328333d751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013759152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mog.0b013e328333d751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013759152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mog.0b013e328333d751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013759152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2000.42", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017065044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-15-511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017616461", 
              "https://doi.org/10.1186/1471-2164-15-511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejcn.2012.199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018043021", 
              "https://doi.org/10.1038/ejcn.2012.199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12889-015-1435-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018404169", 
              "https://doi.org/10.1186/s12889-015-1435-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12889-015-1435-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018404169", 
              "https://doi.org/10.1186/s12889-015-1435-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/4441022a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018798093", 
              "https://doi.org/10.1038/4441022a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/4441022a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018798093", 
              "https://doi.org/10.1038/4441022a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/4441022a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018798093", 
              "https://doi.org/10.1038/4441022a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms3469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020010565", 
              "https://doi.org/10.1038/ncomms3469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fmicb.2014.00494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020230066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2458-14-397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020312923", 
              "https://doi.org/10.1186/1471-2458-14-397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/00207713-47-2-590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021105966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/dc14-s014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022230985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1005963107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023427228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1462-2920.2012.02845.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023642358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023893418", 
              "https://doi.org/10.1038/nature05414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023893418", 
              "https://doi.org/10.1038/nature05414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023893418", 
              "https://doi.org/10.1038/nature05414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023901695", 
              "https://doi.org/10.1038/nmeth.3176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1570-0232(02)00827-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023987162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1570-0232(02)00827-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023987162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0065465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024027498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nutres.2010.04.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024984714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.diabres.2013.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025250404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3945/ajcn.110.007278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025404089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2458-11-927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025796414", 
              "https://doi.org/10.1186/1471-2458-11-927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026204536", 
              "https://doi.org/10.1038/nature09944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btt589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026993064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2891-12-158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027869215", 
              "https://doi.org/10.1186/1475-2891-12-158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diabetes.51.3.599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028211724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1741-7015-3-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028816079", 
              "https://doi.org/10.1186/1741-7015-3-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2042-5783-1-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030642249", 
              "https://doi.org/10.1186/2042-5783-1-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3402/mehd.v26.27663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031307715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.aje.a009159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031753934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12038-012-9244-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032115783", 
              "https://doi.org/10.1007/s12038-012-9244-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0802469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032205525", 
              "https://doi.org/10.1038/sj.ijo.0802469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0802469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032205525", 
