Clinical response and pharmacokinetics of bendamustine as a component of salvage R-B(O)AD therapy for the treatment of primary central nervous ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Therasa Kim, He Yun Choi, Hyun-Seo Lee, Sung-Hoon Jung, Jae-Sook Ahn, Hyeoung-Joon Kim, Je-Jung Lee, Hee-Doo Yoo, Deok-Hwan Yang

ABSTRACT

BACKGROUND: A relatively high proportion of patients diagnosed with primary CNS lymphoma will experience recurrent disease, yet therapy options are limited in salvage therapy. This is the first study to evaluate a bendamustine-based combination regimen for the treatment of relapsed/refractory PCNSL and to characterize bendamustine pharmacokinetics in the human CSF. METHODS: Patients received bendamustine 75 mg/m2 for two days as part of R-B(O)AD administered intravenously every 4 weeks for up to 4 cycles. Response and adverse events of the regimen were assessed. A sparse sampling strategy and population based modeling approach was utilized for evaluation of plasma and CSF levels of bendamustine. RESULTS: Ten patients were enrolled into study of whom 70% were of refractory disease and with high IELSG prognostic risk scores. The ORR of R-BOAD was 50% (95% CI, 0.24 to 0.76) with one patient achieving CR and four PR. Primary toxicity of the regimen was reversible myelosuppression, mostly grade 3 or 4 neutropenia. The Cmax mean for plasma and CSF were 2669 ng/mL and 0.397 ng/mL, respectively, and patients with response at deep tumor sites displayed higher trends in peak exposure. Pharmacokinetic data was best described by a four-compartment model with first-order elimination of drug from central plasma and CSF compartments. CONCLUSIONS: R-BOAD is an effective salvage option for PCNSL, but with significant hematologic toxicity. Bendamustine CSF levels are minimal; however correspond to plasma exposure and response. TRIAL REGISTRATION: ClinicalTrials.gov NCT03392714 ; retrospectively registered January 8, 2018. More... »

PAGES

729

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-018-4632-y

DOI

http://dx.doi.org/10.1186/s12885-018-4632-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105448295

