Repurposing existing medications as cancer therapy: design and feasibility of a randomized pilot investigating propranolol administration in patients receiving hematopoietic ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-05-24

AUTHORS

Jennifer M. Knight, Stephanie A. Kerswill, Parameswaran Hari, Steve W. Cole, Brent R. Logan, Anita D’Souza, Nirav N. Shah, Mary M. Horowitz, Melinda R. Stolley, Erica K. Sloan, Karen E. Giles, Erin S. Costanzo, Mehdi Hamadani, Saurabh Chhabra, Binod Dhakal, J. Douglas Rizzo

ABSTRACT

BackgroundRepurposing existing medications for antineoplastic purposes can provide a safe, cost-effective, and efficacious means to further augment available cancer care. Clinical and preclinical studies suggest a role for the ß-adrenergic antagonist (ß-blocker) propranolol in reducing rates of tumor progression in both solid and hematologic malignancies. In patients undergoing hematopoietic cell transplantation (HCT), the peri-transplant period is a time of increased activity of the ß-adrenergically-mediated stress response.MethodsWe conducted a proof-of-concept randomized controlled pilot study assessing the feasibility of propranolol administration to patients between ages 18–75 who received an autologous HCT for multiple myeloma. Feasibility was assessed by enrollment rate, tolerability, adherence, and retention.ResultsOne hundred fifty-four patients underwent screening; 31 (20%) enrolled in other oncology trials that precluded dual trial enrollment and 9 (6%) declined to enroll in the current trial. Eighty-nine (58%) did not meet eligibility requirements and 25 (16%) were eligible; of the remaining eligible patients, all were successfully enrolled and randomized. The most common reasons for ineligibility were current ß-blocker use, age, logistics, and medical contraindications. 92% of treatment arm patients tolerated and remained on propranolol for the study duration; 1 patient discontinued due to hypotension. Adherence rate in assessable patients (n = 10) was 94%. Study retention was 100%.ConclusionsFindings show that it is feasible to recruit and treat multiple myeloma patients with propranolol during HCT, with the greatest obstacle being other competing oncology trials. These data support further studies examining propranolol and other potentially repurposed drugs in oncology populations.Trial registrationThis randomized controlled trial was registered at clinicaltrials.gov with the identifier NCT02420223 on April 17, 2015. More... »

PAGES

593

References to SciGraph publications

  • 2004-10-25. Routine screening for psychosocial distress following hematopoietic stem cell transplantation in BONE MARROW TRANSPLANTATION
  • 2006-03. The influence of bio-behavioural factors on tumour biology: pathways and mechanisms in NATURE REVIEWS CANCER
  • 2012-10-19. New indication for therapeutic potential of an old well-known drug (propranolol) for multiple myeloma in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2007-09-13. Social regulation of gene expression in human leukocytes in GENOME BIOLOGY
  • 2006-06-19. Do negative or positive emotions differentially impact mortality after adult stem cell transplant? in BONE MARROW TRANSPLANTATION
  • 2011-05-23. Quality of life in patients before and after haematopoietic stem cell transplantation measured with the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire QLQ-C30 in BONE MARROW TRANSPLANTATION
  • 1998-03-01. Quality of life and psychological distress of bone marrow transplant recipients: the ‘time trajectory’ to recovery over the first year in BONE MARROW TRANSPLANTATION
  • 2011-08-05. Reciprocal regulation of the neural and innate immune systems in NATURE REVIEWS IMMUNOLOGY
  • 2015-08-24. Sympathetic nervous system regulation of the tumour microenvironment in NATURE REVIEWS CANCER
  • 2008-03-26. Health-related quality of life among adults with serious psychological distress and chronic medical conditions in QUALITY OF LIFE RESEARCH
  • 2015-10-20. Drug repurposing in oncology—patient and health systems opportunities in NATURE REVIEWS CLINICAL ONCOLOGY
  • Journal

    TITLE

    BMC Cancer

    ISSUE

    1

    VOLUME

    18

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-018-4509-0

    DOI

    http://dx.doi.org/10.1186/s12885-018-4509-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104168496

