Cytoplasmic TRAIL-R1 is a positive prognostic marker in PDAC View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Jan-Paul Gundlach, Charlotte Hauser, Franka Maria Schlegel, Christine Böger, Christian Röder, Christoph Röcken, Thomas Becker, Jan-Hendrik Egberts, Holger Kalthoff, Anna Trauzold

ABSTRACT

BACKGROUND: The death receptors TRAIL-R1 and TRAIL-R2 are frequently overexpressed in cancer and there is an emerging evidence for their important role in malignant progression, also in the case of pancreatic ductal adenocarcinoma (PDAC). In their canonical localization at the plasma membrane, TRAIL-R1/-R2 may induce cell death and/or pro-inflammatory signaling leading to cell migration, invasion and metastasis. Although, they have repeatedly been found intracellular, in the cytoplasm and in the nucleus, their functions in intracellular locations are still not well understood. Likewise, studies dealing with the prognostic relevance of TRAIL-Rs located in particular cellular compartments are very rare. For PDAC, the correlation of nuclear TRAIL-R2 with worse patients' prognosis has been shown recently. Corresponding data on TRAIL-R1 are not available so far. METHODS: In the present study we analyzed the expression of TRAIL-R1 in 106 PDACs and 28 adjacent, peritumoral non-malignant pancreatic ducts with special emphasis on its cytoplasmic and nuclear localization and correlated the immunohistochemical findings with clinico-pathological patient characteristics. RESULTS: TRAIL-R1 was found in 93.4% of all PDAC samples. Cytoplasmic staining was present with very similar intensity in tumor and normal tissue. In contrast, nuclear TRAIL-R1 staining was significantly stronger in tumor compared to normal tissue (p = 0.006). Interestingly, we found that the number of cells with cytoplasmic TRAIL-R1 staining negatively correlates with tumor grading (p = 0.043). No such correlation could be detected for nuclear TRAIL-R1. Neither, cytoplasmic nor nuclear TRAIL-R1 staining showed a correlation with other clinico-pathological parameter such as pTNM categories. However, Kaplan-Meier analyses revealed significantly prolonged median survival of patients with positive cytoplasmic TRAIL-R1 expression in more than 80% of tumor cells compared to patients with tumors containing a smaller quantity of cells positively stained for cytoplasmic TRAIL-R1 (20 vs. 8 months; p = 0.004). CONCLUSION: Cytoplasmic TRAIL-R1 is a positive prognostic marker for patients with PDAC. Our findings indicate that loss of cytoplasmic TRAIL-R1 results in recurrent disease with more malignant phenotype thus suggesting anti-tumor activities of cytoplasmic TRAIL-R1 in PDAC. More... »

PAGES

777

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-018-4688-8

DOI

http://dx.doi.org/10.1186/s12885-018-4688-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105932508

