Clinical management and outcome of patients with advanced NSCLC carrying EGFR mutations in Spain View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Edurne Arriola, Ramón García Gómez, Pilar Diz, Margarita Majem, Maite Martínez Aguillo, Javier Valdivia, Alfredo Paredes, José Miguel Sánchez-Torres, Sergio Peralta Muñoz, Isidoro Barneto, Vanesa Gutierrez, Jesús Manuel Andrade Santiago, Francisco Aparisi, Dolores Isla, Santiago Ponce, David Vicente Baz, Angel Artal, Mariluz Amador, Mariano Provencio

ABSTRACT

BACKGROUND: Although the benefit of first-line epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs) over chemotherapy has been demonstrated in several clinical trials, data from clinical practice is lacking and the optimal EGFR TKI to be used remains unclear. This study aims to assess the real-life diagnostic and clinical management and outcome of patients with advanced non-small-cell lung cancer (NSCLC) carrying EGFR mutations in Spain. METHODS: All consecutive patients recently diagnosed with advanced or metastatic NSCLC from April 2010 to December 2011 in 18 Spanish hospitals and carrying EGFR mutations were retrospectively evaluated. RESULTS: Between March and November 2013, a total of 187 patients were enrolled (98.3% Caucasian, 61.9% female, 54.9% never-smokers, 89.0% adenocarcinoma). Mutation testing was mainly performed on biopsy tumour tissue specimens (69.0%) using a qPCR-based test (90%) (47.0% Therascreen EGFR PCR Kit). Common sensitising mutations were detected in 79.8% of patients: 57.1% had exon 19 deletions and 22.6% exon 21 L858R point mutations. The vast majority of patients received first-line therapy (n = 168; 92.8%). EGFR TKIs were the most commonly used first-line treatment (81.5%), while chemotherapy was more frequently administered as a second- and third-line option (51.9% and 56.0%, respectively). Of 141 patients who experienced disease progression, 79 (56.0%) received second-line treatment. After disease progression on first-line TKIs (n = 112), 33.9% received chemotherapy, 8.9% chemotherapy and a TKI, and 9.8% continued TKI therapy. Most patients received first-line gefitinib (83.0%), while erlotinib was more frequently used in the second-line setting (83.0%). Progression-free survival (PFS) and overall survival (OS) in patients harbouring common mutations were 11.1 months and 20.1 months respectively (exon 19 deletions: 12.4 and 21.4 months; L858R: 8.3 and 14.5 months), and 3.9 months and 11.1 months respectively for those with rare mutations. CONCLUSION: EGFR TKIs (gefitinib and erlotinib) are used as the preferred first-line treatment while chemotherapy is more frequently administered as a second- and third-line option in routine clinical practice in Spain. In addition, efficacy data obtained in the real-life setting seem to concur with data from EGFR TKI phase III pivotal studies in NSCLC. More... »

PAGES

106

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-018-4004-7

DOI

http://dx.doi.org/10.1186/s12885-018-4004-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100718347

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29382302


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Non-Small-Cell Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Erlotinib Hydrochloride", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinazolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital Del Mar", 
          "id": "https://www.grid.ac/institutes/grid.411142.3", 
          "name": [
            "Medical Oncology Department, Hospital del Mar, Passeig Mar\u00edtim, 25-29, 08018, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arriola", 
        "givenName": "Edurne", 
        "id": "sg:person.01302630647.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302630647.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital General Universitario Gregorio Mara\u00f1\u00f3n", 
          "id": "https://www.grid.ac/institutes/grid.410526.4", 
          "name": [
            "Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda G\u00f3mez", 
        "givenName": "Ram\u00f3n", 
        "id": "sg:person.012752413463.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012752413463.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital de Le\u00f3n", 
          "id": "https://www.grid.ac/institutes/grid.411969.2", 
          "name": [
            "Hospital Universitario de Le\u00f3n, Le\u00f3n, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diz", 
        "givenName": "Pilar", 
        "id": "sg:person.0604464234.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604464234.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital de Sant Pau", 
          "id": "https://www.grid.ac/institutes/grid.413396.a", 
          "name": [
            "Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Majem", 
        "givenName": "Margarita", 
        "id": "sg:person.01322640302.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322640302.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Complejo Hospitalario de Navarra", 
          "id": "https://www.grid.ac/institutes/grid.497559.3", 
          "name": [
            "Complejo Hospitalario de Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00ednez Aguillo", 
        "givenName": "Maite", 
        "id": "sg:person.015462057372.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015462057372.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Virgen de las Nieves", 
          "id": "https://www.grid.ac/institutes/grid.411380.f", 
          "name": [
            "Hospital Universitario Virgen de las Nieves, Granada, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valdivia", 