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29793446


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adrenergic beta-Antagonists", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemotherapy, Adjuvant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Repositioning", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Feasibility Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multiple Myeloma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Patient Compliance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pilot Projects", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proof of Concept Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Propranolol", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Research Design", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation, Autologous", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Departments of Psychiatry, Medicine, and Microbiology & Immunology, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA", 
                "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knight", 
            "givenName": "Jennifer M.", 
            "id": "sg:person.01106161351.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106161351.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical College of Wisconsin, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Medical College of Wisconsin, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kerswill", 
            "givenName": "Stephanie A.", 
            "id": "sg:person.016017161004.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016017161004.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hari", 
            "givenName": "Parameswaran", 
            "id": "sg:person.01170403141.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170403141.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Division of Hematology-Oncology, and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, Division of Hematology-Oncology, and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cole", 
            "givenName": "Steve W.", 
            "id": "sg:person.07554162312.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07554162312.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Biostatistics, Institute for Health & Society, Medical College of Wisconsin, Milwaukee, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Center for International Blood and Marrow Transplant Research; Medical College of Wisconsin, Milwaukee, WI, USA", 
                "Division of Biostatistics, Institute for Health & Society, Medical College of Wisconsin, Milwaukee, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Logan", 
            "givenName": "Brent R.", 
            "id": "sg:person.0604532000.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604532000.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for International Blood and Marrow Transplant Research; Medical College of Wisconsin, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA", 
                "Center for International Blood and Marrow Transplant Research; Medical College of Wisconsin, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "D\u2019Souza", 
            "givenName": "Anita", 
            "id": "sg:person.01152771506.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152771506.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shah", 
            "givenName": "Nirav N.", 
            "id": "sg:person.015270014615.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015270014615.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for International Blood and Marrow Transplant Research; Medical College of Wisconsin, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA", 
                "Center for International Blood and Marrow Transplant Research; Medical College of Wisconsin, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Horowitz", 
            "givenName": "Mary M.", 
            "id": "sg:person.010360225632.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010360225632.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stolley", 
            "givenName": "Melinda R.", 
            "id": "sg:person.016566202147.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016566202147.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cancer Surgery, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia", 
              "id": "http://www.grid.ac/institutes/grid.1055.1", 
              "name": [
                "Monash Institute of Pharmaceutical Sciences, Monash University, Clayton, VIC, Australia", 
                "Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Jonsson Comprehensive Cancer Center, and UCLA AIDS Institute, UCLA, Los Angeles, CA, USA", 
                "Division of Cancer Surgery, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sloan", 
            "givenName": "Erica K.", 
            "id": "sg:person.01226143323.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226143323.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical College of Wisconsin, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Medical College of Wisconsin, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giles", 
