Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo-controlled double-blind crossover study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Kazuo Takiguchi, Akihito Uezato, Michio Itasaka, Hidenori Atsuta, Kenji Narushima, Naoki Yamamoto, Akeo Kurumaji, Makoto Tomita, Kazunari Oshima, Kosaku Shoda, Mai Tamaru, Masahito Nakataki, Mitsutoshi Okazaki, Sayuri Ishiwata, Yasuyoshi Ishiwata, Masato Yasuhara, Kunimasa Arima, Tetsuro Ohmori, Toru Nishikawa

ABSTRACT

BACKGROUND: It has been reported that drugs which promote the N-Methyl-D-aspartate-type glutamate receptor function by stimulating the glycine modulatory site in the receptor improve negative symptoms and cognitive dysfunction in schizophrenia patients being treated with antipsychotic drugs. METHODS: We performed a placebo-controlled double-blind crossover study involving 41 schizophrenia patients in which D-cycloserine 50 mg/day was added-on, and the influence of the onset age and association with white matter integrity on MR diffusion tensor imaging were investigated for the first time. The patients were evaluated using the Positive and Negative Syndrome Scale (PANSS), Scale for the Assessment of Negative Symptoms (SANS), Brief Assessment of Cognition in Schizophrenia (BACS), and other scales. RESULTS: D-cycloserine did not improve positive or negative symptoms or cognitive dysfunction in schizophrenia. The investigation in consideration of the onset age suggests that D-cycloserine may aggravate negative symptoms of early-onset schizophrenia. The better treatment effect of D-cycloserine on BACS was observed when the white matter integrity of the sagittal stratum/ cingulum/fornix stria terminalis/genu of corpus callosum/external capsule was higher, and the better treatment effect on PANSS general psychopathology (PANSS-G) was observed when the white matter integrity of the splenium of corpus callosum was higher. In contrast, the better treatment effect of D-cycloserine on PANSS-G and SANS-IV were observed when the white matter integrity of the posterior thalamic radiation (left) was lower. CONCLUSION: It was suggested that response to D-cycloserine is influenced by the onset age and white matter integrity. TRIAL REGISTRATION: UMIN Clinical Trials Registry (number UMIN000000468 ). Registered 18 August 2006. More... »

PAGES

249

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12888-017-1410-3

DOI

http://dx.doi.org/10.1186/s12888-017-1410-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090600225

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28701225


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age of Onset", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antipsychotic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Over Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cycloserine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diffusion Tensor Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycine Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Schizophrenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Schizophrenic Psychology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "White Matter", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan", 
            "Haryugaoka Hospital, Tensyoudan 11, Otsukimachi, Koriyama-shi, 963-0201, Fukushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takiguchi", 
        "givenName": "Kazuo", 
        "id": "sg:person.013127204277.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013127204277.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uezato", 
        "givenName": "Akihito", 
        "id": "sg:person.0723134715.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723134715.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Itasaka", 
        "givenName": "Michio", 
        "id": "sg:person.01134701240.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134701240.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atsuta", 
        "givenName": "Hidenori", 
        "id": "sg:person.01301341461.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301341461.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Narushima", 
        "givenName": "Kenji", 
        "id": "sg:person.01030624354.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030624354.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Tama Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.417089.3", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan", 
            "Psychiatry Department, Tokyo Metropolitan Tama Medical Center, 2-8-29 Musashidai, Fuchu-shi, 183-8524, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Naoki", 
        "id": "sg:person.01367000404.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367000404.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurumaji", 
        "givenName": "Akeo", 
        "id": "sg:person.0576215717.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576215717.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Clinical Research Center, Medical Hospital of Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomita", 
