The PANDA study: a randomized phase II study of first-line FOLFOX plus panitumumab versus 5FU plus panitumumab in RAS and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Francesca Battaglin, Marta Schirripa, Federica Buggin, Filippo Pietrantonio, Federica Morano, Giorgia Boscolo, Giuseppe Tonini, Eufemia Stefania Lutrino, Jessica Lucchetti, Lisa Salvatore, Alessandro Passardi, Chiara Cremolini, Ermenegildo Arnoldi, Mario Scartozzi, Nicoletta Pella, Luca Boni, Francesca Bergamo, Vittorina Zagonel, Fotios Loupakis, Sara Lonardi

ABSTRACT

BACKGROUND: Few data are available regarding the treatment of metastatic colorectal cancer elderly patients with anti-EGFR agents in combination with chemotherapy. FOLFOX plus panitumumab is a standard first-line option for RAS wild-type metastatic colorectal cancer. Slight adjustments in chemo-dosage are commonly applied in clinical practice to elderly patients, but those modified schedules have never been prospectively tested. Clinical definition of elderly (≥70 years old) patients that may deserve a more or less intensive combination therapy is still debated. Several geriatric screening tools have been developed to predict survival and risk of toxicity from treatment. Among those, the G8 screening tool has been tested in cancer patients showing the strongest prognostic value for overall survival, while the CRASH score can stratify patients according to an estimated risk of treatment-related toxicities. METHODS: The PANDA study is a prospective, open-label, multicenter, randomized phase II trial of first-line therapy with panitumumab in combination with dose-adjusted FOLFOX or with 5-fluorouracil monotherapy, in previously untreated elderly patients (≥70 years) with RAS and BRAF wild-type unresectable metastatic colorectal cancer. RAS and BRAF analyses are centralized. Geriatric assessment by means of G8 and CRASH score is planned at baseline and G8 will be re-evaluated at disease progression. The primary endpoint is duration of progression-free survival in both arms. Secondary endpoints include prospective evaluation of the prognostic role of G8 score and the correlation of CRASH risk categories with toxicity. DISCUSSION: The PANDA study aims at exploring safety and efficacy of panitumumab in combination with FOLFOX or with 5FU/LV in elderly patients affected by RAS and BRAF wild-type metastatic colorectal cancer, to identify the most promising treatment strategy in this setting. Additionally, this is the first trial in which the prognostic role of the G8 score will be prospectively evaluated. Results of this study will drive further experimental developments for one or both combinations. TRIAL REGISTRATION: PANDA is registered at Clinicaltrials.gov : NCT02904031 , July 11, 2016. PANDA is registered at EudraCT-No.: 2015-003888-10, September 3, 2015. More... »

PAGES

98

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-018-4001-x

DOI

http://dx.doi.org/10.1186/s12885-018-4001-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100622516

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29370781


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leucovorin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organoplatinum Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins B-raf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ras Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Istituto Oncologico Veneto - IRCCS, S.C. Oncologia Medica 1, Dipartimento di Oncologia Clinica e Sperimentale, Via Gattamelata, 64, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Battaglin", 
        "givenName": "Francesca", 
        "id": "sg:person.01057302043.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057302043.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Istituto Oncologico Veneto - IRCCS, S.C. Oncologia Medica 1, Dipartimento di Oncologia Clinica e Sperimentale, Via Gattamelata, 64, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schirripa", 
        "givenName": "Marta", 
        "id": "sg:person.01225165353.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225165353.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Istituto Oncologico Veneto - IRCCS, S.C. Oncologia Medica 1, Dipartimento di Oncologia Clinica e Sperimentale, Via Gattamelata, 64, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buggin", 
        "givenName": "Federica", 
        "id": "sg:person.013543667462.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013543667462.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Fondazione IRCCS Istituto Nazionale Tumori, Dipartimento di Oncologia Medica, Via Venezian, 1, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pietrantonio", 
        "givenName": "Filippo", 
        "id": "sg:person.01122027227.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122027227.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Fondazione IRCCS Istituto Nazionale Tumori, Dipartimento di Oncologia Medica, Via Venezian, 1, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morano", 
        "givenName": "Federica", 
        "id": "sg:person.015552564055.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015552564055.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Azienda Unita Locale Socio-Sanitaria N\u00b03 Serenissima \u2013 Distretto Mirano, Dolo, Noale \u2013 Dipartimento di Scienze Mediche, U.O.C. Oncologia ed Ematologia Oncologica, Via Don G. Sartor, 4, 30035, Mirano, VE, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boscolo", 
        "givenName": "Giorgia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Policlinico Universitario Campus Bio-Medico, U.O.C. Oncologia Medica, Via Alvaro del Portillo, 200, 00128, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tonini", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01236745400.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236745400.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Ospedale Senatore A. Perrino, U.O.C. Oncologia Medica, Strada Statale 7 (Appia), 72100, Brindisi, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lutrino", 
