Substance use in people at clinical high-risk for psychosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Debra A Russo, Jan Stochl, Michelle Painter, Peter B Jones, Jesus Perez

ABSTRACT

BACKGROUND: Some high-risk (HR) mental states for psychosis may lack diagnostic specificity and predictive value. Furthermore, psychotic-like experiences found in young populations may act not only as markers for psychosis but also for other non-psychotic psychiatric disorders. A neglected consideration in these populations is the effect of substance misuse and its role in the development of such mental states or its influence in the evolution toward full psychotic presentations. Therefore, the main aim of this study was to thoroughly describe past and current substance use profiles of HR individuals by comparing a consecutive cohort of young people at high risk referred to a population-based early intervention clinical service with a random sample of healthy volunteers (HV) recruited from the same geographical area. METHODS: We compared alcohol and substance use profiles of sixty help-seeking HR individuals and 60 healthy volunteers (HV). In addition to identification of abuse/dependence and influence on psychotic-like experiences, differences between HR individuals and HV were assessed for gender, ethnicity, occupational status, age of lifetime first substance use, prevalence and frequency of substance use. RESULTS: There were no cases of substance use disorder or dependence in either groups. HR individuals were significantly younger than HV when they first started to use substances (p = 0.014). The prevalence of overall HR substance use was similar to that of HV. Although HR individuals reported less cannabinoid use than HV currently (15% vs. 27%), and more in the past (40% vs. 30%), the differences were not statistically significant (p = 0.177 & 0.339 respectively). Current frequency of use was significantly higher for HR individuals than HV for alcohol (p = 0.001) and cannabinoids (p = 0.03). In this sample, only 5% of HR individuals converted to psychosis over a two-year follow-up. CONCLUSIONS: Certain profiles of substance use could potentially play a significant part in the evolution of HR presentations. Therefore, substance use may well represent a clinical domain that requires further emphasis and more detailed consideration in future studies. More... »

PAGES

361

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12888-014-0361-1

DOI

http://dx.doi.org/10.1186/s12888-014-0361-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013656923