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30064384


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of General Surgery, Visceral, Thoracic, Transplantation and Pediatric Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller Str. 3, Haus 18, 24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gundlach", 
        "givenName": "Jan-Paul", 
        "id": "sg:person.0672044666.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672044666.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of General Surgery, Visceral, Thoracic, Transplantation and Pediatric Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller Str. 3, Haus 18, 24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hauser", 
        "givenName": "Charlotte", 
        "id": "sg:person.0636376460.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636376460.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller Str. 3 (Haus 17), D-24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlegel", 
        "givenName": "Franka Maria", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Pathology, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller Str. 3, Haus 14, 24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00f6ger", 
        "givenName": "Christine", 
        "id": "sg:person.01100255750.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100255750.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller Str. 3 (Haus 17), D-24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "R\u00f6der", 
        "givenName": "Christian", 
        "id": "sg:person.0613645340.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613645340.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Pathology, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller Str. 3, Haus 14, 24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "R\u00f6cken", 
        "givenName": "Christoph", 
        "id": "sg:person.011714711304.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011714711304.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of General Surgery, Visceral, Thoracic, Transplantation and Pediatric Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller Str. 3, Haus 18, 24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Becker", 
        "givenName": "Thomas", 
        "id": "sg:person.0627200700.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627200700.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of General Surgery, Visceral, Thoracic, Transplantation and Pediatric Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller Str. 3, Haus 18, 24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Egberts", 
        "givenName": "Jan-Hendrik", 
        "id": "sg:person.01005117224.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005117224.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller Str. 3 (Haus 17), D-24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kalthoff", 
        "givenName": "Holger", 
        "id": "sg:person.01343470677.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343470677.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Department of General Surgery, Visceral, Thoracic, Transplantation and Pediatric Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller Str. 3, Haus 18, 24105, Kiel, Germany", 
            "Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller Str. 3 (Haus 17), D-24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trauzold", 
        "givenName": "Anna", 
        "id": "sg:person.01331213700.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331213700.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.humpath.2006.04.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000171874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2015.02.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001104602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-04-0136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004928527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2009.02.071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005082210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005625008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.14285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008837002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-9-203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009180870", 
          "https://doi.org/10.1186/1476-4598-9-203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2013.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009870724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.24698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010294913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012894256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.1174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013190107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014894112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016625331", 
          "https://doi.org/10.1038/sj.onc.1209719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016625331", 
          "https://doi.org/10.1038/sj.onc.1209719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-0985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018123906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2013.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021526067", 
          "https://doi.org/10.1038/cdd.2013.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-009-0510-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021739345", 
          "https://doi.org/10.1007/s00109-009-0510-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-009-0510-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021739345", 
          "https://doi.org/10.1007/s00109-009-0510-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-009-0510-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021739345", 
          "https://doi.org/10.1007/s00109-009-0510-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-0158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023032870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031651913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2014.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031757707", 
          "https://doi.org/10.1038/cdd.2014.81"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032671175", 
          "https://doi.org/10.1038/onc.2010.235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032671175", 