              "https://doi.org/10.1038/sj.ijo.0802469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1032573094", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-84858-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032573094", 
              "https://doi.org/10.1007/978-0-387-84858-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-84858-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032573094", 
              "https://doi.org/10.1007/978-0-387-84858-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/msystems.00009-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033107289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12889-015-2233-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033112096", 
              "https://doi.org/10.1186/s12889-015-2233-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0801650", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033474161", 
              "https://doi.org/10.1038/sj.ijo.0801650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0801650", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033474161", 
              "https://doi.org/10.1038/sj.ijo.0801650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci64801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034688529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/oby.20761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035435389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2012.06.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035569044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1271/bbb.70474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037034117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004872-199816050-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038448014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004872-199816050-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038448014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.20737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038790462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.20737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038790462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00325481.2015.1098519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039243296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/07853890.2015.1085125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039712203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2049-2618-1-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041339275", 
              "https://doi.org/10.1186/2049-2618-1-11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(11)60812-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043461736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bts174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044126939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ismej.2010.118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046790587", 
              "https://doi.org/10.1038/ismej.2010.118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1002358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047130335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10389-006-0024-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047146886", 
              "https://doi.org/10.1007/s10389-006-0024-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10389-006-0024-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047146886", 
              "https://doi.org/10.1007/s10389-006-0024-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gku702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048024597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7717/peerj.1165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048540869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-069x-13-90", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048885276", 
              "https://doi.org/10.1186/1476-069x-13-90"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s000711451400405x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049332457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1743-7075-11-48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049659602", 
              "https://doi.org/10.1186/1743-7075-11-48"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1254529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049689866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/07420528.2015.1038559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050234277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1002533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051462445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-010-0701-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052163899", 
              "https://doi.org/10.1007/s00726-010-0701-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-010-0701-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052163899", 
              "https://doi.org/10.1007/s00726-010-0701-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gene.2013.10.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052462279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12982-015-0044-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052972271", 