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25540036


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alcohol Drinking", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anxiety Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Depressive Disorder, Major", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Marijuana Abuse", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Psychoses, Substance-Induced", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substance-Related Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Fulbourn Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415163.4", 
          "name": [
            "CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK", 
            "Department of Psychiatry, University of Cambridge, Cambridge, UK", 
            "Fulbourn Hospital, Block 7, Ida Darwin Site, CB21 5EE, FulbournCambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russo", 
        "givenName": "Debra A", 
        "id": "sg:person.01125175625.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125175625.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of York", 
          "id": "https://www.grid.ac/institutes/grid.5685.e", 
          "name": [
            "Department of Health Sciences, University of York, York, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stochl", 
        "givenName": "Jan", 
        "id": "sg:person.0626444663.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626444663.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cambridgeshire and Peterborough NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.450563.1", 
          "name": [
            "CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Painter", 
        "givenName": "Michelle", 
        "id": "sg:person.01014043766.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014043766.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK", 
            "Department of Psychiatry, University of Cambridge, Cambridge, UK", 
            "NIHR Collaboration for Leadership in Applied Health Research & Care, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Peter B", 
        "id": "sg:person.07710300022.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07710300022.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK", 
            "Department of Psychiatry, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perez", 
        "givenName": "Jesus", 
        "id": "sg:person.01245265325.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245265325.57"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1751-7893.2009.00133.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005305012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-7893.2009.00133.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005305012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/schbul/sbm015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008227354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001270170044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008935589", 
          "https://doi.org/10.1007/s001270170044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.clinpsy.121208.131220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011992110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2005.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016615022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.2051-5545.2008.tb00158.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018647680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1192/bjp.bp.106.024448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020707276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.332.7534.172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022087313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2013.05.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027731392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archgenpsychiatry.2011.1472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029135239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/schbul/13.2.261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030255298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0447.2011.01763.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030940439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1614.2005.01714.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031816808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1192/bjp.181.4.321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034504575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1192/bjp.bp.111.101543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034913606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0033291710002461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039872544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/070674371005500308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042406314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/070674371005500308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042406314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1990.03450190043026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048143589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/eip.12100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049039269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamapsychiatry.2013.1270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049533011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/schbul/sbr196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050973808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0447.2006.00900.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051348317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0033291712000803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053785307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.264.19.2511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054151964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.2009.09030311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063498608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00048670903487118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070975584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00048670903487118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070975584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083371524", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "BACKGROUND: Some high-risk (HR) mental states for psychosis may lack diagnostic specificity and predictive value. Furthermore, psychotic-like experiences found in young populations may act not only as markers for psychosis but also for other non-psychotic psychiatric disorders. A neglected consideration in these populations is the effect of substance misuse and its role in the development of such mental states or its influence in the evolution toward full psychotic presentations. Therefore, the main aim of this study was to thoroughly describe past and current substance use profiles of HR individuals by comparing a consecutive cohort of young people at high risk referred to a population-based early intervention clinical service with a random sample of healthy volunteers (HV) recruited from the same geographical area.\nMETHODS: We compared alcohol and substance use profiles of sixty help-seeking HR individuals and 60 healthy volunteers (HV). In addition to identification of abuse/dependence and influence on psychotic-like experiences, differences between HR individuals and HV were assessed for gender, ethnicity, occupational status, age of lifetime first substance use, prevalence and frequency of substance use.\nRESULTS: There were no cases of substance use disorder or dependence in either groups. HR individuals were significantly younger than HV when they first started to use substances (p = 0.014). The prevalence of overall HR substance use was similar to that of HV. Although HR individuals reported less cannabinoid use than HV currently (15% vs. 27%), and more in the past (40% vs. 30%), the differences were not statistically significant (p = 0.177 & 0.339 respectively). Current frequency of use was significantly higher for HR individuals than HV for alcohol (p = 0.001) and cannabinoids (p = 0.03). In this sample, only 5% of HR individuals converted to psychosis over a two-year follow-up.\nCONCLUSIONS: Certain profiles of substance use could potentially play a significant part in the evolution of HR presentations. Therefore, substance use may well represent a clinical domain that requires further emphasis and more detailed consideration in future studies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12888-014-0361-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3641885", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5144961", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2762165", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024952", 
        "issn": [
          "1471-244X"
        ], 
        "name": "BMC Psychiatry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Substance use in people at clinical high-risk for psychosis", 
    "pagination": "361", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "410ed0e698f9241ba03583ac09b69b903c59eaf64860475b00472b951c7fb9ff"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25540036"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968559"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12888-014-0361-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013656923"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12888-014-0361-1", 
      "https://app.dimensions.ai/details/publication/pub.1013656923"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89826_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12888-014-0361-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12888-014-0361-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12888-014-0361-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12888-014-0361-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12888-014-0361-1'


 

This table displays all metadata directly associated to this object as RDF triples.

