Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-06-08

AUTHORS

David J. Barnes, Peter Dutton, Øyvind Bruland, Hans Gelderblom, Ade Faleti, Claudia Bühnemann, Annemiek van Maldegem, Hannah Johnson, Lisa Poulton, Sharon Love, Gesa Tiemeier, Els van Beelen, Karin Herbschleb, Caroline Haddon, Lucinda Billingham, Kevin Bradley, Stefano Ferrari, Emanuela Palmerini, Piero Picci, Uta Dirksen, Sandra J. Strauss, Pancras C. W. Hogendoorn, Emmeline Buddingh, Jean-Yves Blay, Anne Marie Cleton-Jansen, Andrew Bassim Hassan

ABSTRACT

The phase III clinical study of adjuvant liposomal muramyl tripeptide (MTP-PE) in resected high-grade osteosarcoma (OS) documented positive results that have been translated into regulatory approval, supporting initial promise for innate immune therapies in OS. There remains, however, no new approved treatment such as MTP-PE for either metastatic or recurrent OS. Whilst the addition of different agents, including liposomal MTP-PE, to surgery for metastatic or recurrent high-grade osteosarcoma has tried to improve response rates, a mechanistic hiatus exists in terms of a detailed understanding the therapeutic strategies required in advanced disease. Here we report a Bayesian designed multi-arm, multi-centre, open-label phase II study with randomisation in patients with metastatic and/or recurrent OS, designed to investigate how patients with OS might respond to liposomal MTP-PE, either given alone or in combination with ifosfamide. Despite the trial closing because of poor recruitment within the allocated funding period, with no objective responses in eight patients, we report the design and feasibility outcomes for patients registered into the trial. We demonstrate the feasibility of the Bayesian design, European collaboration, tissue collection with genomic analysis and serum cytokine characterisation. Further mechanistic investigation of liposomal MTP-PE alone and in combination with other agents remains warranted in metastatic OS. More... »

PAGES

629

References to SciGraph publications

  • 2011-01-19. Identification of fusion genes in breast cancer by paired-end RNA-sequencing in GENOME BIOLOGY
  • 2014-03-10. Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2021-03-31. The role of tumor-associated macrophages in osteosarcoma progression – therapeutic implications in CELLULAR ONCOLOGY
  • 2011-01-15. Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2009-08-12. Osteosarcoma Lung Metastases Detection and Principles of Multimodal Therapy in PEDIATRIC AND ADOLESCENT OSTEOSARCOMA
  • 2017-06-23. Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma in NATURE COMMUNICATIONS
  • 2020-12-10. Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma in NATURE COMMUNICATIONS
  • 2007-07-26. Post Operative Infection and Increased Survival in Osteosarcoma Patients: Are They Associated? in ANNALS OF SURGICAL ONCOLOGY
  • 1992-07. Unique histological changes in lung metastases of osteosarcoma patients following therapy with liposomal muramyl tripeptide (CGP 19835A lipid) in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2020-06-02. Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma in CURRENT ADVANCES IN OSTEOSARCOMA
  • 2012-03-10. Intact interferon signaling in peripheral blood leukocytes of high-grade osteosarcoma patients in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2012-03-01. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks in NATURE PROTOCOLS
  • Journal

    TITLE

    BMC Cancer

    ISSUE

    1

    VOLUME

    22

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-022-09697-9

    DOI

    http://dx.doi.org/10.1186/s12885-022-09697-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1148512911

