Assessment of Ramucirumab plus paclitaxel as switch maintenance versus continuation of first-line chemotherapy in patients with advanced HER-2 negative gastric ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Maria Di Bartolomeo, Monica Niger, Federica Morano, Salvatore Corallo, Maria Antista, Stefano Tamberi, Sara Lonardi, Samantha Di Donato, Rossana Berardi, Mario Scartozzi, Giovanni Gerardo Cardellino, Francesco Di Costanzo, Lorenza Rimassa, Alberto Gianluigi Luporini, Raffaella Longarini, Alberto Zaniboni, Alessandro Bertolini, Gianluca Tomasello, Graziella Pinotti, Giorgio Scagliotti, Giampaolo Tortora, Andrea Bonetti, Andrea Spallanzani, Giovanni Luca Frassineti, Davide Tassinari, Francesco Giuliani, Saverio Cinieri, Evaristo Maiello, Claudio Verusio, Sergio Bracarda, Vincenzo Catalano, Michele Basso, Libero Ciuffreda, Ferdinando De Vita, Hector Soto Parra, Lorenzo Fornaro, Marta Caporale, Filippo de Braud, Filippo Pietrantonio

ABSTRACT

BACKGROUND: Platinum/fluoropyrimidine regimens are the backbone of first-line chemotherapy for advanced gastric cancer (AGC). However response rates to first line chemotherapy range from 30 to 50% and disease progression occurs after 4-6 cycles. The optimal duration of first-line therapy is still unknown and its continuation until disease progression represents the standard. However this strategy is often associated with cumulative toxicity and rapid development of drug resistance. Moreover, only about 40% of AGC pts. are eligible for second-line treatment. METHODS: This is a randomized, open-label, multicenter phase III trial. It aims at assessing whether switch maintenance to ramucirumab plus paclitaxel will extend the progression-free survival (PFS) of subjects with HER-2 negative AGC who have not progressed after 3 months of a first-line with a platinum/fluoropyrimidine regimen (either FOLFOX4, mFOLFOX6 or XELOX). The primary endpoint is to compare Progression-Free Survival (PFS) of patients in ARM A (switch maintenance to ramucirumab and placlitaxel) versus ARM B (continuation of the same first-line therapy with oxaliplatin/fluoropyrimidine). Secondary endpoints are: overall survival, time-to-treatment failure, overall response rate, duration of response, percentage of patients that will receive a second line therapy according to arm treatment, safety, quality of life. Exploratory studies including Next-Generation Sequencing (NGS) in archival tumor tissues are planned in order to identify potential biomarkers of primary resistance and prognosis. DISCUSSION: The ARMANI study estimates if patients treated with early swich with ramucirumab plus paclitaxel received benefit when compared to those treated with continuation of first line therapy. The hypothesis is that the early administration of an active, non-cross resistant second-line regimen such as ramucirumab plus paclitaxel may prolong the time in which patients are progression-free, and consequently have a better quality of life. Moreover, this strategy may rescue all those subjects that become ineligible for second-line therapy due to the rapid deterioration of health status after the first disease progression. TRIAL REGISTRATION: ARMANI is registered at ClinicalTrials.gov ( NCT02934464 , October 17, 2016) and EudraCT(2016-001783-12, April 202,016). More... »

PAGES

283

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-019-5498-3

DOI

http://dx.doi.org/10.1186/s12885-019-5498-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113059578

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30922323


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Bartolomeo", 
        "givenName": "Maria", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niger", 
        "givenName": "Monica", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morano", 
        "givenName": "Federica", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corallo", 
        "givenName": "Salvatore", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antista", 
        "givenName": "Maria", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.419563.c", 
          "name": [
            "Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Ravenna Viale Randi, 5, 48121, Ravenna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tamberi", 
        "givenName": "Stefano", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, IOV Istituto Oncologico Veneto, Via Gattamelata, 64, 35128, Padova, PD, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lonardi", 
        "givenName": "Sara", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nuovo Ospedale di Prato", 
          "id": "https://www.grid.ac/institutes/grid.417208.8", 
          "name": [
            "Sandro Pitigliani Medical Oncology Department, Nuovo Ospedale di Prato, Via Suor Niccolina Infermiera, 20, 59100, Prato, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Donato", 
        "givenName": "Samantha", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, AOU Ospedali Riuniti Di Ancona, via Corridoni, 11, 60123, Ancona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berardi", 
        "givenName": "Rossana", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, AOU Cagliari, Via Ospedale, 54, 09124, Cagliari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scartozzi", 
        "givenName": "Mario", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Santa Maria della Misericordia di Udine", 
          "id": "https://www.grid.ac/institutes/grid.411492.b", 
          "name": [
            "Department of Medical Oncology, Azienda Sanitaria Universitaria Integrata di Udine, Via Pozzuolo, 330 \u2013 33100, piazzale Santa Maria della misericordia 15, 33100, Udine, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cardellino", 
        "givenName": "Giovanni Gerardo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, AOU Careggi di Firenze, Largo Brambilla, 3, 50134, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Costanzo", 
        "givenName": "Francesco", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Medical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center, Via Alessandro Manzoni, 56, 20089, Rozzano, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rimassa", 
        "givenName": "Lorenza", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico San Donato", 
          "id": "https://www.grid.ac/institutes/grid.419557.b", 
          "name": [
            "Department of Medical Oncology, IRCCS Policlinico San Donato, Piazza Edmondo Malan, 2, 20097, San Donato Milanese, MI, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luporini", 
        "givenName": "Alberto Gianluigi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera San Gerardo", 
          "id": "https://www.grid.ac/institutes/grid.415025.7", 
          "name": [
            "Department of Medical Oncology, Ospedale San Gerardo, Via G. B. Pergolesi, 33, 20900, Monza, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Longarini", 
        "givenName": "Raffaella", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fondazione Poliambulanza Istituto Ospedaliero", 
          "id": "https://www.grid.ac/institutes/grid.415090.9", 
          "name": [
            "Department of Medical Oncology, Fondazione Poliambulanza, Via Leonida Bissolati, 57, 25124, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zaniboni", 
        "givenName": "Alberto", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "ASST della Valtellina e dell'Alto Lario", 
          "id": "https://www.grid.ac/institutes/grid.476844.d", 
          "name": [
            "Department of Medical Oncology, ASST della Valtellina e dell\u2019Alto Lario, Via Stelvio, 25, 23100, Sondrio, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bertolini", 
        "givenName": "Alessandro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, Ospedale di Cremona, Viale Concordia, 1, 26100, Cremona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomasello", 
        "givenName": "Gianluca", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale di Circolo e Fondazione Macchi", 
          "id": "https://www.grid.ac/institutes/grid.412972.b", 
          "name": [
            "Department of Medical Oncology, Ospedale di Circolo e Fondazione Macchi, Viale Luigi Borri, 57, 21100, Varese, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinotti", 
        "givenName": "Graziella", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, AOU San Luigi Gonzaga, Regione Gonzole, 10, 10043, Orbassano, Torino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scagliotti", 