        "givenName": "Javier", 
        "id": "sg:person.07751521722.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07751521722.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Donostia Unibertsitate Ospitalea", 
          "id": "https://www.grid.ac/institutes/grid.414651.3", 
          "name": [
            "Hospital Universitario Donostia, San Sebasti\u00e1n, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paredes", 
        "givenName": "Alfredo", 
        "id": "sg:person.01015457763.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015457763.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario de La Princesa", 
          "id": "https://www.grid.ac/institutes/grid.411251.2", 
          "name": [
            "Hospital Universitario de La Princesa, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00e1nchez-Torres", 
        "givenName": "Jos\u00e9 Miguel", 
        "id": "sg:person.01073174565.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073174565.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitari Sant Joan de Reus", 
          "id": "https://www.grid.ac/institutes/grid.411136.0", 
          "name": [
            "Hospital Universitari Sant Joan de Reus, Reus, Tarragona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peralta Mu\u00f1oz", 
        "givenName": "Sergio", 
        "id": "sg:person.016605711740.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016605711740.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Reina Sof\u00eda de C\u00f3rdoba", 
          "id": "https://www.grid.ac/institutes/grid.411349.a", 
          "name": [
            "Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barneto", 
        "givenName": "Isidoro", 
        "id": "sg:person.01020642531.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020642531.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Regional Universitario de M\u00e1laga", 
          "id": "https://www.grid.ac/institutes/grid.411457.2", 
          "name": [
            "Hospital Regional Universitario Carlos Haya, M\u00e1laga, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gutierrez", 
        "givenName": "Vanesa", 
        "id": "sg:person.0744162445.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744162445.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Virgen de la Salud", 
          "id": "https://www.grid.ac/institutes/grid.413514.6", 
          "name": [
            "Hospital Virgen de la Salud, Toledo, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andrade Santiago", 
        "givenName": "Jes\u00fas Manuel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Virgen de los Lirios", 
          "id": "https://www.grid.ac/institutes/grid.413522.3", 
          "name": [
            "Hospital Virgen de los Lirios, Alcoy, Alicante, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aparisi", 
        "givenName": "Francisco", 
        "id": "sg:person.01224655036.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224655036.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Cl\u00ednico Universitario Lozano Blesa", 
          "id": "https://www.grid.ac/institutes/grid.411050.1", 
          "name": [
            "Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Isla", 
        "givenName": "Dolores", 
        "id": "sg:person.01103254434.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103254434.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario 12 De Octubre", 
          "id": "https://www.grid.ac/institutes/grid.144756.5", 
          "name": [
            "Hospital Universitario 12 de Octubre, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ponce", 
        "givenName": "Santiago", 
        "id": "sg:person.01353670656.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353670656.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Virgen Macarena", 
          "id": "https://www.grid.ac/institutes/grid.411375.5", 
          "name": [
            "Hospital Universitario Virgen Macarena, Sevilla, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vicente Baz", 
        "givenName": "David", 
        "id": "sg:person.015056034305.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015056034305.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Miguel Servet", 
          "id": "https://www.grid.ac/institutes/grid.411106.3", 
          "name": [
            "Hospital Universitario Miguel Servet, Zaragoza, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Artal", 
        "givenName": "Angel", 
        "id": "sg:person.0673172415.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673172415.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AstraZeneca (Spain)", 
          "id": "https://www.grid.ac/institutes/grid.476014.0", 
          "name": [
            "AstraZeneca, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amador", 
        "givenName": "Mariluz", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Provencio", 
        "givenName": "Mariano", 