          "https://doi.org/10.1038/onc.2010.235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.3.1356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033991928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0056760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035442839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2010.02.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035460257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2014.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035651871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.309377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036296739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2014.351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036379849", 
          "https://doi.org/10.1038/cddis.2014.351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20011171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041271616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041444968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.12406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042121736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-3403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042492903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-010-0619-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042596499", 
          "https://doi.org/10.1007/s00109-010-0619-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-010-0619-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042596499", 
          "https://doi.org/10.1007/s00109-010-0619-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-015-1508-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046657925", 
          "https://doi.org/10.1186/s12885-015-1508-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-015-1508-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046657925", 
          "https://doi.org/10.1186/s12885-015-1508-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2009.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046763417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-005-9081-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048565258", 
          "https://doi.org/10.1007/s11060-005-9081-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-005-9081-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048565258", 
          "https://doi.org/10.1007/s11060-005-9081-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2008.06.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048810908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1254312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052628416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1254312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052628416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.164.8.3961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074619205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075201526", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075344787", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v21.i11.3157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079061259"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: The death receptors TRAIL-R1 and TRAIL-R2 are frequently overexpressed in cancer and there is an emerging evidence for their important role in malignant progression, also in the case of pancreatic ductal adenocarcinoma (PDAC). In their canonical localization at the plasma membrane, TRAIL-R1/-R2 may induce cell death and/or pro-inflammatory signaling leading to cell migration, invasion and metastasis. Although, they have repeatedly been found intracellular, in the cytoplasm and in the nucleus, their functions in intracellular locations are still not well understood. Likewise, studies dealing with the prognostic relevance of TRAIL-Rs located in particular cellular compartments are very rare. For PDAC, the correlation of nuclear TRAIL-R2 with worse patients' prognosis has been shown recently. Corresponding data on TRAIL-R1 are not available so far.\nMETHODS: In the present study we analyzed the expression of TRAIL-R1 in 106 PDACs and 28 adjacent, peritumoral non-malignant pancreatic ducts with special emphasis on its cytoplasmic and nuclear localization and correlated the immunohistochemical findings with clinico-pathological patient characteristics.\nRESULTS: TRAIL-R1 was found in 93.4% of all PDAC samples. Cytoplasmic staining was present with very similar intensity in tumor and normal tissue. In contrast, nuclear TRAIL-R1 staining was significantly stronger in tumor compared to normal tissue (p\u00a0=\u20090.006). Interestingly, we found that the number of cells with cytoplasmic TRAIL-R1 staining negatively correlates with tumor grading (p\u00a0=\u20090.043). No such correlation could be detected for nuclear TRAIL-R1. Neither, cytoplasmic nor nuclear TRAIL-R1 staining showed a correlation with other clinico-pathological parameter such as pTNM categories. However, Kaplan-Meier analyses revealed significantly prolonged median survival of patients with positive cytoplasmic TRAIL-R1 expression in more than 80% of tumor cells compared to patients with tumors containing a smaller quantity of cells positively stained for cytoplasmic TRAIL-R1 (20 vs. 8\u00a0months; p\u00a0=\u20090.004).\nCONCLUSION: Cytoplasmic TRAIL-R1 is a positive prognostic marker for patients with PDAC. Our findings indicate that loss of cytoplasmic TRAIL-R1 results in recurrent disease with more malignant phenotype thus suggesting anti-tumor activities of cytoplasmic TRAIL-R1 in PDAC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12885-018-4688-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Cytoplasmic TRAIL-R1 is a positive prognostic marker in PDAC", 
    "pagination": "777", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e14badae34ad4b33056a8de02b0a5e14e08efd867b0c3bf852b9c3e8a21a7197"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30064384"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12885-018-4688-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105932508"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12885-018-4688-8", 
      "https://app.dimensions.ai/details/publication/pub.1105932508"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000572.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12885-018-4688-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4688-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4688-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4688-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4688-8'