        "givenName": "Eufemia Stefania", 
        "id": "sg:person.011722334353.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011722334353.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Rome Tor Vergata", 
          "id": "https://www.grid.ac/institutes/grid.6530.0", 
          "name": [
            "U.O. Oncologia Medica, Dipartimento di Medicina, Ospedale Universitario Policlinico Tor Vergata, Universit\u00e0 degli Studi di Roma Tor Vergata, Viale Oxford, 81, 00133, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lucchetti", 
        "givenName": "Jessica", 
        "id": "sg:person.010220414175.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010220414175.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Integrata Verona", 
          "id": "https://www.grid.ac/institutes/grid.411475.2", 
          "name": [
            "Oncologia, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Scuro, 10, 37134, Verona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salvatore", 
        "givenName": "Lisa", 
        "id": "sg:person.01157052153.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157052153.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.419563.c", 
          "name": [
            "IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), U.O. Oncologia Medica, Via P. Maroncelli, 40, 47014, Meldola, FC, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Passardi", 
        "givenName": "Alessandro", 
        "id": "sg:person.0650341574.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650341574.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Azienda Ospedaliero Universitaria Pisana, U.O. Oncologia Medica 2 Universitaria, Via Roma, 67, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cremolini", 
        "givenName": "Chiara", 
        "id": "sg:person.01257327771.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257327771.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "ASST Papa Giovanni XXIII, U.O. Oncologia Medica, Piazza OMS, 1, 24127, Bergamo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arnoldi", 
        "givenName": "Ermenegildo", 
        "id": "sg:person.01031340710.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031340710.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "U.O. Oncologia Medica, Azienda Ospedaliero-Universitaria di Cagliari e Universit\u00e0 di Cagliari, via Ospedale, 54, 09124, Cagliari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scartozzi", 
        "givenName": "Mario", 
        "id": "sg:person.01222636463.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222636463.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Santa Maria della Misericordia di Udine", 
          "id": "https://www.grid.ac/institutes/grid.411492.b", 
          "name": [
            "Azienda Sanitaria Universitaria Integrata di Udine, Dipartimento di Oncologia, Piazzale Santa Maria della Misericordia, 15, 33100, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pella", 
        "givenName": "Nicoletta", 
        "id": "sg:person.0776162450.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776162450.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Centro Coordinamento Sperimentazioni Cliniche \u2013 Istituto Toscano Tumori, Via Taddeo Alderotti, 26/N, 50139, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boni", 
        "givenName": "Luca", 
        "id": "sg:person.01277427123.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277427123.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Istituto Oncologico Veneto - IRCCS, S.C. Oncologia Medica 1, Dipartimento di Oncologia Clinica e Sperimentale, Via Gattamelata, 64, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergamo", 
        "givenName": "Francesca", 
        "id": "sg:person.0702340342.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702340342.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Istituto Oncologico Veneto - IRCCS, S.C. Oncologia Medica 1, Dipartimento di Oncologia Clinica e Sperimentale, Via Gattamelata, 64, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zagonel", 
        "givenName": "Vittorina", 
        "id": "sg:person.0622706463.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622706463.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Istituto Oncologico Veneto - IRCCS, S.C. Oncologia Medica 1, Dipartimento di Oncologia Clinica e Sperimentale, Via Gattamelata, 64, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loupakis", 
        "givenName": "Fotios", 
        "id": "sg:person.01175106504.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175106504.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Istituto Oncologico Veneto - IRCCS, S.C. Oncologia Medica 1, Dipartimento di Oncologia Clinica e Sperimentale, Via Gattamelata, 64, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lonardi", 
        "givenName": "Sara", 
        "id": "sg:person.01155122733.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155122733.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ejca.2015.01.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000197424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2014.346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001034099", 
