Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats View Full Text


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Article Info

DATE

2017-12-21

AUTHORS

Tayyaba Afsar, Suhail Razak, Muhammad Rashid khan, Ali Almajwal

ABSTRACT

BackgroundCisplatin (CP), an effective anticancer agent, carries the risk of impairing testicular function leading to infertility. The present study aimed at evaluating the protective effect of A. hydaspica ethyl acetate extract (AHE) against CP-induced oxidative stress and testicular injuries in rats.MethodsRats were divided into six groups (n = 6). Group I (control), group II (CP single dose on day 16). Group III received AHE for 21 days. Group IV (CP + AHE; post- treatment group). Group V (AHE + CP; pre-treatment group) and group VI (CP + Sily).ResultsCP treatment reduced serum testosterone (T), LH and FSH, decreased the activity level of antioxidant enzymes while increased the concentration of oxidative stress markers, i.e. thiobarbituric acid reactive substances (TBARS), H2O2 and nitric oxide (NO) along with corresponding DNA damages. Furthermore, CP induced adverse morphological changes in testis of rats including reduced epithelial height and tubular diameter, increased luminal diameter with impaired spermatogenesis. Pre and post-treatment with AHE reduced the side effects of CP in testis tissues through improvement in the reproductive hormonal secretions, enzymatic activities, histological and DNA damage parameters. Pretreatment seems to be more effective and equivalent to silymarin group in reversing the CP deleterious effects as compared to post-treatment.ConclusionThe results demonstrated that A. hydaspica treatment in CP-induced testicular toxicity augments the antioxidants defense mechanism, reverted the level of fertility hormones, suppressed the histomorphological alterations and DNA damages and thus provides the evidence that it may have a therapeutic role in free radical mediated diseases. More... »

PAGES

883

References to SciGraph publications

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  • 2005-03. Anatomical characters of the phyllode and stem of Acacia podalyriifolia A. Cunn. ex G. Don (Fabaceae) in REVISTA BRASILEIRA DE FARMACOGNOSIA
  • 2014-09-28. Aged garlic extract protects against oxidative stress and renal changes in cisplatin-treated adult male rats in CANCER CELL INTERNATIONAL
  • 2009-11-25. Histological and morphometric analyses of seasonal testicular variations in the Jungle Crow (Corvus macrorhynchos) in ANATOMICAL SCIENCE INTERNATIONAL
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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29268699


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