        "id": "sg:person.0726612567.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726612567.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/annonc/mdu199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001793280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70393-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004429924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-1468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006534187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cca.2013.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007823348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009055747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(13)70604-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009186895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-0560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011971166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0904554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012351385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.128.1.452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013928792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)00121-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014173002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e3181f1c8de", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014214560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0019601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014451161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jcmm.12278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014872646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-2246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017730793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019179559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70184-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019948065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.06.3958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020082714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0810699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020150048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cas.12081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021603870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.44.2806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022055849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.44.2806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022055849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.33.4235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022283608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.33.4235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022283608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2008.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026558254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jclinpath-2012-201194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029931326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.31.8923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031018412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032628685", 
          "https://doi.org/10.1038/nrc2088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1411817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034131988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2013.721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034863913", 
          "https://doi.org/10.1038/bjc.2013.721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.290.16.2149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035075882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12094-012-0806-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036284378", 
          "https://doi.org/10.1007/s12094-012-0806-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.29397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039701828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa040938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042907590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2015.4921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044624632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc052564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045724849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(09)70364-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046378249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0909530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047104724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048128648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa011954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052159806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0043842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052499981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053160786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.02.068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2011.0137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078483976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2011.0137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078483976"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Although the benefit of first-line epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs) over chemotherapy has been demonstrated in several clinical trials, data from clinical practice is lacking and the optimal EGFR TKI to be used remains unclear. This study aims to assess the real-life diagnostic and clinical management and outcome of patients with advanced non-small-cell lung cancer (NSCLC) carrying EGFR mutations in Spain.\nMETHODS: All consecutive patients recently diagnosed with advanced or metastatic NSCLC from April 2010 to December 2011 in 18 Spanish hospitals and carrying EGFR mutations were retrospectively evaluated.