        "givenName": "Giorgio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, AOUI Verona Ospedale Policlinico \u2018Giambattista Rossi\u2019 di Borgo Roma, Piazzale L.A. Scuro, 10, 37134, Verona, VR, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tortora", 
        "givenName": "Giampaolo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, Ospedale Mater Salutis, Via Carlo Gianella, 1, 37045 Legnago, Verona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonetti", 
        "givenName": "Andrea", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, AOU di Modena, Via Emilia Est, 583-585, 41122, Modena, MO, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spallanzani", 
        "givenName": "Andrea", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.419563.c", 
          "name": [
            "Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, via P. Maroncelli, 40, 47014, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frassineti", 
        "givenName": "Giovanni Luca", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Infermi di Rimini", 
          "id": "https://www.grid.ac/institutes/grid.414614.2", 
          "name": [
            "Department of Medical Oncology, Ospedale degli infermi di Rimini, Viale L. Settembrini, 2, 47923, Rimini, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tassinari", 
        "givenName": "Davide", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, I.R.C.C.S. Istituto Tumori Bari, Viale Orazio Flacco, 65, 70124, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giuliani", 
        "givenName": "Francesco", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, Ospedale A. Perrino di Brindisi, Strada Statale 7 per Mesagne, 72100, Brindisi, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cinieri", 
        "givenName": "Saverio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Casa Sollievo della Sofferenza", 
          "id": "https://www.grid.ac/institutes/grid.413503.0", 
          "name": [
            "Department of Medical Oncology, Casa Sollievo della Sofferenza, Viale Cappuccini, 1, 71013, San Giovanni Rotondo, FG, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maiello", 
        "givenName": "Evaristo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, ASST Valle Olona, PO Saronno Piazzale Borella 1, 21047, Saronno, Varese, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verusio", 
        "givenName": "Claudio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Donato", 
          "id": "https://www.grid.ac/institutes/grid.416351.4", 
          "name": [
            "Department of Medical Oncology, Ospedale San Donato, Azienda USL Toscana Sudest Via Pietro Nenni, 20/22, 52100, Arezzo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bracarda", 
        "givenName": "Sergio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedali Riuniti Marche Nord", 
          "id": "https://www.grid.ac/institutes/grid.476115.0", 
          "name": [
            "Department of Medical Oncology, Azienda Ospedaliera \u201cOspedali Riuniti Marche Nord\u201d, Piazzale Cinelli, 4, 61121, Pesaro, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Catalano", 
        "givenName": "Vincenzo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catholic University of the Sacred Heart", 
          "id": "https://www.grid.ac/institutes/grid.8142.f", 
          "name": [
            "Department of Medical Oncology, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d - IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Basso", 
        "givenName": "Michele", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, A.O.U. Citta della Salute e della Scienza di Torino, H Molinette, corso Bramante, 88, 10126, Torino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ciuffreda", 
        "givenName": "Libero", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology, Department of Precision Medicine, University of Campania \u2018Luigi Vanvitelli\u2019 - School of Medicine, Via S.Pansini, 5, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Vita", 
        "givenName": "Ferdinando", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, P.O. G. Rodolico, Via Plebiscito, 628, Catania, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parra", 
        "givenName": "Hector Soto", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, AOU Pisana, Polo Oncologico - Osp. S. Chiara, via Roma 67, 56100, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fornaro", 
        "givenName": "Lorenzo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caporale", 
        "givenName": "Marta", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Milan", 
          "id": "https://www.grid.ac/institutes/grid.4708.b", 
          "name": [
            "Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20133, Milan, Italy", 
            "Department of Hematology-Oncology, University Milan, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Braud", 
        "givenName": "Filippo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Milan", 
          "id": "https://www.grid.ac/institutes/grid.4708.b", 
          "name": [
            "Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20133, Milan, Italy", 
            "Department of Hematology-Oncology, University Milan, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pietrantonio", 
        "givenName": "Filippo", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(16)30354-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005290224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-010-0555-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007946888", 
          "https://doi.org/10.1007/s10120-010-0555-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-010-0555-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007946888", 
          "https://doi.org/10.1007/s10120-010-0555-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdn166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009962018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd004064.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012727308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd004064.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012727308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa073149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014019609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.54.1011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014148840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(14)70420-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018632115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2000.1631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020520952", 
          "https://doi.org/10.1054/bjoc.2000.1631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.06.8429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023864538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(13)61719-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026636148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(13)61719-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026636148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200009000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032374760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200009000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032374760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2013-0137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034792547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038773439", 
          "https://doi.org/10.1038/sj.bjc.6600310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038773439", 
          "https://doi.org/10.1038/sj.bjc.6600310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)61121-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044182432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdn717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053015328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-15-0578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063224193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077881828", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd004064.pub4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091386701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11523-018-0562-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101776408", 