              "https://doi.org/10.1186/s12982-015-0044-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diacare.20.3.343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070747598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.2001.81.3.1031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074840904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/75.6.1045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075060888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075929443", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/45.2.443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079965786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/38.6.901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081881182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/67.3.391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083225053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/msystems.00191-16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084222343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092446313", 
              "https://doi.org/10.1038/nature24621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092446313", 
              "https://doi.org/10.1038/nature24621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092446313", 
              "https://doi.org/10.1038/nature24621"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "BACKGROUND: While some of the variance observed in adiposity and weight change within populations can be accounted for by traditional risk factors, a new factor, the gut microbiota, has recently been associated with obesity. However, the causal mechanisms through which the gut microbiota and its metabolites, short chain fatty acids (SCFAs) influence obesity are unknown, as are the individual obesogenic effects of the individual SCFAs (butyrate, acetate and propionate). This study, METS-Microbiome, proposes to examine the influence of novel risk factors, the gut microbiota and SCFAs, on obesity, adiposity and weight change in an international established cohort spanning the epidemiologic transition.\nMETHODS: The parent study; Modeling the Epidemiologic Transition Study (METS) is a well-established and ongoing prospective cohort study designed to assess the association between body composition, physical activity, and relative weight, weight gain and cardiometabolic disease risk in five diverse population-based samples in 2500 people of African descent. The cohort has been prospectively followed since 2009. Annual measures of obesity risk factors, including body composition, objectively measured physical activity and dietary intake, components which vary across the spectrum of social and economic development. In our new study; METS-Microbiome, in addition to continuing yearly measures of obesity risk, we will also measure gut microbiota and stool SCFAs in all contactable participants, and follow participants for a further 3\u00a0years, thus providing one of the largest gut microbiota population-based studies to date.\nDISCUSSION: This new study capitalizes upon an existing, extensively well described cohort of adults of African-origin, with significant variability as a result of the widespread geographic distributions, and therefore variation in the environmental covariate exposures. The METS-Microbiome study will substantially advance the understanding of the role gut microbiota and SCFAs play in the development of obesity and provide novel obesity therapeutic targets targeting SCFAs producing features of the gut microbiota.\nTRIAL REGISTRATION: Registered NCT03378765 Date first posted: December 20, 2017.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s12889-018-5879-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6664521", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2439001", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6618396", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1024954", 
            "issn": [
              "1471-2458"
            ], 
            "name": "BMC Public Health", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "name": "Gut microbiota, short chain fatty acids, and obesity across the epidemiologic transition: the METS-Microbiome study protocol", 
        "pagination": "978", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "75066a0922e38e0d20d6e4d35a26560c76817c431f5e4cb9c29ed5febaaf57e2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30081857"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100968562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12889-018-5879-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1106018893"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12889-018-5879-6", 
          "https://app.dimensions.ai/details/publication/pub.1106018893"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99802_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs12889-018-5879-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12889-018-5879-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12889-018-5879-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12889-018-5879-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12889-018-5879-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    475 TRIPLES      21 PREDICATES      124 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12889-018-5879-6 schema:about anzsrc-for:11
    2 anzsrc-for:1117
    3 schema:author N5e023f334149441bba4bb17eefe16d8c
    4 schema:citation sg:pub.10.1007/978-0-387-84858-7
    5 sg:pub.10.1007/s00726-010-0701-5
    6 sg:pub.10.1007/s10389-006-0024-x
    7 sg:pub.10.1007/s11306-011-0366-4
    8 sg:pub.10.1007/s12038-012-9244-0
    9 sg:pub.10.1007/s40273-014-0243-x
    10 sg:pub.10.1038/4441022a
    11 sg:pub.10.1038/ejcn.2012.199
    12 sg:pub.10.1038/ejcn.2013.123
    13 sg:pub.10.1038/ismej.2010.118
    14 sg:pub.10.1038/nature05414
    15 sg:pub.10.1038/nature09944
    16 sg:pub.10.1038/nature11552
    17 sg:pub.10.1038/nature18850
    18 sg:pub.10.1038/nature24621
    19 sg:pub.10.1038/ncomms3469
    20 sg:pub.10.1038/nmeth.2066
    21 sg:pub.10.1038/nmeth.3176
    22 sg:pub.10.1038/nmeth.f.303
    23 sg:pub.10.1038/sj.ijo.0801650
    24 sg:pub.10.1038/sj.ijo.0802469
    25 sg:pub.10.1186/1471-2164-15-511