        "givenName": "Makoto", 
        "id": "sg:person.01326667740.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326667740.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan", 
            "Ohmiya Kousei Hospital, Katayanagi 1, Minuma-ku, Saitama-shi, 337-0024, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oshima", 
        "givenName": "Kazunari", 
        "id": "sg:person.012434250321.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012434250321.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Ohmiya Kousei Hospital, Katayanagi 1, Minuma-ku, Saitama-shi, 337-0024, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shoda", 
        "givenName": "Kosaku", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokushima", 
          "id": "https://www.grid.ac/institutes/grid.267335.6", 
          "name": [
            "Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto, 770-8503, Tokushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tamaru", 
        "givenName": "Mai", 
        "id": "sg:person.01306776201.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306776201.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokushima", 
          "id": "https://www.grid.ac/institutes/grid.267335.6", 
          "name": [
            "Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto, 770-8503, Tokushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakataki", 
        "givenName": "Masahito", 
        "id": "sg:person.01267435624.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267435624.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Psychiatry, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, 187-8551, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okazaki", 
        "givenName": "Mitsutoshi", 
        "id": "sg:person.0721355624.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721355624.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishiwata", 
        "givenName": "Sayuri", 
        "id": "sg:person.01047570332.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047570332.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Hospital Pharmacy, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishiwata", 
        "givenName": "Yasuyoshi", 
        "id": "sg:person.01112510530.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112510530.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Hospital Pharmacy, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yasuhara", 
        "givenName": "Masato", 
        "id": "sg:person.015641621571.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015641621571.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Psychiatry, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, 187-8551, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arima", 
        "givenName": "Kunimasa", 
        "id": "sg:person.01107334530.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107334530.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokushima", 
          "id": "https://www.grid.ac/institutes/grid.267335.6", 
          "name": [
            "Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto, 770-8503, Tokushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohmori", 
        "givenName": "Tetsuro", 
        "id": "sg:person.010224003632.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010224003632.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishikawa", 
        "givenName": "Toru", 
        "id": "sg:person.01047042446.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047042446.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.pscychresns.2010.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003972049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(96)00311-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004429481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.56.1.21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011467146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012284028", 
          "https://doi.org/10.1038/nature01497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012284028", 
          "https://doi.org/10.1038/nature01497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0161406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012621977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-244x-12-150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015362238", 