          "https://doi.org/10.1038/bjc.2014.346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005188668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005188668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(13)70154-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005860041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jgo.2012.10.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005991749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.51.1345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011867975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdw235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017105693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.63.9674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021955201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2008.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026558254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdr587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027461333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2016.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028959624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1305275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030588737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2015.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030906359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.42.9894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032455782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045901470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(11)60399-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047680687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2015.173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048637377", 
          "https://doi.org/10.1038/bjc.2015.173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.55.1960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050314408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051614592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2015-0171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068164535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2015-0171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068164535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077813950", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu333.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083556433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu333.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083556454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084430952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdx175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084601886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2017-0031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085768622"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Few data are available regarding the treatment of metastatic colorectal cancer elderly patients with anti-EGFR agents in combination with chemotherapy. FOLFOX plus panitumumab is a standard first-line option for RAS wild-type metastatic colorectal cancer. Slight adjustments in chemo-dosage are commonly applied in clinical practice to elderly patients, but those modified schedules have never been prospectively tested. Clinical definition of elderly (\u226570\u00a0years old) patients that may deserve a more or less intensive combination therapy is still debated. Several geriatric screening tools have been developed to predict survival and risk of toxicity from treatment. Among those, the G8 screening tool has been tested in cancer patients showing the strongest prognostic value for overall survival, while the CRASH score can stratify patients according to an estimated risk of treatment-related toxicities.\nMETHODS: The PANDA study is a prospective, open-label, multicenter, randomized phase II trial of first-line therapy with panitumumab in combination with dose-adjusted FOLFOX or with 5-fluorouracil monotherapy, in previously untreated elderly patients (\u226570\u00a0years) with RAS and BRAF wild-type unresectable metastatic colorectal cancer. RAS and BRAF analyses are centralized. Geriatric assessment by means of G8 and CRASH score is planned at baseline and G8 will be re-evaluated at disease progression. The primary endpoint is duration of progression-free survival in both arms. Secondary endpoints include prospective evaluation of the prognostic role of G8 score and the correlation of CRASH risk categories with toxicity.\nDISCUSSION: The PANDA study aims at exploring safety and efficacy of panitumumab in combination with FOLFOX or with 5FU/LV in elderly patients affected by RAS and BRAF wild-type metastatic colorectal cancer, to identify the most promising treatment strategy in this setting. Additionally, this is the first trial in which the prognostic role of the G8 score will be prospectively evaluated. Results of this study will drive further experimental developments for one or both combinations.\nTRIAL REGISTRATION: PANDA is registered at Clinicaltrials.gov : NCT02904031 , July 11, 2016. PANDA is registered at EudraCT-No.: 2015-003888-10, September 3, 2015.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12885-018-4001-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "The PANDA study: a randomized phase II study of first-line FOLFOX plus panitumumab versus 5FU plus panitumumab in RAS and BRAF wild-type elderly metastatic colorectal cancer patients", 
    "pagination": "98", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d62518a93324476e78bdc222f8e3cd71d46a54b603c41aa09f235324eb01390d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29370781"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12885-018-4001-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100622516"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12885-018-4001-x", 
      "https://app.dimensions.ai/details/publication/pub.1100622516"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000493.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s12885-018-4001-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4001-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4001-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4001-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-018-4001-x'


 

This table displays all metadata directly associated to this object as RDF triples.