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29986691


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanakro, Gwanakgu, 08826, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Therasa", 
        "id": "sg:person.0576614356.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576614356.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hwasun Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411602.0", 
          "name": [
            "Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, 58128, Jeollanamdo, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "He Yun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hwasun Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411602.0", 
          "name": [
            "Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, 58128, Jeollanamdo, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyun-Seo", 
        "id": "sg:person.01203011754.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203011754.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hwasun Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411602.0", 
          "name": [
            "Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, 58128, Jeollanamdo, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Sung-Hoon", 
        "id": "sg:person.01346642620.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346642620.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hwasun Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411602.0", 
          "name": [
            "Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, 58128, Jeollanamdo, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "Jae-Sook", 
        "id": "sg:person.01017560023.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017560023.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hwasun Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411602.0", 
          "name": [
            "Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, 58128, Jeollanamdo, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyeoung-Joon", 
        "id": "sg:person.0617770714.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617770714.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hwasun Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411602.0", 
          "name": [
            "Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, 58128, Jeollanamdo, Republic of Korea", 
            "Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, 58128, Jeollanamdo, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Je-Jung", 
        "id": "sg:person.01204441075.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204441075.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Biostatistics and Bioinformatics, Pharma Partnering Inc., 74 Olympicro, Songpagu, 05556, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoo", 
        "givenName": "Hee-Doo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hwasun Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411602.0", 
          "name": [
            "Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, 58128, Jeollanamdo, Republic of Korea", 
            "Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, 58128, Jeollanamdo, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Deok-Hwan", 
        "id": "sg:person.0753367262.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753367262.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2008.18.7252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000657227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/chromsci/bmt075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001508359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.9861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003057178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.13.524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003658256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.45.9842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004450217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/nos218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006436675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0090675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006671454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10543406.2014.1000544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011347736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10428194.2012.688200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013917553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)00076-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019209751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-014-1370-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019739839", 
          "https://doi.org/10.1007/s11060-014-1370-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-0159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021593241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10428194.2012.698736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023764131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-010-1254-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024033620", 
          "https://doi.org/10.1007/s00280-010-1254-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-010-1254-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024033620", 
          "https://doi.org/10.1007/s00280-010-1254-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-005-0023-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024121433", 
          "https://doi.org/10.1007/s00432-005-0023-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-005-0023-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024121433", 
          "https://doi.org/10.1007/s00432-005-0023-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jchromb.2012.02.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025957034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-006-9165-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028814652", 
          "https://doi.org/10.1007/s11060-006-9165-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40268-012-0001-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029167592", 
          "https://doi.org/10.1007/s40268-012-0001-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40268-012-0001-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029167592", 
          "https://doi.org/10.1007/s40268-012-0001-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-006-0331-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030689330", 
          "https://doi.org/10.1007/s00280-006-0331-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-006-0331-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030689330", 
          "https://doi.org/10.1007/s00280-006-0331-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2352-3026(16)30185-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041173016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.64.9897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042937879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11899-014-0217-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046300816", 
          "https://doi.org/10.1007/s11899-014-0217-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11899-014-0217-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046300816", 
          "https://doi.org/10.1007/s11899-014-0217-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-014-1411-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046834783", 
          "https://doi.org/10.1007/s11060-014-1411-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-011-0788-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048958167", 
          "https://doi.org/10.1007/s11060-011-0788-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-0781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049961776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-011-0612-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050266838", 
          "https://doi.org/10.1007/s11060-011-0612-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-007-9361-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050287322", 
          "https://doi.org/10.1007/s11095-007-9361-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2011.357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052077972", 
          "https://doi.org/10.1038/bjc.2011.357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.112.045229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052410111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.09.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e31820f2d94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064355987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e31820f2d94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064355987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e31820f2d94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064355987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/mmr_00000186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071524982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077456234", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e328165d11a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077456234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e328165d11a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077456234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e328165d11a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077456234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-016-2241-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083842670", 
          "https://doi.org/10.1007/s11060-016-2241-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-016-2241-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083842670", 
          "https://doi.org/10.1007/s11060-016-2241-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2017.72.7602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086133657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12185-017-2316-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091611108", 
          "https://doi.org/10.1007/s12185-017-2316-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: A relatively high proportion of patients diagnosed with primary CNS lymphoma will experience recurrent disease, yet therapy options are limited in salvage therapy. This is the first study to evaluate a bendamustine-based combination regimen for the treatment of relapsed/refractory PCNSL and to characterize bendamustine pharmacokinetics in the human CSF.\nMETHODS: Patients received bendamustine 75\u00a0mg/m2 for two days as part of R-B(O)AD administered intravenously every 4\u00a0weeks for up to 4\u00a0cycles. Response and adverse events of the regimen were assessed. A sparse sampling strategy and population based modeling approach was utilized for evaluation of plasma and CSF levels of bendamustine.\nRESULTS: Ten patients were enrolled into study of whom 70% were of refractory disease and with high IELSG prognostic risk scores. The ORR of R-BOAD was 50% (95% CI, 0.24 to 0.76) with one patient achieving CR and four PR. Primary toxicity of the regimen was reversible myelosuppression, mostly grade 3 or 4 neutropenia. The Cmax mean for plasma and CSF were 2669\u00a0ng/mL and 0.397\u00a0ng/mL, respectively, and patients with response at deep tumor sites displayed higher trends in peak exposure. Pharmacokinetic data was best described by a four-compartment model with first-order elimination of drug from central plasma and CSF compartments.\nCONCLUSIONS: R-BOAD is an effective salvage option for PCNSL, but with significant hematologic toxicity. Bendamustine CSF levels are minimal; however correspond to plasma exposure and response.\nTRIAL REGISTRATION: ClinicalTrials.gov NCT03392714 ; retrospectively registered January 8, 2018.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12885-018-4632-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Clinical response and pharmacokinetics of bendamustine as a component of salvage R-B(O)AD therapy for the treatment of primary central nervous system lymphoma (PCNSL)", 
    "pagination": "729", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f78c80ae90f601d85278945323137b1725c6242a2c157b4142afe6cb3317d80f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29986691"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12885-018-4632-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105448295"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12885-018-4632-y", 
      "https://app.dimensions.ai/details/publication/pub.1105448295"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000571.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12885-018-4632-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4632-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4632-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4632-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4632-y'