          "https://doi.org/10.1186/1471-244x-12-150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2005.06.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016046481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2005.06.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016046481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(94)90687-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016410364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(94)90687-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016410364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2016.03.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019765960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002826-199619050-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022921368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2006.02.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023372670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nlm.2005.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025356673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2016.11.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027470267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2008.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028640610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(89)90379-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028846386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(89)90379-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028846386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2450-14.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030370441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4001551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030532610", 
          "https://doi.org/10.1038/sj.mp.4001551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4001551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030532610", 
          "https://doi.org/10.1038/sj.mp.4001551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pscychresns.2014.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033588031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.npp.1300313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035089392", 
          "https://doi.org/10.1038/sj.npp.1300313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.npp.1300313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035089392", 
          "https://doi.org/10.1038/sj.npp.1300313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(99)00014-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036198831", 
          "https://doi.org/10.1016/s0893-133x(99)00014-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2007.05.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036202764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01276429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038636375", 
          "https://doi.org/10.1007/bf01276429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01276429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038636375", 
          "https://doi.org/10.1007/bf01276429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0920-9964(01)00220-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040860995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-004-2032-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044357502", 
          "https://doi.org/10.1007/s00213-004-2032-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2004.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046563323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pscychresns.2016.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046826256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(98)00367-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048295619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2008.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049462644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tp.2015.154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051618956", 
          "https://doi.org/10.1038/tp.2015.154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1461145798001242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054934284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/cap.2015.0097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059241937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/ajp.152.8.1213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063483976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/ajp.153.12.1628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063484262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.159.3.480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063494510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.2007.06081358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063497725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138161210790361452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069167203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077615654", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079051105", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: It has been reported that drugs which promote the N-Methyl-D-aspartate-type glutamate receptor function by stimulating the glycine modulatory site in the receptor improve negative symptoms and cognitive dysfunction in schizophrenia patients being treated with antipsychotic drugs.\nMETHODS: We performed a placebo-controlled double-blind crossover study involving 41 schizophrenia patients in which D-cycloserine 50\u00a0mg/day was added-on, and the influence of the onset age and association with white matter integrity on MR diffusion tensor imaging were investigated for the first time. The patients were evaluated using the Positive and Negative Syndrome Scale (PANSS), Scale for the Assessment of Negative Symptoms (SANS), Brief Assessment of Cognition in Schizophrenia (BACS), and other scales.