Long-term efficacy of crizotinib in a metastatic papillary renal carcinoma with MET amplification: a case report and literature review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Philippe Rochigneux, Jeanne Thomassin-Piana, Sophy Laibe, Serge Brunelle, Naji Salem, Bernard Escudier, Gilles Vassal, Gwenaelle Gravis

ABSTRACT

BACKGROUND: Papillary renal cell carcinoma (pRCC) is the 2nd most frequent histological type of kidney cancer and accounts for approximately 15% of all renal cell carcinoma. It has a poorer prognosis than clear cell RCC (ccRCC) with a lack of standard treatments. CASE PRESENTATION: We report the case of a 51 year old man with a metastatic pRCC (hepatic dome and left colonic peritoneal carcinomatosis) progressive after sunitinib, with a MET amplification. The patient was enrolled in the UNICANCER-sponsored AcSé crizotinib trial (NCT02034981), designed to give an access to crizotinib for patients with tumors harboring a genomic alteration on one of the biological targets of the drug. With 2nd line crizotinib (250 mg twice/day), the patient had a very good tolerance, a partial response in the target lesions using RECIST 1.1, and a 19 months' clinical efficacy. CONCLUSIONS: In metastatic pRCC with a MET amplification, crizotinib maybe a potential met-inhibitory therapeutic option. More... »

PAGES

1159

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-018-5049-3

DOI

http://dx.doi.org/10.1186/s12885-018-5049-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110132953

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30466410


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