\nRESULTS: Between March and November 2013, a total of 187 patients were enrolled (98.3% Caucasian, 61.9% female, 54.9% never-smokers, 89.0% adenocarcinoma). Mutation testing was mainly performed on biopsy tumour tissue specimens (69.0%) using a qPCR-based test (90%) (47.0% Therascreen EGFR PCR Kit). Common sensitising mutations were detected in 79.8% of patients: 57.1% had exon 19 deletions and 22.6% exon 21 L858R point mutations. The vast majority of patients received first-line therapy (n\u00a0=\u2009168; 92.8%). EGFR TKIs were the most commonly used first-line treatment (81.5%), while chemotherapy was more frequently administered as a second- and third-line option (51.9% and 56.0%, respectively). Of 141 patients who experienced disease progression, 79 (56.0%) received second-line treatment. After disease progression on first-line TKIs (n\u00a0=\u2009112), 33.9% received chemotherapy, 8.9% chemotherapy and a TKI, and 9.8% continued TKI therapy. Most patients received first-line gefitinib (83.0%), while erlotinib was more frequently used in the second-line setting (83.0%). Progression-free survival (PFS) and overall survival (OS) in patients harbouring common mutations were 11.1\u00a0months and 20.1\u00a0months respectively (exon 19 deletions: 12.4 and 21.4\u00a0months; L858R: 8.3 and 14.5\u00a0months), and 3.9\u00a0months and 11.1\u00a0months respectively for those with rare mutations.\nCONCLUSION: EGFR TKIs (gefitinib and erlotinib) are used as the preferred first-line treatment while chemotherapy is more frequently administered as a second- and third-line option in routine clinical practice in Spain. In addition, efficacy data obtained in the real-life setting seem to concur with data from EGFR TKI phase III pivotal studies in NSCLC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12885-018-4004-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Clinical management and outcome of patients with advanced NSCLC carrying EGFR mutations in Spain", 
    "pagination": "106", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b58cd8adc921ad7cb593680386059b421a81f3cf9d384c2db446829e9c3e6724"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29382302"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12885-018-4004-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100718347"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12885-018-4004-7", 
      "https://app.dimensions.ai/details/publication/pub.1100718347"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000484.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s12885-018-4004-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4004-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4004-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4004-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4004-7'


 

This table displays all metadata directly associated to this object as RDF triples.

432 TRIPLES      21 PREDICATES      85 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12885-018-4004-7 schema:about N1a035306d6f14234bce7b8bdf0b0afc9
2 N1e8e0cf5c42c42b0bc56c67e25c93cd5
3 N204569fda2f24d99b09f1df9493bfd2d
4 N3f6525a8d9554479918f856137b699a5
5 N6fbbad401c4c49c981ccfbc6184739d4
6 N72db78234c564961a2bb5a55714f7d2c
7 N7723e494d0c141518c32b20595eb1550
8 N77f25d324f1840378b98e0511c7f39b3
9 N8ab54137413b4c7b84f25e203b9e09b9
10 N96f83ea1a8fb41eaa0d73af8057c2e55
11 Nc80bd4c4a19b492aba228371f956061c
12 Ncad2568d14694c758addf29197a7c415
13 Ndfcdfcac7a6743a5b2505bdc38ef6b35
14 Ne9400fbed6a943028278796eb1a0cc1d
15 Nee86de24980f4500964641575cbe4b6a
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N94038d162f6e4d648280cef7d2089c27
19 schema:citation sg:pub.10.1007/s12094-012-0806-2
20 sg:pub.10.1038/bjc.2013.721
21 sg:pub.10.1038/nrc2088
22 https://doi.org/10.1001/jama.290.16.2149
23 https://doi.org/10.1001/jamaoncol.2015.4921
24 https://doi.org/10.1002/cncr.29397
25 https://doi.org/10.1016/j.cca.2013.11.014
26 https://doi.org/10.1016/j.ejca.2008.10.026
27 https://doi.org/10.1016/s1470-2045(09)70364-x
28 https://doi.org/10.1016/s1470-2045(11)70184-x
29 https://doi.org/10.1016/s1470-2045(11)70393-x
30 https://doi.org/10.1016/s1470-2045(13)70604-1
31 https://doi.org/10.1016/s1470-2045(15)00121-7
32 https://doi.org/10.1056/nejmc052564
33 https://doi.org/10.1056/nejmoa011954
34 https://doi.org/10.1056/nejmoa040938
35 https://doi.org/10.1056/nejmoa0810699
36 https://doi.org/10.1056/nejmoa0904554
37 https://doi.org/10.1056/nejmoa0909530
38 https://doi.org/10.1056/nejmoa1411817
39 https://doi.org/10.1093/annonc/mds121
40 https://doi.org/10.1093/annonc/mds214
41 https://doi.org/10.1093/annonc/mdu199
42 https://doi.org/10.1097/jto.0b013e3181f1c8de
43 https://doi.org/10.1111/cas.12081
44 https://doi.org/10.1111/jcmm.12278
45 https://doi.org/10.1136/jclinpath-2012-201194
46 https://doi.org/10.1158/1078-0432.ccr-07-0560
47 https://doi.org/10.1158/1078-0432.ccr-10-2692
48 https://doi.org/10.1158/1078-0432.ccr-11-1468
49 https://doi.org/10.1158/1078-0432.ccr-12-2246
50 https://doi.org/10.1200/jco.2002.02.068
51 https://doi.org/10.1200/jco.2006.06.3958
52 https://doi.org/10.1200/jco.2010.31.8923
53 https://doi.org/10.1200/jco.2010.33.4235
54 https://doi.org/10.1200/jco.2012.44.2806
55 https://doi.org/10.1371/journal.pone.0019601
56 https://doi.org/10.1371/journal.pone.0043842
57 https://doi.org/10.1378/chest.128.1.452
58 https://doi.org/10.3322/caac.20107
59 https://doi.org/10.6004/jnccn.2011.0137
60 schema:datePublished 2018-12
61 schema:datePublishedReg 2018-12-01
