Brain biomarkers and pre-injury cognition are associated with long-term cognitive outcome in children with traumatic brain injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-24

AUTHORS

Amy A. Wilkinson, Maureen Dennis, Nevena Simic, Margot J. Taylor, Benjamin R. Morgan, Helena Frndova, Karen Choong, Craig Campbell, Douglas Fraser, Vicki Anderson, Anne-Marie Guerguerian, Russell Schachar, Jamie Hutchison, For the Canadian Critical Care Trials Group (CCCTG), The Canadian Critical Care Translational Biology Group (CCCTBG)

ABSTRACT

BackgroundChildren with traumatic brain injury (TBI) are frequently at risk of long-term impairments of attention and executive functioning but these problems are difficult to predict. Although deficits have been reported to vary with injury severity, age at injury and sex, prognostication of outcome remains imperfect at a patient-specific level. The objective of this proof of principle study was to evaluate a variety of patient variables, along with six brain-specific and inflammatory serum protein biomarkers, as predictors of long-term cognitive outcome following paediatric TBI.MethodOutcome was assessed in 23 patients via parent-rated questionnaires related to attention deficit hyperactivity disorder (ADHD) and executive functioning, using the Conners 3rd Edition Rating Scales (Conners-3) and Behaviour Rating Inventory of Executive Function (BRIEF) at a mean time since injury of 3.1 years. Partial least squares (PLS) analyses were performed to identify factors measured at the time of injury that were most closely associated with outcome on (1) the Conners-3 and (2) the Behavioural Regulation Index (BRI) and (3) Metacognition Index (MI) of the BRIEF.ResultsHigher levels of neuron specific enolase (NSE) and lower levels of soluble neuron cell adhesion molecule (sNCAM) were associated with higher scores on the inattention, hyperactivity/impulsivity and executive functioning scales of the Conners-3, as well as working memory and initiate scales of the MI from the BRIEF. Higher levels of NSE only were associated with higher scores on the inhibit scale of the BRI.ConclusionsNSE and sNCAM show promise as reliable, early predictors of long-term attention-related and executive functioning problems following paediatric TBI. More... »

PAGES

173

References to SciGraph publications

  • 1993-12. Partial Least Squares (PLS): Its strengths and limitations in JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
  • 1999-10. Brain development during childhood and adolescence: a longitudinal MRI study in NATURE NEUROSCIENCE
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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28738850


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    25 schema:description BackgroundChildren with traumatic brain injury (TBI) are frequently at risk of long-term impairments of attention and executive functioning but these problems are difficult to predict. Although deficits have been reported to vary with injury severity, age at injury and sex, prognostication of outcome remains imperfect at a patient-specific level. The objective of this proof of principle study was to evaluate a variety of patient variables, along with six brain-specific and inflammatory serum protein biomarkers, as predictors of long-term cognitive outcome following paediatric TBI.MethodOutcome was assessed in 23 patients via parent-rated questionnaires related to attention deficit hyperactivity disorder (ADHD) and executive functioning, using the Conners 3rd Edition Rating Scales (Conners-3) and Behaviour Rating Inventory of Executive Function (BRIEF) at a mean time since injury of 3.1 years. Partial least squares (PLS) analyses were performed to identify factors measured at the time of injury that were most closely associated with outcome on (1) the Conners-3 and (2) the Behavioural Regulation Index (BRI) and (3) Metacognition Index (MI) of the BRIEF.ResultsHigher levels of neuron specific enolase (NSE) and lower levels of soluble neuron cell adhesion molecule (sNCAM) were associated with higher scores on the inattention, hyperactivity/impulsivity and executive functioning scales of the Conners-3, as well as working memory and initiate scales of the MI from the BRIEF. Higher levels of NSE only were associated with higher scores on the inhibit scale of the BRI.ConclusionsNSE and sNCAM show promise as reliable, early predictors of long-term attention-related and executive functioning problems following paediatric TBI.
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    41 Rating Inventory
    42 Rating Scale
    43 Regulation Index
    44 ResultsHigher levels
    45 adhesion molecules
    46 age
    47 analysis
    48 attention
    49 attention deficit hyperactivity disorder
    50 biomarkers
    51 brain biomarkers
    52 brain injury
    53 brief
    54 cell adhesion molecule
    55 children
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    59 deficits
    60 disorders
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    66 factors
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    68 functioning
    69 functioning problems
    70 high levels
    71 higher scores
    72 hyperactivity disorder
    73 hyperactivity/impulsivity
    74 impairment
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    76 inattention
    77 index
    78 initiate scale
    79 injury
    80 injury severity
    81 least squares analysis
    82 levels
    83 long-term cognitive outcomes
    84 long-term impairment
    85 low levels
    86 mean time
    87 memory
    88 molecules
    89 neuron-specific enolase
    90 objective
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    92 parent-rated questionnaire
    93 partial least squares analysis
    94 patient variables
    95 patient-specific level
    96 patients
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    98 predictors
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    103 promise
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    111 severity
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