Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Robert Mechera, Savas D. Soysal, Salvatore Piscuoglio, Charlotte K. Y. Ng, Jasmin Zeindler, Edin Mujagic, Silvio Däster, Philippe Glauser, Henry Hoffmann, Ergin Kilic, Raoul A. Droeser, Walter P. Weber, Simone Muenst

ABSTRACT

BACKGROUND: The Rearranged during Transfection (RET) protein is overexpressed in a subset of Estrogen Receptor (ER) positive breast cancer, with both signalling pathways functionally interacting. This cross-talk plays a pivotal role in the resistance of breast cancer cells to anti-endocrine therapies, and RET expression is assumed to correlate with poor prognosis based on findings in small patient cohorts. The aim of our study was to investigate the impact of RET expression on patient outcome in human breast cancer. METHODS: We performed an immunohistochemical analysis of RET protein expression on a tissue microarray encompassing 990 breast cancer patients and correlated its expression with clinicopathological parameters and survival data. RESULTS: Expression of RET was detected in 409 out of 990 cases (41.3%). RET and ER expression significantly correlated (p < 0.0001). The Luminal B HER2-positive subtype showed the highest expression rate (48.9%). In univariate and multivariate survival analyses, RET expression had no impact on overall survival. CONCLUSION: We confirmed the co-expression of RET and ER, but we did not find RET expression to be an independent prognostic factor in human breast cancer. Clinical trials with newly developed RET inhibitors are needed to evaluate if RET inhibition has a beneficial impact on patient survival in ER positive breast cancer. More... »

PAGES

41

References to SciGraph publications

  • 2005-03. A phase II trial of imatinib mesylate monotherapy in patients with metastatic breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2011-01. Phase I/II study of sorafenib with anastrozole in patients with hormone receptor positive aromatase inhibitor resistant metastatic breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2009-08. Functional RET G691S polymorphism in cutaneous malignant melanoma in ONCOGENE
  • 2010-08. Diverse somatic mutation patterns and pathway alterations in human cancers in NATURE
  • 2010-05. Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2014-07. Randomised, phase II, placebo-controlled, trial of fulvestrant plus vandetanib in postmenopausal women with bone only or bone predominant, hormone-receptor-positive metastatic breast cancer (MBC): the OCOG ZAMBONEY study in BREAST CANCER RESEARCH AND TREATMENT
  • 2009-09. Biological determinants of endocrine resistance in breast cancer in NATURE REVIEWS CANCER
  • 2002-02. Endocrine-responsive breast cancer and strategies for combating resistance in NATURE REVIEWS CANCER
  • 2010-08. Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance in ONCOGENE
  • 2007-03. High-throughput oncogene mutation profiling in human cancer in NATURE GENETICS
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2000-01. Preferential induction of RET/PTC1 rearrangement by X-ray irradiation in ONCOGENE
  • 2014-02. Targeting RET–interleukin-6 crosstalk to impair metastatic dissemination in breast cancer in BREAST CANCER RESEARCH
  • 2017-11-28. Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes in NATURE REVIEWS CLINICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-018-5262-0

    DOI

    http://dx.doi.org/10.1186/s12885-018-5262-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111258988

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30621641


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mechera", 
            "givenName": "Robert", 
            "id": "sg:person.01206741437.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206741437.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soysal", 
            "givenName": "Savas D.", 
            "id": "sg:person.01010021003.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010021003.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Institute of Pathology, University Hospital Basel, Schoenbeinstrasse 40, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Piscuoglio", 
            "givenName": "Salvatore", 
            "id": "sg:person.01125606555.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125606555.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Institute of Pathology, University Hospital Basel, Schoenbeinstrasse 40, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ng", 
            "givenName": "Charlotte K. Y.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zeindler", 
            "givenName": "Jasmin", 
            "id": "sg:person.07477276143.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07477276143.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mujagic", 
            "givenName": "Edin", 
            "id": "sg:person.01045546227.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045546227.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "D\u00e4ster", 
            "givenName": "Silvio", 
            "id": "sg:person.0761012721.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761012721.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Glauser", 
            "givenName": "Philippe", 
            "id": "sg:person.01027302221.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027302221.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hoffmann", 
            "givenName": "Henry", 
            "id": "sg:person.0770061073.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770061073.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Klinikum Leverkusen", 
              "id": "https://www.grid.ac/institutes/grid.419829.f", 
              "name": [
                "Institute of Pathology, Klinikum Leverkusen, Am Gesundheitspark 11, 51375, Leverkusen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kilic", 
            "givenName": "Ergin", 