\nRESULTS: D-cycloserine did not improve positive or negative symptoms or cognitive dysfunction in schizophrenia. The investigation in consideration of the onset age suggests that D-cycloserine may aggravate negative symptoms of early-onset schizophrenia. The better treatment effect of D-cycloserine on BACS was observed when the white matter integrity of the sagittal stratum/ cingulum/fornix stria terminalis/genu of corpus callosum/external capsule was higher, and the better treatment effect on PANSS general psychopathology (PANSS-G) was observed when the white matter integrity of the splenium of corpus callosum was higher. In contrast, the better treatment effect of D-cycloserine on PANSS-G and SANS-IV were observed when the white matter integrity of the posterior thalamic radiation (left) was lower.\nCONCLUSION: It was suggested that response to D-cycloserine is influenced by the onset age and white matter integrity.\nTRIAL REGISTRATION: UMIN Clinical Trials Registry (number UMIN000000468 ). Registered 18 August 2006.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12888-017-1410-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5974500", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6009441", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024952", 
        "issn": [
          "1471-244X"
        ], 
        "name": "BMC Psychiatry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo-controlled double-blind crossover study", 
    "pagination": "249", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3ca85bf5b55210bfd210c76d3ab0411450fe0fcc51d6ec88ae75052109af5a19"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28701225"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968559"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12888-017-1410-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1090600225"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12888-017-1410-3", 
      "https://app.dimensions.ai/details/publication/pub.1090600225"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87115_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12888-017-1410-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12888-017-1410-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12888-017-1410-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12888-017-1410-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12888-017-1410-3'


 

This table displays all metadata directly associated to this object as RDF triples.

398 TRIPLES      21 PREDICATES      83 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12888-017-1410-3 schema:about N0ada60e8aa3444eabcbd49b5a8b88405
2 N509477808b054a6d89e35cadff4e86b6
3 N72bb3bbe66bc479b81639a26a81a7640
4 N7d361a6e8a8e465e8fa4d356a562f5be
5 N7d60320300024e7ab02de3127d51f705
6 N8d72fa16e0de4ebea679fd5b578c89e1
7 N907f9198a0834a9b89b7739eb0e3935b
8 N957484c23e0d4e018eaac706a0a7c364
9 Na0a2ba44e1144157a9d98be904a17970
10 Nba030f39a6bf411d9ab747f82b3a9619
11 Nc380b1366f3343708cae191eab84bbf7
12 Nd91944fd2eb140a1b7423944451e4f5b
13 Ne3d99e4e92324511a63e55f505c608df
14 Ne486391a72ed4b05a80b8b1564c8e705
15 Nf316dbd9adcf4677b071a97d804981e1
16 Nf7c218c813e64ac2bfedef9208406a3f
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N8c91c197b03b4d25875d69839930e759
20 schema:citation sg:pub.10.1007/bf01276429
21 sg:pub.10.1007/s00213-004-2032-2
22 sg:pub.10.1016/s0893-133x(99)00014-7
23 sg:pub.10.1038/nature01497
24 sg:pub.10.1038/sj.mp.4001551
25 sg:pub.10.1038/sj.npp.1300313
26 sg:pub.10.1038/tp.2015.154
27 sg:pub.10.1186/1471-244x-12-150
28 https://app.dimensions.ai/details/publication/pub.1077615654
29 https://app.dimensions.ai/details/publication/pub.1079051105
30 https://doi.org/10.1001/archpsyc.56.1.21
31 https://doi.org/10.1016/0014-2999(94)90687-4
32 https://doi.org/10.1016/0304-3940(89)90379-0
33 https://doi.org/10.1016/j.biopsych.2005.06.032
34 https://doi.org/10.1016/j.neuroimage.2006.02.024
35 https://doi.org/10.1016/j.nlm.2005.01.001
36 https://doi.org/10.1016/j.pscychresns.2010.04.013
37 https://doi.org/10.1016/j.pscychresns.2014.06.001
38 https://doi.org/10.1016/j.pscychresns.2016.01.011
39 https://doi.org/10.1016/j.schres.2004.03.013
40 https://doi.org/10.1016/j.schres.2007.05.044
41 https://doi.org/10.1016/j.schres.2008.03.008
42 https://doi.org/10.1016/j.schres.2008.08.012
43 https://doi.org/10.1016/j.schres.2016.03.035
44 https://doi.org/10.1016/j.schres.2016.11.045
45 https://doi.org/10.1016/s0006-3223(96)00311-3
46 https://doi.org/10.1016/s0006-3223(98)00367-9
47 https://doi.org/10.1016/s0920-9964(01)00220-1
48 https://doi.org/10.1017/s1461145798001242
49 https://doi.org/10.1089/cap.2015.0097
50 https://doi.org/10.1097/00002826-199619050-00008
51 https://doi.org/10.1176/ajp.152.8.1213
52 https://doi.org/10.1176/ajp.153.12.1628
53 https://doi.org/10.1176/appi.ajp.159.3.480
54 https://doi.org/10.1176/appi.ajp.2007.06081358