            "givenName": "Karen E.", 
            "id": "sg:person.014717632706.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014717632706.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Carbone Cancer Center and Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "Carbone Cancer Center and Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Costanzo", 
            "givenName": "Erin S.", 
            "id": "sg:person.0717476233.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717476233.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for International Blood and Marrow Transplant Research; Medical College of Wisconsin, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA", 
                "Center for International Blood and Marrow Transplant Research; Medical College of Wisconsin, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hamadani", 
            "givenName": "Mehdi", 
            "id": "sg:person.01333152475.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333152475.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chhabra", 
            "givenName": "Saurabh", 
            "id": "sg:person.012647475207.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012647475207.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dhakal", 
            "givenName": "Binod", 
            "id": "sg:person.01047372670.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047372670.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for International Blood and Marrow Transplant Research; Medical College of Wisconsin, Milwaukee, WI, USA", 
              "id": "http://www.grid.ac/institutes/grid.30760.32", 
              "name": [
                "Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA", 
                "Center for International Blood and Marrow Transplant Research; Medical College of Wisconsin, Milwaukee, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rizzo", 
            "givenName": "J. Douglas", 
            "id": "sg:person.0735274405.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735274405.45"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.bmt.1705419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013542743", 
              "https://doi.org/10.1038/sj.bmt.1705419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11136-008-9330-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013059643", 
              "https://doi.org/10.1007/s11136-008-9330-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2007-8-9-r189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039129712", 
              "https://doi.org/10.1186/gb-2007-8-9-r189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1701115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001832546", 
              "https://doi.org/10.1038/sj.bmt.1701115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2015.169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047157332", 
              "https://doi.org/10.1038/nrclinonc.2015.169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014613805", 
              "https://doi.org/10.1038/nrc1820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1704709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014866337", 
              "https://doi.org/10.1038/sj.bmt.1704709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029154545", 
              "https://doi.org/10.1038/nrc3978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-012-1331-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025806074", 
              "https://doi.org/10.1007/s00432-012-1331-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2011.107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014012805", 
              "https://doi.org/10.1038/bmt.2011.107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032780647", 
              "https://doi.org/10.1038/nri3042"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-05-24", 
        "datePublishedReg": "2018-05-24", 
        "description": "BackgroundRepurposing existing medications for antineoplastic purposes can provide a safe, cost-effective, and efficacious means to further augment available cancer care. Clinical and preclinical studies suggest a role for the \u00df-adrenergic antagonist (\u00df-blocker) propranolol in reducing rates of tumor progression in both solid and hematologic malignancies. In patients undergoing hematopoietic cell transplantation (HCT), the peri-transplant period is a time of increased activity of the \u00df-adrenergically-mediated stress response.MethodsWe conducted a proof-of-concept randomized controlled pilot study assessing the feasibility of propranolol administration to patients between ages 18\u201375 who received an autologous HCT for multiple myeloma. Feasibility was assessed by enrollment rate, tolerability, adherence, and retention.ResultsOne hundred fifty-four patients underwent screening; 31 (20%) enrolled in other oncology trials that precluded dual trial enrollment and 9 (6%) declined to enroll in the current trial. Eighty-nine (58%) did not meet eligibility requirements and 25 (16%) were eligible; of the remaining eligible patients, all were successfully enrolled and randomized. The most common reasons for ineligibility were current \u00df-blocker use, age, logistics, and medical contraindications. 