 

This table displays all metadata directly associated to this object as RDF triples.

252 TRIPLES      21 PREDICATES      66 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12885-018-4632-y schema:about anzsrc-for:11
2 anzsrc-for:1117
3 schema:author N683e1e7f5c674527baacd5e4dc78addc
4 schema:citation sg:pub.10.1007/s00280-006-0331-5
5 sg:pub.10.1007/s00280-010-1254-8
6 sg:pub.10.1007/s00432-005-0023-2
7 sg:pub.10.1007/s11060-006-9165-6
8 sg:pub.10.1007/s11060-011-0612-7
9 sg:pub.10.1007/s11060-011-0788-x
10 sg:pub.10.1007/s11060-014-1370-0
11 sg:pub.10.1007/s11060-014-1411-8
12 sg:pub.10.1007/s11060-016-2241-7
13 sg:pub.10.1007/s11095-007-9361-x
14 sg:pub.10.1007/s11899-014-0217-2
15 sg:pub.10.1007/s12185-017-2316-z
16 sg:pub.10.1007/s40268-012-0001-5
17 sg:pub.10.1038/bjc.2011.357
18 https://app.dimensions.ai/details/publication/pub.1077456234
19 https://doi.org/10.1016/j.jchromb.2012.02.039
20 https://doi.org/10.1016/s1470-2045(15)00076-5
21 https://doi.org/10.1016/s2352-3026(16)30185-5
22 https://doi.org/10.1080/10543406.2014.1000544
23 https://doi.org/10.1093/chromsci/bmt075
24 https://doi.org/10.1093/neuonc/nos218
25 https://doi.org/10.1097/cad.0b013e328165d11a
26 https://doi.org/10.1124/dmd.112.045229
27 https://doi.org/10.1158/1078-0432.ccr-04-0159
28 https://doi.org/10.1158/1078-0432.ccr-07-0781
29 https://doi.org/10.1200/jco.2003.09.139
30 https://doi.org/10.1200/jco.2005.13.524
31 https://doi.org/10.1200/jco.2006.09.9861
32 https://doi.org/10.1200/jco.2008.18.7252
33 https://doi.org/10.1200/jco.2012.45.9842
34 https://doi.org/10.1200/jco.2015.64.9897
35 https://doi.org/10.1200/jco.2017.72.7602
36 https://doi.org/10.1212/wnl.0b013e31820f2d94
37 https://doi.org/10.1371/journal.pone.0090675
38 https://doi.org/10.3109/10428194.2012.688200
39 https://doi.org/10.3109/10428194.2012.698736
40 https://doi.org/10.3892/mmr_00000186
41 schema:datePublished 2018-12
42 schema:datePublishedReg 2018-12-01
43 schema:description BACKGROUND: A relatively high proportion of patients diagnosed with primary CNS lymphoma will experience recurrent disease, yet therapy options are limited in salvage therapy. This is the first study to evaluate a bendamustine-based combination regimen for the treatment of relapsed/refractory PCNSL and to characterize bendamustine pharmacokinetics in the human CSF. METHODS: Patients received bendamustine 75 mg/m2 for two days as part of R-B(O)AD administered intravenously every 4 weeks for up to 4 cycles. Response and adverse events of the regimen were assessed. A sparse sampling strategy and population based modeling approach was utilized for evaluation of plasma and CSF levels of bendamustine. RESULTS: Ten patients were enrolled into study of whom 70% were of refractory disease and with high IELSG prognostic risk scores. The ORR of R-BOAD was 50% (95% CI, 0.24 to 0.76) with one patient achieving CR and four PR. Primary toxicity of the regimen was reversible myelosuppression, mostly grade 3 or 4 neutropenia. The Cmax mean for plasma and CSF were 2669 ng/mL and 0.397 ng/mL, respectively, and patients with response at deep tumor sites displayed higher trends in peak exposure. Pharmacokinetic data was best described by a four-compartment model with first-order elimination of drug from central plasma and CSF compartments. CONCLUSIONS: R-BOAD is an effective salvage option for PCNSL, but with significant hematologic toxicity. Bendamustine CSF levels are minimal; however correspond to plasma exposure and response. TRIAL REGISTRATION: ClinicalTrials.gov NCT03392714 ; retrospectively registered January 8, 2018.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree true
47 schema:isPartOf N0614cf203b0442f6be5c484da659880a
48 Nd3ab46f17a364243ac57fe6caf1bc901
49 sg:journal.1024632
