Chronological occurrence of PI3KCA mutations in breast cancer liver metastases after repeat partial liver resection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Aldrick Ruiz, Mylène Sebagh, Raphaël Saffroy, Marc-Antoine Allard, Nelly Bosselut, Giulia Hardoin, Julie Vasseur, Jocelyne Hamelin, René Adam, Jean-François Morère, Antoinette Lemoine

ABSTRACT

BACKGROUND: Liver metastases of breast cancer are frequent and can recur even after "complete/R0" resection in combination with systemic and hormonal treatments. The aim of this study was to analyze throughout repeat hepatectomies for liver metastases the evolution of PI3KCA gene mutational status. METHODS: All liver metastases nodules (n = 70) from 19 women who underwent at least 2 liver resections were reexamined. DNA extraction from archived tumoral tissue was performed and the major 'hot spot' mutations in the helical and catalytic domains of PI3KCA have been analyzed using Massarray platform (Agena Bioscience) based on allelic discrimination PCR amplification followed by sensitive mass spectrometry detection. RESULTS: The two major somatic hot spot PI3KCA mutations were found in 27 (38.6%) nodules corresponding to 8 of the 19 patients (42%). The frequency of women whose breast cancer liver metastases (BCLM) carries PI3KCA mutations increased from the first to the third hepatectomy. Tumors carrying PI3KCA mutations are significantly larger and more frequently observed when resections were R0 compared to patients with no PI3KCA mutation. CONCLUSION: PI3KCA mutations are frequently observed in BCLM and persist along with the recurrence. Their identification in circulating tumor cells should become a useful biomarker in the routine practice of breast cancer management to prevent tumor recurrence and overcome the problems of intra- and inter-tumoral heterogeneity of the current biomarkers. More... »

PAGES

169

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-019-5365-2

DOI

http://dx.doi.org/10.1186/s12885-019-5365-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112315608