            "id": "sg:person.01042746007.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042746007.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Droeser", 
            "givenName": "Raoul A.", 
            "id": "sg:person.01106126030.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106126030.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weber", 
            "givenName": "Walter P.", 
            "id": "sg:person.01070304064.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070304064.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Institute of Pathology, University Hospital Basel, Schoenbeinstrasse 40, 4031, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muenst", 
            "givenName": "Simone", 
            "id": "sg:person.0773447031.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773447031.32"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-5100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000276458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-1164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002920346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molmed.2010.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005054811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-010-1226-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006963157", 
              "https://doi.org/10.1007/s10549-010-1226-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-010-1226-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006963157", 
              "https://doi.org/10.1007/s10549-010-1226-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdr304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009166329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009178333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90659-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009651973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.8417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010151719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010728744", 
              "https://doi.org/10.1038/onc.2010.209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010728744", 
              "https://doi.org/10.1038/onc.2010.209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/147323000803600406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011121585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/147323000803600406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011121585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3182a6f552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012375147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3182a6f552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012375147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-3835(03)00456-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013061179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.11826", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014113619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.15.5242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015727358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018166274", 
              "https://doi.org/10.1038/nrc2713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018166274", 
              "https://doi.org/10.1038/nrc2713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021860958", 
              "https://doi.org/10.1038/ng1975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.893", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023558420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-014-3015-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023620699", 
              "https://doi.org/10.1007/s10549-014-3015-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jclinpath-2015-202907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023918141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024942368", 
              "https://doi.org/10.1038/nature11412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-2843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025407714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1001216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025496032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-010-0788-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027199206", 
              "https://doi.org/10.1007/s10549-010-0788-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-010-0788-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027199206", 
              "https://doi.org/10.1007/s10549-010-0788-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027532046", 
              "https://doi.org/10.1038/onc.2009.164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027532046", 
              "https://doi.org/10.1038/onc.2009.164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdn352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029758282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1109653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029978324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033032980", 
              "https://doi.org/10.1038/nrc721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033032980", 
              "https://doi.org/10.1038/nrc721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033872440", 
              "https://doi.org/10.1038/sj.onc.1203343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033872440", 
              "https://doi.org/10.1038/sj.onc.1203343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-2221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035226197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-2343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035462110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-004-3974-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036237794", 
              "https://doi.org/10.1007/s10549-004-3974-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-004-3974-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036237794", 