    26 sg:pub.10.1186/1471-2164-9-75
    27 sg:pub.10.1186/1471-2458-11-927
    28 sg:pub.10.1186/1471-2458-14-397
    29 sg:pub.10.1186/1471-2458-14-882
    30 sg:pub.10.1186/1475-2891-12-158
    31 sg:pub.10.1186/1476-069x-13-90
    32 sg:pub.10.1186/1741-7015-3-2
    33 sg:pub.10.1186/1743-7075-11-48
    34 sg:pub.10.1186/2042-5783-1-4
    35 sg:pub.10.1186/2049-2618-1-11
    36 sg:pub.10.1186/s12889-015-1435-9
    37 sg:pub.10.1186/s12889-015-2233-0
    38 sg:pub.10.1186/s12982-015-0044-5
    39 sg:pub.10.1186/s13059-014-0550-8
    40 https://app.dimensions.ai/details/publication/pub.1032573094
    41 https://app.dimensions.ai/details/publication/pub.1075929443
    42 https://doi.org/10.1002/ibd.20737
    43 https://doi.org/10.1002/oby.20761
    44 https://doi.org/10.1016/j.cell.2014.05.052
    45 https://doi.org/10.1016/j.diabres.2013.11.002
    46 https://doi.org/10.1016/j.gene.2013.10.015
    47 https://doi.org/10.1016/j.jhep.2013.11.034
    48 https://doi.org/10.1016/j.mib.2016.03.008
    49 https://doi.org/10.1016/j.nutres.2010.04.006
    50 https://doi.org/10.1016/s0140-6736(11)60812-x
    51 https://doi.org/10.1016/s0140-6736(12)61728-0
    52 https://doi.org/10.1016/s1047-2797(96)00107-x
    53 https://doi.org/10.1016/s1570-0232(02)00827-9
    54 https://doi.org/10.1017/s000711451400405x
    55 https://doi.org/10.1038/oby.2000.42
    56 https://doi.org/10.1038/oby.2008.330
    57 https://doi.org/10.1053/j.gastro.2012.06.031
    58 https://doi.org/10.1073/pnas.1005963107
    59 https://doi.org/10.1080/00325481.2015.1098519
    60 https://doi.org/10.1093/ajcn/38.6.901
    61 https://doi.org/10.1093/ajcn/45.2.443
    62 https://doi.org/10.1093/ajcn/67.3.391
    63 https://doi.org/10.1093/ajcn/75.6.1045
    64 https://doi.org/10.1093/bioinformatics/bts174
    65 https://doi.org/10.1093/bioinformatics/btt589
    66 https://doi.org/10.1093/nar/gkm882
    67 https://doi.org/10.1093/nar/gku702
    68 https://doi.org/10.1093/oxfordjournals.aje.a008708
    69 https://doi.org/10.1093/oxfordjournals.aje.a009159
    70 https://doi.org/10.1097/00001648-199607000-00012
    71 https://doi.org/10.1097/00004872-199816050-00003
    72 https://doi.org/10.1097/mco.0b013e32832e6776
    73 https://doi.org/10.1097/mog.0b013e328333d751
    74 https://doi.org/10.1099/00207713-47-2-590
    75 https://doi.org/10.1111/j.1462-2920.2012.02845.x
    76 https://doi.org/10.1111/j.1472-765x.1989.tb00278.x
    77 https://doi.org/10.1126/science.1254529
    78 https://doi.org/10.1128/msystems.00009-15
    79 https://doi.org/10.1128/msystems.00191-16
    80 https://doi.org/10.1152/physrev.2001.81.3.1031
    81 https://doi.org/10.1155/2014/651895
    82 https://doi.org/10.1172/jci64801
    83 https://doi.org/10.1271/bbb.70474
    84 https://doi.org/10.1371/journal.pbio.1002533
    85 https://doi.org/10.1371/journal.pcbi.1002358
    86 https://doi.org/10.1371/journal.pone.0065465
    87 https://doi.org/10.2337/dc14-s014
    88 https://doi.org/10.2337/diabetes.51.3.599
    89 https://doi.org/10.2337/diacare.20.3.343
    90 https://doi.org/10.3109/07420528.2015.1038559
    91 https://doi.org/10.3109/07853890.2015.1085125
    92 https://doi.org/10.3389/fmicb.2014.00494
    93 https://doi.org/10.3402/mehd.v26.27663
    94 https://doi.org/10.3945/ajcn.110.007278
    95 https://doi.org/10.3945/ajcn.113.066605
    96 https://doi.org/10.3945/ajcn.2008.26630
    97 https://doi.org/10.4137/ehi.s13130
    98 https://doi.org/10.7717/peerj.1165
    99 schema:datePublished 2018-12
    100 schema:datePublishedReg 2018-12-01
    101 schema:description BACKGROUND: While some of the variance observed in adiposity and weight change within populations can be accounted for by traditional risk factors, a new factor, the gut microbiota, has recently been associated with obesity. However, the causal mechanisms through which the gut microbiota and its metabolites, short chain fatty acids (SCFAs) influence obesity are unknown, as are the individual obesogenic effects of the individual SCFAs (butyrate, acetate and propionate). This study, METS-Microbiome, proposes to examine the influence of novel risk factors, the gut microbiota and SCFAs, on obesity, adiposity and weight change in an international established cohort spanning the epidemiologic transition. METHODS: The parent study; Modeling the Epidemiologic Transition Study (METS) is a well-established and ongoing prospective cohort study designed to assess the association between body composition, physical activity, and relative weight, weight gain and cardiometabolic disease risk in five diverse population-based samples in 2500 people of African descent. The cohort has been prospectively followed since 2009. Annual measures of obesity risk factors, including body composition, objectively measured physical activity and dietary intake, components which vary across the spectrum of social and economic development. In our new study; METS-Microbiome, in addition to continuing yearly measures of obesity risk, we will also measure gut microbiota and stool SCFAs in all contactable participants, and follow participants for a further 3 years, thus providing one of the largest gut microbiota population-based studies to date. DISCUSSION: This new study capitalizes upon an existing, extensively well described cohort of adults of African-origin, with significant variability as a result of the widespread geographic distributions, and therefore variation in the environmental covariate exposures. The METS-Microbiome study will substantially advance the understanding of the role gut microbiota and SCFAs play in the development of obesity and provide novel obesity therapeutic targets targeting SCFAs producing features of the gut microbiota. TRIAL REGISTRATION: Registered NCT03378765 Date first posted: December 20, 2017.
