Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis View Full Text


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Article Info

DATE

2019-12

AUTHORS

Khadiga Abdulrashid, Nour AlHussaini, Wifag Ahmed, Lukman Thalib

ABSTRACT

BACKGROUND: To systematically assess the prevalence of BRCA1 and BRCA2 gene mutations in women with Hereditary Breast and/or Ovarian Cancer (HBOC) in Arab countries and to describe the variability in the BRCA gene mutations in different regions of the Arab world. METHODS: Observational studies reporting prevalence of BRCA mutations from 22 Arab countries were systematically searched in databases including PUBMED, EMBASE, Web of Science, and Google Scholar. Two reviewers independently screened the studies and extracted data and assessed the risk of bias. Hoy's risk of Bias tool was used to assess the biases in individual studies. Due to substantial heterogeneity, pooled weighted estimates were calculated using Quality Effect Models (QEM) that adjust for bias, while the Random Effect Models (REM) estimates served as the sensitivity estimates. RESULTS: Fourteen studies reporting prevalence of BRCA were included. The pooled estimate of BRCA among HBOC was 20% (95% CI: 7-36%). Subgroup analysis including only those with low risk of bias provided an estimate of 11% (95% CI: 1-27%). Levant region had higher prevalence 28% (95% CI: 11-49%) compared to Arabian Gulf region and North Africa but differences are not statistically significant, when tested using Z-test for proportions. CONCLUSION: Given the pooled estimates vary widely with substantial heterogeneity, larger, well-designed studies are warranted to better understand the frequency and the impact of BRCA gene mutations among Arab women. TRIAL REGISTRATION: International Prospective Register of Systematic Reviews (PROSPERO) registration number: CRD42018095905 . More... »

PAGES

256

References to SciGraph publications

  • 2007-12. A novel BRCA-1 mutation in Arab kindred from east Jerusalem with breast and ovarian cancer in BMC CANCER
  • 2017-08. Family history and risk of breast cancer: an analysis accounting for family structure in BREAST CANCER RESEARCH AND TREATMENT
  • 2018-04. High prevalence of deleterious BRCA1 and BRCA2 germline mutations in arab breast and ovarian cancer patients in BREAST CANCER RESEARCH AND TREATMENT
  • 2017-03. Family history predictors of BRCA1/BRCA2 mutation status among Tunisian breast/ovarian cancer families in BREAST CANCER
  • 2016-12. Tumor characteristics and prognosis in familial breast cancer in BMC CANCER
  • 2013-03. The prevalence of BRCA mutations among familial breast cancer patients in Korea: results of the Korean Hereditary Breast Cancer study in FAMILIAL CANCER
  • 2012-02. Hereditary breast cancer in Middle Eastern and North African (MENA) populations: identification of novel, recurrent and founder BRCA1 mutations in the Tunisian population in MOLECULAR BIOLOGY REPORTS
  • 2018-12. Germline BRCA1/BRCA2 mutations among high risk breast cancer patients in Jordan in BMC CANCER
  • 2014-06. Germline BRCA mutation evaluation in a prospective triple-negative breast cancer registry: implications for hereditary breast and/or ovarian cancer syndrome testing in BREAST CANCER RESEARCH AND TREATMENT
  • 2017-12. High frequency of the recurrent c.1310_1313delAAGA BRCA2 mutation in the North-East of Morocco and implication for hereditary breast–ovarian cancer prevention and control in BMC RESEARCH NOTES
  • 2010-12. Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2003-06. Similar contributions of BRCA1 and BRCA2 germline mutations to early-onset breast cancer in Germany in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2012-12. Prevalance of BRCA1 and BRCA2 mutations in familial breast cancer patients in Lebanon in HEREDITARY CANCER IN CLINICAL PRACTICE
  • Journal

    TITLE

    BMC Cancer

    ISSUE

    1

    VOLUME

    19

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-019-5463-1

    DOI

    http://dx.doi.org/10.1186/s12885-019-5463-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112926599

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30898109


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    45 schema:description BACKGROUND: To systematically assess the prevalence of BRCA1 and BRCA2 gene mutations in women with Hereditary Breast and/or Ovarian Cancer (HBOC) in Arab countries and to describe the variability in the BRCA gene mutations in different regions of the Arab world. METHODS: Observational studies reporting prevalence of BRCA mutations from 22 Arab countries were systematically searched in databases including PUBMED, EMBASE, Web of Science, and Google Scholar. Two reviewers independently screened the studies and extracted data and assessed the risk of bias. Hoy's risk of Bias tool was used to assess the biases in individual studies. Due to substantial heterogeneity, pooled weighted estimates were calculated using Quality Effect Models (QEM) that adjust for bias, while the Random Effect Models (REM) estimates served as the sensitivity estimates. RESULTS: Fourteen studies reporting prevalence of BRCA were included. The pooled estimate of BRCA among HBOC was 20% (95% CI: 7-36%). Subgroup analysis including only those with low risk of bias provided an estimate of 11% (95% CI: 1-27%). Levant region had higher prevalence 28% (95% CI: 11-49%) compared to Arabian Gulf region and North Africa but differences are not statistically significant, when tested using Z-test for proportions. CONCLUSION: Given the pooled estimates vary widely with substantial heterogeneity, larger, well-designed studies are warranted to better understand the frequency and the impact of BRCA gene mutations among Arab women. TRIAL REGISTRATION: International Prospective Register of Systematic Reviews (PROSPERO) registration number: CRD42018095905 .
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