252 TRIPLES      21 PREDICATES      70 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12888-014-0361-1 schema:about N1d093e9f5b7147aab0d0f3b182db8bde
2 N48189216a7994e7198f9f8e0eb3b80c9
3 N4c096aacd372411891948903356424e9
4 N63604bf87b42496e867cf1902258084a
5 N6bccf178fd804cc3aa2c69b5dbb8ed5e
6 N7452e3e952ab4667a9671ffc4caa215b
7 N77aeb68fa1034195b74767791ab937b3
8 N7931fa090c1c4e35bbe4f907b6c2eb6d
9 N9684cc2693c44eafb59436c067b0fb9c
10 Nb3ab8a0602404606bff5b2dd5d08f850
11 Nba0fc7ef4d534093b06104339ab9fb20
12 Nc644085b39a145be80be70c87c5358d8
13 Ne4ed86e14fcd484280bb911317b4cbe4
14 Ne56c454029fe4ebf8a124adbdb7a6a86
15 anzsrc-for:11
16 anzsrc-for:1117
17 schema:author N07ee689ccce44007b9bd6ec9026f586d
18 schema:citation sg:pub.10.1007/s001270170044
19 https://app.dimensions.ai/details/publication/pub.1083371524
20 https://doi.org/10.1001/archgenpsychiatry.2011.1472
21 https://doi.org/10.1001/jama.1990.03450190043026
22 https://doi.org/10.1001/jama.264.19.2511
23 https://doi.org/10.1001/jamapsychiatry.2013.1270
24 https://doi.org/10.1002/j.2051-5545.2008.tb00158.x
25 https://doi.org/10.1016/j.schres.2005.04.008
26 https://doi.org/10.1016/j.schres.2013.05.026
27 https://doi.org/10.1017/s0033291710002461
28 https://doi.org/10.1017/s0033291712000803
29 https://doi.org/10.1093/schbul/13.2.261
30 https://doi.org/10.1093/schbul/sbm015
31 https://doi.org/10.1093/schbul/sbr196
32 https://doi.org/10.1111/eip.12100
33 https://doi.org/10.1111/j.1440-1614.2005.01714.x
34 https://doi.org/10.1111/j.1600-0447.2006.00900.x
35 https://doi.org/10.1111/j.1600-0447.2011.01763.x
36 https://doi.org/10.1111/j.1751-7893.2009.00133.x
37 https://doi.org/10.1136/bmj.332.7534.172
38 https://doi.org/10.1146/annurev.clinpsy.121208.131220
39 https://doi.org/10.1176/appi.ajp.2009.09030311
40 https://doi.org/10.1177/070674371005500308
41 https://doi.org/10.1192/bjp.181.4.321
42 https://doi.org/10.1192/bjp.bp.106.024448
43 https://doi.org/10.1192/bjp.bp.111.101543
44 https://doi.org/10.3109/00048670903487118
45 schema:datePublished 2014-12
46 schema:datePublishedReg 2014-12-01
47 schema:description BACKGROUND: Some high-risk (HR) mental states for psychosis may lack diagnostic specificity and predictive value. Furthermore, psychotic-like experiences found in young populations may act not only as markers for psychosis but also for other non-psychotic psychiatric disorders. A neglected consideration in these populations is the effect of substance misuse and its role in the development of such mental states or its influence in the evolution toward full psychotic presentations. Therefore, the main aim of this study was to thoroughly describe past and current substance use profiles of HR individuals by comparing a consecutive cohort of young people at high risk referred to a population-based early intervention clinical service with a random sample of healthy volunteers (HV) recruited from the same geographical area. METHODS: We compared alcohol and substance use profiles of sixty help-seeking HR individuals and 60 healthy volunteers (HV). In addition to identification of abuse/dependence and influence on psychotic-like experiences, differences between HR individuals and HV were assessed for gender, ethnicity, occupational status, age of lifetime first substance use, prevalence and frequency of substance use. RESULTS: There were no cases of substance use disorder or dependence in either groups. HR individuals were significantly younger than HV when they first started to use substances (p = 0.014). The prevalence of overall HR substance use was similar to that of HV. Although HR individuals reported less cannabinoid use than HV currently (15% vs. 27%), and more in the past (40% vs. 30%), the differences were not statistically significant (p = 0.177 & 0.339 respectively). Current frequency of use was significantly higher for HR individuals than HV for alcohol (p = 0.001) and cannabinoids (p = 0.03). In this sample, only 5% of HR individuals converted to psychosis over a two-year follow-up. CONCLUSIONS: Certain profiles of substance use could potentially play a significant part in the evolution of HR presentations. Therefore, substance use may well represent a clinical domain that requires further emphasis and more detailed consideration in future studies.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N63456f63e9824d3fb92bee0840726ed0
52 Naf31afd2f9e040a7862c18ab894caf67
53 sg:journal.1024952
54 schema:name Substance use in people at clinical high-risk for psychosis
55 schema:pagination 361
56 schema:productId N6283d6c2b90d45099d66a7f25e35d06d
57 N7067849e239f49a8b0fe067c819acafe
58 N83dbde722ee34c959c3764ad3a0e3148
59 Nbf7f05b878b549119de47deb8a131b01
60 Nfc42ee024bd9432ba2a6761aebaaa3b0
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013656923
62 https://doi.org/10.1186/s12888-014-0361-1
63 schema:sdDatePublished 2019-04-11T10:04
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nc72d1dd84b8b4aad894b4fcba2878e7b
66 schema:url http://link.springer.com/10.1186%2Fs12888-014-0361-1