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35672690


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acetylmuramyl-Alanyl-Isoglutamine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bayes Theorem", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liposomes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Recurrence, Local", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Osteosarcoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphatidylethanolamines", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, OX1 3RE, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, OX1 3RE, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barnes", 
            "givenName": "David J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, OX3 7LD, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, OX3 7LD, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dutton", 
            "givenName": "Peter", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Clinical Medicine, Faculty of Medicine, University of Oslo and Department of Oncology-Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway", 
              "id": "http://www.grid.ac/institutes/grid.55325.34", 
              "name": [
                "Institute of Clinical Medicine, Faculty of Medicine, University of Oslo and Department of Oncology-Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bruland", 
            "givenName": "\u00d8yvind", 
            "id": "sg:person.0701243537.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701243537.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10419.3d", 
              "name": [
                "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gelderblom", 
            "givenName": "Hans", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Faleti", 
            "givenName": "Ade", 
            "id": "sg:person.011625342127.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011625342127.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, OX1 3RE, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, OX1 3RE, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "B\u00fchnemann", 
            "givenName": "Claudia", 
            "id": "sg:person.0640314645.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640314645.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10419.3d", 
              "name": [
                "Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, OX1 3RE, Oxford, UK", 
                "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Maldegem", 
            "givenName": "Annemiek", 
            "id": "sg:person.01256657747.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256657747.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johnson", 
            "givenName": "Hannah", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Poulton", 
            "givenName": "Lisa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, OX3 7LD, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, OX3 7LD, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Love", 
            "givenName": "Sharon", 
            "id": "sg:person.015437315512.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015437315512.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10419.3d", 
              "name": [
                "Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, OX1 3RE, Oxford, UK", 
                "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tiemeier", 
            "givenName": "Gesa", 
            "id": "sg:person.01076403101.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076403101.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10419.3d", 
              "name": [
                "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Beelen", 
            "givenName": "Els", 
            "id": "sg:person.01364312305.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364312305.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herbschleb", 
            "givenName": "Karin", 
            "id": "sg:person.015465242534.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015465242534.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haddon", 
            "givenName": "Caroline", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Research Clinical Trials Unit (Cancer Sciences), Institute of Cancer and Genomic Sciences, Robert Aitken Building, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK", 
              "id": "http://www.grid.ac/institutes/grid.6572.6", 
              "name": [
                "Cancer Research Clinical Trials Unit (Cancer Sciences), Institute of Cancer and Genomic Sciences, Robert Aitken Building, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Billingham", 
            "givenName": "Lucinda", 
            "id": "sg:person.0641614611.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641614611.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Radiology, Churchill Hospital, Oxford University Hospitals Foundation Trust, OX3 7LJ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.415719.f", 
              "name": [
                "Department of Radiology, Churchill Hospital, Oxford University Hospitals Foundation Trust, OX3 7LJ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bradley", 
            "givenName": "Kevin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituti Ortopedici Rizzoli, Via C. Pupilli 1, 40136, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/grid.419038.7", 
              "name": [
                "Istituti Ortopedici Rizzoli, Via C. Pupilli 1, 40136, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferrari", 