 

This table displays all metadata directly associated to this object as RDF triples.

263 TRIPLES      21 PREDICATES      69 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12885-018-4688-8 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N1c7574d0752b44e2b07088fb458c1e71
4 schema:citation sg:pub.10.1007/s00109-009-0510-z
5 sg:pub.10.1007/s00109-010-0619-0
6 sg:pub.10.1007/s11060-005-9081-1
7 sg:pub.10.1038/cdd.2013.28
8 sg:pub.10.1038/cdd.2014.81
9 sg:pub.10.1038/cddis.2014.351
10 sg:pub.10.1038/onc.2010.235
11 sg:pub.10.1038/sj.onc.1209719
12 sg:pub.10.1186/1476-4598-9-203
13 sg:pub.10.1186/s12885-015-1508-2
14 https://app.dimensions.ai/details/publication/pub.1075201526
15 https://app.dimensions.ai/details/publication/pub.1075344787
16 https://doi.org/10.1002/cncr.23528
17 https://doi.org/10.1002/hep.24698
18 https://doi.org/10.1016/j.bcp.2014.08.010
19 https://doi.org/10.1016/j.ccell.2015.02.014
20 https://doi.org/10.1016/j.ejca.2008.06.042
21 https://doi.org/10.1016/j.humpath.2006.04.026
22 https://doi.org/10.1016/j.placenta.2009.07.006
23 https://doi.org/10.1053/j.gastro.2009.02.071
24 https://doi.org/10.1053/j.gastro.2010.02.046
25 https://doi.org/10.1053/j.gastro.2013.10.009
26 https://doi.org/10.1074/jbc.m111.309377
27 https://doi.org/10.1084/jem.20011171
28 https://doi.org/10.1126/science.1254312
29 https://doi.org/10.1158/1078-0432.ccr-05-0158
30 https://doi.org/10.1158/1078-0432.ccr-08-0284
31 https://doi.org/10.1158/1078-0432.ccr-09-3403
32 https://doi.org/10.1158/1078-0432.ccr-10-0985
33 https://doi.org/10.1158/1541-7786.mcr-04-0136
34 https://doi.org/10.1371/journal.pone.0056760
35 https://doi.org/10.18632/oncotarget.1174
36 https://doi.org/10.18632/oncotarget.12406
37 https://doi.org/10.18632/oncotarget.14285
38 https://doi.org/10.18632/oncotarget.542
39 https://doi.org/10.18632/oncotarget.598
40 https://doi.org/10.3322/caac.21387
41 https://doi.org/10.3748/wjg.v21.i11.3157
42 https://doi.org/10.4049/jimmunol.164.8.3961
43 https://doi.org/10.4049/jimmunol.168.3.1356
44 schema:datePublished 2018-12
45 schema:datePublishedReg 2018-12-01
46 schema:description BACKGROUND: The death receptors TRAIL-R1 and TRAIL-R2 are frequently overexpressed in cancer and there is an emerging evidence for their important role in malignant progression, also in the case of pancreatic ductal adenocarcinoma (PDAC). In their canonical localization at the plasma membrane, TRAIL-R1/-R2 may induce cell death and/or pro-inflammatory signaling leading to cell migration, invasion and metastasis. Although, they have repeatedly been found intracellular, in the cytoplasm and in the nucleus, their functions in intracellular locations are still not well understood. Likewise, studies dealing with the prognostic relevance of TRAIL-Rs located in particular cellular compartments are very rare. For PDAC, the correlation of nuclear TRAIL-R2 with worse patients' prognosis has been shown recently. Corresponding data on TRAIL-R1 are not available so far. METHODS: In the present study we analyzed the expression of TRAIL-R1 in 106 PDACs and 28 adjacent, peritumoral non-malignant pancreatic ducts with special emphasis on its cytoplasmic and nuclear localization and correlated the immunohistochemical findings with clinico-pathological patient characteristics. RESULTS: TRAIL-R1 was found in 93.4% of all PDAC samples. Cytoplasmic staining was present with very similar intensity in tumor and normal tissue. In contrast, nuclear TRAIL-R1 staining was significantly stronger in tumor compared to normal tissue (p = 0.006). Interestingly, we found that the number of cells with cytoplasmic TRAIL-R1 staining negatively correlates with tumor grading (p = 0.043). No such correlation could be detected for nuclear TRAIL-R1. Neither, cytoplasmic nor nuclear TRAIL-R1 staining showed a correlation with other clinico-pathological parameter such as pTNM categories. However, Kaplan-Meier analyses revealed significantly prolonged median survival of patients with positive cytoplasmic TRAIL-R1 expression in more than 80% of tumor cells compared to patients with tumors containing a smaller quantity of cells positively stained for cytoplasmic TRAIL-R1 (20 vs. 8 months; p = 0.004). CONCLUSION: Cytoplasmic TRAIL-R1 is a positive prognostic marker for patients with PDAC. Our findings indicate that loss of cytoplasmic TRAIL-R1 results in recurrent disease with more malignant phenotype thus suggesting anti-tumor activities of cytoplasmic TRAIL-R1 in PDAC.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree true
50 schema:isPartOf N8c9879cb1d354569a754e52358679de3
51 Ne2b7a577255948179557c84861ec0deb
52 sg:journal.1024632
53 schema:name Cytoplasmic TRAIL-R1 is a positive prognostic marker in PDAC
54 schema:pagination 777
55 schema:productId N6add82f91cfe41a9b7102cb206ba5d45
56 N70c5a974cc7d49b6b91d9c05d6cf01da
57 N771c1902391b46b4926414cc5fd9af30
58 N95ec50b2437a46eebef72e383bf475ef
59 Nbca8de6ab890425fb0ca22a412711064
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105932508
61 https://doi.org/10.1186/s12885-018-4688-8
62 schema:sdDatePublished 2019-04-10T16:51
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N3b85bfeb5d3c44c5b288c7e0a1d9e6ac
65 schema:url https://link.springer.com/10.1186%2Fs12885-018-4688-8
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N020b95ab9e2746009a6cbd663dc55414 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
70 schema:familyName Schlegel
71 schema:givenName Franka Maria
72 rdf:type schema:Person
73 N1c7574d0752b44e2b07088fb458c1e71 rdf:first sg:person.0672044666.15
