Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ß-catenin View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Kyu Sang Lee, Yoonjin Kwak, Kyung Han Nam, Duck-Woo Kim, Sung-Bum Kang, Gheeyoung Choe, Woo Ho Kim, Hye Seung Lee

ABSTRACT

BACKGROUND: The purpose of our research was to determine the prognostic impact and clinicopathological feature of c-MYC and β-catenin overexpression in colorectal cancer (CRC) patients. METHODS: Using immunohistochemistry (IHC), we measured the c-MYC and β-catenin expression in 367 consecutive CRC patients retrospectively (cohort 1). Also, c-MYC expression was measured by mRNA in situ hybridization. Moreover, to analyze regional heterogeneity, three sites of CRC including the primary, distant and lymph node metastasis were evaluated in 176 advanced CRC patients (cohort 2). RESULTS: In cohort 1, c-MYC protein and mRNA overexpression and ß-catenin nuclear expression were found in 201 (54.8 %), 241 (65.7 %) and 221 (60.2 %) of 367 patients, respectively, each of which was associated with improved prognosis (P = 0.011, P = 0.012 and P = 0.033, respectively). Moreover, co-expression of c-MYC and ß-catenin was significantly correlated with longer survival by univariate (P = 0.012) and multivariate (P = 0.048) studies. Overexpression of c-MYC protein was associated with mRNA overexpression (ρ, 0.479; P < 0.001) and nuclear ß-catenin expression (ρ, 0.282; P < 0.001). Expression of c-MYC and ß-catenin was heterogeneous depending on location in advanced CRC patients (cohort 2). Nevertheless, both c-MYC and ß-catenin expression in primary cancer were significantly correlated with improved survival in univariate (P = 0.001) and multivariate (P = 0.002) analyses. c-MYC and ß-catenin expression of lymph node or distant metastatic tumor was not significantly correlated with patients' prognosis (P > 0.05). CONCLUSIONS: Co-expression of c-MYC and ß-catenin was independently correlated with favorable prognosis in CRC patient. We concluded that the expression of c-MYC and ß-catenin might be useful predicting indicator of CRC patient's prognosis. More... »

PAGES

730

References to SciGraph publications

  • 2014-05. Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas in BRITISH JOURNAL OF CANCER
  • 2011-03. Prognostic value of β-catenin, c-myc, and cyclin D1 expressions in patients with esophageal squamous cell carcinoma in MEDICAL ONCOLOGY
  • 1999-05. MYC oncogenes and human neoplastic disease in ONCOGENE
  • 2015-11. The consensus molecular subtypes of colorectal cancer in NATURE MEDICINE
  • 1999-04. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells in NATURE
  • 2010-02-18. The landscape of somatic copy-number alteration across human cancers in NATURE
  • 2008-09. Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer in BRITISH JOURNAL OF CANCER
  • 1992-09. APC mutations occur early during colorectal tumorigenesis in NATURE
  • 2009-02. Heterogeneity of tumor prognostic markers: a reproducibility study applied to liver metastases of pancreatic endocrine tumors in MODERN PATHOLOGY
  • 2009-09. Slow proliferation as a biological feature of colorectal cancer metastasis in BRITISH JOURNAL OF CANCER
  • 2009-11. Prognostic significance of c-Myc expression in soft tissue leiomyosarcoma in MODERN PATHOLOGY
  • 2015-12. Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for survival prognosis of colorectal cancer patients: a retrospective cohort study in BMC CANCER
  • 2011-10. Analysis of KRAS, BRAF, PTEN, IGF1R, EGFR intron 1 CA status in both primary tumors and paired metastases in determining benefit from cetuximab therapy in colon cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2013-04-14. Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-016-2770-7

    DOI

    http://dx.doi.org/10.1186/s12885-016-2770-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025304106