    102 schema:genre research_article
    103 schema:inLanguage en
    104 schema:isAccessibleForFree true
    105 schema:isPartOf N07fb40dcfa7d473e8fd1003f98d906de
    106 N9075071339c04fd1a05cf9029b02eaa8
    107 sg:journal.1024954
    108 schema:name Gut microbiota, short chain fatty acids, and obesity across the epidemiologic transition: the METS-Microbiome study protocol
    109 schema:pagination 978
    110 schema:productId N0d1d0bdef2ff4d708c3b74307f98e10d
    111 N21e30a93a2c8467e97de6d134f4cda3d
    112 N9bb42e1852d24a3a83c5ff922025ecfc
    113 Nb10cdecf536d43398a90200c9c9264aa
    114 Nb958b4766ab84fac83bc8ee62af5f670
    115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106018893
    116 https://doi.org/10.1186/s12889-018-5879-6
    117 schema:sdDatePublished 2019-04-11T09:30
    118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    119 schema:sdPublisher Ne67549b7f6c947f48b70d434f5a3c6a7
    120 schema:url https://link.springer.com/10.1186%2Fs12889-018-5879-6
    121 sgo:license sg:explorer/license/
    122 sgo:sdDataset articles
    123 rdf:type schema:ScholarlyArticle
    124 N07fb40dcfa7d473e8fd1003f98d906de schema:issueNumber 1
    125 rdf:type schema:PublicationIssue
    126 N0ba730863f154f4d9576852784a31c8c rdf:first sg:person.013454700177.37
    127 rdf:rest N4560bf555b0244b8870820e50859d1e8
    128 N0d1d0bdef2ff4d708c3b74307f98e10d schema:name readcube_id
    129 schema:value 75066a0922e38e0d20d6e4d35a26560c76817c431f5e4cb9c29ed5febaaf57e2
    130 rdf:type schema:PropertyValue
    131 N21e30a93a2c8467e97de6d134f4cda3d schema:name nlm_unique_id
    132 schema:value 100968562
    133 rdf:type schema:PropertyValue
    134 N3de93ee4a02845838ab3eaed936ea798 rdf:first sg:person.0753126627.62
    135 rdf:rest N82696ac091cc499f87f6827c168bc547
    136 N3f9d9030d3894edb93098947289e7ed8 schema:name Microbiome Center, Department of Surgery, University of Chicago, Chicago, IL, USA
    137 rdf:type schema:Organization
    138 N4560bf555b0244b8870820e50859d1e8 rdf:first sg:person.012567461417.17
    139 rdf:rest N4cedb478d2a649ac9ad65c2f5f0e965c
    140 N4cedb478d2a649ac9ad65c2f5f0e965c rdf:first sg:person.01024436530.09
    141 rdf:rest Ned1fa601a7c44c6f80de8449f29854fe
    142 N4d0bdafc82a249b081f841e0bf2176ba rdf:first sg:person.01275605144.23
    143 rdf:rest N3de93ee4a02845838ab3eaed936ea798
    144 N5e023f334149441bba4bb17eefe16d8c rdf:first sg:person.01347453053.50
    145 rdf:rest Na1d3baf4052844e4b0b6d215c3e6c063
    146 N82696ac091cc499f87f6827c168bc547 rdf:first sg:person.01117020021.02
    147 rdf:rest N0ba730863f154f4d9576852784a31c8c
    148 N9075071339c04fd1a05cf9029b02eaa8 schema:volumeNumber 18
    149 rdf:type schema:PublicationVolume
    150 N9bb42e1852d24a3a83c5ff922025ecfc schema:name dimensions_id
    151 schema:value pub.1106018893
    152 rdf:type schema:PropertyValue
    153 Na1d3baf4052844e4b0b6d215c3e6c063 rdf:first sg:person.013341020266.23
    154 rdf:rest N4d0bdafc82a249b081f841e0bf2176ba
    155 Nb10cdecf536d43398a90200c9c9264aa schema:name doi
    156 schema:value 10.1186/s12889-018-5879-6
    157 rdf:type schema:PropertyValue
    158 Nb958b4766ab84fac83bc8ee62af5f670 schema:name pubmed_id
    159 schema:value 30081857
    160 rdf:type schema:PropertyValue
    161 Nd6a1fdf2c988468cbb56b0f0ef6d05e9 rdf:first sg:person.0630770706.32