62 schema:description BACKGROUND: Although the benefit of first-line epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs) over chemotherapy has been demonstrated in several clinical trials, data from clinical practice is lacking and the optimal EGFR TKI to be used remains unclear. This study aims to assess the real-life diagnostic and clinical management and outcome of patients with advanced non-small-cell lung cancer (NSCLC) carrying EGFR mutations in Spain. METHODS: All consecutive patients recently diagnosed with advanced or metastatic NSCLC from April 2010 to December 2011 in 18 Spanish hospitals and carrying EGFR mutations were retrospectively evaluated. RESULTS: Between March and November 2013, a total of 187 patients were enrolled (98.3% Caucasian, 61.9% female, 54.9% never-smokers, 89.0% adenocarcinoma). Mutation testing was mainly performed on biopsy tumour tissue specimens (69.0%) using a qPCR-based test (90%) (47.0% Therascreen EGFR PCR Kit). Common sensitising mutations were detected in 79.8% of patients: 57.1% had exon 19 deletions and 22.6% exon 21 L858R point mutations. The vast majority of patients received first-line therapy (n = 168; 92.8%). EGFR TKIs were the most commonly used first-line treatment (81.5%), while chemotherapy was more frequently administered as a second- and third-line option (51.9% and 56.0%, respectively). Of 141 patients who experienced disease progression, 79 (56.0%) received second-line treatment. After disease progression on first-line TKIs (n = 112), 33.9% received chemotherapy, 8.9% chemotherapy and a TKI, and 9.8% continued TKI therapy. Most patients received first-line gefitinib (83.0%), while erlotinib was more frequently used in the second-line setting (83.0%). Progression-free survival (PFS) and overall survival (OS) in patients harbouring common mutations were 11.1 months and 20.1 months respectively (exon 19 deletions: 12.4 and 21.4 months; L858R: 8.3 and 14.5 months), and 3.9 months and 11.1 months respectively for those with rare mutations. CONCLUSION: EGFR TKIs (gefitinib and erlotinib) are used as the preferred first-line treatment while chemotherapy is more frequently administered as a second- and third-line option in routine clinical practice in Spain. In addition, efficacy data obtained in the real-life setting seem to concur with data from EGFR TKI phase III pivotal studies in NSCLC.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf N1c02af03146d4149ae35b306d3f2650a
67 N255c833dfd4c429b940e18ed251e2f93
68 sg:journal.1024632
69 schema:name Clinical management and outcome of patients with advanced NSCLC carrying EGFR mutations in Spain
70 schema:pagination 106
71 schema:productId N2fd8988d32c44489adbf1597dc1f427b
72 N4d5386c6c1f64a8a84f6f52e92891454
73 N63c4997aad0c455394ba6f71be3cbf11
74 N7ec9b75239474a1495683f7c95d9854a
75 N9ea684a7a89a45038b5c91b1cc4ae765
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100718347
77 https://doi.org/10.1186/s12885-018-4004-7
78 schema:sdDatePublished 2019-04-11T01:53
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher N8cb095fdd24f46129a485ab7e50e7b70
81 schema:url http://link.springer.com/10.1186/s12885-018-4004-7
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N03442cc589dc4df6abd207cdb0e0b375 rdf:first N7e9c2c05dff344e08a6f5faeb8291007
86 rdf:rest N087f9ed089e14042acc88783560179d9
87 N08628a38361f4e418f25b1e7e061d29f rdf:first sg:person.01015457763.13
88 rdf:rest N3a8b2d85fb5d49b385f156262f120031
89 N087f9ed089e14042acc88783560179d9 rdf:first sg:person.0726612567.62
90 rdf:rest rdf:nil
91 N104e8cb8388f48799b7b8d98ac6adc2c rdf:first sg:person.012752413463.51
92 rdf:rest N9d9a475c6032419e9c4abf8a6b3d1791
93 N1a035306d6f14234bce7b8bdf0b0afc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Erlotinib Hydrochloride
95 rdf:type schema:DefinedTerm
96 N1c02af03146d4149ae35b306d3f2650a schema:volumeNumber 18
97 rdf:type schema:PublicationVolume
98 N1c58565add8d4c46b769e139f206f5c8 rdf:first N6b44357c566c472ca8266d3a7598e957
99 rdf:rest Nc1314581b80b49b69f0482bc26eff4a1
100 N1e8e0cf5c42c42b0bc56c67e25c93cd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Receptor, Epidermal Growth Factor
102 rdf:type schema:DefinedTerm
103 N204569fda2f24d99b09f1df9493bfd2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Neoplasm Staging
105 rdf:type schema:DefinedTerm
106 N255c833dfd4c429b940e18ed251e2f93 schema:issueNumber 1
107 rdf:type schema:PublicationIssue
108 N2fd8988d32c44489adbf1597dc1f427b schema:name nlm_unique_id
109 schema:value 100967800
110 rdf:type schema:PropertyValue
111 N33d8935cff8d4ed6a198da59fa536fcc rdf:first sg:person.01103254434.93
112 rdf:rest Nc0fb92907f6d4d00961452aa0ca6244a
113 N3a8b2d85fb5d49b385f156262f120031 rdf:first sg:person.01073174565.35
114 rdf:rest N5e25bc50ac2745d6b17890de7a2552df
115 N3f6525a8d9554479918f856137b699a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Disease-Free Survival
117 rdf:type schema:DefinedTerm
118 N4d5386c6c1f64a8a84f6f52e92891454 schema:name dimensions_id
119 schema:value pub.1100718347
120 rdf:type schema:PropertyValue
121 N54fd528aff384aebafbf31194d80011c rdf:first sg:person.0744162445.91
122 rdf:rest N1c58565add8d4c46b769e139f206f5c8
123 N5bd1f0daf79947dc82470d17d2a626dc rdf:first sg:person.015056034305.28
124 rdf:rest N8efe2b87947c44d68d103bffd8218e8b
125 N5e25bc50ac2745d6b17890de7a2552df rdf:first sg:person.016605711740.57
126 rdf:rest N811fa2e165804fa2a3ede58c3eaf387d
127 N63c4997aad0c455394ba6f71be3cbf11 schema:name readcube_id
128 schema:value b58cd8adc921ad7cb593680386059b421a81f3cf9d384c2db446829e9c3e6724
129 rdf:type schema:PropertyValue
130 N6b44357c566c472ca8266d3a7598e957 schema:affiliation https://www.grid.ac/institutes/grid.413514.6
131 schema:familyName Andrade Santiago
132 schema:givenName Jesús Manuel
133 rdf:type schema:Person
134 N6fbbad401c4c49c981ccfbc6184739d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Carcinoma, Non-Small-Cell Lung
136 rdf:type schema:DefinedTerm
137 N72db78234c564961a2bb5a55714f7d2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Quinazolines