          "https://doi.org/10.1007/s11523-018-0562-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11523-018-0562-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101776408", 
          "https://doi.org/10.1007/s11523-018-0562-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11523-018-0562-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101776408", 
          "https://doi.org/10.1007/s11523-018-0562-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2018.36.4_suppl.tps195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111064966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(18)30791-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111841259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(18)30791-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111841259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(18)30791-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111841259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(18)30791-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111841259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(18)30791-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111841259"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Platinum/fluoropyrimidine regimens are the backbone of first-line chemotherapy for advanced gastric cancer (AGC). However response rates to first line chemotherapy range from 30 to 50% and disease progression occurs after 4-6\u2009cycles. The optimal duration of first-line therapy is still unknown and its continuation until disease progression represents the standard. However this strategy is often associated with cumulative toxicity and rapid development of drug resistance. Moreover, only about 40% of AGC pts. are eligible for second-line treatment.\nMETHODS: This is a randomized, open-label, multicenter phase III trial. It aims at assessing whether switch maintenance to ramucirumab plus paclitaxel will extend the progression-free survival (PFS) of subjects with HER-2 negative AGC who have not progressed after 3\u2009months of a first-line with a platinum/fluoropyrimidine regimen (either FOLFOX4, mFOLFOX6 or XELOX). The primary endpoint is to compare Progression-Free Survival (PFS) of patients in ARM A (switch maintenance to ramucirumab and placlitaxel) versus ARM B (continuation of the same first-line therapy with oxaliplatin/fluoropyrimidine). Secondary endpoints are: overall survival, time-to-treatment failure, overall response rate, duration of response, percentage of patients that will receive a second line therapy according to arm treatment, safety, quality of life. Exploratory studies including Next-Generation Sequencing (NGS) in archival tumor tissues are planned in order to identify potential biomarkers of primary resistance and prognosis.\nDISCUSSION: The ARMANI study estimates if patients treated with early swich with ramucirumab plus paclitaxel received benefit when compared to those treated with continuation of first line therapy. The hypothesis is that the early administration of an active, non-cross resistant second-line regimen such as ramucirumab plus paclitaxel may prolong the time in which patients are progression-free, and consequently have a better quality of life. Moreover, this strategy may rescue all those subjects that become ineligible for second-line therapy due to the rapid deterioration of health status after the first disease progression.\nTRIAL REGISTRATION: ARMANI is registered at ClinicalTrials.gov ( NCT02934464 , October 17, 2016) and EudraCT(2016-001783-12, April 202,016).", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12885-019-5498-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Assessment of Ramucirumab plus paclitaxel as switch maintenance versus continuation of first-line chemotherapy in patients with advanced HER-2 negative gastric or gastroesophageal junction cancers: the ARMANI phase III trial", 
    "pagination": "283", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12885-019-5498-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113059578"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d12945b2fd8799ad0b640a8e749461eacbe602c514d28469d751ac73bea26115"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30922323"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12885-019-5498-3", 
      "https://app.dimensions.ai/details/publication/pub.1113059578"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-16T06:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106828_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12885-019-5498-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-019-5498-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-019-5498-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-019-5498-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-019-5498-3'


 

This table displays all metadata directly associated to this object as RDF triples.

440 TRIPLES      21 PREDICATES      50 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12885-019-5498-3 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nc46e84d127c54c8ebe2fb37061c880c3
4 schema:citation sg:pub.10.1007/s10120-010-0555-2
5 sg:pub.10.1007/s11523-018-0562-5
6 sg:pub.10.1038/sj.bjc.6600310
7 sg:pub.10.1054/bjoc.2000.1631
8 https://app.dimensions.ai/details/publication/pub.1077881828
9 https://doi.org/10.1002/14651858.cd004064.pub3
10 https://doi.org/10.1002/14651858.cd004064.pub4
11 https://doi.org/10.1016/s0140-6736(10)61121-x
12 https://doi.org/10.1016/s0140-6736(13)61719-5
13 https://doi.org/10.1016/s0140-6736(16)30354-3
14 https://doi.org/10.1016/s1470-2045(14)70420-6
15 https://doi.org/10.1016/s1470-2045(18)30791-5
16 https://doi.org/10.1056/nejmoa073149
17 https://doi.org/10.1093/annonc/mdn166
18 https://doi.org/10.1093/annonc/mdn717
19 https://doi.org/10.1097/00000658-200009000-00008
20 https://doi.org/10.1158/1055-9965.epi-15-0578
21 https://doi.org/10.1200/jco.2006.06.8429
22 https://doi.org/10.1200/jco.2013.54.1011
23 https://doi.org/10.1200/jco.2018.36.4_suppl.tps195
24 https://doi.org/10.1634/theoncologist.2013-0137
25 schema:datePublished 2019-12
26 schema:datePublishedReg 2019-12-01
27 schema:description BACKGROUND: Platinum/fluoropyrimidine regimens are the backbone of first-line chemotherapy for advanced gastric cancer (AGC). However response rates to first line chemotherapy range from 30 to 50% and disease progression occurs after 4-6 cycles. The optimal duration of first-line therapy is still unknown and its continuation until disease progression represents the standard. However this strategy is often associated with cumulative toxicity and rapid development of drug resistance. Moreover, only about 40% of AGC pts. are eligible for second-line treatment. METHODS: This is a randomized, open-label, multicenter phase III trial. It aims at assessing whether switch maintenance to ramucirumab plus paclitaxel will extend the progression-free survival (PFS) of subjects with HER-2 negative AGC who have not progressed after 3 months of a first-line with a platinum/fluoropyrimidine regimen (either FOLFOX4, mFOLFOX6 or XELOX). The primary endpoint is to compare Progression-Free Survival (PFS) of patients in ARM A (switch maintenance to ramucirumab and placlitaxel) versus ARM B (continuation of the same first-line therapy with oxaliplatin/fluoropyrimidine). Secondary endpoints are: overall survival, time-to-treatment failure, overall response rate, duration of response, percentage of patients that will receive a second line therapy according to arm treatment, safety, quality of life. Exploratory studies including Next-Generation Sequencing (NGS) in archival tumor tissues are planned in order to identify potential biomarkers of primary resistance and prognosis. DISCUSSION: The ARMANI study estimates if patients treated with early swich with ramucirumab plus paclitaxel received benefit when compared to those treated with continuation of first line therapy. The hypothesis is that the early administration of an active, non-cross resistant second-line regimen such as ramucirumab plus paclitaxel may prolong the time in which patients are progression-free, and consequently have a better quality of life. Moreover, this strategy may rescue all those subjects that become ineligible for second-line therapy due to the rapid deterioration of health status after the first disease progression. TRIAL REGISTRATION: ARMANI is registered at ClinicalTrials.gov ( NCT02934464 , October 17, 2016) and EudraCT(2016-001783-12, April 202,016).