365 TRIPLES      21 PREDICATES      69 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12885-018-4001-x schema:about N2d8454d5daa244fa849e7bbc76c75755
2 N3aeba6ad7ce94f89851172f4d1788b70
3 N3b7d8a48e8e74ab2a491a0c200d3a9f4
4 N4ef075ca61614dc3bb625807446cb079
5 N5c6cd2d1343a4f4884ad24d269dd6d72
6 N6eb4b79e883f49a285a1d6ff052e7ba0
7 N802d19c9355e4e86a4ae4486f4f6b643
8 N89fda263f7504b878153d5d60bc7a251
9 N9d10fbe827d24000a291d5c8586f73de
10 Na2a370e77b5046d397f0ebfee5cd8a9d
11 Nb8415a29d45a4116ad03c80259bbc780
12 Ndc277c3583d846c58c0b13cc86d140c9
13 Ne4595969d0de4985bbb6457a4245a201
14 Nf7acf93f136547fd9e71b7e7fc5dc2ac
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N3cb18a6c25f1419b89833498fa7f8b6e
18 schema:citation sg:pub.10.1038/bjc.2014.346
19 sg:pub.10.1038/bjc.2015.173
20 https://app.dimensions.ai/details/publication/pub.1077813950
21 https://doi.org/10.1002/cncr.24527
22 https://doi.org/10.1002/cncr.26646
23 https://doi.org/10.1016/j.ejca.2008.10.026
24 https://doi.org/10.1016/j.ejca.2015.01.054
25 https://doi.org/10.1016/j.ejca.2015.04.013
26 https://doi.org/10.1016/j.ejca.2016.10.007
27 https://doi.org/10.1016/j.jgo.2012.10.024
28 https://doi.org/10.1016/s0140-6736(11)60399-1
29 https://doi.org/10.1016/s1470-2045(13)70154-2
30 https://doi.org/10.1056/nejmoa1305275
31 https://doi.org/10.1093/annonc/mdr587
32 https://doi.org/10.1093/annonc/mdu253
33 https://doi.org/10.1093/annonc/mdu333.3
34 https://doi.org/10.1093/annonc/mdu333.49
35 https://doi.org/10.1093/annonc/mdw235
36 https://doi.org/10.1093/annonc/mdx175
37 https://doi.org/10.1200/jco.2012.42.9894
38 https://doi.org/10.1200/jco.2013.51.1345
39 https://doi.org/10.1200/jco.2014.55.1960
40 https://doi.org/10.1200/jco.2015.63.9674
41 https://doi.org/10.1634/theoncologist.2015-0171
42 https://doi.org/10.1634/theoncologist.2017-0031
43 https://doi.org/10.3322/caac.21395
44 schema:datePublished 2018-12
45 schema:datePublishedReg 2018-12-01
46 schema:description BACKGROUND: Few data are available regarding the treatment of metastatic colorectal cancer elderly patients with anti-EGFR agents in combination with chemotherapy. FOLFOX plus panitumumab is a standard first-line option for RAS wild-type metastatic colorectal cancer. Slight adjustments in chemo-dosage are commonly applied in clinical practice to elderly patients, but those modified schedules have never been prospectively tested. Clinical definition of elderly (≥70 years old) patients that may deserve a more or less intensive combination therapy is still debated. Several geriatric screening tools have been developed to predict survival and risk of toxicity from treatment. Among those, the G8 screening tool has been tested in cancer patients showing the strongest prognostic value for overall survival, while the CRASH score can stratify patients according to an estimated risk of treatment-related toxicities. METHODS: The PANDA study is a prospective, open-label, multicenter, randomized phase II trial of first-line therapy with panitumumab in combination with dose-adjusted FOLFOX or with 5-fluorouracil monotherapy, in previously untreated elderly patients (≥70 years) with RAS and BRAF wild-type unresectable metastatic colorectal cancer. RAS and BRAF analyses are centralized. Geriatric assessment by means of G8 and CRASH score is planned at baseline and G8 will be re-evaluated at disease progression. The primary endpoint is duration of progression-free survival in both arms. Secondary endpoints include prospective evaluation of the prognostic role of G8 score and the correlation of CRASH risk categories with toxicity. DISCUSSION: The PANDA study aims at exploring safety and efficacy of panitumumab in combination with FOLFOX or with 5FU/LV in elderly patients affected by RAS and BRAF wild-type metastatic colorectal cancer, to identify the most promising treatment strategy in this setting. Additionally, this is the first trial in which the prognostic role of the G8 score will be prospectively evaluated. Results of this study will drive further experimental developments for one or both combinations. TRIAL REGISTRATION: PANDA is registered at Clinicaltrials.gov : NCT02904031 , July 11, 2016. PANDA is registered at EudraCT-No.: 2015-003888-10, September 3, 2015.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree true
50 schema:isPartOf N0b498474567242f1bc159f7695fb93f9
51 N9710a81993ad4fd2909528d9a93639c7
52 sg:journal.1024632