    162 rdf:rest rdf:nil
    163 Ne67549b7f6c947f48b70d434f5a3c6a7 schema:name Springer Nature - SN SciGraph project
    164 rdf:type schema:Organization
    165 Ned1fa601a7c44c6f80de8449f29854fe rdf:first sg:person.0727626545.37
    166 rdf:rest Nd6a1fdf2c988468cbb56b0f0ef6d05e9
    167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Medical and Health Sciences
    169 rdf:type schema:DefinedTerm
    170 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Public Health and Health Services
    172 rdf:type schema:DefinedTerm
    173 sg:grant.2439001 http://pending.schema.org/fundedItem sg:pub.10.1186/s12889-018-5879-6
    174 rdf:type schema:MonetaryGrant
    175 sg:grant.6618396 http://pending.schema.org/fundedItem sg:pub.10.1186/s12889-018-5879-6
    176 rdf:type schema:MonetaryGrant
    177 sg:grant.6664521 http://pending.schema.org/fundedItem sg:pub.10.1186/s12889-018-5879-6
    178 rdf:type schema:MonetaryGrant
    179 sg:journal.1024954 schema:issn 1471-2458
    180 schema:name BMC Public Health
    181 rdf:type schema:Periodical
    182 sg:person.01024436530.09 schema:affiliation https://www.grid.ac/institutes/grid.164971.c
    183 schema:familyName Luke
    184 schema:givenName Amy
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024436530.09
    186 rdf:type schema:Person
    187 sg:person.01117020021.02 schema:affiliation https://www.grid.ac/institutes/grid.482968.9
    188 schema:familyName Bovet
    189 schema:givenName Pascal
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117020021.02
    191 rdf:type schema:Person
    192 sg:person.012567461417.17 schema:affiliation https://www.grid.ac/institutes/grid.12916.3d
    193 schema:familyName Forrester
    194 schema:givenName Terrence E.
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012567461417.17
    196 rdf:type schema:Person
    197 sg:person.01275605144.23 schema:affiliation https://www.grid.ac/institutes/grid.9829.a
    198 schema:familyName Plange-Rhule
    199 schema:givenName Jacob
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275605144.23
    201 rdf:type schema:Person
    202 sg:person.013341020266.23 schema:affiliation https://www.grid.ac/institutes/grid.164971.c
    203 schema:familyName Lie
    204 schema:givenName Louise
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013341020266.23
    206 rdf:type schema:Person
    207 sg:person.013454700177.37 schema:affiliation https://www.grid.ac/institutes/grid.7836.a
    208 schema:familyName Lambert
    209 schema:givenName Estelle V.
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013454700177.37
    211 rdf:type schema:Person
    212 sg:person.01347453053.50 schema:affiliation https://www.grid.ac/institutes/grid.164971.c
    213 schema:familyName Dugas
    214 schema:givenName Lara R.
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347453053.50
    216 rdf:type schema:Person
    217 sg:person.0630770706.32 schema:affiliation https://www.grid.ac/institutes/grid.280892.9
    218 schema:familyName Layden
    219 schema:givenName Brian T.
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630770706.32
    221 rdf:type schema:Person
    222 sg:person.0727626545.37 schema:affiliation N3f9d9030d3894edb93098947289e7ed8
    223 schema:familyName Gilbert
    224 schema:givenName Jack A.