28 schema:genre research_article
29 schema:inLanguage en
30 schema:isAccessibleForFree true
31 schema:isPartOf N7639ac1e23a34e7c88bf031fe39b7ceb
32 Ndc5c574142294c6f92dc8dadaff6290e
33 sg:journal.1024632
34 schema:name Assessment of Ramucirumab plus paclitaxel as switch maintenance versus continuation of first-line chemotherapy in patients with advanced HER-2 negative gastric or gastroesophageal junction cancers: the ARMANI phase III trial
35 schema:pagination 283
36 schema:productId N0805ec27eb484f56be06ef2def75d9cb
37 N15d20f4f05a34d18a0151f3115191a37
38 N1a9ed8ae91594dfe82e3c656e30f4626
39 N6703123175144497a3554d378cd30a66
40 Ne7760f93b4fc49fe86c991233b9328e6
41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113059578
42 https://doi.org/10.1186/s12885-019-5498-3
43 schema:sdDatePublished 2019-04-16T06:24
44 schema:sdLicense https://scigraph.springernature.com/explorer/license/
45 schema:sdPublisher N62899f1116b440bd9af9ce1c570e1efa
46 schema:url https://link.springer.com/10.1186%2Fs12885-019-5498-3
47 sgo:license sg:explorer/license/
48 sgo:sdDataset articles
49 rdf:type schema:ScholarlyArticle
50 N0200c84447b84edda0811ca18150012a schema:affiliation https://www.grid.ac/institutes/grid.415090.9
51 schema:familyName Zaniboni
52 schema:givenName Alberto
53 rdf:type schema:Person
54 N05e265b0dc2843b4bda735032764a5e7 schema:affiliation https://www.grid.ac/institutes/grid.4708.b
55 schema:familyName de Braud
56 schema:givenName Filippo
57 rdf:type schema:Person
58 N06e6d6a85f8d4fb99df4fe3a077e7216 rdf:first N94377cd4938a45bd8d723b33128b603d
59 rdf:rest N8e4f9a8315ba447eb66d8b262136ff3b
60 N070d274710094356bd4d2f7469a2bce4 schema:affiliation https://www.grid.ac/institutes/grid.476115.0
61 schema:familyName Catalano
62 schema:givenName Vincenzo
63 rdf:type schema:Person
64 N0805ec27eb484f56be06ef2def75d9cb schema:name doi
65 schema:value 10.1186/s12885-019-5498-3
66 rdf:type schema:PropertyValue
67 N09b7e863c5b84eedacaefb2ab586f895 rdf:first N64d33cf45d344a1ba279478945e53121
68 rdf:rest Nd8e461b4dbc24197ba3fe4f27b9dc8e7
69 N0aab22079a9b4f6f87fd04f7320127c2 rdf:first Nf77002f5b0d24eeda183c5dc64528324
70 rdf:rest Ncef9197450b342cba449494053d23350
71 N0b2efa88c48b470fa70ed1697c2e02f6 rdf:first N25775d4d82d5449da60b54ccd3d034c4
72 rdf:rest N7a987f6bf883433990804da5dfbb52f3
73 N12b31f8ce3984c13b54afc4e66bfc730 schema:affiliation N8429477822c94211b9598913f7bb9c1d
74 schema:familyName Parra
75 schema:givenName Hector Soto
76 rdf:type schema:Person
77 N15086738730c4c97832914cf8c50edbd rdf:first N3b37ea18e6e74d9a9de845c27dd5b93e
78 rdf:rest N8403c2c964b54b95a39ad0a03c495719
79 N15d20f4f05a34d18a0151f3115191a37 schema:name readcube_id
80 schema:value d12945b2fd8799ad0b640a8e749461eacbe602c514d28469d751ac73bea26115
81 rdf:type schema:PropertyValue
82 N18ca5eb08aa34105872380d07b06c994 rdf:first N9dad76be69a04cd5a770c616d1957c4c
83 rdf:rest N9001b229bdef4457a692ab41c4183f6e
84 N190ab46428d642aeb093ac25d2a5ed9e schema:affiliation https://www.grid.ac/institutes/grid.417893.0
85 schema:familyName Caporale
86 schema:givenName Marta
87 rdf:type schema:Person
88 N1a9ed8ae91594dfe82e3c656e30f4626 schema:name dimensions_id
89 schema:value pub.1113059578
90 rdf:type schema:PropertyValue
91 N1f7d8e811fe94a0b9b5e5f0bab9327b7 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
92 schema:familyName Di Bartolomeo
93 schema:givenName Maria
94 rdf:type schema:Person
95 N20b793021e194811918bd136f7195cfa schema:name Department of Medical Oncology, Ospedale A. Perrino di Brindisi, Strada Statale 7 per Mesagne, 72100, Brindisi, Italy
96 rdf:type schema:Organization
97 N247ab0991cc946d9a2ea52b276e2bbea schema:affiliation N566a066173ad4d50ba4fffb6ea26953d
98 schema:familyName Lonardi
99 schema:givenName Sara
100 rdf:type schema:Person
101 N25775d4d82d5449da60b54ccd3d034c4 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
102 schema:familyName Niger
103 schema:givenName Monica
104 rdf:type schema:Person
105 N29aaf93535624d4ea179c33c369d7e20 rdf:first N5b1f6deef39341d4980dc4ecf68e8c8a
106 rdf:rest N9fe0524d8fb04ede824793296503471e
107 N2a59692b4493447ca24722be44f20432 schema:affiliation Na56da8df5dd94e69be7a5381e0787995
108 schema:familyName Scartozzi
109 schema:givenName Mario
110 rdf:type schema:Person
111 N2fa9203138e84c56bc4b27fe3cf889a0 schema:affiliation https://www.grid.ac/institutes/grid.416351.4
112 schema:familyName Bracarda
113 schema:givenName Sergio
114 rdf:type schema:Person
115 N3ab3ecab55d74e50913142c6e43ffc87 rdf:first N64be08ff674041b7bf9fd36bfdb6a294
116 rdf:rest N817c1ae90a5e48cf8bab512e290f8ee2
117 N3b37ea18e6e74d9a9de845c27dd5b93e schema:affiliation N42789493619540fda3e1dd6d6126a921
118 schema:familyName Fornaro
119 schema:givenName Lorenzo
120 rdf:type schema:Person
121 N3fd9c670bc354831bb9f1022579b6a75 schema:name Department of Medical Oncology, AOU Ospedali Riuniti Di Ancona, via Corridoni, 11, 60123, Ancona, Italy
122 rdf:type schema:Organization
123 N3fed30f588df46cf9d7e391725ef98bb rdf:first N4629e5acc99440d99178c8494bb37e34
124 rdf:rest rdf:nil
