Increased MET gene copy number negatively affects the survival of esophageal squamous cell carcinoma patients View Full Text


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Article Info

DATE

2019-12

AUTHORS

Yanqiu Wang, Zhengzeng Jiang, Chen Xu, Hao Wang, Lijie Tan, Jieakesu Su, Xin Wang, Dongxian Jiang, Yingyong Hou, Qi Song

ABSTRACT

BACKGROUNDS: Since Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, its clinical pathologic characteristics are not well known in esophageal squamous cell carcinoma (ESCC). METHODS: We investigated MET gene status with fluorescence in situ hybridization (FISH) assay in 495 ESCC cases using tissue microarrays. Prognostic significance as well as correlations with various clinicopathological parameters was evaluated. RESULTS: Among 495 patients, 28 (5.7%) cases were MET FISH positive, including 5 cases (1%) with true gene amplification. There were no statistically significant associations between MET FISH-positivity and clinicopathologic characteristics. A significantly poorer prognosis was observed in 28 patients with MET FISH-positivity (disease free survival/DFS, P < 0.001 and overall survival/OS, P = 0.001). Multivariate analysis revealed MET FISH-positivity was an independent prognostic factor for DFS (hazard ratio/HR, 1.953; 95% confidence interval/CI, 1.271-2.999; P = 0.002) and OS (HR, 1.926; 95% CI, 1.243-2.983; P = 0.003). MET FISH-positivity was associated with DFS (P = 0.022 and 0.020) and OS (P = 0.046 and 0.024) both in stage I-II ESCC and in stage III-IVa ESCC. No statistical significance (DFS, P = 0.492 and OS, P = 0.344) was detected between stage I-II ESCC with MET FISH-positivity and stage III-IVa ESCC with FISH-negativity. CONCLUSIONS: Increased MET gene copy number is an independent prognostic factor in ESCC, and ESCC might have potentially been up-staged by increased MET gene copy number. The results indicate that increased MET gene copy number is a very promising parameter, in clinical therapy and follow-up plans. More... »

PAGES

240

References to SciGraph publications

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  • Journal

    TITLE

    BMC Cancer

    ISSUE

    1

    VOLUME

    19

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-019-5450-6

    DOI

    http://dx.doi.org/10.1186/s12885-019-5450-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112856394

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30885149


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        "description": "BACKGROUNDS: Since Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, its clinical pathologic characteristics are not well known in esophageal squamous cell carcinoma (ESCC).\nMETHODS: We investigated MET gene status with fluorescence in situ hybridization (FISH) assay in 495 ESCC cases using tissue microarrays. Prognostic significance as well as correlations with various clinicopathological parameters was evaluated.\nRESULTS: Among 495 patients, 28 (5.7%) cases were MET FISH positive, including 5 cases (1%) with true gene amplification. There were no statistically significant associations between MET FISH-positivity and clinicopathologic characteristics. A significantly poorer prognosis was observed in 28 patients with MET FISH-positivity (disease free survival/DFS, P\u2009<\u20090.001 and overall survival/OS, P\u2009=\u20090.001). Multivariate analysis revealed MET FISH-positivity was an independent prognostic factor for DFS (hazard ratio/HR, 1.953; 95% confidence interval/CI, 1.271-2.999; P\u2009=\u20090.002) and OS (HR, 1.926; 95% CI, 1.243-2.983; P\u2009=\u20090.003). MET FISH-positivity was associated with DFS (P\u2009=\u20090.022 and 0.020) and OS (P\u2009=\u20090.046 and 0.024) both in stage I-II ESCC and in stage III-IVa ESCC. No statistical significance (DFS, P\u2009=\u20090.492 and OS, P\u2009=\u20090.344) was detected between stage I-II ESCC with MET FISH-positivity and stage III-IVa ESCC with FISH-negativity.\nCONCLUSIONS: Increased MET gene copy number is an independent prognostic factor in ESCC, and ESCC might have potentially been up-staged by increased MET gene copy number. The results indicate that increased MET gene copy number is a very promising parameter, in clinical therapy and follow-up plans.", 
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    N-Triples is a line-based linked data format ideal for batch operations.

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    Turtle is a human-readable linked data format.

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    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-019-5450-6'


     

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    270 Department of Pathology, Zhongshan Hospital, Fudan University, 200032, Shanghai, People’s Republic of China
    271 rdf:type schema:Organization
     




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