              "https://doi.org/10.1007/s10549-004-3974-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mds190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037862382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(02)00528-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038114186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/erc.1.01120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040101583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/erc.1.01120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040101583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdl016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040588612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr3608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045222196", 
              "https://doi.org/10.1186/bcr3608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.25.9820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045520644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-4265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047393587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.surg.2005.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047944194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.surg.2005.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047944194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048324405", 
              "https://doi.org/10.1038/nature09208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/emmm.201302625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050726278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0010279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053279403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2470152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062539373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138955710791185154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069183139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.25.6.1551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071515512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncoscience.345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084850983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2017.188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093043252", 
              "https://doi.org/10.1038/nrclinonc.2017.188"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "BACKGROUND: The Rearranged during Transfection (RET) protein is overexpressed in a subset of Estrogen Receptor (ER) positive breast cancer, with both signalling pathways functionally interacting. This cross-talk plays a pivotal role in the resistance of breast cancer cells to anti-endocrine therapies, and RET expression is assumed to correlate with poor prognosis based on findings in small patient cohorts. The aim of our study was to investigate the impact of RET expression on patient outcome in human breast cancer.\nMETHODS: We performed an immunohistochemical analysis of RET protein expression on a tissue microarray encompassing 990 breast cancer patients and correlated its expression with clinicopathological parameters and survival data.\nRESULTS: Expression of RET was detected in 409 out of 990 cases (41.3%). RET and ER expression significantly correlated (p\u2009<\u20090.0001). The Luminal B HER2-positive subtype showed the highest expression rate (48.9%). In univariate and multivariate survival analyses, RET expression had no impact on overall survival.\nCONCLUSION: We confirmed the co-expression of RET and ER, but we did not find RET expression to be an independent prognostic factor in human breast cancer. Clinical trials with newly developed RET inhibitors are needed to evaluate if RET inhibition has a beneficial impact on patient survival in ER positive breast cancer.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s12885-018-5262-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6662577", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1024632", 
            "issn": [
              "1471-2407"
            ], 
            "name": "BMC Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "name": "Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer", 
        "pagination": "41", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3335e1d2d10cd7bb1640ad546649be552ed469ce8ea4e2b0becd7bf653dd509e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30621641"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100967800"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12885-018-5262-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111258988"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12885-018-5262-0", 
          "https://app.dimensions.ai/details/publication/pub.1111258988"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:36", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000314_0000000314/records_55835_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs12885-018-5262-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-5262-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-5262-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-5262-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-5262-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    312 TRIPLES      21 PREDICATES      76 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12885-018-5262-0 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N648d6ae5d5fa488397651bd776619c38
    4 schema:citation sg:pub.10.1007/s10549-004-3974-0
    5 sg:pub.10.1007/s10549-010-0788-0
    6 sg:pub.10.1007/s10549-010-1226-z
    7 sg:pub.10.1007/s10549-014-3015-6
    8 sg:pub.10.1038/nature09208
    9 sg:pub.10.1038/nature11412
    10 sg:pub.10.1038/ng1975
    11 sg:pub.10.1038/nrc2713
    12 sg:pub.10.1038/nrc721
    13 sg:pub.10.1038/nrclinonc.2017.188
    14 sg:pub.10.1038/onc.2009.164
    15 sg:pub.10.1038/onc.2010.209
