Role of geriatric intervention in the treatment of older patients with cancer: rationale and design of a phase III multicenter ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Pierre Soubeyran, Catherine Terret, Carine Bellera, Franck Bonnetain, Olivier Saint Jean, Angéline Galvin, Camille Chakiba, Marie-Dominique Zwolakowski, Simone Mathoulin-Pélissier, Muriel Rainfray

ABSTRACT

BACKGROUND: In the general geriatric population, programs linking geriatric evaluation with interventions are effective for improving functional status and survival of the patients. Whether or not these interventions improve health related quality of life (HRQoL) or overall survival (OS) in older patients with cancer is not yet clear. Indeed, randomized data on the effect of such interventions on survival and HRQoL are rare and conflicting. We describe the rationale and design of a phase III multicenter trial aimed at assessing the efficacy of geriatric intervention in the management of elderly patients with cancer. METHODS/DESIGN: Approximately 1200 patients, 70 years and older, considered in need of a geriatric intervention based on the G8 screening tool will be randomized into two intervention arms. The 'Usual-care' arm involves standard oncological care based on pre-defined oncological protocols. In addition to the standard oncological care, the 'Case-management' arm involves a multidimensional geriatric assessment and interventions tailored for the patient. Efficacy will be assessed using a co-primary endpoint encompassing OS and HRQoL. DISCUSSION: This trial has been designed to assess whether focused geriatric case management can either improve OS or HRQoL in elderly cancer patients considered in need of geriatric assessment. TRIAL REGISTRATION: Clinicaltrials.gov ID: NCT02704832 . More... »

PAGES

932

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-016-2927-4

DOI

http://dx.doi.org/10.1186/s12885-016-2927-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034011686

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27908282


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2927-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2927-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2927-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2927-4'


 

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295 French National Cancer Institute (INCa) Integrated Cancer Research Site (SIRIC), Institut Bergonié, Comprehensive Cancer Center, F-33000, Bordeaux, France
296 Inserm U1219 Research Centre, Epicene Team (Epidemiology of Cancer and Environmental Exposure) University of Bordeaux, 33076, Bordeaux, France
297 University of Bordeaux, F-33000, Bordeaux, France
298 rdf:type schema:Organization
299 https://www.grid.ac/institutes/grid.457371.3 schema:alternateName Délégation Aquitaine, Poitou-Charentes
300 schema:name French National Cancer Institute (INCa) Integrated Cancer Research Site (SIRIC), Institut Bergonié, Comprehensive Cancer Center, F-33000, Bordeaux, France
301 Inserm, CIC-EC14.01 (Clinical Investigation Centre – Clinical Epidemiology Unit), F-33000, Bordeaux, France
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.476460.7 schema:alternateName Institut Bergonié
304 schema:name Department of Medical Oncology, Institut Bergonié, Comprehensive Cancer Center, F-33000, Bordeaux, France
305 French National Cancer Institute (INCa) Integrated Cancer Research Site (SIRIC), Institut Bergonié, Comprehensive Cancer Center, F-33000, Bordeaux, France
306 Medical Oncology, Institut Bergonié, Comprehensive Cancer Center, 229 cours de l’Argonne, 33076, Bordeaux, France
307 University of Bordeaux, F-33000, Bordeaux, France
308 rdf:type schema:Organization
 




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