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N07ee689ccce44007b9bd6ec9026f586d rdf:first sg:person.01125175625.50
71 rdf:rest N3c9992b9c6a549c998844b7d1c863f1a
72 N10633393018a4b1ea43f9aee8eca4f03 rdf:first sg:person.01014043766.00
73 rdf:rest N64b5196eb04b4711b9b0f5ac78b0f7b3
74 N146b39262c1e49de82beeb61af95bcf5 rdf:first sg:person.01245265325.57
75 rdf:rest rdf:nil
76 N1d093e9f5b7147aab0d0f3b182db8bde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Case-Control Studies
78 rdf:type schema:DefinedTerm
79 N3c9992b9c6a549c998844b7d1c863f1a rdf:first sg:person.0626444663.25
80 rdf:rest N10633393018a4b1ea43f9aee8eca4f03
81 N48189216a7994e7198f9f8e0eb3b80c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Anxiety Disorders
83 rdf:type schema:DefinedTerm
84 N4c096aacd372411891948903356424e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Marijuana Abuse
86 rdf:type schema:DefinedTerm
87 N6283d6c2b90d45099d66a7f25e35d06d schema:name pubmed_id
88 schema:value 25540036
89 rdf:type schema:PropertyValue
90 N63456f63e9824d3fb92bee0840726ed0 schema:issueNumber 1
91 rdf:type schema:PublicationIssue
92 N63604bf87b42496e867cf1902258084a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Adolescent
94 rdf:type schema:DefinedTerm
95 N64b5196eb04b4711b9b0f5ac78b0f7b3 rdf:first sg:person.07710300022.89
96 rdf:rest N146b39262c1e49de82beeb61af95bcf5
97 N6bccf178fd804cc3aa2c69b5dbb8ed5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Psychoses, Substance-Induced
99 rdf:type schema:DefinedTerm
100 N7067849e239f49a8b0fe067c819acafe schema:name nlm_unique_id
101 schema:value 100968559
102 rdf:type schema:PropertyValue
103 N7452e3e952ab4667a9671ffc4caa215b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Female
105 rdf:type schema:DefinedTerm
106 N77aeb68fa1034195b74767791ab937b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Humans
108 rdf:type schema:DefinedTerm
109 N7931fa090c1c4e35bbe4f907b6c2eb6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Substance-Related Disorders
111 rdf:type schema:DefinedTerm
112 N83dbde722ee34c959c3764ad3a0e3148 schema:name doi
113 schema:value 10.1186/s12888-014-0361-1
114 rdf:type schema:PropertyValue
115 N9684cc2693c44eafb59436c067b0fb9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Male
117 rdf:type schema:DefinedTerm
118 Naf31afd2f9e040a7862c18ab894caf67 schema:volumeNumber 14
119 rdf:type schema:PublicationVolume
120 Nb3ab8a0602404606bff5b2dd5d08f850 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Alcohol Drinking
122 rdf:type schema:DefinedTerm
123 Nba0fc7ef4d534093b06104339ab9fb20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Depressive Disorder, Major
125 rdf:type schema:DefinedTerm
126 Nbf7f05b878b549119de47deb8a131b01 schema:name readcube_id
127 schema:value 410ed0e698f9241ba03583ac09b69b903c59eaf64860475b00472b951c7fb9ff
128 rdf:type schema:PropertyValue
129 Nc644085b39a145be80be70c87c5358d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Young Adult
131 rdf:type schema:DefinedTerm
132 Nc72d1dd84b8b4aad894b4fcba2878e7b schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 Ne4ed86e14fcd484280bb911317b4cbe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Adult
136 rdf:type schema:DefinedTerm
137 Ne56c454029fe4ebf8a124adbdb7a6a86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Risk Factors
139 rdf:type schema:DefinedTerm
140 Nfc42ee024bd9432ba2a6761aebaaa3b0 schema:name dimensions_id
141 schema:value pub.1013656923
142 rdf:type schema:PropertyValue
143 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
144 schema:name Medical and Health Sciences
145 rdf:type schema:DefinedTerm
146 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
147 schema:name Public Health and Health Services
148 rdf:type schema:DefinedTerm
149 sg:grant.2762165 http://pending.schema.org/fundedItem sg:pub.10.1186/s12888-014-0361-1
150 rdf:type schema:MonetaryGrant
151 sg:grant.3641885 http://pending.schema.org/fundedItem sg:pub.10.1186/s12888-014-0361-1
152 rdf:type schema:MonetaryGrant
153 sg:grant.5144961 http://pending.schema.org/fundedItem sg:pub.10.1186/s12888-014-0361-1
154 rdf:type schema:MonetaryGrant
155 sg:journal.1024952 schema:issn 1471-244X
156 schema:name BMC Psychiatry
157 rdf:type schema:Periodical
158 sg:person.01014043766.00 schema:affiliation https://www.grid.ac/institutes/grid.450563.1
159 schema:familyName Painter
160 schema:givenName Michelle
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014043766.00
162 rdf:type schema:Person
163 sg:person.01125175625.50 schema:affiliation https://www.grid.ac/institutes/grid.415163.4
164 schema:familyName Russo
165 schema:givenName Debra A
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125175625.50
167 rdf:type schema:Person
168 sg:person.01245265325.57 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
169 schema:familyName Perez
170 schema:givenName Jesus
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245265325.57
172 rdf:type schema:Person
173 sg:person.0626444663.25 schema:affiliation https://www.grid.ac/institutes/grid.5685.e
174 schema:familyName Stochl
175 schema:givenName Jan
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626444663.25