139 rdf:type schema:DefinedTerm
140 N7723e494d0c141518c32b20595eb1550 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Protein Kinase Inhibitors
142 rdf:type schema:DefinedTerm
143 N77f25d324f1840378b98e0511c7f39b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Middle Aged
145 rdf:type schema:DefinedTerm
146 N7e9c2c05dff344e08a6f5faeb8291007 schema:affiliation https://www.grid.ac/institutes/grid.476014.0
147 schema:familyName Amador
148 schema:givenName Mariluz
149 rdf:type schema:Person
150 N7ec9b75239474a1495683f7c95d9854a schema:name pubmed_id
151 schema:value 29382302
152 rdf:type schema:PropertyValue
153 N811fa2e165804fa2a3ede58c3eaf387d rdf:first sg:person.01020642531.84
154 rdf:rest N54fd528aff384aebafbf31194d80011c
155 N8ab54137413b4c7b84f25e203b9e09b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Female
157 rdf:type schema:DefinedTerm
158 N8cb095fdd24f46129a485ab7e50e7b70 schema:name Springer Nature - SN SciGraph project
159 rdf:type schema:Organization
160 N8efe2b87947c44d68d103bffd8218e8b rdf:first sg:person.0673172415.36
161 rdf:rest N03442cc589dc4df6abd207cdb0e0b375
162 N94038d162f6e4d648280cef7d2089c27 rdf:first sg:person.01302630647.73
163 rdf:rest N104e8cb8388f48799b7b8d98ac6adc2c
164 N96f83ea1a8fb41eaa0d73af8057c2e55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Male
166 rdf:type schema:DefinedTerm
167 N9a8cc785be094965a247efe74e0e359f rdf:first sg:person.015462057372.46
168 rdf:rest Nd57f942ffdb941f2bc59422295c52a43
169 N9d9a475c6032419e9c4abf8a6b3d1791 rdf:first sg:person.0604464234.77
170 rdf:rest Nc9e011b2689d4185b711f6e7b4395221
171 N9ea684a7a89a45038b5c91b1cc4ae765 schema:name doi
172 schema:value 10.1186/s12885-018-4004-7
173 rdf:type schema:PropertyValue
174 Nc0fb92907f6d4d00961452aa0ca6244a rdf:first sg:person.01353670656.61
175 rdf:rest N5bd1f0daf79947dc82470d17d2a626dc
176 Nc1314581b80b49b69f0482bc26eff4a1 rdf:first sg:person.01224655036.29
177 rdf:rest N33d8935cff8d4ed6a198da59fa536fcc
178 Nc80bd4c4a19b492aba228371f956061c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 Nc9e011b2689d4185b711f6e7b4395221 rdf:first sg:person.01322640302.82
182 rdf:rest N9a8cc785be094965a247efe74e0e359f
183 Ncad2568d14694c758addf29197a7c415 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Mutation
185 rdf:type schema:DefinedTerm
186 Nd57f942ffdb941f2bc59422295c52a43 rdf:first sg:person.07751521722.30
187 rdf:rest N08628a38361f4e418f25b1e7e061d29f
188 Ndfcdfcac7a6743a5b2505bdc38ef6b35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Aged
190 rdf:type schema:DefinedTerm
191 Ne9400fbed6a943028278796eb1a0cc1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Treatment Outcome
193 rdf:type schema:DefinedTerm
194 Nee86de24980f4500964641575cbe4b6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Spain
196 rdf:type schema:DefinedTerm
197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
198 schema:name Medical and Health Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
201 schema:name Oncology and Carcinogenesis
202 rdf:type schema:DefinedTerm
203 sg:journal.1024632 schema:issn 1471-2407
204 schema:name BMC Cancer
205 rdf:type schema:Periodical
206 sg:person.01015457763.13 schema:affiliation https://www.grid.ac/institutes/grid.414651.3
207 schema:familyName Paredes
208 schema:givenName Alfredo
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015457763.13
210 rdf:type schema:Person
211 sg:person.01020642531.84 schema:affiliation https://www.grid.ac/institutes/grid.411349.a
212 schema:familyName Barneto
213 schema:givenName Isidoro
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020642531.84
215 rdf:type schema:Person
216 sg:person.01073174565.35 schema:affiliation https://www.grid.ac/institutes/grid.411251.2
217 schema:familyName Sánchez-Torres
218 schema:givenName José Miguel
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073174565.35
220 rdf:type schema:Person
221 sg:person.01103254434.93 schema:affiliation https://www.grid.ac/institutes/grid.411050.1
222 schema:familyName Isla
223 schema:givenName Dolores
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103254434.93
225 rdf:type schema:Person
226 sg:person.01224655036.29 schema:affiliation https://www.grid.ac/institutes/grid.413522.3
227 schema:familyName Aparisi
228 schema:givenName Francisco
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224655036.29
230 rdf:type schema:Person
231 sg:person.012752413463.51 schema:affiliation https://www.grid.ac/institutes/grid.410526.4
232 schema:familyName García Gómez
233 schema:givenName Ramón
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012752413463.51
235 rdf:type schema:Person
236 sg:person.01302630647.73 schema:affiliation https://www.grid.ac/institutes/grid.411142.3
237 schema:familyName Arriola
238 schema:givenName Edurne
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302630647.73
240 rdf:type schema:Person
241 sg:person.01322640302.82 schema:affiliation https://www.grid.ac/institutes/grid.413396.a
242 schema:familyName Majem
243 schema:givenName Margarita
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322640302.82
245 rdf:type schema:Person
246 sg:person.01353670656.61 schema:affiliation https://www.grid.ac/institutes/grid.144756.5
247 schema:familyName Ponce
248 schema:givenName Santiago
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353670656.61
250 rdf:type schema:Person
251 sg:person.015056034305.28 schema:affiliation https://www.grid.ac/institutes/grid.411375.5
252 schema:familyName Vicente Baz
253 schema:givenName David
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015056034305.28
255 rdf:type schema:Person