92% of treatment arm patients tolerated and remained on propranolol for the study duration; 1 patient discontinued due to hypotension. Adherence rate in assessable patients (n\u00a0=\u200910) was 94%. Study retention was 100%.ConclusionsFindings show that it is feasible to recruit and treat multiple myeloma patients with propranolol during HCT, with the greatest obstacle being other competing oncology trials. These data support further studies examining propranolol and other potentially repurposed drugs in oncology populations.Trial registrationThis randomized controlled trial was registered at clinicaltrials.gov with the identifier NCT02420223 on April 17, 2015.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12885-018-4509-0", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2343593", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4243900", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4242340", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1024632", 
            "issn": [
              "1471-2407"
            ], 
            "name": "BMC Cancer", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "keywords": [
          "hematopoietic cell transplantation", 
          "propranolol administration", 
          "cell transplantation", 
          "oncology trials", 
          "autologous hematopoietic cell transplantation", 
          "peri-transplant period", 
          "\u00df-blocker use", 
          "multiple myeloma patients", 
          "ResultsOne hundred fifty", 
          "adrenergic antagonist propranolol", 
          "treatment arm patients", 
          "eligible patients", 
          "assessable patients", 
          "medical contraindications", 
          "ARM patients", 
          "oncology population", 
          "trial enrollment", 
          "myeloma patients", 
          "multiple myeloma", 
          "adherence rates", 
          "cancer care", 
          "antagonist propranolol", 
          "hematologic malignancies", 
          "hundred fifty", 
          "preclinical studies", 
          "study retention", 
          "common reason", 
          "patients", 
          "study duration", 
          "randomized pilot", 
          "tumor progression", 
          "current trial", 
          "propranolol", 
          "age 18", 
          "pilot study", 
          "trials", 
          "cancer therapy", 
          "efficacious means", 
          "medications", 
          "Further studies", 
          "transplantation", 
          "eligibility requirements", 
          "administration", 
          "hypotension", 
          "tolerability", 
          "contraindications", 
          "myeloma", 
          "malignancy", 
          "therapy", 
          "MethodsWe", 
          "stress response", 
          "ineligibility", 
          "progression", 
          "care", 
          "study", 
          "adherence", 
          "drugs", 
          "enrollment rates", 
          "age", 
          "rate", 
          "enrollment", 
          "duration", 
          "ConclusionsFindings", 
          "screening", 
          "population", 
          "fifties", 
          "response", 
          "feasibility", 
          "retention", 
          "period", 
          "activity", 
          "role", 
          "greatest obstacle", 
          "pilot", 
          "use", 
          "purpose", 
          "data", 
          "reasons", 
          "time", 
          "means", 
          "identifiers", 
          "obstacles", 
          "design", 
          "requirements", 
          "proof", 
          "logistics", 
          "concept"
        ], 
        "name": "Repurposing existing medications as cancer therapy: design and feasibility of a randomized pilot investigating propranolol administration in patients receiving hematopoietic cell transplantation", 
        "pagination": "593", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1104168496"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12885-018-4509-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29793446"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12885-018-4509-0", 
          "https://app.dimensions.ai/details/publication/pub.1104168496"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_771.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12885-018-4509-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4509-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4509-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4509-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4509-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    406 TRIPLES      21 PREDICATES      144 URIs      125 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12885-018-4509-0 schema:about N20b01d6728624c9796ed178c53768da5
    2 N23a7124eb37f49068ed1a8919cceb868
    3 N2978d7d15f16493b809558dded469d1a
    4 N3d143667fbfc44baa0d3b2122217d39d
    5 N45825e71888e4873a0285b0cf68b035f
    6 N471a60346143475ca3caa0edb72ec5c7
    7 N4b5b1ca0c0114dc9ad7a90ae55ffbe9f
    8 N608ff0787c0840b4b6f2748a04f98b1b
    9 N77d2ef27709046afb2b5569ae3d84a1b