177 rdf:type schema:Person
178 sg:person.07710300022.89 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
179 schema:familyName Jones
180 schema:givenName Peter B
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07710300022.89
182 rdf:type schema:Person
183 sg:pub.10.1007/s001270170044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008935589
184 https://doi.org/10.1007/s001270170044
185 rdf:type schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1083371524 schema:CreativeWork
187 https://doi.org/10.1001/archgenpsychiatry.2011.1472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029135239
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1001/jama.1990.03450190043026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048143589
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1001/jama.264.19.2511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054151964
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1001/jamapsychiatry.2013.1270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049533011
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1002/j.2051-5545.2008.tb00158.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018647680
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.schres.2005.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016615022
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.schres.2013.05.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027731392
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1017/s0033291710002461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039872544
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1017/s0033291712000803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053785307
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1093/schbul/13.2.261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030255298
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1093/schbul/sbm015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008227354
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1093/schbul/sbr196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050973808
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1111/eip.12100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049039269
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1111/j.1440-1614.2005.01714.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031816808
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1111/j.1600-0447.2006.00900.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051348317
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1111/j.1600-0447.2011.01763.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030940439
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1111/j.1751-7893.2009.00133.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005305012
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1136/bmj.332.7534.172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022087313
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1146/annurev.clinpsy.121208.131220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011992110
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1176/appi.ajp.2009.09030311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063498608
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1177/070674371005500308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042406314
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1192/bjp.181.4.321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034504575
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1192/bjp.bp.106.024448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020707276
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1192/bjp.bp.111.101543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034913606
234 rdf:type schema:CreativeWork
235 https://doi.org/10.3109/00048670903487118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070975584
236 rdf:type schema:CreativeWork
237 https://www.grid.ac/institutes/grid.415163.4 schema:alternateName Fulbourn Hospital
238 schema:name CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK
239 Department of Psychiatry, University of Cambridge, Cambridge, UK
240 Fulbourn Hospital, Block 7, Ida Darwin Site, CB21 5EE, FulbournCambridge, UK
241 rdf:type schema:Organization
242 https://www.grid.ac/institutes/grid.450563.1 schema:alternateName Cambridgeshire and Peterborough NHS Foundation Trust
243 schema:name CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK
244 rdf:type schema:Organization
245 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
246 schema:name CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK
247 Department of Psychiatry, University of Cambridge, Cambridge, UK
248 NIHR Collaboration for Leadership in Applied Health Research & Care, Cambridge, UK
249 rdf:type schema:Organization
250 https://www.grid.ac/institutes/grid.5685.e schema:alternateName University of York
251 schema:name Department of Health Sciences, University of York, York, UK
252 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...