            "givenName": "Stefano", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituti Ortopedici Rizzoli, Via C. Pupilli 1, 40136, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/grid.419038.7", 
              "name": [
                "Istituti Ortopedici Rizzoli, Via C. Pupilli 1, 40136, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Palmerini", 
            "givenName": "Emanuela", 
            "id": "sg:person.01210215667.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210215667.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituti Ortopedici Rizzoli, Via C. Pupilli 1, 40136, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/grid.419038.7", 
              "name": [
                "Istituti Ortopedici Rizzoli, Via C. Pupilli 1, 40136, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Picci", 
            "givenName": "Piero", 
            "id": "sg:person.0753274552.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753274552.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pediatrics III, West German Cancer Centre Network Essen-Muenster, University Hospital Essen, Hufelanstr 55, 45147, Essen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.410718.b", 
              "name": [
                "Pediatrics III, West German Cancer Centre Network Essen-Muenster, University Hospital Essen, Hufelanstr 55, 45147, Essen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dirksen", 
            "givenName": "Uta", 
            "id": "sg:person.0744212622.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744212622.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology, UCLH NHS Foundation Trust, 250 Euston Road, NW1 2PG, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.52996.31", 
              "name": [
                "Department of Oncology, UCLH NHS Foundation Trust, 250 Euston Road, NW1 2PG, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Strauss", 
            "givenName": "Sandra J.", 
            "id": "sg:person.01142646030.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142646030.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10419.3d", 
              "name": [
                "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, OX3 7LD, Oxford, UK", 
                "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hogendoorn", 
            "givenName": "Pancras C. W.", 
            "id": "sg:person.0577703344.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577703344.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10419.3d", 
              "name": [
                "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Buddingh", 
            "givenName": "Emmeline", 
            "id": "sg:person.013077670227.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013077670227.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e8 Lyon 1 Claude Bernard, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.7849.2", 
              "name": [
                "Universit\u00e8 Lyon 1 Claude Bernard, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blay", 
            "givenName": "Jean-Yves", 
            "id": "sg:person.01336605441.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336605441.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10419.3d", 
              "name": [
                "Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cleton-Jansen", 
            "givenName": "Anne Marie", 
            "id": "sg:person.01370505366.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370505366.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, OX3 7LD, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, OX1 3RE, Oxford, UK", 
                "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, OX3 7LD, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hassan", 
            "givenName": "Andrew Bassim", 
            "id": "sg:person.01107657620.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107657620.45"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s13402-021-00598-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1136818161", 
              "https://doi.org/10.1007/s13402-021-00598-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-012-1232-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020833996", 
              "https://doi.org/10.1007/s00262-012-1232-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4419-0284-9_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011255526", 
              "https://doi.org/10.1007/978-1-4419-0284-9_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-010-0965-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041928952", 
              "https://doi.org/10.1007/s00262-010-0965-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms15936", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086127147", 
              "https://doi.org/10.1038/ncomms15936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-030-43032-0_11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1128142224", 
              "https://doi.org/10.1007/978-3-030-43032-0_11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-9966-33-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045119737", 
              "https://doi.org/10.1186/1756-9966-33-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2012.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030124536", 
              "https://doi.org/10.1038/nprot.2012.016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01741788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025418606", 
