Outcomes of non-high grade serous carcinoma after neoadjuvant chemotherapy for advanced-stage ovarian cancer: a Korean gynecologic oncology group study (OV ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-04-11

AUTHORS

Young Shin Chung, Sang-Yoon Park, Jung-Yun Lee, Jeong-Yeol Park, Jeong-Won Lee, Hee Seung Kim, Dong Soo Suh, Yun Hwan Kim, Jong-Min Lee, Miseon Kim, Min Chul Choi, Seung-Hyuk Shim, Keun Ho Lee, Taejong Song, Jin Hwa Hong, Won Moo Lee, Banghyun Lee, In Ho Lee

ABSTRACT

BackgroundOutcomes of patients with ovarian high-grade serous carcinoma (HGSC) treated with neoadjuvant chemotherapy (NAC) have been widely studied, but there is limited information on the outcomes of patients with non-HGSC. This study aimed to evaluate the outcomes of NAC in non-HGSC patients with advanced-stage ovarian cancer.MethodsWe conducted a retrospective cohort study of patients who underwent NAC for advanced stage non-HGSC between 2002 and 2017 in 17 institutions. Demographics, surgical outcomes, and survival rates were evaluated according to histological subtypes.ResultsA total of 154 patients were included in this study, comprising 20 cases (13.0%) of mucinous adenocarcinoma, 31 cases (20.1%) of endometrioid adenocarcinoma, 28 (18.2%) cases of clear cell carcinoma, 29 (18.8%) cases of low-grade serous carcinoma and 12 cases (7.8%) of carcinosarcoma. Complete remission/partial remission after the third cycle of NAC was achieved in 100 (64.9%) patients and optimal debulking surgery (residual disease ≤1 cm) at interval debulking surgery was achieved in 103 (66.9%) patients. The most common reason for performing NAC was high tumor burden (n = 106, 68.8%). The median progression-free survival (PFS) was 14.3 months and median overall survival (OS) was 52.9 months. In multivariate analyses, mucinous and clear cell carcinoma were negative prognostic factors for both PFS (p = 0.007 and p = 0.017, respectively) and OS (p = 0.002 and p = 0.013, respectively).ConclusionsIn this study, poor survival outcomes were observed in patients with mucinous and clear cell carcinoma undergoing NAC. Different treatment strategies are urgently required to improve survival outcomes for this disease subset. More... »

PAGES

341

Journal

TITLE

BMC Cancer

ISSUE

1

VOLUME

19

Author Affiliations

  • Department of Obstetrics and Gynecology, Institute of Women’s Life Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, South Korea
  • Center for Uterine Cancer, Hospital, National Cancer Center, 323 Ilsan-ro, Ilnsandong-gu, 410-769, Goyang-si, Gyeonggi-do, South Korea
  • Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
  • Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
  • Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea
  • Department of Obstetrics and Gynecology, Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea
  • Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ewha Womans University College of Medicine, Seoul, South Korea
  • Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, South Korea
  • Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University College of Medicine, Seoul, South Korea
  • Comprehensive Gynecologic Cancer Center, CHA Bundang Medical Center, CHA University, Seongnam, South Korea
  • Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, South Korea
  • Department of Obstetrics and Gynecology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
  • Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
  • Department of Obstetrics and Gynecology, Guro Hospital, College of Medicine, Korea University, Seoul, South Korea
  • Department of Obstetrics and Gynecology, Hanyang University College of Medicine, Seoul, South Korea
  • Department of Obstetrics and Gynecology, Hallym University Kangdong Sacred Heart Hospital, Seoul, South Korea
  • Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, Dankook University College of Medicine, Seoul, South Korea
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-019-5514-7

    DOI

    http://dx.doi.org/10.1186/s12885-019-5514-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113355575

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30971221


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        "description": "BackgroundOutcomes of patients with ovarian high-grade serous carcinoma (HGSC) treated with neoadjuvant chemotherapy (NAC) have been widely studied, but there is limited information on the outcomes of patients with non-HGSC. This study aimed to evaluate the outcomes of NAC in non-HGSC patients with advanced-stage ovarian cancer.MethodsWe conducted a retrospective cohort study of patients who underwent NAC for advanced stage non-HGSC between 2002 and 2017 in 17 institutions. Demographics, surgical outcomes, and survival rates were evaluated according to histological subtypes.ResultsA total of 154 patients were included in this study, comprising 20 cases (13.0%) of mucinous adenocarcinoma, 31 cases (20.1%) of endometrioid adenocarcinoma, 28 (18.2%) cases of clear cell carcinoma, 29 (18.8%) cases of low-grade serous carcinoma and 12 cases (7.8%) of carcinosarcoma. Complete remission/partial remission after the third cycle of NAC was achieved in 100 (64.9%) patients and optimal debulking surgery (residual disease \u22641\u2009cm) at interval debulking surgery was achieved in 103 (66.9%) patients. The most common reason for performing NAC was high tumor burden (n\u2009=\u2009106, 68.8%). The median progression-free survival (PFS) was 14.3\u2009months and median overall survival (OS) was 52.9\u2009months. In multivariate analyses, mucinous and clear cell carcinoma were negative prognostic factors for both PFS (p\u2009=\u20090.007 and p\u2009=\u20090.017, respectively) and OS (p\u2009=\u20090.002 and p\u2009=\u20090.013, respectively).ConclusionsIn this study, poor survival outcomes were observed in patients with mucinous and clear cell carcinoma undergoing NAC. Different treatment strategies are urgently required to improve survival outcomes for this disease subset.", 
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