    16 sg:pub.10.1038/sj.onc.1203343
    17 sg:pub.10.1186/bcr3608
    18 https://doi.org/10.1002/emmm.201302625
    19 https://doi.org/10.1002/path.2004
    20 https://doi.org/10.1002/path.893
    21 https://doi.org/10.1016/0092-8674(90)90659-3
    22 https://doi.org/10.1016/j.molmed.2010.12.007
    23 https://doi.org/10.1016/j.surg.2005.07.007
    24 https://doi.org/10.1016/s0006-291x(02)00528-4
    25 https://doi.org/10.1016/s0304-3835(03)00456-7
    26 https://doi.org/10.1056/nejmoa1109653
    27 https://doi.org/10.1093/annonc/mdl016
    28 https://doi.org/10.1093/annonc/mdn352
    29 https://doi.org/10.1093/annonc/mdr304
    30 https://doi.org/10.1093/annonc/mds190
    31 https://doi.org/10.1097/sla.0b013e3182a6f552
    32 https://doi.org/10.1126/science.2470152
    33 https://doi.org/10.1136/jclinpath-2015-202907
    34 https://doi.org/10.1158/0008-5472.can-05-2843
    35 https://doi.org/10.1158/0008-5472.can-07-2343
    36 https://doi.org/10.1158/0008-5472.can-07-5100
    37 https://doi.org/10.1158/0008-5472.can-12-4265
    38 https://doi.org/10.1158/1078-0432.ccr-06-1164
    39 https://doi.org/10.1158/1078-0432.ccr-13-2221
    40 https://doi.org/10.1177/147323000803600406
    41 https://doi.org/10.1200/jco.2007.15.5242
    42 https://doi.org/10.1200/jco.2009.25.9820
    43 https://doi.org/10.1371/journal.pmed.1001216
    44 https://doi.org/10.1371/journal.pone.0010279
    45 https://doi.org/10.1677/erc.1.01120
    46 https://doi.org/10.18632/oncoscience.345
    47 https://doi.org/10.18632/oncotarget.11826
    48 https://doi.org/10.18632/oncotarget.8417
    49 https://doi.org/10.2174/138955710791185154
    50 https://doi.org/10.3892/ijo.25.6.1551
    51 schema:datePublished 2019-12
    52 schema:datePublishedReg 2019-12-01
    53 schema:description BACKGROUND: The Rearranged during Transfection (RET) protein is overexpressed in a subset of Estrogen Receptor (ER) positive breast cancer, with both signalling pathways functionally interacting. This cross-talk plays a pivotal role in the resistance of breast cancer cells to anti-endocrine therapies, and RET expression is assumed to correlate with poor prognosis based on findings in small patient cohorts. The aim of our study was to investigate the impact of RET expression on patient outcome in human breast cancer. METHODS: We performed an immunohistochemical analysis of RET protein expression on a tissue microarray encompassing 990 breast cancer patients and correlated its expression with clinicopathological parameters and survival data. RESULTS: Expression of RET was detected in 409 out of 990 cases (41.3%). RET and ER expression significantly correlated (p < 0.0001). The Luminal B HER2-positive subtype showed the highest expression rate (48.9%). In univariate and multivariate survival analyses, RET expression had no impact on overall survival. CONCLUSION: We confirmed the co-expression of RET and ER, but we did not find RET expression to be an independent prognostic factor in human breast cancer. Clinical trials with newly developed RET inhibitors are needed to evaluate if RET inhibition has a beneficial impact on patient survival in ER positive breast cancer.
    54 schema:genre research_article
    55 schema:inLanguage en
    56 schema:isAccessibleForFree true
    57 schema:isPartOf N9a9737e41eae4fc6ad1ebfd497b991b9
    58 Nd45bda2023f4444a8539671992eeabe8
    59 sg:journal.1024632
    60 schema:name Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer
    61 schema:pagination 41
    62 schema:productId N17b7045ab03846768de52d910b9989e5
    63 N2fdb1c7b1c7048eaa1ca634d616544eb
    64 N3c58c11e85d444f39d51d037082576c7
    65 N4ae0ad7229f74b0eaed2c0cb5d29a7c4
    66 N85614dff84074b66978baaf450da6834
    67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111258988
    68 https://doi.org/10.1186/s12885-018-5262-0
    69 schema:sdDatePublished 2019-04-11T08:36
    70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    71 schema:sdPublisher N12b339fab5b84a04bf440eeb050f81ad
    72 schema:url https://link.springer.com/10.1186%2Fs12885-018-5262-0
    73 sgo:license sg:explorer/license/
    74 sgo:sdDataset articles
    75 rdf:type schema:ScholarlyArticle
    76 N0dd0e655172c4d0d90ecb18a04f9ba41 rdf:first sg:person.0773447031.32
    77 rdf:rest rdf:nil
    78 N128600bd8538402d9cbfe37577bf33a1 rdf:first sg:person.0770061073.05
    79 rdf:rest N133525772a0044c7b2dd2ffbd3d3961d
    80 N12b339fab5b84a04bf440eeb050f81ad schema:name Springer Nature - SN SciGraph project
    81 rdf:type schema:Organization
    82 N133525772a0044c7b2dd2ffbd3d3961d rdf:first sg:person.01042746007.33
    83 rdf:rest N3572e8036cf446348e97c0854f11129e
    84 N17b7045ab03846768de52d910b9989e5 schema:name nlm_unique_id
    85 schema:value 100967800
    86 rdf:type schema:PropertyValue
    87 N2fdb1c7b1c7048eaa1ca634d616544eb schema:name doi
    88 schema:value 10.1186/s12885-018-5262-0
    89 rdf:type schema:PropertyValue
    90 N3572e8036cf446348e97c0854f11129e rdf:first sg:person.01106126030.87
    91 rdf:rest Neb412a39e1744a6c98517538f8bc2ebc
    92 N3c58c11e85d444f39d51d037082576c7 schema:name dimensions_id
    93 schema:value pub.1111258988
    94 rdf:type schema:PropertyValue
    95 N3d74415284de4ddb8521f01043e26913 rdf:first sg:person.01027302221.24
    96 rdf:rest N128600bd8538402d9cbfe37577bf33a1
    97 N454c3f4933cf4ea8a7f6ace00684d3f1 rdf:first sg:person.01010021003.50
    98 rdf:rest Nb63c36c4464d42c09f95b713e5d5e302
    99 N4ae0ad7229f74b0eaed2c0cb5d29a7c4 schema:name pubmed_id
    100 schema:value 30621641
    101 rdf:type schema:PropertyValue
    102 N4d2b7144dc1342119aec4ee9a38d6d71 rdf:first sg:person.01045546227.16
    103 rdf:rest Na4206541d8c1493eb899c3c9c00117bf
    104 N648d6ae5d5fa488397651bd776619c38 rdf:first sg:person.01206741437.06
    105 rdf:rest N454c3f4933cf4ea8a7f6ace00684d3f1
    106 N7dd7703d236e4dc5b7c399c32d5567f0 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    107 schema:familyName Ng
    108 schema:givenName Charlotte K. Y.