55 https://doi.org/10.1371/journal.pone.0161406
56 https://doi.org/10.1523/jneurosci.2450-14.2015
57 https://doi.org/10.2174/138161210790361452
58 schema:datePublished 2017-12
59 schema:datePublishedReg 2017-12-01
60 schema:description BACKGROUND: It has been reported that drugs which promote the N-Methyl-D-aspartate-type glutamate receptor function by stimulating the glycine modulatory site in the receptor improve negative symptoms and cognitive dysfunction in schizophrenia patients being treated with antipsychotic drugs. METHODS: We performed a placebo-controlled double-blind crossover study involving 41 schizophrenia patients in which D-cycloserine 50 mg/day was added-on, and the influence of the onset age and association with white matter integrity on MR diffusion tensor imaging were investigated for the first time. The patients were evaluated using the Positive and Negative Syndrome Scale (PANSS), Scale for the Assessment of Negative Symptoms (SANS), Brief Assessment of Cognition in Schizophrenia (BACS), and other scales. RESULTS: D-cycloserine did not improve positive or negative symptoms or cognitive dysfunction in schizophrenia. The investigation in consideration of the onset age suggests that D-cycloserine may aggravate negative symptoms of early-onset schizophrenia. The better treatment effect of D-cycloserine on BACS was observed when the white matter integrity of the sagittal stratum/ cingulum/fornix stria terminalis/genu of corpus callosum/external capsule was higher, and the better treatment effect on PANSS general psychopathology (PANSS-G) was observed when the white matter integrity of the splenium of corpus callosum was higher. In contrast, the better treatment effect of D-cycloserine on PANSS-G and SANS-IV were observed when the white matter integrity of the posterior thalamic radiation (left) was lower. CONCLUSION: It was suggested that response to D-cycloserine is influenced by the onset age and white matter integrity. TRIAL REGISTRATION: UMIN Clinical Trials Registry (number UMIN000000468 ). Registered 18 August 2006.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N9e897eb5739043b592a50ea293739f6c
65 Nb7254e15894c47b696ef36632cea6e1b
66 sg:journal.1024952
67 schema:name Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo-controlled double-blind crossover study
68 schema:pagination 249
69 schema:productId N051624c015dc4f3aaecfe6c2f9c8db9e
70 N6ff7a2557de645479df852baab52db81
71 N9f75120743a647b3bf39c9ab6a2172f4
72 Na44baab51a254c568a3a7d5c94d6e147
73 Nf5a6224af1464a8d94e71036ef16cc54
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090600225
75 https://doi.org/10.1186/s12888-017-1410-3
76 schema:sdDatePublished 2019-04-11T12:27
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Na61beec4032c487ea3eee922541c8839
79 schema:url https://link.springer.com/10.1186%2Fs12888-017-1410-3
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N051624c015dc4f3aaecfe6c2f9c8db9e schema:name readcube_id
84 schema:value 3ca85bf5b55210bfd210c76d3ab0411450fe0fcc51d6ec88ae75052109af5a19
85 rdf:type schema:PropertyValue
86 N092babea84a04bb7a240b7b944847249 rdf:first sg:person.0721355624.44
87 rdf:rest N34d44dcc000e4940947e15c46d51c880
88 N0ada60e8aa3444eabcbd49b5a8b88405 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Double-Blind Method
90 rdf:type schema:DefinedTerm
91 N2c8c5168e87149ebbf39c0c9fe259cb2 rdf:first sg:person.01112510530.08
92 rdf:rest Nd011d9fd444f4c13a0946acf1cfdb772
93 N3153720b8113493ba0e0222bf3e594c7 schema:name Ohmiya Kousei Hospital, Katayanagi 1, Minuma-ku, Saitama-shi, 337-0024, Saitama, Japan
94 rdf:type schema:Organization
95 N34d44dcc000e4940947e15c46d51c880 rdf:first sg:person.01047570332.55
96 rdf:rest N2c8c5168e87149ebbf39c0c9fe259cb2
97 N48ca415f25a14c1f9fea28d5ea86d083 rdf:first sg:person.01030624354.44
98 rdf:rest N8edeefc433e94b88a37ead7950319292
99 N4e811e684abf439cb7022805af8ebc46 rdf:first sg:person.01326667740.26
100 rdf:rest N72ee0fa05c85437996ea47bf621ac006
101 N509477808b054a6d89e35cadff4e86b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cycloserine
103 rdf:type schema:DefinedTerm
104 N61110f60b1934050b07dfdacf95a0611 rdf:first sg:person.010224003632.38
105 rdf:rest N81864caa9a304759bff107962d4a22eb
106 N681af929ea0c4f969dd146c192d82b7f rdf:first sg:person.01134701240.74
107 rdf:rest N7007a32305f942f1be39ba45c5ca304b
108 N6ed052331449425893798036195aa031 rdf:first N90769e0ff0c84480ab81b3b14b65b347
109 rdf:rest Ne17a69bcb2b844f7aa59b4f9d67bc89b
110 N6ff7a2557de645479df852baab52db81 schema:name dimensions_id
111 schema:value pub.1090600225
112 rdf:type schema:PropertyValue
113 N7007a32305f942f1be39ba45c5ca304b rdf:first sg:person.01301341461.03
114 rdf:rest N48ca415f25a14c1f9fea28d5ea86d083
115 N72bb3bbe66bc479b81639a26a81a7640 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Humans
117 rdf:type schema:DefinedTerm
118 N72ee0fa05c85437996ea47bf621ac006 rdf:first sg:person.012434250321.06
119 rdf:rest N6ed052331449425893798036195aa031
120 N75f6f015057646e387effe53fbf64d73 rdf:first sg:person.01107334530.91
121 rdf:rest N61110f60b1934050b07dfdacf95a0611