    10 N788c93c5904d43fc82ce0eaa115fc782
    11 N8c45ee9b59a74954aac4b057ad04a610
    12 N9a59dbd6e4c24542904899ee8cef323f
    13 Na83c0bf4fc1a431abe90161408409d0f
    14 Naeba67240f6a4a0895e146ba1b751561
    15 Nafa4630802234770bb895146a7c48641
    16 Nb817cd0542174854a2c6ca78601e082e
    17 Nb9331dc37cc84f3eaf9855d03eb13297
    18 Nd1bd3fbf3b9a4354bee50f7fe80b1816
    19 Nd7528447e2a241378f90f306eb169470
    20 Ne033bd0cfb524d03a934fb3e3f83770c
    21 Nf3762886ba094778abb517c2a222c273
    22 anzsrc-for:11
    23 anzsrc-for:1112
    24 schema:author N784988c752b24361a2d8776642ffb1b1
    25 schema:citation sg:pub.10.1007/s00432-012-1331-y
    26 sg:pub.10.1007/s11136-008-9330-9
    27 sg:pub.10.1038/bmt.2011.107
    28 sg:pub.10.1038/nrc1820
    29 sg:pub.10.1038/nrc3978
    30 sg:pub.10.1038/nrclinonc.2015.169
    31 sg:pub.10.1038/nri3042
    32 sg:pub.10.1038/sj.bmt.1701115
    33 sg:pub.10.1038/sj.bmt.1704709
    34 sg:pub.10.1038/sj.bmt.1705419
    35 sg:pub.10.1186/gb-2007-8-9-r189
    36 schema:datePublished 2018-05-24
    37 schema:datePublishedReg 2018-05-24
    38 schema:description BackgroundRepurposing existing medications for antineoplastic purposes can provide a safe, cost-effective, and efficacious means to further augment available cancer care. Clinical and preclinical studies suggest a role for the ß-adrenergic antagonist (ß-blocker) propranolol in reducing rates of tumor progression in both solid and hematologic malignancies. In patients undergoing hematopoietic cell transplantation (HCT), the peri-transplant period is a time of increased activity of the ß-adrenergically-mediated stress response.MethodsWe conducted a proof-of-concept randomized controlled pilot study assessing the feasibility of propranolol administration to patients between ages 18–75 who received an autologous HCT for multiple myeloma. Feasibility was assessed by enrollment rate, tolerability, adherence, and retention.ResultsOne hundred fifty-four patients underwent screening; 31 (20%) enrolled in other oncology trials that precluded dual trial enrollment and 9 (6%) declined to enroll in the current trial. Eighty-nine (58%) did not meet eligibility requirements and 25 (16%) were eligible; of the remaining eligible patients, all were successfully enrolled and randomized. The most common reasons for ineligibility were current ß-blocker use, age, logistics, and medical contraindications. 92% of treatment arm patients tolerated and remained on propranolol for the study duration; 1 patient discontinued due to hypotension. Adherence rate in assessable patients (n = 10) was 94%. Study retention was 100%.ConclusionsFindings show that it is feasible to recruit and treat multiple myeloma patients with propranolol during HCT, with the greatest obstacle being other competing oncology trials. These data support further studies examining propranolol and other potentially repurposed drugs in oncology populations.Trial registrationThis randomized controlled trial was registered at clinicaltrials.gov with the identifier NCT02420223 on April 17, 2015.
    39 schema:genre article
    40 schema:isAccessibleForFree true
    41 schema:isPartOf N8c92a9796e4c423eb358e96a8b37465c
    42 Nf68ca23681244c2f993b72b5140a69a2
    43 sg:journal.1024632
    44 schema:keywords ARM patients
    45 ConclusionsFindings
    46 Further studies
    47 MethodsWe
    48 ResultsOne hundred fifty
    49 activity
    50 adherence
    51 adherence rates
    52 administration
    53 adrenergic antagonist propranolol
    54 age
    55 age 18
    56 antagonist propranolol
    57 assessable patients
    58 autologous hematopoietic cell transplantation
    59 cancer care
    60 cancer therapy
    61 care
    62 cell transplantation
    63 common reason
    64 concept
    65 contraindications
    66 current trial
    67 data
    68 design
    69 drugs
    70 duration
    71 efficacious means
    72 eligibility requirements
    73 eligible patients
    74 enrollment
    75 enrollment rates
    76 feasibility
    77 fifties
    78 greatest obstacle
    79 hematologic malignancies
    80 hematopoietic cell transplantation
    81 hundred fifty
    82 hypotension
    83 identifiers
    84 ineligibility
    85 logistics
    86 malignancy
    87 means
    88 medical contraindications
    89 medications
    90 multiple myeloma
    91 multiple myeloma patients
    92 myeloma
    93 myeloma patients
    94 obstacles
    95 oncology population
    96 oncology trials
    97 patients
    98 peri-transplant period
    99 period
    100 pilot
    101 pilot study
    102 population
    103 preclinical studies
    104 progression
    105 proof
    106 propranolol
    107 propranolol administration
    108 purpose
    109 randomized pilot
    110 rate
    111 reasons
    112 requirements
    113 response
    114 retention
    115 role
    116 screening
    117 stress response
    118 study
    119 study duration
    120 study retention
    121 therapy
    122 time
    123 tolerability
    124 transplantation
    125 treatment arm patients
    126 trial enrollment
    127 trials
    128 tumor progression
    129 use
    130 ß-blocker use