125 N42789493619540fda3e1dd6d6126a921 schema:name Department of Medical Oncology, AOU Pisana, Polo Oncologico - Osp. S. Chiara, via Roma 67, 56100, Pisa, Italy
126 rdf:type schema:Organization
127 N4629e5acc99440d99178c8494bb37e34 schema:affiliation https://www.grid.ac/institutes/grid.4708.b
128 schema:familyName Pietrantonio
129 schema:givenName Filippo
130 rdf:type schema:Person
131 N473722e6700f461da8adc3d3014f56b7 schema:name Department of Medical Oncology, Ospedale di Cremona, Viale Concordia, 1, 26100, Cremona, Italy
132 rdf:type schema:Organization
133 N47f35e7aba3c434da5c112defbb0187d schema:affiliation https://www.grid.ac/institutes/grid.413503.0
134 schema:familyName Maiello
135 schema:givenName Evaristo
136 rdf:type schema:Person
137 N4a821ca4e68d4eeb976c90bb7bfc12e8 rdf:first Nd0b80235428049c2b5d7848333ed3b2c
138 rdf:rest N09b7e863c5b84eedacaefb2ab586f895
139 N4aed74d1fdef43e885f313219a2a50e4 rdf:first N12b31f8ce3984c13b54afc4e66bfc730
140 rdf:rest N15086738730c4c97832914cf8c50edbd
141 N52ca8d724cea402cb8e71d11217ead77 rdf:first Nf2632d8a249a453ab853b917f97eeff0
142 rdf:rest N84633e80e3564e00a036baaff5687e78
143 N53f9236b00284ee3844a166326f4b503 schema:affiliation N9c3faeb0f27a456795a1599f0403dd3b
144 schema:familyName Ciuffreda
145 schema:givenName Libero
146 rdf:type schema:Person
147 N56438b5643b04efbb46c3635584d06d1 schema:affiliation https://www.grid.ac/institutes/grid.8142.f
148 schema:familyName Basso
149 schema:givenName Michele
150 rdf:type schema:Person
151 N566a066173ad4d50ba4fffb6ea26953d schema:name Department of Medical Oncology, IOV Istituto Oncologico Veneto, Via Gattamelata, 64, 35128, Padova, PD, Italy
152 rdf:type schema:Organization
153 N5b1f6deef39341d4980dc4ecf68e8c8a schema:affiliation Ndb5f825b5ac04615bd1d584fff3073b2
154 schema:familyName Bonetti
155 schema:givenName Andrea
156 rdf:type schema:Person
157 N62899f1116b440bd9af9ce1c570e1efa schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 N64be08ff674041b7bf9fd36bfdb6a294 schema:affiliation N3fd9c670bc354831bb9f1022579b6a75
160 schema:familyName Berardi
161 schema:givenName Rossana
162 rdf:type schema:Person
163 N64d33cf45d344a1ba279478945e53121 schema:affiliation https://www.grid.ac/institutes/grid.419557.b
164 schema:familyName Luporini
165 schema:givenName Alberto Gianluigi
166 rdf:type schema:Person
167 N6703123175144497a3554d378cd30a66 schema:name pubmed_id
168 schema:value 30922323
169 rdf:type schema:PropertyValue
170 N6ebd777dd70d429d86f8fa3414ba94f3 schema:affiliation https://www.grid.ac/institutes/grid.419563.c
171 schema:familyName Tamberi
172 schema:givenName Stefano
173 rdf:type schema:Person
174 N739d5914d8b04bbc999d11e9b7308c16 rdf:first N05e265b0dc2843b4bda735032764a5e7
175 rdf:rest N3fed30f588df46cf9d7e391725ef98bb
176 N7639ac1e23a34e7c88bf031fe39b7ceb schema:volumeNumber 19
177 rdf:type schema:PublicationVolume
178 N78332cd362884d668a12d897885c8179 schema:affiliation https://www.grid.ac/institutes/grid.419563.c
179 schema:familyName Frassineti
180 schema:givenName Giovanni Luca
181 rdf:type schema:Person
182 N79684f65b1304746b73783a7d7393b92 rdf:first Ndd97f2ee9ccb48b5980a5d4602d3f180
183 rdf:rest Nc219449faec14dbebb80784b434b58a5
184 N7a987f6bf883433990804da5dfbb52f3 rdf:first Nff97bddfb2d24f0298204088404b1867
185 rdf:rest N79684f65b1304746b73783a7d7393b92
186 N7cdbc007eefb497fb590fd331e3f90c0 schema:name Division of Medical Oncology, Department of Precision Medicine, University of Campania ‘Luigi Vanvitelli’ - School of Medicine, Via S.Pansini, 5, 80131, Naples, Italy
187 rdf:type schema:Organization
188 N7ce01f44c57b44beae4bf67429fe8c59 rdf:first Nccac40b72adc46919b2856af7395053c
189 rdf:rest Nb5398ecaff0d4ca9a5c11c80d0a0839c
190 N817c1ae90a5e48cf8bab512e290f8ee2 rdf:first N2a59692b4493447ca24722be44f20432
191 rdf:rest N06e6d6a85f8d4fb99df4fe3a077e7216
192 N82203955183d425b9e4c84dbdbfb60d0 schema:affiliation Neb2308bc19c64714845b55d1f94d2cde
193 schema:familyName Tortora
194 schema:givenName Giampaolo
195 rdf:type schema:Person
196 N8403c2c964b54b95a39ad0a03c495719 rdf:first N190ab46428d642aeb093ac25d2a5ed9e
197 rdf:rest N739d5914d8b04bbc999d11e9b7308c16
198 N8429477822c94211b9598913f7bb9c1d schema:name Department of Medical Oncology, P.O. G. Rodolico, Via Plebiscito, 628, Catania, Italy
199 rdf:type schema:Organization
200 N84633e80e3564e00a036baaff5687e78 rdf:first N2fa9203138e84c56bc4b27fe3cf889a0
201 rdf:rest Nc571d8e9aa2b493cb463d995e927a3c3
202 N84d5198ed9e8491882ce982dd49d24b5 schema:name Department of Medical Oncology, AOU di Modena, Via Emilia Est, 583-585, 41122, Modena, MO, Italy
203 rdf:type schema:Organization
204 N85a0c357da234a8fa2e55c67c7112374 rdf:first N53f9236b00284ee3844a166326f4b503
205 rdf:rest Ne6521184b79b435db2b25480efcba4b6
206 N8cbcfe4af9c041ecbe88e32dc5f57dcc schema:affiliation https://www.grid.ac/institutes/grid.412972.b
207 schema:familyName Pinotti
208 schema:givenName Graziella
209 rdf:type schema:Person
210 N8e4f9a8315ba447eb66d8b262136ff3b rdf:first Nb943b3cb88a24c4e9d71af03011604f0
211 rdf:rest N4a821ca4e68d4eeb976c90bb7bfc12e8