122 N7d361a6e8a8e465e8fa4d356a562f5be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name White Matter
124 rdf:type schema:DefinedTerm
125 N7d60320300024e7ab02de3127d51f705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Diffusion Tensor Imaging
127 rdf:type schema:DefinedTerm
128 N81864caa9a304759bff107962d4a22eb rdf:first sg:person.01047042446.10
129 rdf:rest rdf:nil
130 N8c91c197b03b4d25875d69839930e759 rdf:first sg:person.013127204277.26
131 rdf:rest Nbfc1bba98e2f4c93b33a5c55cbdd754a
132 N8d72fa16e0de4ebea679fd5b578c89e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Female
134 rdf:type schema:DefinedTerm
135 N8edeefc433e94b88a37ead7950319292 rdf:first sg:person.01367000404.77
136 rdf:rest Nb319a00c10ba4a1ab79e57aaae271c98
137 N90769e0ff0c84480ab81b3b14b65b347 schema:affiliation N3153720b8113493ba0e0222bf3e594c7
138 schema:familyName Shoda
139 schema:givenName Kosaku
140 rdf:type schema:Person
141 N907f9198a0834a9b89b7739eb0e3935b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Adult
143 rdf:type schema:DefinedTerm
144 N957484c23e0d4e018eaac706a0a7c364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Male
146 rdf:type schema:DefinedTerm
147 N9e897eb5739043b592a50ea293739f6c schema:issueNumber 1
148 rdf:type schema:PublicationIssue
149 N9f75120743a647b3bf39c9ab6a2172f4 schema:name nlm_unique_id
150 schema:value 100968559
151 rdf:type schema:PropertyValue
152 Na0a2ba44e1144157a9d98be904a17970 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Drug Therapy, Combination
154 rdf:type schema:DefinedTerm
155 Na44baab51a254c568a3a7d5c94d6e147 schema:name pubmed_id
156 schema:value 28701225
157 rdf:type schema:PropertyValue
158 Na61beec4032c487ea3eee922541c8839 schema:name Springer Nature - SN SciGraph project
159 rdf:type schema:Organization
160 Naf0446791e2f4f2588045d15f2fa4cb6 rdf:first sg:person.01267435624.33
161 rdf:rest N092babea84a04bb7a240b7b944847249
162 Nb319a00c10ba4a1ab79e57aaae271c98 rdf:first sg:person.0576215717.91
163 rdf:rest N4e811e684abf439cb7022805af8ebc46
164 Nb3ce81096aaf4526ad5f0aa3f4a03256 schema:name Department of Psychiatry, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, 187-8551, Tokyo, Japan
165 rdf:type schema:Organization
166 Nb7254e15894c47b696ef36632cea6e1b schema:volumeNumber 17
167 rdf:type schema:PublicationVolume
168 Nba030f39a6bf411d9ab747f82b3a9619 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Schizophrenia
170 rdf:type schema:DefinedTerm
171 Nba22c55a4e9d49eab11fc72a848c5e2e schema:name Department of Psychiatry, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, 187-8551, Tokyo, Japan
172 rdf:type schema:Organization
173 Nbfc1bba98e2f4c93b33a5c55cbdd754a rdf:first sg:person.0723134715.76
174 rdf:rest N681af929ea0c4f969dd146c192d82b7f
175 Nc380b1366f3343708cae191eab84bbf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Age of Onset
177 rdf:type schema:DefinedTerm
178 Nd011d9fd444f4c13a0946acf1cfdb772 rdf:first sg:person.015641621571.65
179 rdf:rest N75f6f015057646e387effe53fbf64d73
180 Nd91944fd2eb140a1b7423944451e4f5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Schizophrenic Psychology
182 rdf:type schema:DefinedTerm
183 Ne17a69bcb2b844f7aa59b4f9d67bc89b rdf:first sg:person.01306776201.63
184 rdf:rest Naf0446791e2f4f2588045d15f2fa4cb6
185 Ne3d99e4e92324511a63e55f505c608df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Antipsychotic Agents
187 rdf:type schema:DefinedTerm
188 Ne486391a72ed4b05a80b8b1564c8e705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Middle Aged
190 rdf:type schema:DefinedTerm
191 Nf316dbd9adcf4677b071a97d804981e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Glycine Agents
193 rdf:type schema:DefinedTerm
194 Nf5a6224af1464a8d94e71036ef16cc54 schema:name doi
195 schema:value 10.1186/s12888-017-1410-3
196 rdf:type schema:PropertyValue
197 Nf7c218c813e64ac2bfedef9208406a3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Cross-Over Studies
199 rdf:type schema:DefinedTerm
200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
201 schema:name Medical and Health Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
204 schema:name Clinical Sciences
205 rdf:type schema:DefinedTerm
206 sg:grant.5974500 http://pending.schema.org/fundedItem sg:pub.10.1186/s12888-017-1410-3
207 rdf:type schema:MonetaryGrant
208 sg:grant.6009441 http://pending.schema.org/fundedItem sg:pub.10.1186/s12888-017-1410-3
209 rdf:type schema:MonetaryGrant
210 sg:journal.1024952 schema:issn 1471-244X
211 schema:name BMC Psychiatry
212 rdf:type schema:Periodical
213 sg:person.010224003632.38 schema:affiliation https://www.grid.ac/institutes/grid.267335.6
214 schema:familyName Ohmori
215 schema:givenName Tetsuro
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010224003632.38
217 rdf:type schema:Person
218 sg:person.01030624354.44 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
219 schema:familyName Narushima
220 schema:givenName Kenji
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030624354.44
222 rdf:type schema:Person
223 sg:person.01047042446.10 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
224 schema:familyName Nishikawa