50 schema:name Clinical response and pharmacokinetics of bendamustine as a component of salvage R-B(O)AD therapy for the treatment of primary central nervous system lymphoma (PCNSL)
51 schema:pagination 729
52 schema:productId N77c73325f37a4e4688ccfe19303b70c5
53 Ncc2fd20215e449d9b48e6f7f08c5a091
54 Nd58219515ad143b98f421048855450e7
55 Neee1dc23a0cd48029d198eb7ccad4c3d
56 Neef7b11f13a74746ac19e63e1a839fad
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105448295
58 https://doi.org/10.1186/s12885-018-4632-y
59 schema:sdDatePublished 2019-04-10T13:27
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N213d9ad0a664455c871970de04fe8668
62 schema:url https://link.springer.com/10.1186%2Fs12885-018-4632-y
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N0614cf203b0442f6be5c484da659880a schema:volumeNumber 18
67 rdf:type schema:PublicationVolume
68 N1e2656e7b7a84ccf866cffd37b957ee1 rdf:first sg:person.01203011754.74
69 rdf:rest N404c44554f3c4f37ab2efc3eb53eba11
70 N213d9ad0a664455c871970de04fe8668 schema:name Springer Nature - SN SciGraph project
71 rdf:type schema:Organization
72 N404c44554f3c4f37ab2efc3eb53eba11 rdf:first sg:person.01346642620.39
73 rdf:rest Nff0d58f47cd74fe98276024a17afc936
74 N47a83805dea342968e3afed3df889813 rdf:first N57f58e4ab44c46fea36bfb74dca70906
75 rdf:rest N1e2656e7b7a84ccf866cffd37b957ee1
76 N49ce70d2e7f242588a412ce5ea3ca03c rdf:first sg:person.0753367262.83
77 rdf:rest rdf:nil
78 N57f58e4ab44c46fea36bfb74dca70906 schema:affiliation https://www.grid.ac/institutes/grid.411602.0
79 schema:familyName Choi
80 schema:givenName He Yun
81 rdf:type schema:Person
82 N683e1e7f5c674527baacd5e4dc78addc rdf:first sg:person.0576614356.22
83 rdf:rest N47a83805dea342968e3afed3df889813
84 N77c73325f37a4e4688ccfe19303b70c5 schema:name readcube_id
85 schema:value f78c80ae90f601d85278945323137b1725c6242a2c157b4142afe6cb3317d80f
86 rdf:type schema:PropertyValue
87 Na020fdebd3b246489cd84dcec14e6a28 schema:name Department of Biostatistics and Bioinformatics, Pharma Partnering Inc., 74 Olympicro, Songpagu, 05556, Seoul, Republic of Korea
88 rdf:type schema:Organization
89 Naadefdbc1d134404b9cf320c5367a5f3 rdf:first sg:person.01204441075.42
90 rdf:rest Nb68f55e702ea4a249fdcb0e500806ffe
91 Nb68f55e702ea4a249fdcb0e500806ffe rdf:first Nd0cea9009b5e475b8762062670d6d996
92 rdf:rest N49ce70d2e7f242588a412ce5ea3ca03c
93 Nba523994180f45cd844bc345533c51ce rdf:first sg:person.0617770714.19
94 rdf:rest Naadefdbc1d134404b9cf320c5367a5f3
95 Ncc2fd20215e449d9b48e6f7f08c5a091 schema:name dimensions_id
96 schema:value pub.1105448295
97 rdf:type schema:PropertyValue
98 Nd0cea9009b5e475b8762062670d6d996 schema:affiliation Na020fdebd3b246489cd84dcec14e6a28
99 schema:familyName Yoo
100 schema:givenName Hee-Doo
101 rdf:type schema:Person
102 Nd3ab46f17a364243ac57fe6caf1bc901 schema:issueNumber 1
103 rdf:type schema:PublicationIssue
104 Nd58219515ad143b98f421048855450e7 schema:name pubmed_id
105 schema:value 29986691
106 rdf:type schema:PropertyValue
107 Neee1dc23a0cd48029d198eb7ccad4c3d schema:name nlm_unique_id
108 schema:value 100967800
109 rdf:type schema:PropertyValue
110 Neef7b11f13a74746ac19e63e1a839fad schema:name doi
111 schema:value 10.1186/s12885-018-4632-y
112 rdf:type schema:PropertyValue
113 Nff0d58f47cd74fe98276024a17afc936 rdf:first sg:person.01017560023.88
114 rdf:rest Nba523994180f45cd844bc345533c51ce
115 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
116 schema:name Medical and Health Sciences
117 rdf:type schema:DefinedTerm
118 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
119 schema:name Public Health and Health Services
120 rdf:type schema:DefinedTerm
121 sg:journal.1024632 schema:issn 1471-2407
122 schema:name BMC Cancer
123 rdf:type schema:Periodical
124 sg:person.01017560023.88 schema:affiliation https://www.grid.ac/institutes/grid.411602.0
125 schema:familyName Ahn
126 schema:givenName Jae-Sook