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30795751


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital Paul Brousse", 
          "id": "https://www.grid.ac/institutes/grid.413133.7", 
          "name": [
            "Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands", 
            "AP-HP H\u00f4pital Paul Brousse, Centre H\u00e9pato-Biliaire, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ruiz", 
        "givenName": "Aldrick", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "Department de Pathologie, AP-HP H\u00f4pital Paul Brousse, Villejuif, France", 
            "Inserm UMR-S 1193, Universit\u00e9 Paris-Sud, Orsay, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sebagh", 
        "givenName": "Myl\u00e8ne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Paul Brousse", 
          "id": "https://www.grid.ac/institutes/grid.413133.7", 
          "name": [
            "Inserm UMR-S 1193, Universit\u00e9 Paris-Sud, Orsay, France", 
            "AP-HP H\u00f4pital Paul Brousse, Department Oncog\u00e9n\u00e9tique, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saffroy", 
        "givenName": "Rapha\u00ebl", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Paul Brousse", 
          "id": "https://www.grid.ac/institutes/grid.413133.7", 
          "name": [
            "AP-HP H\u00f4pital Paul Brousse, Centre H\u00e9pato-Biliaire, Villejuif, France", 
            "Inserm UMR-S 1193, Universit\u00e9 Paris-Sud, Orsay, France", 
            "AP-HP H\u00f4pital Paul Brousse, Department Oncog\u00e9n\u00e9tique, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allard", 
        "givenName": "Marc-Antoine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Paul Brousse", 
          "id": "https://www.grid.ac/institutes/grid.413133.7", 
          "name": [
            "Inserm UMR-S 1193, Universit\u00e9 Paris-Sud, Orsay, France", 
            "AP-HP H\u00f4pital Paul Brousse, Department Oncog\u00e9n\u00e9tique, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bosselut", 
        "givenName": "Nelly", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Paul Brousse", 
          "id": "https://www.grid.ac/institutes/grid.413133.7", 
          "name": [
            "Inserm UMR-S 1193, Universit\u00e9 Paris-Sud, Orsay, France", 
            "AP-HP H\u00f4pital Paul Brousse, Department Oncog\u00e9n\u00e9tique, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hardoin", 
        "givenName": "Giulia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Paul Brousse", 
          "id": "https://www.grid.ac/institutes/grid.413133.7", 
          "name": [
            "Inserm UMR-S 1193, Universit\u00e9 Paris-Sud, Orsay, France", 
            "AP-HP H\u00f4pital Paul Brousse, Department Oncog\u00e9n\u00e9tique, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vasseur", 
        "givenName": "Julie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Paul Brousse", 
          "id": "https://www.grid.ac/institutes/grid.413133.7", 
          "name": [
            "Inserm UMR-S 1193, Universit\u00e9 Paris-Sud, Orsay, France", 
            "AP-HP H\u00f4pital Paul Brousse, Department Oncog\u00e9n\u00e9tique, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamelin", 
        "givenName": "Jocelyne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "AP-HP H\u00f4pital Paul Brousse, Centre H\u00e9pato-Biliaire, Villejuif, France", 
            "Inserm UMR-S 985, Universit\u00e9 Paris-Sud, Orsay, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adam", 
        "givenName": "Ren\u00e9", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Paul Brousse", 
          "id": "https://www.grid.ac/institutes/grid.413133.7", 
          "name": [
            "Inserm UMR-S 1193, Universit\u00e9 Paris-Sud, Orsay, France", 
            "Department. Canc\u00e9rologie, AP-HP H\u00f4pital Paul Brousse, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mor\u00e8re", 
        "givenName": "Jean-Fran\u00e7ois", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Paul Brousse", 
          "id": "https://www.grid.ac/institutes/grid.413133.7", 
          "name": [
            "Inserm UMR-S 1193, Universit\u00e9 Paris-Sud, Orsay, France", 
            "AP-HP H\u00f4pital Paul Brousse, Department Oncog\u00e9n\u00e9tique, Villejuif, France", 
            "Departement of Oncogenetics, APHP, GH Paris-Sud, H\u00f4pital Paul Brousse, Inserm UMR-S 1193, Universit\u00e9 Paris-Saclay, 14 Avenue Paul Vaillant Couturier, 94800, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lemoine", 
        "givenName": "Antoinette", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s12032-012-0388-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002468701", 
          "https://doi.org/10.1007/s12032-012-0388-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12032-012-0388-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002468701", 
          "https://doi.org/10.1007/s12032-012-0388-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-015-4785-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002671205", 
          "https://doi.org/10.1245/s10434-015-4785-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11523-014-0346-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007590290", 
          "https://doi.org/10.1007/s11523-014-0346-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-016-3980-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008310682", 
          "https://doi.org/10.1007/s10549-016-3980-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-016-3980-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008310682", 
          "https://doi.org/10.1007/s10549-016-3980-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clbc.2012.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010906906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0406-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011706736", 
          "https://doi.org/10.1007/s10549-009-0406-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0406-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011706736", 
          "https://doi.org/10.1007/s10549-009-0406-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0406-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011706736", 