225 schema:givenName Toru
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047042446.10
227 rdf:type schema:Person
228 sg:person.01047570332.55 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
229 schema:familyName Ishiwata
230 schema:givenName Sayuri
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047570332.55
232 rdf:type schema:Person
233 sg:person.01107334530.91 schema:affiliation Nb3ce81096aaf4526ad5f0aa3f4a03256
234 schema:familyName Arima
235 schema:givenName Kunimasa
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107334530.91
237 rdf:type schema:Person
238 sg:person.01112510530.08 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
239 schema:familyName Ishiwata
240 schema:givenName Yasuyoshi
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112510530.08
242 rdf:type schema:Person
243 sg:person.01134701240.74 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
244 schema:familyName Itasaka
245 schema:givenName Michio
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134701240.74
247 rdf:type schema:Person
248 sg:person.012434250321.06 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
249 schema:familyName Oshima
250 schema:givenName Kazunari
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012434250321.06
252 rdf:type schema:Person
253 sg:person.01267435624.33 schema:affiliation https://www.grid.ac/institutes/grid.267335.6
254 schema:familyName Nakataki
255 schema:givenName Masahito
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267435624.33
257 rdf:type schema:Person
258 sg:person.01301341461.03 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
259 schema:familyName Atsuta
260 schema:givenName Hidenori
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301341461.03
262 rdf:type schema:Person
263 sg:person.01306776201.63 schema:affiliation https://www.grid.ac/institutes/grid.267335.6
264 schema:familyName Tamaru
265 schema:givenName Mai
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306776201.63
267 rdf:type schema:Person
268 sg:person.013127204277.26 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
269 schema:familyName Takiguchi
270 schema:givenName Kazuo
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013127204277.26
272 rdf:type schema:Person
273 sg:person.01326667740.26 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
274 schema:familyName Tomita
275 schema:givenName Makoto
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326667740.26
277 rdf:type schema:Person
278 sg:person.01367000404.77 schema:affiliation https://www.grid.ac/institutes/grid.417089.3
279 schema:familyName Yamamoto
280 schema:givenName Naoki
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367000404.77
282 rdf:type schema:Person
283 sg:person.015641621571.65 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
284 schema:familyName Yasuhara
285 schema:givenName Masato
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015641621571.65
287 rdf:type schema:Person
288 sg:person.0576215717.91 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
289 schema:familyName Kurumaji
290 schema:givenName Akeo
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576215717.91
292 rdf:type schema:Person
293 sg:person.0721355624.44 schema:affiliation Nba22c55a4e9d49eab11fc72a848c5e2e
294 schema:familyName Okazaki
295 schema:givenName Mitsutoshi
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721355624.44
297 rdf:type schema:Person
298 sg:person.0723134715.76 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
299 schema:familyName Uezato
300 schema:givenName Akihito
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723134715.76
302 rdf:type schema:Person
303 sg:pub.10.1007/bf01276429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038636375
304 https://doi.org/10.1007/bf01276429
305 rdf:type schema:CreativeWork
306 sg:pub.10.1007/s00213-004-2032-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044357502
307 https://doi.org/10.1007/s00213-004-2032-2
308 rdf:type schema:CreativeWork
309 sg:pub.10.1016/s0893-133x(99)00014-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036198831
310 https://doi.org/10.1016/s0893-133x(99)00014-7
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/nature01497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012284028
313 https://doi.org/10.1038/nature01497
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/sj.mp.4001551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030532610
316 https://doi.org/10.1038/sj.mp.4001551
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/sj.npp.1300313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035089392
319 https://doi.org/10.1038/sj.npp.1300313
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/tp.2015.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051618956
322 https://doi.org/10.1038/tp.2015.154
323 rdf:type schema:CreativeWork
324 sg:pub.10.1186/1471-244x-12-150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015362238
325 https://doi.org/10.1186/1471-244x-12-150
326 rdf:type schema:CreativeWork
327 https://app.dimensions.ai/details/publication/pub.1077615654 schema:CreativeWork