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017560023.88
128 rdf:type schema:Person
129 sg:person.01203011754.74 schema:affiliation https://www.grid.ac/institutes/grid.411602.0
130 schema:familyName Lee
131 schema:givenName Hyun-Seo
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203011754.74
133 rdf:type schema:Person
134 sg:person.01204441075.42 schema:affiliation https://www.grid.ac/institutes/grid.411602.0
135 schema:familyName Lee
136 schema:givenName Je-Jung
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204441075.42
138 rdf:type schema:Person
139 sg:person.01346642620.39 schema:affiliation https://www.grid.ac/institutes/grid.411602.0
140 schema:familyName Jung
141 schema:givenName Sung-Hoon
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346642620.39
143 rdf:type schema:Person
144 sg:person.0576614356.22 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
145 schema:familyName Kim
146 schema:givenName Therasa
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576614356.22
148 rdf:type schema:Person
149 sg:person.0617770714.19 schema:affiliation https://www.grid.ac/institutes/grid.411602.0
150 schema:familyName Kim
151 schema:givenName Hyeoung-Joon
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617770714.19
153 rdf:type schema:Person
154 sg:person.0753367262.83 schema:affiliation https://www.grid.ac/institutes/grid.411602.0
155 schema:familyName Yang
156 schema:givenName Deok-Hwan
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753367262.83
158 rdf:type schema:Person
159 sg:pub.10.1007/s00280-006-0331-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030689330
160 https://doi.org/10.1007/s00280-006-0331-5
161 rdf:type schema:CreativeWork
162 sg:pub.10.1007/s00280-010-1254-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024033620
163 https://doi.org/10.1007/s00280-010-1254-8
164 rdf:type schema:CreativeWork
165 sg:pub.10.1007/s00432-005-0023-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024121433
166 https://doi.org/10.1007/s00432-005-0023-2
167 rdf:type schema:CreativeWork
168 sg:pub.10.1007/s11060-006-9165-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028814652
169 https://doi.org/10.1007/s11060-006-9165-6
170 rdf:type schema:CreativeWork
171 sg:pub.10.1007/s11060-011-0612-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050266838
172 https://doi.org/10.1007/s11060-011-0612-7
173 rdf:type schema:CreativeWork
174 sg:pub.10.1007/s11060-011-0788-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048958167
175 https://doi.org/10.1007/s11060-011-0788-x
176 rdf:type schema:CreativeWork
177 sg:pub.10.1007/s11060-014-1370-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019739839
178 https://doi.org/10.1007/s11060-014-1370-0
179 rdf:type schema:CreativeWork
180 sg:pub.10.1007/s11060-014-1411-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046834783
181 https://doi.org/10.1007/s11060-014-1411-8
182 rdf:type schema:CreativeWork
183 sg:pub.10.1007/s11060-016-2241-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083842670
184 https://doi.org/10.1007/s11060-016-2241-7
185 rdf:type schema:CreativeWork
186 sg:pub.10.1007/s11095-007-9361-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050287322
187 https://doi.org/10.1007/s11095-007-9361-x
188 rdf:type schema:CreativeWork
189 sg:pub.10.1007/s11899-014-0217-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046300816
190 https://doi.org/10.1007/s11899-014-0217-2
191 rdf:type schema:CreativeWork
192 sg:pub.10.1007/s12185-017-2316-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1091611108
193 https://doi.org/10.1007/s12185-017-2316-z
194 rdf:type schema:CreativeWork
195 sg:pub.10.1007/s40268-012-0001-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029167592
196 https://doi.org/10.1007/s40268-012-0001-5