          "https://doi.org/10.1007/s10549-009-0406-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmoldx.2012.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012669323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-6216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015739612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000096135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016171708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a003236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018857156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7314/apjcp.2013.14.9.5067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018982711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2006.10.901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020034642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pai.0000000000000315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021365723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pai.0000000000000315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021365723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10552-011-9859-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026353863", 
          "https://doi.org/10.1007/s10552-011-9859-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-016-5522-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028907937", 
          "https://doi.org/10.1245/s10434-016-5522-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-016-5522-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028907937", 
          "https://doi.org/10.1245/s10434-016-5522-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030885951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000357781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033836643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-1173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035440263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038283584", 
          "https://doi.org/10.1038/onc.2008.245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000246847.02058.1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040026283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000246847.02058.1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040026283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.25.9820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045520644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0046-8177(03)00405-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049372103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.959840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062662765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1389450115666141029234200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069181325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.26687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100472218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.26687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100472218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-018-4714-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101127445", 
          "https://doi.org/10.1007/s10549-018-4714-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-018-4714-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101127445", 
          "https://doi.org/10.1007/s10549-018-4714-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-018-4714-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101127445", 
          "https://doi.org/10.1007/s10549-018-4714-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Liver metastases of breast cancer are frequent and can recur even after \"complete/R0\" resection in combination with systemic and hormonal treatments. The aim of this study was to analyze throughout repeat hepatectomies for liver metastases the evolution of PI3KCA gene mutational status.\nMETHODS: All liver metastases nodules (n\u2009=\u200970) from 19 women who underwent at least 2 liver resections were reexamined. DNA extraction from archived tumoral tissue was performed and the major 'hot spot' mutations in the helical and catalytic domains of PI3KCA have been analyzed using Massarray platform (Agena Bioscience) based on allelic discrimination PCR amplification followed by sensitive mass spectrometry detection.\nRESULTS: The two major somatic hot spot PI3KCA mutations were found in 27 (38.6%) nodules corresponding to 8 of the 19 patients (42%). The frequency of women whose breast cancer liver metastases (BCLM) carries PI3KCA mutations increased from the first to the third hepatectomy. Tumors carrying PI3KCA mutations are significantly larger and more frequently observed when resections were R0 compared to patients with no PI3KCA mutation.\nCONCLUSION: PI3KCA mutations are frequently observed in BCLM and persist along with the recurrence. Their identification in circulating tumor cells should become a useful biomarker in the routine practice of breast cancer management to prevent tumor recurrence and overcome the problems of intra- and inter-tumoral heterogeneity of the current biomarkers.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12885-019-5365-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4122385", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Chronological occurrence of PI3KCA mutations in breast cancer liver metastases after repeat partial liver resection", 
    "pagination": "169", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "154dd1090d92c7dd7d83533056f0b65e1ede89cf3aaab5b0ca6a4f70237bfa5a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30795751"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12885-019-5365-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112315608"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12885-019-5365-2", 
      "https://app.dimensions.ai/details/publication/pub.1112315608"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60351_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12885-019-5365-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-019-5365-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-019-5365-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-019-5365-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-019-5365-2'