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27619912


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Nucleus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymph Nodes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-myc", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tissue Array Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Up-Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "beta Catenin", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Seoul National University Bundang Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412480.b", 
              "name": [
                "Department of Pathology, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Kyu Sang", 
            "id": "sg:person.01041235054.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041235054.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University", 
              "id": "https://www.grid.ac/institutes/grid.31501.36", 
              "name": [
                "Department of Pathology, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea", 
                "Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro (Yongon-dong), 110-799, Jongno-gu, Seoul, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kwak", 
            "givenName": "Yoonjin", 
            "id": "sg:person.01116610554.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116610554.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inje University Haeundae Paik Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411631.0", 
              "name": [
                "Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, 612-896, Busan, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nam", 
            "givenName": "Kyung Han", 
            "id": "sg:person.01155463454.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155463454.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University Bundang Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412480.b", 
              "name": [
                "Department of Surgery, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Duck-Woo", 
            "id": "sg:person.01355515405.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355515405.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University Bundang Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412480.b", 
              "name": [
                "Department of Surgery, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kang", 
            "givenName": "Sung-Bum", 
            "id": "sg:person.0747637353.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747637353.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University", 
              "id": "https://www.grid.ac/institutes/grid.31501.36", 
              "name": [
                "Department of Pathology, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea", 
                "Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro (Yongon-dong), 110-799, Jongno-gu, Seoul, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choe", 
            "givenName": "Gheeyoung", 
            "id": "sg:person.01174003730.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174003730.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University", 
              "id": "https://www.grid.ac/institutes/grid.31501.36", 
              "name": [
                "Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro (Yongon-dong), 110-799, Jongno-gu, Seoul, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Woo Ho", 
            "id": "sg:person.016630576674.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016630576674.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University Bundang Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412480.b", 
              "name": [
                "Department of Pathology, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Hye Seung", 
            "id": "sg:person.014357233714.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357233714.08"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1159/000226915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001636012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.275.5307.1787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002102308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604560", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002488471", 
              "https://doi.org/10.1038/sj.bjc.6604560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2011.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005993914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0087456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006765073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/21.11.1935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008043541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010635813", 
              "https://doi.org/10.1038/nature08822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010635813", 
              "https://doi.org/10.1038/nature08822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0139727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012627133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3816/ccc.2007.s.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013770759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014438312", 
              "https://doi.org/10.1038/nm.3967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81333-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014745301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-2446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016545848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2014.218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016777244", 
              "https://doi.org/10.1038/bjc.2014.218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-230x(02)84004-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019234201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.08.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020496443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.08.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020496443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2009.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020674161", 
              "https://doi.org/10.1038/modpathol.2009.113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2009.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020674161", 
              "https://doi.org/10.1038/modpathol.2009.113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2009.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023129201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1521-1878(199912)22:1<1021::aid-bies6>3.0.co;2-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024295171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-011-1586-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024916517", 
              "https://doi.org/10.1007/s00280-011-1586-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-010-9436-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025837979", 
              "https://doi.org/10.1007/s12032-010-9436-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-07-2615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026075620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00336-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026878090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0063854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028670326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.5.8.1969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028674790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-0157-03", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030074112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030221685", 
              "https://doi.org/10.1038/sj.bjc.6605229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gene.2011.12.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032274769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(98)80068-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033092559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/18884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037595361", 
              "https://doi.org/10.1038/18884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/18884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037595361", 
