Association of CTLA-4 and IL-4 polymorphisms in viral induced liver cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-05-07

AUTHORS

Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Janeen H. Trembley, Areeb Rizwan, Fatima Faraz, Syeda Alveena Shah, Mahrukh Farooqi, Naeem Mahmood Ashraf, Tayyaba Afsar, Ali Almajwal, Nawaf W. Alruwaili, Suhail Razak

ABSTRACT

BackgroundHepatocellular carcinoma (HCC) is one of the most prevalent types of cancer and is responsible for close to one million annual deaths globally. In Pakistan, HCC accounts for 10.7% of cancer incidence. Prior studies indicated an association between interleukin 4 (IL-4) and cytotoxic T lymphocyte protein 4 (CTLA-4) gene polymorphisms in many types of cancers, including HCC that are either hepatitis B virus (HBV)- or hepatitis C Virus (HCV)-induced. The association of IL-4 and CTLA-4 genetic polymorphisms with HCV-induced HCC is not yet determined in the Pakistani population. Therefore, this research is designed to investigate the implication of IL-4 and CTLA-4 gene polymorphisms by determining the association of IL-4 -590 C/T (rs2243250) and CTLA-4 + 49 A/G (rs231775) with HCC in Pakistan.MethodsDifferent bioinformatics tools were employed to determine the pathogenicity of these polymorphisms. Samples were collected from HCV-induced HCC patients, followed by DNA extraction and ARMS-PCR analysis.ResultsThe SNP analysis results indicated a positive association of IL-4 -590C/T and CTLA-4 + 49A/G gene polymorphisms with HCV-induced HCC in Pakistan. The CTLA-4 polymorphism might enhance therapeutic efficiency of HCC chemotherapy medicines. The IL-4 polymorphism might introduce new transcription factor binding site in IL-4 promoter region.ConclusionThis study delineated risk factor alleles in CTLA-4 and IL-4 genes associated with HCV-mediated HCC among Pakistani patients that may have application to serve as genetic markers for pre- and early diagnosis and prognosis of HCC in HCV patients. More... »

PAGES

518

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-022-09633-x

DOI

http://dx.doi.org/10.1186/s12885-022-09633-x

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https://app.dimensions.ai/details/publication/pub.1147717540

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35525950


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79 liver cancer
80 markers
81 medicine
82 new transcription factor
83 pathogenicity
84 patients
85 polymorphism
86 population
87 positive association
88 pre
89 prevalent type
90 prior studies
91 prognosis
92 prognosis of HCC
93 promoter region
94 region
95 research
96 results
97 samples
98 sites
99 study
100 therapeutic efficiency
101 tool
102 transcription factors
103 types
104 types of cancer
105 virus
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