 

This table displays all metadata directly associated to this object as RDF triples.

227 TRIPLES      21 PREDICATES      55 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12885-019-5365-2 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Ndd6e5d56e6064c8f8ee7b02e54bcd1a6
4 schema:citation sg:pub.10.1007/s10549-009-0406-1
5 sg:pub.10.1007/s10549-016-3980-z
6 sg:pub.10.1007/s10549-018-4714-1
7 sg:pub.10.1007/s10552-011-9859-8
8 sg:pub.10.1007/s11523-014-0346-5
9 sg:pub.10.1007/s12032-012-0388-4
10 sg:pub.10.1038/onc.2008.245
11 sg:pub.10.1245/s10434-015-4785-8
12 sg:pub.10.1245/s10434-016-5522-7
13 https://doi.org/10.1002/jcb.26687
14 https://doi.org/10.1016/j.ajog.2006.10.901
15 https://doi.org/10.1016/j.clbc.2012.11.001
16 https://doi.org/10.1016/j.jmoldx.2012.02.009
17 https://doi.org/10.1016/s0046-8177(03)00405-2
18 https://doi.org/10.1093/annonc/mdu498
19 https://doi.org/10.1097/01.sla.0000246847.02058.1b
20 https://doi.org/10.1097/pai.0000000000000315
21 https://doi.org/10.1101/cshperspect.a003236
22 https://doi.org/10.1126/science.959840
23 https://doi.org/10.1158/0008-5472.can-07-6216
24 https://doi.org/10.1158/1078-0432.ccr-09-1173
25 https://doi.org/10.1159/000096135
26 https://doi.org/10.1159/000357781
27 https://doi.org/10.1200/jco.2009.25.9820
28 https://doi.org/10.2174/1389450115666141029234200
29 https://doi.org/10.7314/apjcp.2013.14.9.5067
30 schema:datePublished 2019-12
31 schema:datePublishedReg 2019-12-01
32 schema:description BACKGROUND: Liver metastases of breast cancer are frequent and can recur even after "complete/R0" resection in combination with systemic and hormonal treatments. The aim of this study was to analyze throughout repeat hepatectomies for liver metastases the evolution of PI3KCA gene mutational status. METHODS: All liver metastases nodules (n = 70) from 19 women who underwent at least 2 liver resections were reexamined. DNA extraction from archived tumoral tissue was performed and the major 'hot spot' mutations in the helical and catalytic domains of PI3KCA have been analyzed using Massarray platform (Agena Bioscience) based on allelic discrimination PCR amplification followed by sensitive mass spectrometry detection. RESULTS: The two major somatic hot spot PI3KCA mutations were found in 27 (38.6%) nodules corresponding to 8 of the 19 patients (42%). The frequency of women whose breast cancer liver metastases (BCLM) carries PI3KCA mutations increased from the first to the third hepatectomy. Tumors carrying PI3KCA mutations are significantly larger and more frequently observed when resections were R0 compared to patients with no PI3KCA mutation. CONCLUSION: PI3KCA mutations are frequently observed in BCLM and persist along with the recurrence. Their identification in circulating tumor cells should become a useful biomarker in the routine practice of breast cancer management to prevent tumor recurrence and overcome the problems of intra- and inter-tumoral heterogeneity of the current biomarkers.
33 schema:genre research_article
34 schema:inLanguage en
35 schema:isAccessibleForFree true
36 schema:isPartOf N1e3ce299e71e481fbd32081576407476
37 N3b0bafd9ff3845a49c2d4ec596be105e
38 sg:journal.1024632
39 schema:name Chronological occurrence of PI3KCA mutations in breast cancer liver metastases after repeat partial liver resection
40 schema:pagination 169
41 schema:productId N07dd639537234a7cac657d1c69d7fd45
42 N09729b67a7ec44ba8bbbc3a6fde9e387
43 N17fe02fcfdb1400998c10108c5319b63
44 N8aac2d24be7a41519ec9f1567061552b
45 Nfc2d42c7d863426ea0b6d6fc94a22634
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112315608
47 https://doi.org/10.1186/s12885-019-5365-2
48 schema:sdDatePublished 2019-04-11T11:02
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher Ndfd430754db74a4bb55ae81b6404b2c1
51 schema:url https://link.springer.com/10.1186%2Fs12885-019-5365-2
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N00e429a9628f44c0a4623d7d8394433e rdf:first N7bc641f528494307a27c364638d5e5aa
56 rdf:rest N5d0d4c5b9a504ab2a4a2fa3271e726f0
57 N07dd639537234a7cac657d1c69d7fd45 schema:name dimensions_id
58 schema:value pub.1112315608
59 rdf:type schema:PropertyValue
60 N09729b67a7ec44ba8bbbc3a6fde9e387 schema:name doi
61 schema:value 10.1186/s12885-019-5365-2
62 rdf:type schema:PropertyValue
63 N17fe02fcfdb1400998c10108c5319b63 schema:name nlm_unique_id
64 schema:value 100967800
65 rdf:type schema:PropertyValue
66 N1e3ce299e71e481fbd32081576407476 schema:volumeNumber 19
67 rdf:type schema:PublicationVolume
68 N23683a7c66e04d17bbdb31da0b92590c rdf:first N9fa8709e01774536a9a47140d7f45584