    131 schema:name Repurposing existing medications as cancer therapy: design and feasibility of a randomized pilot investigating propranolol administration in patients receiving hematopoietic cell transplantation
    132 schema:pagination 593
    133 schema:productId N34b7fa8026ec4e478ce7f586b0677275
    134 Nb05e9e0375f2413faa838ccb32a9a450
    135 Ne1b12b363d3843faa854f4592be1b9f2
    136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104168496
    137 https://doi.org/10.1186/s12885-018-4509-0
    138 schema:sdDatePublished 2022-12-01T06:37
    139 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    140 schema:sdPublisher Ne162591351314f1284f55b2a42fdb5c3
    141 schema:url https://doi.org/10.1186/s12885-018-4509-0
    142 sgo:license sg:explorer/license/
    143 sgo:sdDataset articles
    144 rdf:type schema:ScholarlyArticle
    145 N084ce72bb9f648ab995e96d1e13e6d08 rdf:first sg:person.0735274405.45
    146 rdf:rest rdf:nil
    147 N10161e9394dd4169a595e39076ecdfc3 rdf:first sg:person.01047372670.01
    148 rdf:rest N084ce72bb9f648ab995e96d1e13e6d08
    149 N20b01d6728624c9796ed178c53768da5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Adrenergic beta-Antagonists
    151 rdf:type schema:DefinedTerm
    152 N23a7124eb37f49068ed1a8919cceb868 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Patient Compliance
    154 rdf:type schema:DefinedTerm
    155 N2978d7d15f16493b809558dded469d1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Hematopoietic Stem Cell Transplantation
    157 rdf:type schema:DefinedTerm
    158 N34b7fa8026ec4e478ce7f586b0677275 schema:name dimensions_id
    159 schema:value pub.1104168496
    160 rdf:type schema:PropertyValue
    161 N364b05250a594fb39fa59099277281a2 rdf:first sg:person.016017161004.68
    162 rdf:rest N6016ba57aada4a87a238f873304f1495
    163 N3d143667fbfc44baa0d3b2122217d39d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Middle Aged
    165 rdf:type schema:DefinedTerm
    166 N45825e71888e4873a0285b0cf68b035f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Adult
    168 rdf:type schema:DefinedTerm
    169 N471a60346143475ca3caa0edb72ec5c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Propranolol
    171 rdf:type schema:DefinedTerm
    172 N4b5b1ca0c0114dc9ad7a90ae55ffbe9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Female
    174 rdf:type schema:DefinedTerm
    175 N6016ba57aada4a87a238f873304f1495 rdf:first sg:person.01170403141.13
    176 rdf:rest Na5ce5866ef814eefa5c6f4757b8dac47
    177 N608ff0787c0840b4b6f2748a04f98b1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Drug Repositioning
    179 rdf:type schema:DefinedTerm
    180 N65cd4b2c92444277bce51c4c0bd86bda rdf:first sg:person.014717632706.02
    181 rdf:rest Ndeeeeb2367b84c3299b904ed809257d9
    182 N681e48754d8d4a3fbc168be22ce04db2 rdf:first sg:person.01226143323.92
    183 rdf:rest N65cd4b2c92444277bce51c4c0bd86bda
    184 N77d2ef27709046afb2b5569ae3d84a1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Aged
    186 rdf:type schema:DefinedTerm
    187 N784988c752b24361a2d8776642ffb1b1 rdf:first sg:person.01106161351.14
    188 rdf:rest N364b05250a594fb39fa59099277281a2
    189 N788c93c5904d43fc82ce0eaa115fc782 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Disease Progression
    191 rdf:type schema:DefinedTerm
    192 N7a592560d7b7419d9386e4ca3c964619 rdf:first sg:person.01152771506.25
    193 rdf:rest Ne0194acbfd3e4dac89f7608fef816bc9
    194 N8c45ee9b59a74954aac4b057ad04a610 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Treatment Outcome
    196 rdf:type schema:DefinedTerm
    197 N8c92a9796e4c423eb358e96a8b37465c schema:issueNumber 1
    198 rdf:type schema:PublicationIssue
    199 N9a59dbd6e4c24542904899ee8cef323f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Transplantation, Autologous
    201 rdf:type schema:DefinedTerm
    202 Na05f07b8da4a42e288126f3c61dc9819 rdf:first sg:person.0604532000.22
    203 rdf:rest N7a592560d7b7419d9386e4ca3c964619
    204 Na5ce5866ef814eefa5c6f4757b8dac47 rdf:first sg:person.07554162312.13
    205 rdf:rest Na05f07b8da4a42e288126f3c61dc9819
    206 Na83c0bf4fc1a431abe90161408409d0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Male
    208 rdf:type schema:DefinedTerm
    209 Nadd4e4b224cb4107aa6c1d27a35ec329 rdf:first sg:person.01333152475.54
    210 rdf:rest Nba39637dea7242b296f691b5ea946a92
    211 Naeba67240f6a4a0895e146ba1b751561 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Proof of Concept Study
    213 rdf:type schema:DefinedTerm
    214 Nafa4630802234770bb895146a7c48641 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Feasibility Studies
    216 rdf:type schema:DefinedTerm
    217 Nb05e9e0375f2413faa838ccb32a9a450 schema:name doi
    218 schema:value 10.1186/s12885-018-4509-0
    219 rdf:type schema:PropertyValue
    220 Nb817cd0542174854a2c6ca78601e082e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Pilot Projects
    222 rdf:type schema:DefinedTerm
    223 Nb9331dc37cc84f3eaf9855d03eb13297 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Multiple Myeloma
    225 rdf:type schema:DefinedTerm
    226 Nba39637dea7242b296f691b5ea946a92 rdf:first sg:person.012647475207.14
    227 rdf:rest N10161e9394dd4169a595e39076ecdfc3
    228 Nc3f63fa89d014d47bad74e7e758be1ad rdf:first sg:person.010360225632.91