212 N9001b229bdef4457a692ab41c4183f6e rdf:first N8cbcfe4af9c041ecbe88e32dc5f57dcc
213 rdf:rest N7ce01f44c57b44beae4bf67429fe8c59
214 N90174ab24f85495bb9ff4c0d40156cb0 schema:affiliation N20b793021e194811918bd136f7195cfa
215 schema:familyName Cinieri
216 schema:givenName Saverio
217 rdf:type schema:Person
218 N922580c968cc4c51a0fc9c2676e57407 rdf:first Nab0c79d069c14daab6126d0221d2f8e9
219 rdf:rest N3ab3ecab55d74e50913142c6e43ffc87
220 N94377cd4938a45bd8d723b33128b603d schema:affiliation https://www.grid.ac/institutes/grid.411492.b
221 schema:familyName Cardellino
222 schema:givenName Giovanni Gerardo
223 rdf:type schema:Person
224 N977d695153e4490abc6c3b4310554174 schema:name Department of Medical Oncology, ASST Valle Olona, PO Saronno Piazzale Borella 1, 21047, Saronno, Varese, Italy
225 rdf:type schema:Organization
226 N9c3faeb0f27a456795a1599f0403dd3b schema:name Department of Medical Oncology, A.O.U. Citta della Salute e della Scienza di Torino, H Molinette, corso Bramante, 88, 10126, Torino, Italy
227 rdf:type schema:Organization
228 N9dad76be69a04cd5a770c616d1957c4c schema:affiliation N473722e6700f461da8adc3d3014f56b7
229 schema:familyName Tomasello
230 schema:givenName Gianluca
231 rdf:type schema:Person
232 N9e3b2130b77c44baaf69b9c07ace19af rdf:first Nd4c9d6567f124a0f99a05ca9cb57d4a2
233 rdf:rest N18ca5eb08aa34105872380d07b06c994
234 N9fe0524d8fb04ede824793296503471e rdf:first Ne66c3bef653849b78f599a54431fde58
235 rdf:rest Nf7a54c216b4c4a7b87b9f2540617d08e
236 Na56da8df5dd94e69be7a5381e0787995 schema:name Department of Medical Oncology, AOU Cagliari, Via Ospedale, 54, 09124, Cagliari, Italy
237 rdf:type schema:Organization
238 Nab0c79d069c14daab6126d0221d2f8e9 schema:affiliation https://www.grid.ac/institutes/grid.417208.8
239 schema:familyName Di Donato
240 schema:givenName Samantha
241 rdf:type schema:Person
242 Nb03ca58f77f44dfaa06d17be7ceaf10a schema:affiliation Nf12ae34eea6d42f789da12e51e056341
243 schema:familyName Giuliani
244 schema:givenName Francesco
245 rdf:type schema:Person
246 Nb5398ecaff0d4ca9a5c11c80d0a0839c rdf:first N82203955183d425b9e4c84dbdbfb60d0
247 rdf:rest N29aaf93535624d4ea179c33c369d7e20
248 Nb7ce6215bf4444e7bc792daa8583a4ad rdf:first N47f35e7aba3c434da5c112defbb0187d
249 rdf:rest N52ca8d724cea402cb8e71d11217ead77
250 Nb943b3cb88a24c4e9d71af03011604f0 schema:affiliation Nbb632c6e8d2c4bbaba43b3977565724f
251 schema:familyName Di Costanzo
252 schema:givenName Francesco
253 rdf:type schema:Person
254 Nbb632c6e8d2c4bbaba43b3977565724f schema:name Department of Medical Oncology, AOU Careggi di Firenze, Largo Brambilla, 3, 50134, Florence, Italy
255 rdf:type schema:Organization
256 Nc219449faec14dbebb80784b434b58a5 rdf:first Nf967d65d91ef4104b07ca3b85e811962
257 rdf:rest Ncd550a63425d419a8953e473ae833f02
258 Nc46e84d127c54c8ebe2fb37061c880c3 rdf:first N1f7d8e811fe94a0b9b5e5f0bab9327b7
259 rdf:rest N0b2efa88c48b470fa70ed1697c2e02f6
260 Nc571d8e9aa2b493cb463d995e927a3c3 rdf:first N070d274710094356bd4d2f7469a2bce4
261 rdf:rest Neb12c1363d3843bf9f1d3d1ce981351c
262 Nccac40b72adc46919b2856af7395053c schema:affiliation Nd6cae7dc9ba54db484d1cf026522b30b
263 schema:familyName Scagliotti
264 schema:givenName Giorgio
265 rdf:type schema:Person
266 Ncd550a63425d419a8953e473ae833f02 rdf:first N6ebd777dd70d429d86f8fa3414ba94f3
267 rdf:rest Nd0c335e3a2444f329efe93798276e641
268 Ncef9197450b342cba449494053d23350 rdf:first Nb03ca58f77f44dfaa06d17be7ceaf10a
269 rdf:rest Nd6c64a6d4d304ffd8ff615bc640eec53
270 Ncf564652930e42ebba75205a8ed76e8e schema:affiliation N7cdbc007eefb497fb590fd331e3f90c0
271 schema:familyName De Vita
272 schema:givenName Ferdinando
273 rdf:type schema:Person
274 Nd0b80235428049c2b5d7848333ed3b2c schema:affiliation https://www.grid.ac/institutes/grid.417728.f
275 schema:familyName Rimassa
276 schema:givenName Lorenza
277 rdf:type schema:Person
278 Nd0c335e3a2444f329efe93798276e641 rdf:first N247ab0991cc946d9a2ea52b276e2bbea
279 rdf:rest N922580c968cc4c51a0fc9c2676e57407
280 Nd4c9d6567f124a0f99a05ca9cb57d4a2 schema:affiliation https://www.grid.ac/institutes/grid.476844.d
281 schema:familyName Bertolini
282 schema:givenName Alessandro
283 rdf:type schema:Person
284 Nd6c64a6d4d304ffd8ff615bc640eec53 rdf:first N90174ab24f85495bb9ff4c0d40156cb0
285 rdf:rest Nb7ce6215bf4444e7bc792daa8583a4ad
286 Nd6cae7dc9ba54db484d1cf026522b30b schema:name Department of Medical Oncology, AOU San Luigi Gonzaga, Regione Gonzole, 10, 10043, Orbassano, Torino, Italy
287 rdf:type schema:Organization
288 Nd8e461b4dbc24197ba3fe4f27b9dc8e7 rdf:first Nf52198097fc2475eb85dccc7fd4bb14a
289 rdf:rest Nf2ab37621c9b42349576a4fd824e5e49
290 Ndb5f825b5ac04615bd1d584fff3073b2 schema:name Department of Medical Oncology, Ospedale Mater Salutis, Via Carlo Gianella, 1, 37045 Legnago, Verona, Italy
291 rdf:type schema:Organization
292 Ndc5c574142294c6f92dc8dadaff6290e schema:issueNumber 1
293 rdf:type schema:PublicationIssue
294 Ndd97f2ee9ccb48b5980a5d4602d3f180 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
295 schema:familyName Corallo