69 rdf:rest Nf80d9f570cb94dba8f076e26f4ee3712
70 N315aaf3ebdcb4fbbbadfaaa4331d26bb rdf:first N88db8b3d4d5a47a280af9cf8e0d4642b
71 rdf:rest N00e429a9628f44c0a4623d7d8394433e
72 N376ae20bcb74425a8f77c9cdfc9e901f rdf:first N9f5f30d1e9a4492d8ad92dc100b23b1a
73 rdf:rest N315aaf3ebdcb4fbbbadfaaa4331d26bb
74 N3b0bafd9ff3845a49c2d4ec596be105e schema:issueNumber 1
75 rdf:type schema:PublicationIssue
76 N58786128ee194210b036991092b4bc0c rdf:first Na6aa1145cd604782be9e49451b86f0a5
77 rdf:rest rdf:nil
78 N5d0d4c5b9a504ab2a4a2fa3271e726f0 rdf:first N8695df2b5d34490dab472e5a95f4a91a
79 rdf:rest N58786128ee194210b036991092b4bc0c
80 N64ab6558fc824be3a8c1428e1d9d0cb3 schema:affiliation https://www.grid.ac/institutes/grid.413133.7
81 schema:familyName Bosselut
82 schema:givenName Nelly
83 rdf:type schema:Person
84 N6e9148c6b5074e5ca6e96ae38e0b2d30 schema:affiliation https://www.grid.ac/institutes/grid.413133.7
85 schema:familyName Ruiz
86 schema:givenName Aldrick
87 rdf:type schema:Person
88 N7bc641f528494307a27c364638d5e5aa schema:affiliation https://www.grid.ac/institutes/grid.5842.b
89 schema:familyName Adam
90 schema:givenName René
91 rdf:type schema:Person
92 N8695df2b5d34490dab472e5a95f4a91a schema:affiliation https://www.grid.ac/institutes/grid.413133.7
93 schema:familyName Morère
94 schema:givenName Jean-François
95 rdf:type schema:Person
96 N88db8b3d4d5a47a280af9cf8e0d4642b schema:affiliation https://www.grid.ac/institutes/grid.413133.7
97 schema:familyName Hamelin
98 schema:givenName Jocelyne
99 rdf:type schema:Person
100 N8aac2d24be7a41519ec9f1567061552b schema:name readcube_id
101 schema:value 154dd1090d92c7dd7d83533056f0b65e1ede89cf3aaab5b0ca6a4f70237bfa5a
102 rdf:type schema:PropertyValue
103 N9324436484c74f0bbc8fac5df956ae1b schema:affiliation https://www.grid.ac/institutes/grid.5842.b
104 schema:familyName Sebagh
105 schema:givenName Mylène
106 rdf:type schema:Person
107 N9f5f30d1e9a4492d8ad92dc100b23b1a schema:affiliation https://www.grid.ac/institutes/grid.413133.7
108 schema:familyName Vasseur
109 schema:givenName Julie
110 rdf:type schema:Person
111 N9fa8709e01774536a9a47140d7f45584 schema:affiliation https://www.grid.ac/institutes/grid.413133.7
112 schema:familyName Saffroy
113 schema:givenName Raphaël
114 rdf:type schema:Person
115 Na6aa1145cd604782be9e49451b86f0a5 schema:affiliation https://www.grid.ac/institutes/grid.413133.7
116 schema:familyName Lemoine
117 schema:givenName Antoinette
118 rdf:type schema:Person
119 Nb8d1b31f743b41fe8d0ea3bfeaa522cd rdf:first N64ab6558fc824be3a8c1428e1d9d0cb3
120 rdf:rest Nb967817956734d9a84c671f2b982f462
121 Nb967817956734d9a84c671f2b982f462 rdf:first Nbcb9c8e91c4a45528d5c90869dd36ed2
122 rdf:rest N376ae20bcb74425a8f77c9cdfc9e901f
123 Nbcb9c8e91c4a45528d5c90869dd36ed2 schema:affiliation https://www.grid.ac/institutes/grid.413133.7
124 schema:familyName Hardoin
125 schema:givenName Giulia
126 rdf:type schema:Person
127 Nd230b9b2360c4b91a5f222cba5afa2a5 schema:affiliation https://www.grid.ac/institutes/grid.413133.7
128 schema:familyName Allard
129 schema:givenName Marc-Antoine
130 rdf:type schema:Person
131 Ndd6e5d56e6064c8f8ee7b02e54bcd1a6 rdf:first N6e9148c6b5074e5ca6e96ae38e0b2d30
132 rdf:rest Nfa1573a4a9f647f6b9d5b09b458197cd
133 Ndfd430754db74a4bb55ae81b6404b2c1 schema:name Springer Nature - SN SciGraph project
134 rdf:type schema:Organization
135 Nf80d9f570cb94dba8f076e26f4ee3712 rdf:first Nd230b9b2360c4b91a5f222cba5afa2a5
136 rdf:rest Nb8d1b31f743b41fe8d0ea3bfeaa522cd
137 Nfa1573a4a9f647f6b9d5b09b458197cd rdf:first N9324436484c74f0bbc8fac5df956ae1b
138 rdf:rest N23683a7c66e04d17bbdb31da0b92590c
139 Nfc2d42c7d863426ea0b6d6fc94a22634 schema:name pubmed_id
140 schema:value 30795751
141 rdf:type schema:PropertyValue
142 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
143 schema:name Medical and Health Sciences
144 rdf:type schema:DefinedTerm
145 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
146 schema:name Oncology and Carcinogenesis
147 rdf:type schema:DefinedTerm
148 sg:grant.4122385 http://pending.schema.org/fundedItem sg:pub.10.1186/s12885-019-5365-2
149 rdf:type schema:MonetaryGrant
150 sg:journal.1024632 schema:issn 1471-2407
151 schema:name BMC Cancer
152 rdf:type schema:Periodical
153 sg:pub.10.1007/s10549-009-0406-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011706736
154 https://doi.org/10.1007/s10549-009-0406-1
155 rdf:type schema:CreativeWork
156 sg:pub.10.1007/s10549-016-3980-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1008310682
157 https://doi.org/10.1007/s10549-016-3980-z
158 rdf:type schema:CreativeWork
159 sg:pub.10.1007/s10549-018-4714-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101127445