53 schema:name The PANDA study: a randomized phase II study of first-line FOLFOX plus panitumumab versus 5FU plus panitumumab in RAS and BRAF wild-type elderly metastatic colorectal cancer patients
54 schema:pagination 98
55 schema:productId N06caeabff1f54499bd6bc0f818503dd8
56 N0924c728476047fda2426ceb31cac8cc
57 N292f0f6aac294760a46c7e80c196d938
58 N61902e104d674b4b88b2b00d85a3192e
59 Nf892adbbe2aa403fbdea365f344bc78f
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100622516
61 https://doi.org/10.1186/s12885-018-4001-x
62 schema:sdDatePublished 2019-04-10T17:27
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher Na95c5438b49e4f23893929fb5a73637e
65 schema:url http://link.springer.com/10.1186/s12885-018-4001-x
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N06caeabff1f54499bd6bc0f818503dd8 schema:name nlm_unique_id
70 schema:value 100967800
71 rdf:type schema:PropertyValue
72 N0707e957e16f4dfd8140235db7ad57ee schema:affiliation Nfae66396196c4bba93c6a8f9aa7cf02b
73 schema:familyName Boscolo
74 schema:givenName Giorgia
75 rdf:type schema:Person
76 N0924c728476047fda2426ceb31cac8cc schema:name pubmed_id
77 schema:value 29370781
78 rdf:type schema:PropertyValue
79 N0b498474567242f1bc159f7695fb93f9 schema:volumeNumber 18
80 rdf:type schema:PublicationVolume
81 N1a2620e5c5d344c4936b6a4baf272cdf rdf:first sg:person.01157052153.90
82 rdf:rest N6a39914f7d4746d5b994bda22820a7ca
83 N21c036cc0a8247da8841ecf067a83916 rdf:first sg:person.01122027227.93
84 rdf:rest N5bf3ab3228894b769b9be1e9e40a8bb8
85 N26e7b441bde94db69d009eda37984963 rdf:first sg:person.0776162450.70
86 rdf:rest N3b960f38fb204c69a93b987c2d7ab655
87 N292f0f6aac294760a46c7e80c196d938 schema:name dimensions_id
88 schema:value pub.1100622516
89 rdf:type schema:PropertyValue
90 N2cfcc15cfda5401fbdd97038b4867732 rdf:first sg:person.01031340710.77
91 rdf:rest N4834e34ec29747d8ae535d3a32f13126
92 N2d8454d5daa244fa849e7bbc76c75755 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Disease-Free Survival
94 rdf:type schema:DefinedTerm
95 N373656ba8b624759a92e6ad3130b181e schema:name Ospedale Senatore A. Perrino, U.O.C. Oncologia Medica, Strada Statale 7 (Appia), 72100, Brindisi, Italy
96 rdf:type schema:Organization
97 N3aeba6ad7ce94f89851172f4d1788b70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Mutation
99 rdf:type schema:DefinedTerm
100 N3b7d8a48e8e74ab2a491a0c200d3a9f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Colorectal Neoplasms
102 rdf:type schema:DefinedTerm
103 N3b960f38fb204c69a93b987c2d7ab655 rdf:first sg:person.01277427123.05
104 rdf:rest N820ba5e1b0424972b2eeab56b88b7796
105 N3cb18a6c25f1419b89833498fa7f8b6e rdf:first sg:person.01057302043.89
106 rdf:rest Nb819bbc60c9e47aeb229d3c95a583238
107 N4834e34ec29747d8ae535d3a32f13126 rdf:first sg:person.01222636463.05
108 rdf:rest N26e7b441bde94db69d009eda37984963
109 N4ef075ca61614dc3bb625807446cb079 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Prognosis
111 rdf:type schema:DefinedTerm
112 N5bf3ab3228894b769b9be1e9e40a8bb8 rdf:first sg:person.015552564055.27
113 rdf:rest Nd646210e6b9b4ee9bd57522e81baf857
114 N5c6cd2d1343a4f4884ad24d269dd6d72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Humans
116 rdf:type schema:DefinedTerm
117 N6143bdb55c064f29bc4a6ba48a821f1f schema:name Centro Coordinamento Sperimentazioni Cliniche – Istituto Toscano Tumori, Via Taddeo Alderotti, 26/N, 50139, Florence, Italy
118 rdf:type schema:Organization
119 N61902e104d674b4b88b2b00d85a3192e schema:name readcube_id
120 schema:value d62518a93324476e78bdc222f8e3cd71d46a54b603c41aa09f235324eb01390d
121 rdf:type schema:PropertyValue
122 N642b368f121a41c39c88a03a185a04fd rdf:first sg:person.0622706463.81
123 rdf:rest Ncd3b2a0bbf304a1391dbc3153af99ff9
124 N6a39914f7d4746d5b994bda22820a7ca rdf:first sg:person.0650341574.44
125 rdf:rest Na71b5b2b017740ed97feadb7bdd2fe96
126 N6eb4b79e883f49a285a1d6ff052e7ba0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Fluorouracil
128 rdf:type schema:DefinedTerm
129 N802d19c9355e4e86a4ae4486f4f6b643 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Organoplatinum Compounds
131 rdf:type schema:DefinedTerm
132 N820ba5e1b0424972b2eeab56b88b7796 rdf:first sg:person.0702340342.11
133 rdf:rest N642b368f121a41c39c88a03a185a04fd
134 N89fda263f7504b878153d5d60bc7a251 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Proto-Oncogene Proteins B-raf
136 rdf:type schema:DefinedTerm
137 N8e133d7601ee477886374d1c3b56e273 rdf:first sg:person.011722334353.07
138 rdf:rest Ne3110a7b0b76445da8ac6ae2032a1928