              "https://doi.org/10.1007/bf01741788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-1-r6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050465130", 
              "https://doi.org/10.1186/gb-2011-12-1-r6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-007-9483-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004180860", 
              "https://doi.org/10.1245/s10434-007-9483-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-020-20059-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1133370771", 
              "https://doi.org/10.1038/s41467-020-20059-6"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-06-08", 
        "datePublishedReg": "2022-06-08", 
        "description": "The phase III clinical study of adjuvant liposomal muramyl tripeptide (MTP-PE) in resected high-grade osteosarcoma (OS) documented positive results that have been translated into regulatory approval, supporting initial promise for innate immune therapies in OS. There remains, however, no new approved treatment such as MTP-PE for either metastatic or recurrent OS. Whilst the addition of different agents, including liposomal MTP-PE, to surgery for metastatic or recurrent high-grade osteosarcoma has tried to improve response rates, a mechanistic hiatus exists in terms of a detailed understanding the therapeutic strategies required in advanced disease. Here we report a Bayesian designed multi-arm, multi-centre, open-label phase II study with randomisation in patients with metastatic and/or recurrent OS, designed to investigate how patients with OS might respond to liposomal MTP-PE, either given alone or in combination with ifosfamide. Despite the trial closing because of poor recruitment within the allocated funding period, with no objective responses in eight patients, we report the design and feasibility outcomes for patients registered into the trial. We demonstrate the feasibility of the Bayesian design, European collaboration, tissue collection with genomic analysis and serum cytokine characterisation. Further mechanistic investigation of liposomal MTP-PE alone and in combination with other agents remains warranted in metastatic OS.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12885-022-09697-9", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3781490", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1024632", 
            "issn": [
              "1471-2407"
            ], 
            "name": "BMC Cancer", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "22"
          }
        ], 
        "keywords": [
          "liposomal MTP-PE", 
          "high-grade osteosarcoma", 
          "MTP-PE", 
          "recurrent OS", 
          "open-label phase II study", 
          "recurrent high-grade osteosarcoma", 
          "phase III clinical studies", 
          "liposomal muramyl tripeptide", 
          "innate immune therapy", 
          "phase II study", 
          "advanced disease", 
          "II study", 
          "objective response", 
          "feasibility outcomes", 
          "immune therapy", 
          "recurrent osteosarcoma", 
          "Further mechanistic investigations", 
          "clinical studies", 
          "mechanistic biomarkers", 
          "therapeutic strategies", 
          "response rate", 
          "metastatic OS", 
          "muramyl tripeptide", 
          "patients", 
          "osteosarcoma", 
          "tissue collection", 
          "regulatory approval", 
          "positive results", 
          "trials", 
          "outcomes", 
          "initial promise", 
          "ifosfamide", 
          "randomisation", 
          "therapy", 
          "agents", 
          "different agents", 
          "disease", 
          "biomarkers", 
          "study", 
          "European collaboration", 
          "poor recruitment", 
          "funding period", 
          "treatment", 
          "Bayesian design", 
          "approval", 
          "Mechanistic investigations", 
          "genomic analysis", 
          "recruitment", 
          "response", 
          "combination", 
          "period", 
          "rate", 
          "promise", 
          "detailed understanding", 
          "addition", 
          "strategies", 
          "tripeptide", 
          "feasibility", 
          "investigation", 
          "analysis", 
          "hiatus", 
          "results", 
          "understanding", 
          "collaboration", 
          "collection", 
          "design", 
          "terms", 
          "characterisation", 
          "Bayesian"
        ], 
        "name": "Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial)", 
        "pagination": "629", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1148512911"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12885-022-09697-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "35672690"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12885-022-09697-9", 
          "https://app.dimensions.ai/details/publication/pub.1148512911"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:07", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_941.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12885-022-09697-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-022-09697-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-022-09697-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-022-09697-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-022-09697-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    412 TRIPLES      21 PREDICATES      115 URIs      95 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12885-022-09697-9 schema:about N5e6e71fb5c774d568f9fb08e30dcf84a