    229 rdf:rest Ndef533f6b72547ce9e450ac37a66b41d
    230 Nd1bd3fbf3b9a4354bee50f7fe80b1816 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    231 schema:name Humans
    232 rdf:type schema:DefinedTerm
    233 Nd7528447e2a241378f90f306eb169470 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Young Adult
    235 rdf:type schema:DefinedTerm
    236 Ndeeeeb2367b84c3299b904ed809257d9 rdf:first sg:person.0717476233.78
    237 rdf:rest Nadd4e4b224cb4107aa6c1d27a35ec329
    238 Ndef533f6b72547ce9e450ac37a66b41d rdf:first sg:person.016566202147.04
    239 rdf:rest N681e48754d8d4a3fbc168be22ce04db2
    240 Ne0194acbfd3e4dac89f7608fef816bc9 rdf:first sg:person.015270014615.39
    241 rdf:rest Nc3f63fa89d014d47bad74e7e758be1ad
    242 Ne033bd0cfb524d03a934fb3e3f83770c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    243 schema:name Chemotherapy, Adjuvant
    244 rdf:type schema:DefinedTerm
    245 Ne162591351314f1284f55b2a42fdb5c3 schema:name Springer Nature - SN SciGraph project
    246 rdf:type schema:Organization
    247 Ne1b12b363d3843faa854f4592be1b9f2 schema:name pubmed_id
    248 schema:value 29793446
    249 rdf:type schema:PropertyValue
    250 Nf3762886ba094778abb517c2a222c273 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    251 schema:name Research Design
    252 rdf:type schema:DefinedTerm
    253 Nf68ca23681244c2f993b72b5140a69a2 schema:volumeNumber 18
    254 rdf:type schema:PublicationVolume
    255 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    256 schema:name Medical and Health Sciences
    257 rdf:type schema:DefinedTerm
    258 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    259 schema:name Oncology and Carcinogenesis
    260 rdf:type schema:DefinedTerm
    261 sg:grant.2343593 http://pending.schema.org/fundedItem sg:pub.10.1186/s12885-018-4509-0
    262 rdf:type schema:MonetaryGrant
    263 sg:grant.4242340 http://pending.schema.org/fundedItem sg:pub.10.1186/s12885-018-4509-0
    264 rdf:type schema:MonetaryGrant
    265 sg:grant.4243900 http://pending.schema.org/fundedItem sg:pub.10.1186/s12885-018-4509-0
    266 rdf:type schema:MonetaryGrant
    267 sg:journal.1024632 schema:issn 1471-2407
    268 schema:name BMC Cancer
    269 schema:publisher Springer Nature
    270 rdf:type schema:Periodical
    271 sg:person.010360225632.91 schema:affiliation grid-institutes:grid.30760.32
    272 schema:familyName Horowitz
    273 schema:givenName Mary M.
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010360225632.91
    275 rdf:type schema:Person
    276 sg:person.01047372670.01 schema:affiliation grid-institutes:grid.30760.32
    277 schema:familyName Dhakal
    278 schema:givenName Binod
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047372670.01
    280 rdf:type schema:Person
    281 sg:person.01106161351.14 schema:affiliation grid-institutes:grid.30760.32
    282 schema:familyName Knight
    283 schema:givenName Jennifer M.
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106161351.14
    285 rdf:type schema:Person
    286 sg:person.01152771506.25 schema:affiliation grid-institutes:grid.30760.32
    287 schema:familyName D’Souza
    288 schema:givenName Anita
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152771506.25
    290 rdf:type schema:Person
    291 sg:person.01170403141.13 schema:affiliation grid-institutes:grid.30760.32
    292 schema:familyName Hari
    293 schema:givenName Parameswaran
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170403141.13
    295 rdf:type schema:Person
    296 sg:person.01226143323.92 schema:affiliation grid-institutes:grid.1055.1
    297 schema:familyName Sloan
    298 schema:givenName Erica K.
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226143323.92
    300 rdf:type schema:Person
    301 sg:person.012647475207.14 schema:affiliation grid-institutes:grid.30760.32
    302 schema:familyName Chhabra
    303 schema:givenName Saurabh
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012647475207.14
    305 rdf:type schema:Person
    306 sg:person.01333152475.54 schema:affiliation grid-institutes:grid.30760.32
    307 schema:familyName Hamadani
    308 schema:givenName Mehdi
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333152475.54
    310 rdf:type schema:Person
    311 sg:person.014717632706.02 schema:affiliation grid-institutes:grid.30760.32
    312 schema:familyName Giles
    313 schema:givenName Karen E.
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014717632706.02
    315 rdf:type schema:Person
    316 sg:person.015270014615.39 schema:affiliation grid-institutes:grid.30760.32
    317 schema:familyName Shah
    318 schema:givenName Nirav N.
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015270014615.39
    320 rdf:type schema:Person
    321 sg:person.016017161004.68 schema:affiliation grid-institutes:grid.30760.32
    322 schema:familyName Kerswill
    323 schema:givenName Stephanie A.
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016017161004.68
    325 rdf:type schema:Person
    326 sg:person.016566202147.04 schema:affiliation grid-institutes:grid.30760.32
    327 schema:familyName Stolley
    328 schema:givenName Melinda R.