    109 rdf:type schema:Person
    110 N7deda7ee872d42b0b233f3705048d376 rdf:first N7dd7703d236e4dc5b7c399c32d5567f0
    111 rdf:rest Nb5bb0a60d38c44dfae09d4f89af0fbce
    112 N85614dff84074b66978baaf450da6834 schema:name readcube_id
    113 schema:value 3335e1d2d10cd7bb1640ad546649be552ed469ce8ea4e2b0becd7bf653dd509e
    114 rdf:type schema:PropertyValue
    115 N9a9737e41eae4fc6ad1ebfd497b991b9 schema:volumeNumber 19
    116 rdf:type schema:PublicationVolume
    117 Na4206541d8c1493eb899c3c9c00117bf rdf:first sg:person.0761012721.35
    118 rdf:rest N3d74415284de4ddb8521f01043e26913
    119 Nb5bb0a60d38c44dfae09d4f89af0fbce rdf:first sg:person.07477276143.16
    120 rdf:rest N4d2b7144dc1342119aec4ee9a38d6d71
    121 Nb63c36c4464d42c09f95b713e5d5e302 rdf:first sg:person.01125606555.21
    122 rdf:rest N7deda7ee872d42b0b233f3705048d376
    123 Nd45bda2023f4444a8539671992eeabe8 schema:issueNumber 1
    124 rdf:type schema:PublicationIssue
    125 Neb412a39e1744a6c98517538f8bc2ebc rdf:first sg:person.01070304064.03
    126 rdf:rest N0dd0e655172c4d0d90ecb18a04f9ba41
    127 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    128 schema:name Medical and Health Sciences
    129 rdf:type schema:DefinedTerm
    130 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    131 schema:name Oncology and Carcinogenesis
    132 rdf:type schema:DefinedTerm
    133 sg:grant.6662577 http://pending.schema.org/fundedItem sg:pub.10.1186/s12885-018-5262-0
    134 rdf:type schema:MonetaryGrant
    135 sg:journal.1024632 schema:issn 1471-2407
    136 schema:name BMC Cancer
    137 rdf:type schema:Periodical
    138 sg:person.01010021003.50 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    139 schema:familyName Soysal
    140 schema:givenName Savas D.
    141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010021003.50
    142 rdf:type schema:Person
    143 sg:person.01027302221.24 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    144 schema:familyName Glauser
    145 schema:givenName Philippe
    146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027302221.24
    147 rdf:type schema:Person
    148 sg:person.01042746007.33 schema:affiliation https://www.grid.ac/institutes/grid.419829.f
    149 schema:familyName Kilic
    150 schema:givenName Ergin
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042746007.33
    152 rdf:type schema:Person
    153 sg:person.01045546227.16 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    154 schema:familyName Mujagic
    155 schema:givenName Edin
    156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045546227.16
    157 rdf:type schema:Person
    158 sg:person.01070304064.03 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    159 schema:familyName Weber
    160 schema:givenName Walter P.
    161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070304064.03
    162 rdf:type schema:Person
    163 sg:person.01106126030.87 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    164 schema:familyName Droeser
    165 schema:givenName Raoul A.