    2 N5f04f9b8009f49f489e12654aaec5dd4
    3 N72852e6277374f959a33f0afd63b03fc
    4 N8defd24823b64d46bc70f93af6668095
    5 Na18cccb5497d4c1387cf3cc672e59c0c
    6 Nb2c922c45c6d4d0abc672b0f15a0fb07
    7 Nd5684c1636334c70814273e38afd20e6
    8 Nefb8a2ac5f984ce7851f57eab0480540
    9 Nf22c39c3a0a44c25ace4468e63f3d2f7
    10 anzsrc-for:11
    11 anzsrc-for:1112
    12 schema:author N7ade81bf92374f619f86a7b65f1b9371
    13 schema:citation sg:pub.10.1007/978-1-4419-0284-9_8
    14 sg:pub.10.1007/978-3-030-43032-0_11
    15 sg:pub.10.1007/bf01741788
    16 sg:pub.10.1007/s00262-010-0965-3
    17 sg:pub.10.1007/s00262-012-1232-6
    18 sg:pub.10.1007/s13402-021-00598-w
    19 sg:pub.10.1038/ncomms15936
    20 sg:pub.10.1038/nprot.2012.016
    21 sg:pub.10.1038/s41467-020-20059-6
    22 sg:pub.10.1186/1756-9966-33-27
    23 sg:pub.10.1186/gb-2011-12-1-r6
    24 sg:pub.10.1245/s10434-007-9483-8
    25 schema:datePublished 2022-06-08
    26 schema:datePublishedReg 2022-06-08
    27 schema:description The phase III clinical study of adjuvant liposomal muramyl tripeptide (MTP-PE) in resected high-grade osteosarcoma (OS) documented positive results that have been translated into regulatory approval, supporting initial promise for innate immune therapies in OS. There remains, however, no new approved treatment such as MTP-PE for either metastatic or recurrent OS. Whilst the addition of different agents, including liposomal MTP-PE, to surgery for metastatic or recurrent high-grade osteosarcoma has tried to improve response rates, a mechanistic hiatus exists in terms of a detailed understanding the therapeutic strategies required in advanced disease. Here we report a Bayesian designed multi-arm, multi-centre, open-label phase II study with randomisation in patients with metastatic and/or recurrent OS, designed to investigate how patients with OS might respond to liposomal MTP-PE, either given alone or in combination with ifosfamide. Despite the trial closing because of poor recruitment within the allocated funding period, with no objective responses in eight patients, we report the design and feasibility outcomes for patients registered into the trial. We demonstrate the feasibility of the Bayesian design, European collaboration, tissue collection with genomic analysis and serum cytokine characterisation. Further mechanistic investigation of liposomal MTP-PE alone and in combination with other agents remains warranted in metastatic OS.
    28 schema:genre article
    29 schema:isAccessibleForFree true
    30 schema:isPartOf N22784da39e5e42a283ed78735b3e1ca0
    31 N270ea3d77a6649e68a8b6c1fa6a05953
    32 sg:journal.1024632
    33 schema:keywords Bayesian
    34 Bayesian design
    35 European collaboration
    36 Further mechanistic investigations
    37 II study
    38 MTP-PE
    39 Mechanistic investigations
    40 addition
    41 advanced disease
    42 agents
    43 analysis
    44 approval
    45 biomarkers
    46 characterisation
    47 clinical studies
    48 collaboration
    49 collection
    50 combination
    51 design
    52 detailed understanding
    53 different agents
    54 disease
    55 feasibility
    56 feasibility outcomes
    57 funding period
    58 genomic analysis
    59 hiatus
    60 high-grade osteosarcoma
    61 ifosfamide
    62 immune therapy
    63 initial promise
    64 innate immune therapy
    65 investigation
    66 liposomal MTP-PE
    67 liposomal muramyl tripeptide
    68 mechanistic biomarkers
    69 metastatic OS
    70 muramyl tripeptide
    71 objective response
    72 open-label phase II study
    73 osteosarcoma
    74 outcomes
    75 patients
    76 period
    77 phase II study
    78 phase III clinical studies
    79 poor recruitment
    80 positive results
    81 promise
    82 randomisation
    83 rate
    84 recruitment
    85 recurrent OS
    86 recurrent high-grade osteosarcoma
    87 recurrent osteosarcoma
    88 regulatory approval
    89 response
    90 response rate
    91 results
    92 strategies
    93 study
    94 terms
    95 therapeutic strategies
    96 therapy
    97 tissue collection
    98 treatment
    99 trials
    100 tripeptide
    101 understanding
    102 schema:name Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial)
    103 schema:pagination 629
    104 schema:productId N0ecc256af4c24c8da3f58d8f7a62c398
    105 N947186cc054a42598f0046dab5dabacf
    106 Na4376e6f0c28475ab8e028f3ffd0d880
    107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1148512911
    108 https://doi.org/10.1186/s12885-022-09697-9
    109 schema:sdDatePublished 2022-09-02T16:07
    110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    111 schema:sdPublisher Nb27710886dc24753b549d50e751023b7
    112 schema:url https://doi.org/10.1186/s12885-022-09697-9
    113 sgo:license sg:explorer/license/
    114 sgo:sdDataset articles
    115 rdf:type schema:ScholarlyArticle
    116 N071bc14bba4440fea94b79d175b6fc09 rdf:first sg:person.0701243537.32
    117 rdf:rest Nb53dfe025daa456da9a90b1a5876237d
    118 N0a67e1341b5b41dd82995b551afa41ba rdf:first sg:person.013077670227.67
    119 rdf:rest N968b9f7eaea14d9db0f2f3ce4a49520e
    120 N0dfb3d381f7d40e695c6d8240a026f44 schema:affiliation grid-institutes:grid.4991.5
    121 schema:familyName Johnson
    122 schema:givenName Hannah
    123 rdf:type schema:Person
    124 N0ecc256af4c24c8da3f58d8f7a62c398 schema:name doi
    125 schema:value 10.1186/s12885-022-09697-9
    126 rdf:type schema:PropertyValue
    127 N1021a35ef24b41a3bdfa0d3067f736af schema:affiliation grid-institutes:grid.4991.5
