Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Swetlana Rot, Tom Kaune, Helge Taubert, Thomas Greither, Johanna Kotrba, Antje Güttler, Henri Wichmann, Udo Bilkenroth, Andreas Wienke, Bilal Al-Nawas, Matthias Bache, Dirk Vordermark, Claudia Wickenhauser, Daniel Bethmann, Alexander W. Eckert, Matthias Kappler

ABSTRACT

BACKGROUND: The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5FL) in progression and prognosis of several cancers was reported. However, the biological function of three splice variants of LGR5 (LGR5Δ5, LGR5Δ8 and LGR5Δ5-8) has yet to be thoroughly investigated. METHODS: Seventy-eight frozen tumor samples from adult OSCC patients were studied using quantitative real-time TaqMan™ PCR analysis. The mRNA levels of full length LGR5, the splice variant of LGR5 lacking exon 5 (LGR5Δ5), the splice variant of LGR5 lacking exon 8 (LGR5Δ8) and the mRNA level of all known transcript variants together (LGR5all) were quantified and correlated to overall and disease-specific survival of OSCC patients, clinical parameters and the mRNA level of different tumor-associated markers. RESULTS: An elevated level of tumoral LGR5Δ5 mRNA, but not LGR5FL, LGR5Δ8 or LGR5all mRNA was significantly associated with a poor prognosis for the overall and disease-specific survival of OSCC patients (hazard ratio (HR) = 2.0; p = 0.02; 95% CI: 1.1-3.7; HR = 3.2; p = 0.01; 95% CI: 1.3-8.0; multivariable Cox regression), respectively. Additionally, a higher tumoral level of LGR5Δ5 mRNA in primary tumors was associated with the occurrence of regional lymph node metastases in OSCC patients (odds ratio (OR) = 3.1; p = 0.022; 95% CI: 1.2-7.9; binary logistic regression). Furthermore, the mRNA levels of all investigated LGR5 transcript variants were significantly correlated with the mRNA expression of Wnt-target genes and markers of epithelial-to-mesenchymal transition (EMT). CONCLUSION: The mRNA level of the LGR5 splice variant LGR5Δ5 is an independent negative prognostic marker for overall and disease-specific survival and metastasis in OSCC patients. Additionally, we suggest, all LGR5 transcript variants are involved in the EMT process mainly through activating the Wnt-signalling pathway. More... »

PAGES

155

References to SciGraph publications

  • 2016-05. Full-length LGR5-positive cells have chemoresistant characteristics in colorectal cancer in BRITISH JOURNAL OF CANCER
  • 2016-12. Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2010-12. Elevated tumor and serum levels of the hypoxia-associated protein osteopontin are associated with prognosis for soft tissue sarcoma patients in BMC CANCER
  • 2011-04. Significance of Lgr5+ve Cancer Stem Cells in the Colon and Rectum in ANNALS OF SURGICAL ONCOLOGY
  • 2012-01. Clonal evolution in cancer in NATURE
  • 2011-12. A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients in BMC CANCER
  • 2010-05. Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with β-catenin in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2009-01. Crypt stem cells as the cells-of-origin of intestinal cancer in NATURE
  • 2011-03. The cancer stem cell: premises, promises and challenges in NATURE MEDICINE
  • 2011-08. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling in NATURE
  • 2008-06. Analyzing real-time PCR data by the comparative CT method in NATURE PROTOCOLS
  • 2012-12. Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival in WORLD JOURNAL OF SURGICAL ONCOLOGY
  • 2007-10-25. Identification of stem cells in small intestine and colon by marker gene Lgr5 in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-019-5327-8

    DOI

    http://dx.doi.org/10.1186/s12885-019-5327-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112168783

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30770730


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