328 https://app.dimensions.ai/details/publication/pub.1079051105 schema:CreativeWork
329 https://doi.org/10.1001/archpsyc.56.1.21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011467146
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/0014-2999(94)90687-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016410364
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/0304-3940(89)90379-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028846386
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.biopsych.2005.06.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016046481
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.neuroimage.2006.02.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023372670
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.nlm.2005.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025356673
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.pscychresns.2010.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003972049
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/j.pscychresns.2014.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033588031
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/j.pscychresns.2016.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046826256
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/j.schres.2004.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046563323
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/j.schres.2007.05.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036202764
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/j.schres.2008.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049462644
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1016/j.schres.2008.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028640610
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1016/j.schres.2016.03.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019765960
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1016/j.schres.2016.11.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027470267
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1016/s0006-3223(96)00311-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004429481
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1016/s0006-3223(98)00367-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048295619
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1016/s0920-9964(01)00220-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040860995
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1017/s1461145798001242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054934284
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1089/cap.2015.0097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059241937
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1097/00002826-199619050-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022921368
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1176/ajp.152.8.1213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063483976
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1176/ajp.153.12.1628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063484262
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1176/appi.ajp.159.3.480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063494510
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1176/appi.ajp.2007.06081358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063497725
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1371/journal.pone.0161406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012621977
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1523/jneurosci.2450-14.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030370441
382 rdf:type schema:CreativeWork
383 https://doi.org/10.2174/138161210790361452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069167203
384 rdf:type schema:CreativeWork
385 https://www.grid.ac/institutes/grid.265073.5 schema:alternateName Tokyo Medical and Dental University
386 schema:name Clinical Research Center, Medical Hospital of Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan
387 Department of Hospital Pharmacy, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan
388 Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan
389 Haryugaoka Hospital, Tensyoudan 11, Otsukimachi, Koriyama-shi, 963-0201, Fukushima, Japan
390 Ohmiya Kousei Hospital, Katayanagi 1, Minuma-ku, Saitama-shi, 337-0024, Saitama, Japan
391 rdf:type schema:Organization
392 https://www.grid.ac/institutes/grid.267335.6 schema:alternateName University of Tokushima
393 schema:name Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto, 770-8503, Tokushima, Japan
394 rdf:type schema:Organization
395 https://www.grid.ac/institutes/grid.417089.3 schema:alternateName Tokyo Metropolitan Tama Medical Center
396 schema:name Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan
397 Psychiatry Department, Tokyo Metropolitan Tama Medical Center, 2-8-29 Musashidai, Fuchu-shi, 183-8524, Tokyo, Japan
398 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...