139 N8e2afea1858a44fda907f1e76cf2b42e rdf:first sg:person.01236745400.24
140 rdf:rest N8e133d7601ee477886374d1c3b56e273
141 N9710a81993ad4fd2909528d9a93639c7 schema:issueNumber 1
142 rdf:type schema:PublicationIssue
143 N9cf40a45422443e08f283581099a530c schema:name Policlinico Universitario Campus Bio-Medico, U.O.C. Oncologia Medica, Via Alvaro del Portillo, 200, 00128, Rome, Italy
144 rdf:type schema:Organization
145 N9d10fbe827d24000a291d5c8586f73de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Treatment Outcome
147 rdf:type schema:DefinedTerm
148 Na2a370e77b5046d397f0ebfee5cd8a9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Receptor, Epidermal Growth Factor
150 rdf:type schema:DefinedTerm
151 Na71b5b2b017740ed97feadb7bdd2fe96 rdf:first sg:person.01257327771.59
152 rdf:rest N2cfcc15cfda5401fbdd97038b4867732
153 Na95c5438b49e4f23893929fb5a73637e schema:name Springer Nature - SN SciGraph project
154 rdf:type schema:Organization
155 Nb57d10fb9daf4b308b07a028b9b69e9b rdf:first sg:person.01155122733.59
156 rdf:rest rdf:nil
157 Nb819bbc60c9e47aeb229d3c95a583238 rdf:first sg:person.01225165353.57
158 rdf:rest Ne882adedfb724e878fe30b8daf71fa55
159 Nb8415a29d45a4116ad03c80259bbc780 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Leucovorin
161 rdf:type schema:DefinedTerm
162 Ncd3b2a0bbf304a1391dbc3153af99ff9 rdf:first sg:person.01175106504.32
163 rdf:rest Nb57d10fb9daf4b308b07a028b9b69e9b
164 Nd5f1f0ff6d684392b32adb480d846f54 schema:name U.O. Oncologia Medica, Azienda Ospedaliero-Universitaria di Cagliari e Università di Cagliari, via Ospedale, 54, 09124, Cagliari, Italy
165 rdf:type schema:Organization
166 Nd646210e6b9b4ee9bd57522e81baf857 rdf:first N0707e957e16f4dfd8140235db7ad57ee
167 rdf:rest N8e2afea1858a44fda907f1e76cf2b42e
168 Ndc277c3583d846c58c0b13cc86d140c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name ras Proteins
170 rdf:type schema:DefinedTerm
171 Ne3110a7b0b76445da8ac6ae2032a1928 rdf:first sg:person.010220414175.02
172 rdf:rest N1a2620e5c5d344c4936b6a4baf272cdf
173 Ne4595969d0de4985bbb6457a4245a201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Antibodies, Monoclonal
175 rdf:type schema:DefinedTerm
176 Ne882adedfb724e878fe30b8daf71fa55 rdf:first sg:person.013543667462.05
177 rdf:rest N21c036cc0a8247da8841ecf067a83916
178 Nec3061d3a5b7458a80a46f02128938e3 schema:name ASST Papa Giovanni XXIII, U.O. Oncologia Medica, Piazza OMS, 1, 24127, Bergamo, Italy
179 rdf:type schema:Organization
180 Nf7acf93f136547fd9e71b7e7fc5dc2ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Antineoplastic Combined Chemotherapy Protocols
182 rdf:type schema:DefinedTerm
183 Nf892adbbe2aa403fbdea365f344bc78f schema:name doi
184 schema:value 10.1186/s12885-018-4001-x
185 rdf:type schema:PropertyValue
186 Nfae66396196c4bba93c6a8f9aa7cf02b schema:name Azienda Unita Locale Socio-Sanitaria N°3 Serenissima – Distretto Mirano, Dolo, Noale – Dipartimento di Scienze Mediche, U.O.C. Oncologia ed Ematologia Oncologica, Via Don G. Sartor, 4, 30035, Mirano, VE, Italy
187 rdf:type schema:Organization
188 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
189 schema:name Medical and Health Sciences
190 rdf:type schema:DefinedTerm
191 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
192 schema:name Oncology and Carcinogenesis
193 rdf:type schema:DefinedTerm
194 sg:journal.1024632 schema:issn 1471-2407
195 schema:name BMC Cancer
196 rdf:type schema:Periodical
197 sg:person.010220414175.02 schema:affiliation https://www.grid.ac/institutes/grid.6530.0
198 schema:familyName Lucchetti
199 schema:givenName Jessica
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010220414175.02
201 rdf:type schema:Person
202 sg:person.01031340710.77 schema:affiliation Nec3061d3a5b7458a80a46f02128938e3
203 schema:familyName Arnoldi
204 schema:givenName Ermenegildo
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031340710.77
206 rdf:type schema:Person
207 sg:person.01057302043.89 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
208 schema:familyName Battaglin
209 schema:givenName Francesca
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057302043.89
211 rdf:type schema:Person
212 sg:person.01122027227.93 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
213 schema:familyName Pietrantonio
214 schema:givenName Filippo
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122027227.93
216 rdf:type schema:Person
217 sg:person.01155122733.59 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