296 schema:givenName Salvatore
297 rdf:type schema:Person
298 Ne6521184b79b435db2b25480efcba4b6 rdf:first Ncf564652930e42ebba75205a8ed76e8e
299 rdf:rest N4aed74d1fdef43e885f313219a2a50e4
300 Ne66c3bef653849b78f599a54431fde58 schema:affiliation N84d5198ed9e8491882ce982dd49d24b5
301 schema:familyName Spallanzani
302 schema:givenName Andrea
303 rdf:type schema:Person
304 Ne7760f93b4fc49fe86c991233b9328e6 schema:name nlm_unique_id
305 schema:value 100967800
306 rdf:type schema:PropertyValue
307 Neb12c1363d3843bf9f1d3d1ce981351c rdf:first N56438b5643b04efbb46c3635584d06d1
308 rdf:rest N85a0c357da234a8fa2e55c67c7112374
309 Neb2308bc19c64714845b55d1f94d2cde schema:name Department of Medical Oncology, AOUI Verona Ospedale Policlinico ‘Giambattista Rossi’ di Borgo Roma, Piazzale L.A. Scuro, 10, 37134, Verona, VR, Italy
310 rdf:type schema:Organization
311 Nf12ae34eea6d42f789da12e51e056341 schema:name Department of Medical Oncology, I.R.C.C.S. Istituto Tumori Bari, Viale Orazio Flacco, 65, 70124, Bari, Italy
312 rdf:type schema:Organization
313 Nf2632d8a249a453ab853b917f97eeff0 schema:affiliation N977d695153e4490abc6c3b4310554174
314 schema:familyName Verusio
315 schema:givenName Claudio
316 rdf:type schema:Person
317 Nf2ab37621c9b42349576a4fd824e5e49 rdf:first N0200c84447b84edda0811ca18150012a
318 rdf:rest N9e3b2130b77c44baaf69b9c07ace19af
319 Nf52198097fc2475eb85dccc7fd4bb14a schema:affiliation https://www.grid.ac/institutes/grid.415025.7
320 schema:familyName Longarini
321 schema:givenName Raffaella
322 rdf:type schema:Person
323 Nf77002f5b0d24eeda183c5dc64528324 schema:affiliation https://www.grid.ac/institutes/grid.414614.2
324 schema:familyName Tassinari
325 schema:givenName Davide
326 rdf:type schema:Person
327 Nf7a54c216b4c4a7b87b9f2540617d08e rdf:first N78332cd362884d668a12d897885c8179
328 rdf:rest N0aab22079a9b4f6f87fd04f7320127c2
329 Nf967d65d91ef4104b07ca3b85e811962 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
330 schema:familyName Antista
331 schema:givenName Maria
332 rdf:type schema:Person
333 Nff97bddfb2d24f0298204088404b1867 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
334 schema:familyName Morano
335 schema:givenName Federica
336 rdf:type schema:Person
337 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
338 schema:name Medical and Health Sciences
339 rdf:type schema:DefinedTerm
340 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
341 schema:name Oncology and Carcinogenesis
342 rdf:type schema:DefinedTerm
343 sg:journal.1024632 schema:issn 1471-2407
344 schema:name BMC Cancer
345 rdf:type schema:Periodical
346 sg:pub.10.1007/s10120-010-0555-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007946888
347 https://doi.org/10.1007/s10120-010-0555-2
348 rdf:type schema:CreativeWork
349 sg:pub.10.1007/s11523-018-0562-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101776408
350 https://doi.org/10.1007/s11523-018-0562-5
351 rdf:type schema:CreativeWork
352 sg:pub.10.1038/sj.bjc.6600310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038773439
353 https://doi.org/10.1038/sj.bjc.6600310
354 rdf:type schema:CreativeWork
355 sg:pub.10.1054/bjoc.2000.1631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020520952
356 https://doi.org/10.1054/bjoc.2000.1631
357 rdf:type schema:CreativeWork
358 https://app.dimensions.ai/details/publication/pub.1077881828 schema:CreativeWork
359 https://doi.org/10.1002/14651858.cd004064.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012727308
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1002/14651858.cd004064.pub4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091386701
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1016/s0140-6736(10)61121-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044182432
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1016/s0140-6736(13)61719-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026636148
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1016/s0140-6736(16)30354-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005290224
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1016/s1470-2045(14)70420-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018632115
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1016/s1470-2045(18)30791-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111841259
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1056/nejmoa073149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014019609
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1093/annonc/mdn166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009962018
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1093/annonc/mdn717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053015328
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1097/00000658-200009000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032374760
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1158/1055-9965.epi-15-0578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063224193
