Identification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Omer Faruk Karatas, Ilknur Suer, Betul Yuceturk, Mehmet Yilmaz, Buge Oz, Gulgun Guven, Harun Cansiz, Chad J. Creighton, Michael Ittmann, Mustafa Ozen

ABSTRACT

BACKGROUND: Emerging evidences proposed that microRNAs are associated with regulation of distinct physio-pathological processes including development of normal stem cells and carcinogenesis. In this study we aimed to investigate microRNA profile of cancer stem-like cells (CSLCs) isolated form freshly resected larynx cancer (LCa) tissue samples. METHODS: CD133 positive (CD133+) stem-like cells were isolated from freshly resected LCa tumor specimens. MicroRNA profile of 12 pair of CD133+ and CD133- cells was determined using microRNA microarray and differential expressions of selvected microRNAs were validated by quantitative real time PCR (qRT-PCR). RESULTS: MicroRNA profiling of CD133+ and CD133- LCa samples with microarray revealed that miR-26b, miR-203, miR-200c, and miR-363-3p were significantly downregulated and miR-1825 was upregulated in CD133+ larynx CSLCs. qRT-PCR analysis in a total of 25 CD133+/CD133- sample pairs confirmed the altered expressions of these five microRNAs. Expressions of miR-26b, miR-200c, and miR-203 were significantly correlated with miR-363-3p, miR-203, and miR-363-3p expressions, respectively. Furthermore, in silico analysis revealed that these microRNAs target both cancer and stem-cell associated signaling pathways. CONCLUSIONS: Our results showed that certain microRNAs in CD133+ cells could be used as cancer stem cell markers. Based on these results, we propose that this panel of microRNAs might carry crucial roles in LCa pathogenesis through regulating stem cell properties of tumor cells. More... »

PAGES

853

References to SciGraph publications

  • 2014-06. MiR-203 is downregulated in laryngeal squamous cell carcinoma and can suppress proliferation and induce apoptosis of tumours in TUMOR BIOLOGY
  • 2011-02. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 in NATURE MEDICINE
  • 2008-03. A skin microRNA promotes differentiation by repressing ‘stemness’ in NATURE
  • 2009-12. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs in NATURE CELL BIOLOGY
  • 2013-12. MicroRNAs miR-26a, miR-26b, and miR-29b accelerate osteogenic differentiation of unrestricted somatic stem cells from human cord blood in BMC GENOMICS
  • 2014-12. The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumourigenesis in NATURE COMMUNICATIONS
  • 2006-06. Functions of microRNAs and related small RNAs in plants in NATURE GENETICS
  • 2011-06. Recurrent copy number variations in human induced pluripotent stem cells in NATURE BIOTECHNOLOGY
  • 2012-10. Genetic and epigenetic stability of human pluripotent stem cells in NATURE REVIEWS GENETICS
  • 2005-07. Sizing up miRNAs as cancer genes in NATURE MEDICINE
  • 2015-03. MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways in BRITISH JOURNAL OF CANCER
  • 2014-12. MiR-363 sensitizes cisplatin-induced apoptosis targeting in Mcl-1 in breast cancer in MEDICAL ONCOLOGY
  • 2009-01. Characterization of human embryonic stem cells with features of neoplastic progression in NATURE BIOTECHNOLOGY
  • 2015-12. Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential in ONCOGENE
  • 2012-12. MicroRNA profiling of a CD133+spheroid-forming subpopulation of the OVCAR3 human ovarian cancer cell line in BMC MEDICAL GENOMICS
  • 2007-10-25. Identification of stem cells in small intestine and colon by marker gene Lgr5 in NATURE
  • 2011-10. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable in NATURE
  • 2016-11. Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma in SCIENTIFIC REPORTS
  • 2006-12. The cancer stem cell hypothesis: a work in progress in LABORATORY INVESTIGATION
  • 2008-05. An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors in NATURE GENETICS
  • 2013-12. Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties in SCIENTIFIC REPORTS
  • 2011-02. Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-016-2863-3

    DOI

    http://dx.doi.org/10.1186/s12885-016-2863-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014752821

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27816053


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