256 sg:person.015462057372.46 schema:affiliation https://www.grid.ac/institutes/grid.497559.3
257 schema:familyName Martínez Aguillo
258 schema:givenName Maite
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015462057372.46
260 rdf:type schema:Person
261 sg:person.016605711740.57 schema:affiliation https://www.grid.ac/institutes/grid.411136.0
262 schema:familyName Peralta Muñoz
263 schema:givenName Sergio
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016605711740.57
265 rdf:type schema:Person
266 sg:person.0604464234.77 schema:affiliation https://www.grid.ac/institutes/grid.411969.2
267 schema:familyName Diz
268 schema:givenName Pilar
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604464234.77
270 rdf:type schema:Person
271 sg:person.0673172415.36 schema:affiliation https://www.grid.ac/institutes/grid.411106.3
272 schema:familyName Artal
273 schema:givenName Angel
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673172415.36
275 rdf:type schema:Person
276 sg:person.0726612567.62 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
277 schema:familyName Provencio
278 schema:givenName Mariano
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726612567.62
280 rdf:type schema:Person
281 sg:person.0744162445.91 schema:affiliation https://www.grid.ac/institutes/grid.411457.2
282 schema:familyName Gutierrez
283 schema:givenName Vanesa
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744162445.91
285 rdf:type schema:Person
286 sg:person.07751521722.30 schema:affiliation https://www.grid.ac/institutes/grid.411380.f
287 schema:familyName Valdivia
288 schema:givenName Javier
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07751521722.30
290 rdf:type schema:Person
291 sg:pub.10.1007/s12094-012-0806-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036284378
292 https://doi.org/10.1007/s12094-012-0806-2
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/bjc.2013.721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034863913
295 https://doi.org/10.1038/bjc.2013.721
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/nrc2088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032628685
298 https://doi.org/10.1038/nrc2088
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1001/jama.290.16.2149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035075882
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1001/jamaoncol.2015.4921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044624632
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1002/cncr.29397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039701828
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.cca.2013.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007823348
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.ejca.2008.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026558254
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s1470-2045(09)70364-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046378249
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s1470-2045(11)70184-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019948065
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s1470-2045(11)70393-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004429924
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s1470-2045(13)70604-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009186895
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/s1470-2045(15)00121-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014173002
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1056/nejmc052564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045724849
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1056/nejmoa011954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052159806
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1056/nejmoa040938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042907590
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1056/nejmoa0810699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020150048
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1056/nejmoa0904554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012351385
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1056/nejmoa0909530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047104724
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1056/nejmoa1411817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034131988
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1093/annonc/mds121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048128648
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/annonc/mds214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019179559
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/annonc/mdu199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001793280
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1097/jto.0b013e3181f1c8de schema:sameAs https://app.dimensions.ai/details/publication/pub.1014214560
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1111/cas.12081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021603870
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1111/jcmm.12278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014872646
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1136/jclinpath-2012-201194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029931326
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1158/1078-0432.ccr-07-0560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011971166
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1158/1078-0432.ccr-10-2692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053160786