74 rdf:rest Nb9787df5f95c494a993da10c4a01ccd8
75 N3b85bfeb5d3c44c5b288c7e0a1d9e6ac schema:name Springer Nature - SN SciGraph project
76 rdf:type schema:Organization
77 N6add82f91cfe41a9b7102cb206ba5d45 schema:name readcube_id
78 schema:value e14badae34ad4b33056a8de02b0a5e14e08efd867b0c3bf852b9c3e8a21a7197
79 rdf:type schema:PropertyValue
80 N6f73ce6b8f974964965c652c567e6f58 rdf:first sg:person.0613645340.20
81 rdf:rest N781a8989eebb4f3299455b10cb79c2c7
82 N70c5a974cc7d49b6b91d9c05d6cf01da schema:name doi
83 schema:value 10.1186/s12885-018-4688-8
84 rdf:type schema:PropertyValue
85 N759b96ea5afd4f8aa38ab5f3e94ffadd rdf:first sg:person.01343470677.13
86 rdf:rest Neef7c44f2acb45a2a3cbb82e0fb4dfd2
87 N771c1902391b46b4926414cc5fd9af30 schema:name dimensions_id
88 schema:value pub.1105932508
89 rdf:type schema:PropertyValue
90 N781a8989eebb4f3299455b10cb79c2c7 rdf:first sg:person.011714711304.99
91 rdf:rest Nc6849705b75b4649910edc762e3aa19e
92 N8c9879cb1d354569a754e52358679de3 schema:issueNumber 1
93 rdf:type schema:PublicationIssue
94 N95ec50b2437a46eebef72e383bf475ef schema:name pubmed_id
95 schema:value 30064384
96 rdf:type schema:PropertyValue
97 Nac05315d92c04114937304fa21eca763 rdf:first N020b95ab9e2746009a6cbd663dc55414
98 rdf:rest Nb5e0f593c82e4b46932382d520ba56ae
99 Nad4f93c264bb4bc496d16f7c302357ec rdf:first sg:person.01005117224.44
100 rdf:rest N759b96ea5afd4f8aa38ab5f3e94ffadd
101 Nb5e0f593c82e4b46932382d520ba56ae rdf:first sg:person.01100255750.94
102 rdf:rest N6f73ce6b8f974964965c652c567e6f58
103 Nb9787df5f95c494a993da10c4a01ccd8 rdf:first sg:person.0636376460.92
104 rdf:rest Nac05315d92c04114937304fa21eca763
105 Nbca8de6ab890425fb0ca22a412711064 schema:name nlm_unique_id
106 schema:value 100967800
107 rdf:type schema:PropertyValue
108 Nc6849705b75b4649910edc762e3aa19e rdf:first sg:person.0627200700.24
109 rdf:rest Nad4f93c264bb4bc496d16f7c302357ec
110 Ne2b7a577255948179557c84861ec0deb schema:volumeNumber 18
111 rdf:type schema:PublicationVolume
112 Neef7c44f2acb45a2a3cbb82e0fb4dfd2 rdf:first sg:person.01331213700.96
113 rdf:rest rdf:nil
114 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
115 schema:name Medical and Health Sciences
116 rdf:type schema:DefinedTerm
117 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
118 schema:name Oncology and Carcinogenesis
119 rdf:type schema:DefinedTerm
120 sg:journal.1024632 schema:issn 1471-2407
121 schema:name BMC Cancer
122 rdf:type schema:Periodical
123 sg:person.01005117224.44 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
124 schema:familyName Egberts
125 schema:givenName Jan-Hendrik
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005117224.44
127 rdf:type schema:Person
128 sg:person.01100255750.94 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
129 schema:familyName Böger
130 schema:givenName Christine
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100255750.94
132 rdf:type schema:Person
133 sg:person.011714711304.99 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
134 schema:familyName Röcken
135 schema:givenName Christoph
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011714711304.99
137 rdf:type schema:Person
138 sg:person.01331213700.96 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
139 schema:familyName Trauzold
140 schema:givenName Anna
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331213700.96
142 rdf:type schema:Person
143 sg:person.01343470677.13 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
144 schema:familyName Kalthoff
145 schema:givenName Holger
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343470677.13
147 rdf:type schema:Person
148 sg:person.0613645340.20 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
149 schema:familyName Röder
150 schema:givenName Christian
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613645340.20
152 rdf:type schema:Person
153 sg:person.0627200700.24 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
154 schema:familyName Becker
155 schema:givenName Thomas
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627200700.24
157 rdf:type schema:Person
158 sg:person.0636376460.92 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
159 schema:familyName Hauser
160 schema:givenName Charlotte
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636376460.92
162 rdf:type schema:Person
163 sg:person.0672044666.15 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
164 schema:familyName Gundlach
165 schema:givenName Jan-Paul
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672044666.15
167 rdf:type schema:Person
168 sg:pub.10.1007/s00109-009-0510-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1021739345
169 https://doi.org/10.1007/s00109-009-0510-z
170 rdf:type schema:CreativeWork
171 sg:pub.10.1007/s00109-010-0619-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042596499
172 https://doi.org/10.1007/s00109-010-0619-0
173 rdf:type schema:CreativeWork
174 sg:pub.10.1007/s11060-005-9081-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048565258
175 https://doi.org/10.1007/s11060-005-9081-1
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/cdd.2013.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021526067
178 https://doi.org/10.1038/cdd.2013.28
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/cdd.2014.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031757707
181 https://doi.org/10.1038/cdd.2014.81
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/cddis.2014.351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036379849
184 https://doi.org/10.1038/cddis.2014.351