218 schema:familyName Lonardi
219 schema:givenName Sara
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155122733.59
221 rdf:type schema:Person
222 sg:person.01157052153.90 schema:affiliation https://www.grid.ac/institutes/grid.411475.2
223 schema:familyName Salvatore
224 schema:givenName Lisa
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157052153.90
226 rdf:type schema:Person
227 sg:person.011722334353.07 schema:affiliation N373656ba8b624759a92e6ad3130b181e
228 schema:familyName Lutrino
229 schema:givenName Eufemia Stefania
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011722334353.07
231 rdf:type schema:Person
232 sg:person.01175106504.32 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
233 schema:familyName Loupakis
234 schema:givenName Fotios
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175106504.32
236 rdf:type schema:Person
237 sg:person.01222636463.05 schema:affiliation Nd5f1f0ff6d684392b32adb480d846f54
238 schema:familyName Scartozzi
239 schema:givenName Mario
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222636463.05
241 rdf:type schema:Person
242 sg:person.01225165353.57 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
243 schema:familyName Schirripa
244 schema:givenName Marta
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225165353.57
246 rdf:type schema:Person
247 sg:person.01236745400.24 schema:affiliation N9cf40a45422443e08f283581099a530c
248 schema:familyName Tonini
249 schema:givenName Giuseppe
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236745400.24
251 rdf:type schema:Person
252 sg:person.01257327771.59 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
253 schema:familyName Cremolini
254 schema:givenName Chiara
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257327771.59
256 rdf:type schema:Person
257 sg:person.01277427123.05 schema:affiliation N6143bdb55c064f29bc4a6ba48a821f1f
258 schema:familyName Boni
259 schema:givenName Luca
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277427123.05
261 rdf:type schema:Person
262 sg:person.013543667462.05 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
263 schema:familyName Buggin
264 schema:givenName Federica
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013543667462.05
266 rdf:type schema:Person
267 sg:person.015552564055.27 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
268 schema:familyName Morano
269 schema:givenName Federica
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015552564055.27
271 rdf:type schema:Person
272 sg:person.0622706463.81 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
273 schema:familyName Zagonel
274 schema:givenName Vittorina
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622706463.81
276 rdf:type schema:Person
277 sg:person.0650341574.44 schema:affiliation https://www.grid.ac/institutes/grid.419563.c
278 schema:familyName Passardi
279 schema:givenName Alessandro
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650341574.44
281 rdf:type schema:Person
282 sg:person.0702340342.11 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
283 schema:familyName Bergamo
284 schema:givenName Francesca
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702340342.11
286 rdf:type schema:Person
287 sg:person.0776162450.70 schema:affiliation https://www.grid.ac/institutes/grid.411492.b
288 schema:familyName Pella
289 schema:givenName Nicoletta
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776162450.70
291 rdf:type schema:Person
292 sg:pub.10.1038/bjc.2014.346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001034099
293 https://doi.org/10.1038/bjc.2014.346
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/bjc.2015.173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048637377
296 https://doi.org/10.1038/bjc.2015.173
297 rdf:type schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1077813950 schema:CreativeWork
299 https://doi.org/10.1002/cncr.24527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005188668
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1002/cncr.26646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045901470
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.ejca.2008.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026558254
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.ejca.2015.01.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000197424
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.ejca.2015.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030906359