160 https://doi.org/10.1007/s10549-018-4714-1
161 rdf:type schema:CreativeWork
162 sg:pub.10.1007/s10552-011-9859-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026353863
163 https://doi.org/10.1007/s10552-011-9859-8
164 rdf:type schema:CreativeWork
165 sg:pub.10.1007/s11523-014-0346-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007590290
166 https://doi.org/10.1007/s11523-014-0346-5
167 rdf:type schema:CreativeWork
168 sg:pub.10.1007/s12032-012-0388-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002468701
169 https://doi.org/10.1007/s12032-012-0388-4
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/onc.2008.245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038283584
172 https://doi.org/10.1038/onc.2008.245
173 rdf:type schema:CreativeWork
174 sg:pub.10.1245/s10434-015-4785-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002671205
175 https://doi.org/10.1245/s10434-015-4785-8
176 rdf:type schema:CreativeWork
177 sg:pub.10.1245/s10434-016-5522-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028907937
178 https://doi.org/10.1245/s10434-016-5522-7
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1002/jcb.26687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100472218
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.ajog.2006.10.901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020034642
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.clbc.2012.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010906906
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.jmoldx.2012.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012669323
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/s0046-8177(03)00405-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049372103
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1093/annonc/mdu498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030885951
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1097/01.sla.0000246847.02058.1b schema:sameAs https://app.dimensions.ai/details/publication/pub.1040026283
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1097/pai.0000000000000315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021365723
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1101/cshperspect.a003236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018857156
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1126/science.959840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062662765
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1158/0008-5472.can-07-6216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015739612
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1158/1078-0432.ccr-09-1173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035440263
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1159/000096135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016171708
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1159/000357781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033836643
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1200/jco.2009.25.9820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045520644
209 rdf:type schema:CreativeWork
210 https://doi.org/10.2174/1389450115666141029234200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069181325
211 rdf:type schema:CreativeWork
212 https://doi.org/10.7314/apjcp.2013.14.9.5067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018982711
213 rdf:type schema:CreativeWork
214 https://www.grid.ac/institutes/grid.413133.7 schema:alternateName Hospital Paul Brousse
215 schema:name AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire, Villejuif, France
216 AP-HP Hôpital Paul Brousse, Department Oncogénétique, Villejuif, France
217 Departement of Oncogenetics, APHP, GH Paris-Sud, Hôpital Paul Brousse, Inserm UMR-S 1193, Université Paris-Saclay, 14 Avenue Paul Vaillant Couturier, 94800, Villejuif, France
218 Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
219 Department. Cancérologie, AP-HP Hôpital Paul Brousse, Villejuif, France
220 Inserm UMR-S 1193, Université Paris-Sud, Orsay, France
221 rdf:type schema:Organization
222 https://www.grid.ac/institutes/grid.5842.b schema:alternateName University of Paris-Sud
223 schema:name AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire, Villejuif, France
224 Department de Pathologie, AP-HP Hôpital Paul Brousse, Villejuif, France
225 Inserm UMR-S 1193, Université Paris-Sud, Orsay, France
226 Inserm UMR-S 985, Université Paris-Sud, Orsay, France
227 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...