Paris MEM: a study protocol for an effectiveness and efficiency trial on the treatment of traumatic stress in France after ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-11-08

AUTHORS

A. Brunet, A. Ayrolles, L. Gambotti, R. Maatoug, C. Estellat, M. Descamps, N. Girault, K. Kalalou, G. Abgrall, F. Ducrocq, G. Vaiva, N. Jaafari, M. O. Krebs, E. Castaigne, I. Hanafy, M. Benoit, S. Mouchabac, M. C. Cabié, O. Guillin, F. Hodeib, I. Durand-Zaleski, B. Millet

ABSTRACT

BackgroundThe Paris and Nice terrorist attacks affected a thousand of trauma victims and first-line responders. Because there were concerns that this might represent the first of several attacks, there was a need to quickly enhance the local capacities to treat a large number of individuals suffering from trauma-related disorders. Since Reconsolidation Therapy (RT) is brief, relatively easy to learn, well tolerated and effective, it appeared as the ideal first-line treatment to teach to clinicians in this context.MethodsThis study protocol is a two-arm non-randomized, multicenter controlled trial, comparing RT to treatment as usual for the treatment of trauma-related disorders. RT consists of actively recalling one’s traumatic event under the influence of the ß-blocker propranolol, once a week, for 10–25 min with a therapist, over 6 consecutive weeks. This protocol evaluates the feasibility, effectiveness, and cost-utility of implementing RT as part of a large multi-center (N = 400) pragmatic trial with a one-year follow-up.DiscussionParis MEM is the largest trial to date assessing the efficiency of RT in the aftermath of a large-scale man-made disaster. RT could possibly reinforce the therapeutic arsenal for the treatment of patients suffering from trauma-related disorders, not only for communities in western countries but also worldwide for terror- or disaster-stricken communities.Trial registrationClinical Trials (ClinicalTrials.gov). June 3, 2016. NCT02789982. More... »

PAGES

351

Journal

TITLE

BMC Psychiatry

ISSUE

1

VOLUME

19

Author Affiliations

  • Department of Psychiatry, McGill University, Montréal, Canada
  • Département de Psychiatrie adulte, Hôpital Universitaire de la Pitié Salpêtrière, Assistance Publique - Hôpitaux de Paris, boulevard de l’Hôpital, 75013, Paris, France
  • Unité de recherche clinique, EPS de Ville Evrard, G03, 5 rue du Dr Delafontaine, 93200, Saint-Denis, France
  • Assistance Publique - Hôpitaux de Paris -, Hôtel-Dieu, 75004, Paris, France
  • France CHRU de Lille, Pôle de Psychiatrie Médecine Légale et Santé en milieu Pénitentiaire, SCA-Lab CNRS UMR 9193, 59037 cedex, Lille, France
  • CIC INSERM U802, CHU de Poitiers, Unité de recherche clinique intersectorielle en psychiatrie du Centre Hospitalier Henri Laborit, 86022, Poitiers, France
  • Centre Hospitalier Sainte Anne, Service Hospitalo-Universitaire, Faculté de Médecine Paris Descartes, Université Paris Descartes, Paris, France
  • Service de Psychiatrie, CHU de Bicêtre, HUPS, APHP 78, rue du général Leclerc, 94270, Le Kremlin Bicêtre, France
  • CH Marne La Vallée, Service de Médecine Légale, 77420, Marne-La-Vallée, France
  • Clinical Neuroscience Department Hospital Pasteur 1, France University of Côte d’Azur, 30 avenue de la voie, 06002 NICE cedex 1, Romaine, France
  • Département de psychiatrie et de psychologie médicale de l’adulte, Hôpital universitaire Saint-Antoine, Université Pierre et Marie Curie, Paris VI - AP-HP, 184 rue du Faubourg-Saint-Antoine, 75012, Paris, France
  • Pôle Paris 11 Les Hôpitaux de Saint Maurice, 12-14 rue Val d’Osne, 94410, St Maurice, France
  • unité Inserm U1079 Faculté de médecine et de pharmacie, 76000, Rouen, France
  • ECEVE, UMR 1123 URCEco Ile de France Hôtel Dieu, 1 place du Parvis de Notre Dame, 75004, Paris, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12888-019-2283-4

    DOI

    http://dx.doi.org/10.1186/s12888-019-2283-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1122421721

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31703570


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