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016566202147.04
    330 rdf:type schema:Person
    331 sg:person.0604532000.22 schema:affiliation grid-institutes:grid.30760.32
    332 schema:familyName Logan
    333 schema:givenName Brent R.
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604532000.22
    335 rdf:type schema:Person
    336 sg:person.0717476233.78 schema:affiliation grid-institutes:grid.14003.36
    337 schema:familyName Costanzo
    338 schema:givenName Erin S.
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717476233.78
    340 rdf:type schema:Person
    341 sg:person.0735274405.45 schema:affiliation grid-institutes:grid.30760.32
    342 schema:familyName Rizzo
    343 schema:givenName J. Douglas
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735274405.45
    345 rdf:type schema:Person
    346 sg:person.07554162312.13 schema:affiliation grid-institutes:grid.19006.3e
    347 schema:familyName Cole
    348 schema:givenName Steve W.
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07554162312.13
    350 rdf:type schema:Person
    351 sg:pub.10.1007/s00432-012-1331-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1025806074
    352 https://doi.org/10.1007/s00432-012-1331-y
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1007/s11136-008-9330-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013059643
    355 https://doi.org/10.1007/s11136-008-9330-9
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/bmt.2011.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014012805
    358 https://doi.org/10.1038/bmt.2011.107
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/nrc1820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014613805
    361 https://doi.org/10.1038/nrc1820
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/nrc3978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029154545
    364 https://doi.org/10.1038/nrc3978
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/nrclinonc.2015.169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047157332
    367 https://doi.org/10.1038/nrclinonc.2015.169
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/nri3042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032780647
    370 https://doi.org/10.1038/nri3042
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/sj.bmt.1701115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001832546
    373 https://doi.org/10.1038/sj.bmt.1701115
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/sj.bmt.1704709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014866337
    376 https://doi.org/10.1038/sj.bmt.1704709
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/sj.bmt.1705419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013542743
    379 https://doi.org/10.1038/sj.bmt.1705419
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1186/gb-2007-8-9-r189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039129712
    382 https://doi.org/10.1186/gb-2007-8-9-r189
    383 rdf:type schema:CreativeWork
    384 grid-institutes:grid.1055.1 schema:alternateName Division of Cancer Surgery, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia
    385 schema:name Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Jonsson Comprehensive Cancer Center, and UCLA AIDS Institute, UCLA, Los Angeles, CA, USA
    386 Division of Cancer Surgery, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia
    387 Monash Institute of Pharmaceutical Sciences, Monash University, Clayton, VIC, Australia
    388 rdf:type schema:Organization
    389 grid-institutes:grid.14003.36 schema:alternateName Carbone Cancer Center and Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA
    390 schema:name Carbone Cancer Center and Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA
    391 rdf:type schema:Organization
    392 grid-institutes:grid.19006.3e schema:alternateName Department of Medicine, Division of Hematology-Oncology, and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    393 schema:name Department of Medicine, Division of Hematology-Oncology, and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    394 rdf:type schema:Organization
    395 grid-institutes:grid.30760.32 schema:alternateName Center for International Blood and Marrow Transplant Research; Medical College of Wisconsin, Milwaukee, WI, USA
    396 Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    397 Division of Biostatistics, Institute for Health & Society, Medical College of Wisconsin, Milwaukee, USA
    398 Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA
    399 Medical College of Wisconsin, Milwaukee, WI, USA
    400 schema:name Center for International Blood and Marrow Transplant Research; Medical College of Wisconsin, Milwaukee, WI, USA
    401 Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    402 Departments of Psychiatry, Medicine, and Microbiology & Immunology, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA
    403 Division of Biostatistics, Institute for Health & Society, Medical College of Wisconsin, Milwaukee, USA
    404 Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA
    405 Medical College of Wisconsin, Milwaukee, WI, USA
    406 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...