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106126030.87
    167 rdf:type schema:Person
    168 sg:person.01125606555.21 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    169 schema:familyName Piscuoglio
    170 schema:givenName Salvatore
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125606555.21
    172 rdf:type schema:Person
    173 sg:person.01206741437.06 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    174 schema:familyName Mechera
    175 schema:givenName Robert
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206741437.06
    177 rdf:type schema:Person
    178 sg:person.07477276143.16 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    179 schema:familyName Zeindler
    180 schema:givenName Jasmin
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07477276143.16
    182 rdf:type schema:Person
    183 sg:person.0761012721.35 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    184 schema:familyName Däster
    185 schema:givenName Silvio
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761012721.35
    187 rdf:type schema:Person
    188 sg:person.0770061073.05 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    189 schema:familyName Hoffmann
    190 schema:givenName Henry
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770061073.05
    192 rdf:type schema:Person
    193 sg:person.0773447031.32 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    194 schema:familyName Muenst
    195 schema:givenName Simone
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773447031.32
    197 rdf:type schema:Person
    198 sg:pub.10.1007/s10549-004-3974-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036237794
    199 https://doi.org/10.1007/s10549-004-3974-0
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1007/s10549-010-0788-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027199206
    202 https://doi.org/10.1007/s10549-010-0788-0
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1007/s10549-010-1226-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1006963157
    205 https://doi.org/10.1007/s10549-010-1226-z
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1007/s10549-014-3015-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023620699
    208 https://doi.org/10.1007/s10549-014-3015-6
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nature09208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048324405
    211 https://doi.org/10.1038/nature09208
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
    214 https://doi.org/10.1038/nature11412
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/ng1975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021860958
    217 https://doi.org/10.1038/ng1975
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nrc2713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018166274
    220 https://doi.org/10.1038/nrc2713
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nrc721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033032980
    223 https://doi.org/10.1038/nrc721
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/nrclinonc.2017.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093043252
    226 https://doi.org/10.1038/nrclinonc.2017.188
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/onc.2009.164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027532046
    229 https://doi.org/10.1038/onc.2009.164
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/onc.2010.209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010728744
    232 https://doi.org/10.1038/onc.2010.209
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/sj.onc.1203343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033872440
    235 https://doi.org/10.1038/sj.onc.1203343
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1186/bcr3608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045222196
    238 https://doi.org/10.1186/bcr3608
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1002/emmm.201302625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050726278
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1002/path.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009178333
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1002/path.893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023558420
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/0092-8674(90)90659-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009651973
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.molmed.2010.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005054811
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.surg.2005.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047944194
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/s0006-291x(02)00528-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038114186
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/s0304-3835(03)00456-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013061179
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1056/nejmoa1109653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029978324
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1093/annonc/mdl016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040588612
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1093/annonc/mdn352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029758282
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1093/annonc/mdr304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009166329
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1093/annonc/mds190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037862382
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1097/sla.0b013e3182a6f552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012375147
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1126/science.2470152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062539373
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1136/jclinpath-2015-202907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023918141
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1158/0008-5472.can-05-2843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025407714
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1158/0008-5472.can-07-2343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035462110
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1158/0008-5472.can-07-5100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000276458
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1158/0008-5472.can-12-4265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047393587
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1158/1078-0432.ccr-06-1164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002920346
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1158/1078-0432.ccr-13-2221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035226197
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1177/147323000803600406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011121585
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1200/jco.2007.15.5242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015727358
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1200/jco.2009.25.9820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045520644
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1371/journal.pmed.1001216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025496032
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1371/journal.pone.0010279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053279403
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1677/erc.1.01120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040101583
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.18632/oncoscience.345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084850983
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.18632/oncotarget.11826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014113619
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.18632/oncotarget.8417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010151719
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.2174/138955710791185154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069183139
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.3892/ijo.25.6.1551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071515512
    305 rdf:type schema:CreativeWork
    306 https://www.grid.ac/institutes/grid.410567.1 schema:alternateName University Hospital of Basel
    307 schema:name Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland
    308 Institute of Pathology, University Hospital Basel, Schoenbeinstrasse 40, 4031, Basel, Switzerland
    309 rdf:type schema:Organization
    310 https://www.grid.ac/institutes/grid.419829.f schema:alternateName Klinikum Leverkusen
    311 schema:name Institute of Pathology, Klinikum Leverkusen, Am Gesundheitspark 11, 51375, Leverkusen, Germany
    312 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...