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1200/jco.2006.06.8429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023864538
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1200/jco.2013.54.1011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014148840
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1200/jco.2018.36.4_suppl.tps195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111064966
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1634/theoncologist.2013-0137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034792547
390 rdf:type schema:CreativeWork
391 https://www.grid.ac/institutes/grid.411492.b schema:alternateName Ospedale Santa Maria della Misericordia di Udine
392 schema:name Department of Medical Oncology, Azienda Sanitaria Universitaria Integrata di Udine, Via Pozzuolo, 330 – 33100, piazzale Santa Maria della misericordia 15, 33100, Udine, Udine, Italy
393 rdf:type schema:Organization
394 https://www.grid.ac/institutes/grid.412972.b schema:alternateName Ospedale di Circolo e Fondazione Macchi
395 schema:name Department of Medical Oncology, Ospedale di Circolo e Fondazione Macchi, Viale Luigi Borri, 57, 21100, Varese, Italy
396 rdf:type schema:Organization
397 https://www.grid.ac/institutes/grid.413503.0 schema:alternateName Casa Sollievo della Sofferenza
398 schema:name Department of Medical Oncology, Casa Sollievo della Sofferenza, Viale Cappuccini, 1, 71013, San Giovanni Rotondo, FG, Italy
399 rdf:type schema:Organization
400 https://www.grid.ac/institutes/grid.414614.2 schema:alternateName Ospedale Infermi di Rimini
401 schema:name Department of Medical Oncology, Ospedale degli infermi di Rimini, Viale L. Settembrini, 2, 47923, Rimini, Italy
402 rdf:type schema:Organization
403 https://www.grid.ac/institutes/grid.415025.7 schema:alternateName Azienda Ospedaliera San Gerardo
404 schema:name Department of Medical Oncology, Ospedale San Gerardo, Via G. B. Pergolesi, 33, 20900, Monza, Italy
405 rdf:type schema:Organization
406 https://www.grid.ac/institutes/grid.415090.9 schema:alternateName Fondazione Poliambulanza Istituto Ospedaliero
407 schema:name Department of Medical Oncology, Fondazione Poliambulanza, Via Leonida Bissolati, 57, 25124, Brescia, Italy
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.416351.4 schema:alternateName Ospedale San Donato
410 schema:name Department of Medical Oncology, Ospedale San Donato, Azienda USL Toscana Sudest Via Pietro Nenni, 20/22, 52100, Arezzo, Italy
411 rdf:type schema:Organization
412 https://www.grid.ac/institutes/grid.417208.8 schema:alternateName Nuovo Ospedale di Prato
413 schema:name Sandro Pitigliani Medical Oncology Department, Nuovo Ospedale di Prato, Via Suor Niccolina Infermiera, 20, 59100, Prato, Italy
414 rdf:type schema:Organization
415 https://www.grid.ac/institutes/grid.417728.f schema:alternateName Humanitas Research Hospital
416 schema:name Medical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center, Via Alessandro Manzoni, 56, 20089, Rozzano, Milan, Italy
417 rdf:type schema:Organization
418 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
419 schema:name Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20133, Milan, Italy
420 rdf:type schema:Organization
421 https://www.grid.ac/institutes/grid.419557.b schema:alternateName Policlinico San Donato
422 schema:name Department of Medical Oncology, IRCCS Policlinico San Donato, Piazza Edmondo Malan, 2, 20097, San Donato Milanese, MI, Italy
423 rdf:type schema:Organization
424 https://www.grid.ac/institutes/grid.419563.c schema:alternateName Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
425 schema:name Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, via P. Maroncelli, 40, 47014, Meldola, Italy
426 Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Ravenna Viale Randi, 5, 48121, Ravenna, Italy
427 rdf:type schema:Organization
428 https://www.grid.ac/institutes/grid.4708.b schema:alternateName University of Milan
429 schema:name Department of Hematology-Oncology, University Milan, Milan, Italy
430 Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, via G. Venezian, 1, 20133, Milan, Italy
431 rdf:type schema:Organization
432 https://www.grid.ac/institutes/grid.476115.0 schema:alternateName Ospedali Riuniti Marche Nord
433 schema:name Department of Medical Oncology, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, Piazzale Cinelli, 4, 61121, Pesaro, Italy
434 rdf:type schema:Organization
435 https://www.grid.ac/institutes/grid.476844.d schema:alternateName ASST della Valtellina e dell'Alto Lario
436 schema:name Department of Medical Oncology, ASST della Valtellina e dell’Alto Lario, Via Stelvio, 25, 23100, Sondrio, Italy
437 rdf:type schema:Organization
438 https://www.grid.ac/institutes/grid.8142.f schema:alternateName Catholic University of the Sacred Heart
439 schema:name Department of Medical Oncology, Fondazione Policlinico Universitario “A. Gemelli” - IRCCS, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168, Rome, Italy
440 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...