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727626545.37
    226 rdf:type schema:Person
    227 sg:person.0753126627.62 schema:affiliation https://www.grid.ac/institutes/grid.9829.a
    228 schema:familyName Bedu-Addo
    229 schema:givenName Kweku
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753126627.62
    231 rdf:type schema:Person
    232 sg:pub.10.1007/978-0-387-84858-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032573094
    233 https://doi.org/10.1007/978-0-387-84858-7
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1007/s00726-010-0701-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052163899
    236 https://doi.org/10.1007/s00726-010-0701-5
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1007/s10389-006-0024-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047146886
    239 https://doi.org/10.1007/s10389-006-0024-x
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1007/s11306-011-0366-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009770929
    242 https://doi.org/10.1007/s11306-011-0366-4
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1007/s12038-012-9244-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032115783
    245 https://doi.org/10.1007/s12038-012-9244-0
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1007/s40273-014-0243-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008014634
    248 https://doi.org/10.1007/s40273-014-0243-x
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/4441022a schema:sameAs https://app.dimensions.ai/details/publication/pub.1018798093
    251 https://doi.org/10.1038/4441022a
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/ejcn.2012.199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018043021
    254 https://doi.org/10.1038/ejcn.2012.199
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/ejcn.2013.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007792312
    257 https://doi.org/10.1038/ejcn.2013.123
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/ismej.2010.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046790587
    260 https://doi.org/10.1038/ismej.2010.118
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nature05414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023893418
    263 https://doi.org/10.1038/nature05414
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nature09944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026204536
    266 https://doi.org/10.1038/nature09944
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nature11552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004952443
    269 https://doi.org/10.1038/nature11552
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nature18850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013019120
    272 https://doi.org/10.1038/nature18850
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nature24621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092446313
    275 https://doi.org/10.1038/nature24621
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/ncomms3469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020010565
    278 https://doi.org/10.1038/ncomms3469
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/nmeth.2066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010611135
    281 https://doi.org/10.1038/nmeth.2066
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/nmeth.3176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023901695
    284 https://doi.org/10.1038/nmeth.3176
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/nmeth.f.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009032055
    287 https://doi.org/10.1038/nmeth.f.303
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/sj.ijo.0801650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033474161
    290 https://doi.org/10.1038/sj.ijo.0801650
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/sj.ijo.0802469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032205525
    293 https://doi.org/10.1038/sj.ijo.0802469
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1186/1471-2164-15-511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017616461
    296 https://doi.org/10.1186/1471-2164-15-511
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1186/1471-2164-9-75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013431920
    299 https://doi.org/10.1186/1471-2164-9-75
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1186/1471-2458-11-927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025796414
    302 https://doi.org/10.1186/1471-2458-11-927
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1186/1471-2458-14-397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020312923
    305 https://doi.org/10.1186/1471-2458-14-397
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1186/1471-2458-14-882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006955503
    308 https://doi.org/10.1186/1471-2458-14-882
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1186/1475-2891-12-158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027869215
    311 https://doi.org/10.1186/1475-2891-12-158
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1186/1476-069x-13-90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048885276
    314 https://doi.org/10.1186/1476-069x-13-90
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1186/1741-7015-3-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028816079
    317 https://doi.org/10.1186/1741-7015-3-2
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1186/1743-7075-11-48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049659602
    320 https://doi.org/10.1186/1743-7075-11-48
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1186/2042-5783-1-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030642249
    323 https://doi.org/10.1186/2042-5783-1-4
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1186/2049-2618-1-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041339275
    326 https://doi.org/10.1186/2049-2618-1-11
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1186/s12889-015-1435-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018404169
    329 https://doi.org/10.1186/s12889-015-1435-9
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1186/s12889-015-2233-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033112096
    332 https://doi.org/10.1186/s12889-015-2233-0
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1186/s12982-015-0044-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052972271
    335 https://doi.org/10.1186/s12982-015-0044-5
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
    338 https://doi.org/10.1186/s13059-014-0550-8
    339 rdf:type schema:CreativeWork
    340 https://app.dimensions.ai/details/publication/pub.1032573094 schema:CreativeWork
    341 https://app.dimensions.ai/details/publication/pub.1075929443 schema:CreativeWork
    342 https://doi.org/10.1002/ibd.20737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038790462
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1002/oby.20761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035435389
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1016/j.cell.2014.05.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005962197
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1016/j.diabres.2013.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025250404
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1016/j.gene.2013.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052462279
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/j.jhep.2013.11.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013244622
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/j.mib.2016.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002907891
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/j.nutres.2010.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024984714
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/s0140-6736(11)60812-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043461736
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1016/s0140-6736(12)61728-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013705877
