A case report of a challenging diagnosis of biliary atresia in a patient receiving total parenteral nutrition View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Atu Agawu, Andrew Wehrman, Jennifer Pogoriler, Natalie A. Terry, Henry C. Lin

ABSTRACT

BACKGROUND: Total parenteral nutrition (TPN) and biliary atresia (BA) are common causes of cholestasis in infancy. The diagnosis of BA is time sensitive due to an inverse correlation between age at intervention (hepatic portoenterostomy - HPE) and survival without liver transplantation. Clinical, laboratory, and histologic features of BA and parenteral nutrition associated cholestasis (PNAC) are similar, creating a diagnostic dilemma for cholestatic infants on parenteral nutrition. There is limited published information about the natural history of PNAC including time to resolution, or diagnostic tests that distinguish BA from other etiologies of cholestasis. CASE PRESENTATION: We present a case of a child diagnosed with BA whose cholestasis began while receiving TPN. His clinical course was notable for transient resolution of his cholestasis after stopping parenteral nutrition and ultimate intraoperative diagnosis. CONCLUSIONS: Clinicians who care for patients who frequently receive TPN should be aware that clinical, laboratory, imaging, and biopsy findings can be similar between BA and PNAC. More... »

PAGES

72

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12887-019-1446-2

DOI

http://dx.doi.org/10.1186/s12887-019-1446-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112645953

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30849955


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