    128 schema:familyName Dutton
    129 schema:givenName Peter
    130 rdf:type schema:Person
    131 N1fc3cdb64e8047ec82e1102e06666a24 rdf:first N0dfb3d381f7d40e695c6d8240a026f44
    132 rdf:rest N9c78bb3636b84c799cf1aee3c053bd0d
    133 N2136344a9b59495f8293454bc581d9bf rdf:first sg:person.01256657747.63
    134 rdf:rest N1fc3cdb64e8047ec82e1102e06666a24
    135 N22784da39e5e42a283ed78735b3e1ca0 schema:issueNumber 1
    136 rdf:type schema:PublicationIssue
    137 N270ea3d77a6649e68a8b6c1fa6a05953 schema:volumeNumber 22
    138 rdf:type schema:PublicationVolume
    139 N2b492596f31244499438c1c8424701d1 rdf:first sg:person.0640314645.12
    140 rdf:rest N2136344a9b59495f8293454bc581d9bf
    141 N3aee6da2877a4103b028e53814ba5779 rdf:first Nf54cc49401844a96a59adda58656c1ea
    142 rdf:rest Ndc1657e976d94144946f894c212e0ddf
    143 N3db72baad79b450581945576a9ec54b3 rdf:first sg:person.01076403101.51
    144 rdf:rest N830d638168c947528cb0313b90c78a63
    145 N4a500528aff649f2bb67220146c833f4 rdf:first sg:person.0753274552.44
    146 rdf:rest Nf383a103a8014ef49d0262fad6fddb34
    147 N5179c8b943ea4377a7a81ca7922de212 rdf:first sg:person.0577703344.59
    148 rdf:rest N0a67e1341b5b41dd82995b551afa41ba
    149 N5dfa15025a034cc69905624d26cb1bb3 schema:affiliation grid-institutes:grid.4991.5
    150 schema:familyName Haddon
    151 schema:givenName Caroline
    152 rdf:type schema:Person
    153 N5e6e71fb5c774d568f9fb08e30dcf84a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Humans
    155 rdf:type schema:DefinedTerm
    156 N5f04f9b8009f49f489e12654aaec5dd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Acetylmuramyl-Alanyl-Isoglutamine
    158 rdf:type schema:DefinedTerm
    159 N72852e6277374f959a33f0afd63b03fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Biomarkers
    161 rdf:type schema:DefinedTerm
    162 N7561a7275eca40e2af6b7a0e07e84cf1 rdf:first N5dfa15025a034cc69905624d26cb1bb3
    163 rdf:rest Nc4d109be7ce1490692cd8065f0a66352
    164 N7ade81bf92374f619f86a7b65f1b9371 rdf:first N9add835d697a46329d14cd35c21475d6
    165 rdf:rest Nfaaa975c3503413fb7f9b4d9cc5bc668
    166 N830d638168c947528cb0313b90c78a63 rdf:first sg:person.01364312305.38
    167 rdf:rest Na53d3091d60a4f31adafbe15a36e5a06
    168 N892c2ec6aadf4724a7b086ed12eb98c7 schema:affiliation grid-institutes:grid.4991.5
    169 schema:familyName Poulton
    170 schema:givenName Lisa
    171 rdf:type schema:Person
    172 N8defd24823b64d46bc70f93af6668095 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Bone Neoplasms
    174 rdf:type schema:DefinedTerm
    175 N947186cc054a42598f0046dab5dabacf schema:name pubmed_id
    176 schema:value 35672690
    177 rdf:type schema:PropertyValue
    178 N968b9f7eaea14d9db0f2f3ce4a49520e rdf:first sg:person.01336605441.13
    179 rdf:rest Nf1e1d0921e164d3e9b18feb721cadd90
    180 N9add835d697a46329d14cd35c21475d6 schema:affiliation grid-institutes:grid.4991.5
    181 schema:familyName Barnes
    182 schema:givenName David J.
    183 rdf:type schema:Person
    184 N9c78bb3636b84c799cf1aee3c053bd0d rdf:first N892c2ec6aadf4724a7b086ed12eb98c7
    185 rdf:rest Nf17bc033e28447048785aba7f1bb502a
    186 Na18cccb5497d4c1387cf3cc672e59c0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Neoplasm Recurrence, Local
    188 rdf:type schema:DefinedTerm
    189 Na4376e6f0c28475ab8e028f3ffd0d880 schema:name dimensions_id
    190 schema:value pub.1148512911
    191 rdf:type schema:PropertyValue
    192 Na53d3091d60a4f31adafbe15a36e5a06 rdf:first sg:person.015465242534.98
    193 rdf:rest N7561a7275eca40e2af6b7a0e07e84cf1
    194 Nb27710886dc24753b549d50e751023b7 schema:name Springer Nature - SN SciGraph project
    195 rdf:type schema:Organization
    196 Nb2c922c45c6d4d0abc672b0f15a0fb07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Bayes Theorem
    198 rdf:type schema:DefinedTerm
    199 Nb53dfe025daa456da9a90b1a5876237d rdf:first Nf5ced3e8d9b245dd89a0149e621eb4c9
    200 rdf:rest Ndf4ad02716c142859f682caee25c2b11
    201 Nbbe0b3a33a0f4d7484470ddd3a893e94 rdf:first sg:person.01142646030.43
    202 rdf:rest N5179c8b943ea4377a7a81ca7922de212
    203 Nc4d109be7ce1490692cd8065f0a66352 rdf:first sg:person.0641614611.49
    204 rdf:rest Ndc9c5c0dae6a4e5f97e0c0513cbb0fdb
    205 Nc78e95741fd445888f2b35df388903de schema:affiliation grid-institutes:grid.415719.f
    206 schema:familyName Bradley
    207 schema:givenName Kevin
    208 rdf:type schema:Person
    209 Nccbf6f46547441be88a0e926997a9b3e rdf:first sg:person.01107657620.45
    210 rdf:rest rdf:nil
    211 Nd5684c1636334c70814273e38afd20e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Liposomes
    213 rdf:type schema:DefinedTerm
    214 Ndc1657e976d94144946f894c212e0ddf rdf:first sg:person.01210215667.35
    215 rdf:rest N4a500528aff649f2bb67220146c833f4
    216 Ndc9c5c0dae6a4e5f97e0c0513cbb0fdb rdf:first Nc78e95741fd445888f2b35df388903de
    217 rdf:rest N3aee6da2877a4103b028e53814ba5779
    218 Ndf4ad02716c142859f682caee25c2b11 rdf:first sg:person.011625342127.40
    219 rdf:rest N2b492596f31244499438c1c8424701d1
    220 Nefb8a2ac5f984ce7851f57eab0480540 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Phosphatidylethanolamines
    222 rdf:type schema:DefinedTerm
    223 Nf17bc033e28447048785aba7f1bb502a rdf:first sg:person.015437315512.94
    224 rdf:rest N3db72baad79b450581945576a9ec54b3
    225 Nf1e1d0921e164d3e9b18feb721cadd90 rdf:first sg:person.01370505366.07
    226 rdf:rest Nccbf6f46547441be88a0e926997a9b3e
    227 Nf22c39c3a0a44c25ace4468e63f3d2f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    228 schema:name Osteosarcoma
