Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: the ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-02-10

AUTHORS

Mica Hartley, Samuel Hoare, Fiona E Lithander, Rachel E Neale, Prue H Hart, Shelley Gorman, Peter Gies, Jill Sherriff, Ashwin Swaminathan, Lawrence J Beilin, Trevor A Mori, Laura King, Lucinda J Black, Kushani Marshall, Fan Xiang, Candy Wyatt, Kerryn King, Terry Slevin, Nirmala Pandeya, Robyn M Lucas

ABSTRACT

BACKGROUND: Adults living in the sunny Australian climate are at high risk of skin cancer, but vitamin D deficiency (defined here as a serum 25-hydroxyvitamin D (25(OH)D) concentration of less than 50 nmol/L) is also common. Vitamin D deficiency may be a risk factor for a range of diseases. However, the optimal strategies to achieve and maintain vitamin D adequacy (sun exposure, vitamin D supplementation or both), and whether sun exposure itself has benefits over and above initiating synthesis of vitamin D, remain unclear. The Sun Exposure and Vitamin D Supplementation (SEDS) Study aims to compare the effectiveness of sun exposure and vitamin D supplementation for the management of vitamin D insufficiency, and to test whether these management strategies differentially affect markers of immune and cardio-metabolic function. METHODS/DESIGN: The SEDS Study is a multi-centre, randomised controlled trial of two different daily doses of vitamin D supplementation, and placebo, in conjunction with guidance on two different patterns of sun exposure. Participants recruited from across Australia are aged 18-64 years and have a recent vitamin D test result showing a serum 25(OH)D level of 40-60 nmol/L. DISCUSSION: This paper discusses the rationale behind the study design, and considers the challenges but necessity of data collection within a non-institutionalised adult population, in order to address the study aims. We also discuss the challenges of participant recruitment and retention, ongoing engagement of referring medical practitioners and address issues of compliance and participant retention. TRIAL REGISTRATION: Australia New Zealand Clinical Trials Registry: ACTRN12613000290796 Registered 14 March 2013. More... »

PAGES

115

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12889-015-1461-7

DOI

http://dx.doi.org/10.1186/s12889-015-1461-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029614451

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25884724


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