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1158/1078-0432.ccr-11-1468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006534187
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1158/1078-0432.ccr-12-2246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017730793
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1200/jco.2002.02.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202925
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1200/jco.2006.06.3958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020082714
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1200/jco.2010.31.8923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031018412
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1200/jco.2010.33.4235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022283608
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1200/jco.2012.44.2806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022055849
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1371/journal.pone.0019601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014451161
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1371/journal.pone.0043842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052499981
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1378/chest.128.1.452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013928792
371 rdf:type schema:CreativeWork
372 https://doi.org/10.3322/caac.20107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055747
373 rdf:type schema:CreativeWork
374 https://doi.org/10.6004/jnccn.2011.0137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078483976
375 rdf:type schema:CreativeWork
376 https://www.grid.ac/institutes/grid.144756.5 schema:alternateName Hospital Universitario 12 De Octubre
377 schema:name Hospital Universitario 12 de Octubre, Madrid, Spain
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.410526.4 schema:alternateName Hospital General Universitario Gregorio Marañón
380 schema:name Hospital General Universitario Gregorio Marañón, Madrid, Spain
381 rdf:type schema:Organization
382 https://www.grid.ac/institutes/grid.411050.1 schema:alternateName Hospital Clínico Universitario Lozano Blesa
383 schema:name Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
384 rdf:type schema:Organization
385 https://www.grid.ac/institutes/grid.411106.3 schema:alternateName Hospital Universitario Miguel Servet
386 schema:name Hospital Universitario Miguel Servet, Zaragoza, Spain
387 rdf:type schema:Organization
388 https://www.grid.ac/institutes/grid.411136.0 schema:alternateName Hospital Universitari Sant Joan de Reus
389 schema:name Hospital Universitari Sant Joan de Reus, Reus, Tarragona, Spain
390 rdf:type schema:Organization
391 https://www.grid.ac/institutes/grid.411142.3 schema:alternateName Hospital Del Mar
392 schema:name Medical Oncology Department, Hospital del Mar, Passeig Marítim, 25-29, 08018, Barcelona, Spain
393 rdf:type schema:Organization
394 https://www.grid.ac/institutes/grid.411251.2 schema:alternateName Hospital Universitario de La Princesa
395 schema:name Hospital Universitario de La Princesa, Madrid, Spain
396 rdf:type schema:Organization
397 https://www.grid.ac/institutes/grid.411349.a schema:alternateName Hospital Reina Sofía de Córdoba
398 schema:name Hospital Universitario Reina Sofía, Córdoba, Spain
399 rdf:type schema:Organization
400 https://www.grid.ac/institutes/grid.411375.5 schema:alternateName Hospital Universitario Virgen Macarena
401 schema:name Hospital Universitario Virgen Macarena, Sevilla, Spain
402 rdf:type schema:Organization
403 https://www.grid.ac/institutes/grid.411380.f schema:alternateName Hospital Universitario Virgen de las Nieves
404 schema:name Hospital Universitario Virgen de las Nieves, Granada, Spain
405 rdf:type schema:Organization
406 https://www.grid.ac/institutes/grid.411457.2 schema:alternateName Hospital Regional Universitario de Málaga
407 schema:name Hospital Regional Universitario Carlos Haya, Málaga, Spain
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.411969.2 schema:alternateName Hospital de León
410 schema:name Hospital Universitario de León, León, Spain
411 rdf:type schema:Organization
412 https://www.grid.ac/institutes/grid.413396.a schema:alternateName Hospital de Sant Pau
413 schema:name Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
414 rdf:type schema:Organization
415 https://www.grid.ac/institutes/grid.413514.6 schema:alternateName Hospital Virgen de la Salud
416 schema:name Hospital Virgen de la Salud, Toledo, Spain
417 rdf:type schema:Organization
418 https://www.grid.ac/institutes/grid.413522.3 schema:alternateName Hospital Virgen de los Lirios
419 schema:name Hospital Virgen de los Lirios, Alcoy, Alicante, Spain
420 rdf:type schema:Organization
421 https://www.grid.ac/institutes/grid.414651.3 schema:alternateName Donostia Unibertsitate Ospitalea
422 schema:name Hospital Universitario Donostia, San Sebastián, Spain
423 rdf:type schema:Organization
424 https://www.grid.ac/institutes/grid.476014.0 schema:alternateName AstraZeneca (Spain)
425 schema:name AstraZeneca, Madrid, Spain
426 rdf:type schema:Organization
427 https://www.grid.ac/institutes/grid.497559.3 schema:alternateName Complejo Hospitalario de Navarra
428 schema:name Complejo Hospitalario de Navarra, Pamplona, Spain
429 rdf:type schema:Organization
430 https://www.grid.ac/institutes/grid.73221.35 schema:alternateName Hospital Universitario Puerta de Hierro Majadahonda
431 schema:name Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain
432 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...