    229 rdf:type schema:DefinedTerm
    230 Nf383a103a8014ef49d0262fad6fddb34 rdf:first sg:person.0744212622.31
    231 rdf:rest Nbbe0b3a33a0f4d7484470ddd3a893e94
    232 Nf54cc49401844a96a59adda58656c1ea schema:affiliation grid-institutes:grid.419038.7
    233 schema:familyName Ferrari
    234 schema:givenName Stefano
    235 rdf:type schema:Person
    236 Nf5ced3e8d9b245dd89a0149e621eb4c9 schema:affiliation grid-institutes:grid.10419.3d
    237 schema:familyName Gelderblom
    238 schema:givenName Hans
    239 rdf:type schema:Person
    240 Nfaaa975c3503413fb7f9b4d9cc5bc668 rdf:first N1021a35ef24b41a3bdfa0d3067f736af
    241 rdf:rest N071bc14bba4440fea94b79d175b6fc09
    242 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    243 schema:name Medical and Health Sciences
    244 rdf:type schema:DefinedTerm
    245 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    246 schema:name Oncology and Carcinogenesis
    247 rdf:type schema:DefinedTerm
    248 sg:grant.3781490 http://pending.schema.org/fundedItem sg:pub.10.1186/s12885-022-09697-9
    249 rdf:type schema:MonetaryGrant
    250 sg:journal.1024632 schema:issn 1471-2407
    251 schema:name BMC Cancer
    252 schema:publisher Springer Nature
    253 rdf:type schema:Periodical
    254 sg:person.01076403101.51 schema:affiliation grid-institutes:grid.10419.3d
    255 schema:familyName Tiemeier
    256 schema:givenName Gesa
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076403101.51
    258 rdf:type schema:Person
    259 sg:person.01107657620.45 schema:affiliation grid-institutes:grid.4991.5
    260 schema:familyName Hassan
    261 schema:givenName Andrew Bassim
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107657620.45
    263 rdf:type schema:Person
    264 sg:person.01142646030.43 schema:affiliation grid-institutes:grid.52996.31
    265 schema:familyName Strauss
    266 schema:givenName Sandra J.
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142646030.43
    268 rdf:type schema:Person
    269 sg:person.011625342127.40 schema:affiliation grid-institutes:grid.4991.5
    270 schema:familyName Faleti
    271 schema:givenName Ade
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011625342127.40
    273 rdf:type schema:Person
    274 sg:person.01210215667.35 schema:affiliation grid-institutes:grid.419038.7
    275 schema:familyName Palmerini
    276 schema:givenName Emanuela
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210215667.35
    278 rdf:type schema:Person
    279 sg:person.01256657747.63 schema:affiliation grid-institutes:grid.10419.3d
    280 schema:familyName van Maldegem
    281 schema:givenName Annemiek
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256657747.63
    283 rdf:type schema:Person
    284 sg:person.013077670227.67 schema:affiliation grid-institutes:grid.10419.3d
    285 schema:familyName Buddingh
    286 schema:givenName Emmeline
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013077670227.67
    288 rdf:type schema:Person
    289 sg:person.01336605441.13 schema:affiliation grid-institutes:grid.7849.2
    290 schema:familyName Blay
    291 schema:givenName Jean-Yves
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336605441.13
    293 rdf:type schema:Person
    294 sg:person.01364312305.38 schema:affiliation grid-institutes:grid.10419.3d
    295 schema:familyName van Beelen
    296 schema:givenName Els
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364312305.38
    298 rdf:type schema:Person
    299 sg:person.01370505366.07 schema:affiliation grid-institutes:grid.10419.3d
    300 schema:familyName Cleton-Jansen
    301 schema:givenName Anne Marie
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370505366.07
    303 rdf:type schema:Person
    304 sg:person.015437315512.94 schema:affiliation grid-institutes:grid.4991.5
    305 schema:familyName Love
    306 schema:givenName Sharon
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015437315512.94
    308 rdf:type schema:Person
    309 sg:person.015465242534.98 schema:affiliation grid-institutes:grid.4991.5
    310 schema:familyName Herbschleb
    311 schema:givenName Karin
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015465242534.98
    313 rdf:type schema:Person
    314 sg:person.0577703344.59 schema:affiliation grid-institutes:grid.10419.3d
    315 schema:familyName Hogendoorn
    316 schema:givenName Pancras C. W.
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577703344.59
    318 rdf:type schema:Person
    319 sg:person.0640314645.12 schema:affiliation grid-institutes:grid.4991.5
    320 schema:familyName Bühnemann
    321 schema:givenName Claudia
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640314645.12
    323 rdf:type schema:Person
    324 sg:person.0641614611.49 schema:affiliation grid-institutes:grid.6572.6
    325 schema:familyName Billingham
    326 schema:givenName Lucinda
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641614611.49
    328 rdf:type schema:Person
    329 sg:person.0701243537.32 schema:affiliation grid-institutes:grid.55325.34
    330 schema:familyName Bruland
    331 schema:givenName Øyvind
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701243537.32
    333 rdf:type schema:Person
    334 sg:person.0744212622.31 schema:affiliation grid-institutes:grid.410718.b
    335 schema:familyName Dirksen
    336 schema:givenName Uta
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744212622.31
    338 rdf:type schema:Person
    339 sg:person.0753274552.44 schema:affiliation grid-institutes:grid.419038.7
    340 schema:familyName Picci
    341 schema:givenName Piero