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1016/s1047-2797(96)00107-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003599567
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1016/s1570-0232(02)00827-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023987162
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1017/s000711451400405x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049332457
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1038/oby.2000.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017065044
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1038/oby.2008.330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010399753
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1053/j.gastro.2012.06.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035569044
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1073/pnas.1005963107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023427228
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1080/00325481.2015.1098519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039243296
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1093/ajcn/38.6.901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081881182
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1093/ajcn/45.2.443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079965786
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1093/ajcn/67.3.391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083225053
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1093/ajcn/75.6.1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075060888
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1093/bioinformatics/bts174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044126939
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1093/bioinformatics/btt589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026993064
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1093/nar/gkm882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007077161
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1093/nar/gku702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048024597
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1093/oxfordjournals.aje.a008708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012474469
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1093/oxfordjournals.aje.a009159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031753934
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1097/00001648-199607000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007205236
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1097/00004872-199816050-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038448014
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1097/mco.0b013e32832e6776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010696798
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1097/mog.0b013e328333d751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013759152
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1099/00207713-47-2-590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021105966
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1111/j.1462-2920.2012.02845.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023642358
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1111/j.1472-765x.1989.tb00278.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001500077
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1126/science.1254529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049689866
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1128/msystems.00009-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033107289
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1128/msystems.00191-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084222343
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1152/physrev.2001.81.3.1031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074840904
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1155/2014/651895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000605957
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1172/jci64801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034688529
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1271/bbb.70474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037034117
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1371/journal.pbio.1002533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051462445
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1371/journal.pcbi.1002358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047130335
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1371/journal.pone.0065465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024027498
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.2337/dc14-s014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022230985
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.2337/diabetes.51.3.599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028211724
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.2337/diacare.20.3.343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070747598
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.3109/07420528.2015.1038559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050234277
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.3109/07853890.2015.1085125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039712203
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.3389/fmicb.2014.00494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020230066
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.3402/mehd.v26.27663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031307715
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.3945/ajcn.110.007278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025404089
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.3945/ajcn.113.066605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008717334
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.3945/ajcn.2008.26630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000845916
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.4137/ehi.s13130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011225353
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.7717/peerj.1165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048540869
    455 rdf:type schema:CreativeWork
    456 https://www.grid.ac/institutes/grid.12916.3d schema:alternateName University of the West Indies
    457 schema:name Solutions for Developing Countries, University of the West Indies, Mona, Kingston, Jamaica
    458 rdf:type schema:Organization
    459 https://www.grid.ac/institutes/grid.164971.c schema:alternateName Loyola University Chicago
    460 schema:name Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, 2160 S. 1st Avenue, 60153, Maywood, IL, USA
    461 rdf:type schema:Organization
    462 https://www.grid.ac/institutes/grid.280892.9 schema:alternateName Jesse Brown VA Medical Center
    463 schema:name Division of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL, USA
    464 Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA
    465 rdf:type schema:Organization
    466 https://www.grid.ac/institutes/grid.482968.9 schema:alternateName Institute of Social and Preventive Medicine
    467 schema:name Institute of Social & Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland
    468 Ministry of Health, Republic of Seychelles, Lausanne, Switzerland
    469 rdf:type schema:Organization
    470 https://www.grid.ac/institutes/grid.7836.a schema:alternateName University of Cape Town
    471 schema:name Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa
    472 rdf:type schema:Organization
    473 https://www.grid.ac/institutes/grid.9829.a schema:alternateName Kwame Nkrumah University of Science and Technology
    474 schema:name Department of Physiology, SMS, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
    475 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...