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.ejca.2016.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028959624
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.jgo.2012.10.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005991749
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/s0140-6736(11)60399-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047680687
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/s1470-2045(13)70154-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005860041
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1056/nejmoa1305275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030588737
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1093/annonc/mdr587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027461333
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1093/annonc/mdu253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051614592
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/annonc/mdu333.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083556433
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1093/annonc/mdu333.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083556454
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1093/annonc/mdw235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017105693
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1093/annonc/mdx175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084601886
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1200/jco.2012.42.9894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032455782
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1200/jco.2013.51.1345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011867975
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1200/jco.2014.55.1960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050314408
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1200/jco.2015.63.9674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021955201
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1634/theoncologist.2015-0171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068164535
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1634/theoncologist.2017-0031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085768622
342 rdf:type schema:CreativeWork
343 https://doi.org/10.3322/caac.21395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084430952
344 rdf:type schema:CreativeWork
345 https://www.grid.ac/institutes/grid.144189.1 schema:alternateName Azienda Ospedaliera Universitaria Pisana
346 schema:name Azienda Ospedaliero Universitaria Pisana, U.O. Oncologia Medica 2 Universitaria, Via Roma, 67, 56126, Pisa, Italy
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.411475.2 schema:alternateName Azienda Ospedaliera Universitaria Integrata Verona
349 schema:name Oncologia, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Scuro, 10, 37134, Verona, Italy
350 rdf:type schema:Organization
351 https://www.grid.ac/institutes/grid.411492.b schema:alternateName Ospedale Santa Maria della Misericordia di Udine
352 schema:name Azienda Sanitaria Universitaria Integrata di Udine, Dipartimento di Oncologia, Piazzale Santa Maria della Misericordia, 15, 33100, Udine, Italy
353 rdf:type schema:Organization
354 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
355 schema:name Fondazione IRCCS Istituto Nazionale Tumori, Dipartimento di Oncologia Medica, Via Venezian, 1, 20133, Milan, Italy
356 rdf:type schema:Organization
357 https://www.grid.ac/institutes/grid.419546.b schema:alternateName Istituto Oncologico Veneto
358 schema:name Istituto Oncologico Veneto - IRCCS, S.C. Oncologia Medica 1, Dipartimento di Oncologia Clinica e Sperimentale, Via Gattamelata, 64, 35128, Padova, Italy
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.419563.c schema:alternateName Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
361 schema:name IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), U.O. Oncologia Medica, Via P. Maroncelli, 40, 47014, Meldola, FC, Italy
362 rdf:type schema:Organization
363 https://www.grid.ac/institutes/grid.6530.0 schema:alternateName University of Rome Tor Vergata
364 schema:name U.O. Oncologia Medica, Dipartimento di Medicina, Ospedale Universitario Policlinico Tor Vergata, Università degli Studi di Roma Tor Vergata, Viale Oxford, 81, 00133, Rome, Italy
365 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...