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753274552.44
    343 rdf:type schema:Person
    344 sg:pub.10.1007/978-1-4419-0284-9_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011255526
    345 https://doi.org/10.1007/978-1-4419-0284-9_8
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1007/978-3-030-43032-0_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1128142224
    348 https://doi.org/10.1007/978-3-030-43032-0_11
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1007/bf01741788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025418606
    351 https://doi.org/10.1007/bf01741788
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1007/s00262-010-0965-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041928952
    354 https://doi.org/10.1007/s00262-010-0965-3
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1007/s00262-012-1232-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020833996
    357 https://doi.org/10.1007/s00262-012-1232-6
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1007/s13402-021-00598-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1136818161
    360 https://doi.org/10.1007/s13402-021-00598-w
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/ncomms15936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086127147
    363 https://doi.org/10.1038/ncomms15936
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/nprot.2012.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030124536
    366 https://doi.org/10.1038/nprot.2012.016
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/s41467-020-20059-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1133370771
    369 https://doi.org/10.1038/s41467-020-20059-6
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1186/1756-9966-33-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045119737
    372 https://doi.org/10.1186/1756-9966-33-27
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1186/gb-2011-12-1-r6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050465130
    375 https://doi.org/10.1186/gb-2011-12-1-r6
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1245/s10434-007-9483-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004180860
    378 https://doi.org/10.1245/s10434-007-9483-8
    379 rdf:type schema:CreativeWork
    380 grid-institutes:grid.10419.3d schema:alternateName Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands
    381 schema:name Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands
    382 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, OX3 7LD, Oxford, UK
    383 Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, OX1 3RE, Oxford, UK
    384 rdf:type schema:Organization
    385 grid-institutes:grid.410718.b schema:alternateName Pediatrics III, West German Cancer Centre Network Essen-Muenster, University Hospital Essen, Hufelanstr 55, 45147, Essen, Germany
    386 schema:name Pediatrics III, West German Cancer Centre Network Essen-Muenster, University Hospital Essen, Hufelanstr 55, 45147, Essen, Germany
    387 rdf:type schema:Organization
    388 grid-institutes:grid.415719.f schema:alternateName Department of Radiology, Churchill Hospital, Oxford University Hospitals Foundation Trust, OX3 7LJ, Oxford, UK
    389 schema:name Department of Radiology, Churchill Hospital, Oxford University Hospitals Foundation Trust, OX3 7LJ, Oxford, UK
    390 rdf:type schema:Organization
    391 grid-institutes:grid.419038.7 schema:alternateName Istituti Ortopedici Rizzoli, Via C. Pupilli 1, 40136, Bologna, Italy
    392 schema:name Istituti Ortopedici Rizzoli, Via C. Pupilli 1, 40136, Bologna, Italy
    393 rdf:type schema:Organization
    394 grid-institutes:grid.4991.5 schema:alternateName Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK
    395 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, OX3 7LD, Oxford, UK
    396 Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, OX1 3RE, Oxford, UK
    397 schema:name Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, OX3 7DQ, Oxford, UK
    398 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, OX3 7LD, Oxford, UK
    399 Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, OX1 3RE, Oxford, UK
    400 rdf:type schema:Organization
    401 grid-institutes:grid.52996.31 schema:alternateName Department of Oncology, UCLH NHS Foundation Trust, 250 Euston Road, NW1 2PG, London, UK
    402 schema:name Department of Oncology, UCLH NHS Foundation Trust, 250 Euston Road, NW1 2PG, London, UK
    403 rdf:type schema:Organization
    404 grid-institutes:grid.55325.34 schema:alternateName Institute of Clinical Medicine, Faculty of Medicine, University of Oslo and Department of Oncology-Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    405 schema:name Institute of Clinical Medicine, Faculty of Medicine, University of Oslo and Department of Oncology-Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    406 rdf:type schema:Organization
    407 grid-institutes:grid.6572.6 schema:alternateName Cancer Research Clinical Trials Unit (Cancer Sciences), Institute of Cancer and Genomic Sciences, Robert Aitken Building, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    408 schema:name Cancer Research Clinical Trials Unit (Cancer Sciences), Institute of Cancer and Genomic Sciences, Robert Aitken Building, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    409 rdf:type schema:Organization
    410 grid-institutes:grid.7849.2 schema:alternateName Universitè Lyon 1 Claude Bernard, Lyon, France
    411 schema:name Universitè Lyon 1 Claude Bernard, Lyon, France
    412 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...