Sentinel node theory helps tracking of primary lesions of cancers of unknown primary View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-07-09

AUTHORS

Yilin Shao, Xin Liu, Silong Hu, Yingjian Zhang, Wentao Li, Xiaoyan Zhou, Qifeng Wang, Yifeng Hou, Yong Chen, Yanli Wang, Yaohui Wang, Zhiguo Luo, Xichun Hu

ABSTRACT

BackgroundSentinel lymph node is the first stop of lymphatic spreading of cancer with known primary. The lymph node metastasis pattern of cancer of unknown primary (CUP) is unclear and has been presumed to follow the same pathway. To test this hypothesis, data of all 716 patients clinically diagnosed as CUP in our center were collected.MethodsDiagnoses of lymph node metastasis were established by 18F-FDG PET-CT and/or biopsy pathology. Three hundred and forty-seven cases meeting the criteria were divided into three groups: pathology-confirmed primary with invasive biopsy or surgery of the suspicious lesion (group A, n = 64), primary still unknown even with invasive biopsy or surgery of the suspicious lesion (group B, n = 204), and others with no suspicious lesion or lesions who had not been sampled due to medical or other reasons (group C, n = 79). We assessed the clinicopathological features between these groups, and the relationship between lymph node metastasis pattern and confirmed primary site.ResultsIn group A, the primary sites of 61 cases were compatible with sentinel node theory, resulting in a positive predictive value of 95%. No significant differences in age, sex, bone metastasis, or visceral metastasis observed between group A and group B, except that group A had a higher ratio of differentiated carcinoma (94% vs. 77%, P = 0.003).ConclusionTo our knowledge, this is the first evidence indicating that the majority of clinical CUP cases follow the sentinel node theory to spread in lymph nodes, which helps tracking the primary, especially for differentiated carcinoma. More... »

PAGES

639

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-020-07042-6

DOI

http://dx.doi.org/10.1186/s12885-020-07042-6

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https://app.dimensions.ai/details/publication/pub.1129131046

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32646508


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33 schema:description BackgroundSentinel lymph node is the first stop of lymphatic spreading of cancer with known primary. The lymph node metastasis pattern of cancer of unknown primary (CUP) is unclear and has been presumed to follow the same pathway. To test this hypothesis, data of all 716 patients clinically diagnosed as CUP in our center were collected.MethodsDiagnoses of lymph node metastasis were established by 18F-FDG PET-CT and/or biopsy pathology. Three hundred and forty-seven cases meeting the criteria were divided into three groups: pathology-confirmed primary with invasive biopsy or surgery of the suspicious lesion (group A, n = 64), primary still unknown even with invasive biopsy or surgery of the suspicious lesion (group B, n = 204), and others with no suspicious lesion or lesions who had not been sampled due to medical or other reasons (group C, n = 79). We assessed the clinicopathological features between these groups, and the relationship between lymph node metastasis pattern and confirmed primary site.ResultsIn group A, the primary sites of 61 cases were compatible with sentinel node theory, resulting in a positive predictive value of 95%. No significant differences in age, sex, bone metastasis, or visceral metastasis observed between group A and group B, except that group A had a higher ratio of differentiated carcinoma (94% vs. 77%, P = 0.003).ConclusionTo our knowledge, this is the first evidence indicating that the majority of clinical CUP cases follow the sentinel node theory to spread in lymph nodes, which helps tracking the primary, especially for differentiated carcinoma.
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41 CUP cases
42 ConclusionTo
43 PET
44 ResultsIn group A
45 age
46 biopsy
47 biopsy pathology
48 bone metastases
49 cancer
50 carcinoma
51 cases
52 center
53 clinicopathological features
54 criteria
55 cup
56 data
57 differences
58 differentiated carcinoma
59 evidence
60 features
61 first evidence
62 first stop
63 group
64 group A
65 group B
66 high ratio
67 hypothesis
68 invasive biopsy
69 knowledge
70 lesions
71 lymph
72 lymph node metastasis
73 lymph node metastasis pattern
74 lymph nodes
75 lymphatic spreading
76 majority
77 metastasis
78 metastasis pattern
79 node metastasis
80 nodes
81 pathology
82 pathway
83 patients
84 patterns
85 positive predictive value
86 predictive value
87 primary
88 primary lesion
89 primary site
90 ratio
91 reasons
92 relationship
93 same pathway
94 sex
95 significant differences
96 sites
97 spreading
98 stops
99 surgery
100 suspicious lesions
101 theory
102 tracking
103 unknown primary
104 values
105 visceral metastases
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