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/onc.2010.235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032671175
187 https://doi.org/10.1038/onc.2010.235
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/sj.onc.1209719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016625331
190 https://doi.org/10.1038/sj.onc.1209719
191 rdf:type schema:CreativeWork
192 sg:pub.10.1186/1476-4598-9-203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009180870
193 https://doi.org/10.1186/1476-4598-9-203
194 rdf:type schema:CreativeWork
195 sg:pub.10.1186/s12885-015-1508-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046657925
196 https://doi.org/10.1186/s12885-015-1508-2
197 rdf:type schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1075201526 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1075344787 schema:CreativeWork
200 https://doi.org/10.1002/cncr.23528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041444968
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/hep.24698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010294913
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.bcp.2014.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035651871
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.ccell.2015.02.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001104602
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.ejca.2008.06.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048810908
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.humpath.2006.04.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000171874
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.placenta.2009.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046763417
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1053/j.gastro.2009.02.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005082210
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1053/j.gastro.2010.02.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035460257
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1053/j.gastro.2013.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009870724
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1074/jbc.m111.309377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036296739
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1084/jem.20011171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041271616
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1126/science.1254312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052628416
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1158/1078-0432.ccr-05-0158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023032870
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1158/1078-0432.ccr-08-0284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012894256
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1158/1078-0432.ccr-09-3403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042492903
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1158/1078-0432.ccr-10-0985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018123906
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1158/1541-7786.mcr-04-0136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004928527
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1371/journal.pone.0056760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035442839
237 rdf:type schema:CreativeWork
238 https://doi.org/10.18632/oncotarget.1174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013190107
239 rdf:type schema:CreativeWork
240 https://doi.org/10.18632/oncotarget.12406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042121736
241 rdf:type schema:CreativeWork
242 https://doi.org/10.18632/oncotarget.14285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008837002
243 rdf:type schema:CreativeWork
244 https://doi.org/10.18632/oncotarget.542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005625008
245 rdf:type schema:CreativeWork
246 https://doi.org/10.18632/oncotarget.598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031651913
247 rdf:type schema:CreativeWork
248 https://doi.org/10.3322/caac.21387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014894112
249 rdf:type schema:CreativeWork
250 https://doi.org/10.3748/wjg.v21.i11.3157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079061259
251 rdf:type schema:CreativeWork
252 https://doi.org/10.4049/jimmunol.164.8.3961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074619205
253 rdf:type schema:CreativeWork
254 https://doi.org/10.4049/jimmunol.168.3.1356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033991928
255 rdf:type schema:CreativeWork
256 https://www.grid.ac/institutes/grid.412468.d schema:alternateName University Hospital Schleswig-Holstein
257 schema:name Department of General Surgery, Visceral, Thoracic, Transplantation and Pediatric Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller Str. 3, Haus 18, 24105, Kiel, Germany
258 Department of Pathology, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller Str. 3, Haus 14, 24105, Kiel, Germany
259 rdf:type schema:Organization
260 https://www.grid.ac/institutes/grid.9764.c schema:alternateName Kiel University
261 schema:name Department of General Surgery, Visceral, Thoracic, Transplantation and Pediatric Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller Str. 3, Haus 18, 24105, Kiel, Germany
262 Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller Str. 3 (Haus 17), D-24105, Kiel, Germany
263 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...