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/bjc.2011.357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052077972
199 https://doi.org/10.1038/bjc.2011.357
200 rdf:type schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1077456234 schema:CreativeWork
202 https://doi.org/10.1016/j.jchromb.2012.02.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025957034
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/s1470-2045(15)00076-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019209751
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/s2352-3026(16)30185-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041173016
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1080/10543406.2014.1000544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011347736
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1093/chromsci/bmt075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001508359
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1093/neuonc/nos218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006436675
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1097/cad.0b013e328165d11a schema:sameAs https://app.dimensions.ai/details/publication/pub.1077456234
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1124/dmd.112.045229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052410111
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1158/1078-0432.ccr-04-0159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021593241
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1158/1078-0432.ccr-07-0781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049961776
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1200/jco.2003.09.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203872
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1200/jco.2005.13.524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003658256
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1200/jco.2006.09.9861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003057178
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1200/jco.2008.18.7252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000657227
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1200/jco.2012.45.9842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004450217
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1200/jco.2015.64.9897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042937879
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1200/jco.2017.72.7602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086133657
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1212/wnl.0b013e31820f2d94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064355987
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1371/journal.pone.0090675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006671454
239 rdf:type schema:CreativeWork
240 https://doi.org/10.3109/10428194.2012.688200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013917553
241 rdf:type schema:CreativeWork
242 https://doi.org/10.3109/10428194.2012.698736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023764131
243 rdf:type schema:CreativeWork
244 https://doi.org/10.3892/mmr_00000186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071524982
245 rdf:type schema:CreativeWork
246 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
247 schema:name College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanakro, Gwanakgu, 08826, Seoul, Republic of Korea
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.411602.0 schema:alternateName Chonnam National University Hwasun Hospital
250 schema:name Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, 58128, Jeollanamdo, Republic of Korea
251 Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, 58128, Jeollanamdo, Republic of Korea
252 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...