              "https://doi.org/10.1038/18884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-0173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038951372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-015-1150-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040426709", 
              "https://doi.org/10.1186/s12885-015-1150-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-015-1150-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040426709", 
              "https://doi.org/10.1186/s12885-015-1150-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.281.5382.1509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042662127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2005.11.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042909945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000227619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043534078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/359235a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044710385", 
              "https://doi.org/10.1038/359235a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2004.10.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045857189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047655881", 
              "https://doi.org/10.1038/nm.3174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2008.177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047673312", 
              "https://doi.org/10.1038/modpathol.2008.177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0091811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048291217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050186337", 
              "https://doi.org/10.1038/sj.onc.1202746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050186337", 
              "https://doi.org/10.1038/sj.onc.1202746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jclinpath-2015-202985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050498560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2002806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062682480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.7.5.5492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072299868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074963966", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078151698", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078647596", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079695334", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083347766", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083350376", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-12", 
        "datePublishedReg": "2016-12-01", 
        "description": "BACKGROUND: The purpose of our research was to determine the prognostic impact and clinicopathological feature of c-MYC and \u03b2-catenin overexpression in colorectal cancer (CRC) patients.\nMETHODS: Using immunohistochemistry (IHC), we measured the c-MYC and \u03b2-catenin expression in 367 consecutive CRC patients retrospectively (cohort 1). Also, c-MYC expression was measured by mRNA in situ hybridization. Moreover, to analyze regional heterogeneity, three sites of CRC including the primary, distant and lymph node metastasis were evaluated in 176 advanced CRC patients (cohort 2).\nRESULTS: In cohort 1, c-MYC protein and mRNA overexpression and \u00df-catenin nuclear expression were found in 201 (54.8\u00a0%), 241 (65.7\u00a0%) and 221 (60.2\u00a0%) of 367 patients, respectively, each of which was associated with improved prognosis (P\u2009=\u20090.011, P\u2009=\u20090.012 and P\u2009=\u20090.033, respectively). Moreover, co-expression of c-MYC and \u00df-catenin was significantly correlated with longer survival by univariate (P\u2009=\u20090.012) and multivariate (P\u2009=\u20090.048) studies. Overexpression of c-MYC protein was associated with mRNA overexpression (\u03c1, 0.479; P\u2009<\u20090.001) and nuclear \u00df-catenin expression (\u03c1, 0.282; P\u2009<\u20090.001). Expression of c-MYC and \u00df-catenin was heterogeneous depending on location in advanced CRC patients (cohort 2). Nevertheless, both c-MYC and \u00df-catenin expression in primary cancer were significantly correlated with improved survival in univariate (P\u2009=\u20090.001) and multivariate (P\u2009=\u20090.002) analyses. c-MYC and \u00df-catenin expression of lymph node or distant metastatic tumor was not significantly correlated with patients' prognosis (P\u2009>\u20090.05).\nCONCLUSIONS: Co-expression of c-MYC and \u00df-catenin was independently correlated with favorable prognosis in CRC patient. We concluded that the expression of c-MYC and \u00df-catenin might be useful predicting indicator of CRC patient's prognosis.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s12885-016-2770-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1024632", 
            "issn": [
              "1471-2407"
            ], 
            "name": "BMC Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "name": "Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and \u00df-catenin", 
        "pagination": "730", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "788ca23b36b93030edaf9f69a308ed9f812d37c3751b43a5a8f2596e1ecf0e56"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27619912"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100967800"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12885-016-2770-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1025304106"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12885-016-2770-7", 
          "https://app.dimensions.ai/details/publication/pub.1025304106"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:27", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87117_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs12885-016-2770-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2770-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2770-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2770-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2770-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    348 TRIPLES      21 PREDICATES      95 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12885-016-2770-7 schema:about N0013e6fe495646a293f3e230afc593b1
    2 N0142f36f2de74160af21bbb41c3181b9
    3 N18eab6b0dcda4ccb8b896e2f24295b39
    4 N1d51a1c763c44b40bea808644552b853
    5 N1efa0dd3fa5c4dd58638fd518c3cc1b6
    6 N3f6221e23c124954b221cf994d43f294
    7 N540963a2dcfb4f5ea6fcad8ad1369c51
    8 N5b88d1a334bf42758f8d482d70d40b49
    9 N5ba878ce167f463da3581c927be068bb
    10 N7255b2e2c98c447584c773c5f7e96b89
    11 N7924d6667966480b9d3f23b08e4c80ba
    12 N899819b432af43a481656ee56bb185e9
    13 Nb4c41d1129e54ecdb819a57ae3ea9a4e
    14 Nb6915ecad1d348fcb16a9f05455b2f0c
    15 Nc85e71b5dbd547698f1512cfbcbca0d2
    16 Ne1162fb20b6e43ec90b197ace5bb0cd1
    17 Nf06cc513be9f49fa8cfdb778f9bedf9a
    18 anzsrc-for:11
    19 anzsrc-for:1112
    20 schema:author Na6869543d9cb42c2b00b2b41c18dd6e4
    21 schema:citation sg:pub.10.1007/s00280-011-1586-z
    22 sg:pub.10.1007/s12032-010-9436-0
    23 sg:pub.10.1038/18884
    24 sg:pub.10.1038/359235a0
    25 sg:pub.10.1038/bjc.2014.218
    26 sg:pub.10.1038/modpathol.2008.177
    27 sg:pub.10.1038/modpathol.2009.113
    28 sg:pub.10.1038/nature08822
    29 sg:pub.10.1038/nm.3174
    30 sg:pub.10.1038/nm.3967
    31 sg:pub.10.1038/sj.bjc.6604560
    32 sg:pub.10.1038/sj.bjc.6605229
    33 sg:pub.10.1038/sj.onc.1202746
    34 sg:pub.10.1186/s12885-015-1150-z
    35 https://app.dimensions.ai/details/publication/pub.1074963966
    36 https://app.dimensions.ai/details/publication/pub.1078151698
    37 https://app.dimensions.ai/details/publication/pub.1078647596
    38 https://app.dimensions.ai/details/publication/pub.1079695334
    39 https://app.dimensions.ai/details/publication/pub.1083347766
    40 https://app.dimensions.ai/details/publication/pub.1083350376
    41 https://doi.org/10.1002/(sici)1521-1878(199912)22:1<1021::aid-bies6>3.0.co;2-p
    42 https://doi.org/10.1016/j.bbrc.2004.10.111
    43 https://doi.org/10.1016/j.cell.2012.08.026
    44 https://doi.org/10.1016/j.ejca.2005.11.022
    45 https://doi.org/10.1016/j.gene.2011.12.027
    46 https://doi.org/10.1016/j.stem.2009.07.003
    47 https://doi.org/10.1016/j.stem.2011.10.008
    48 https://doi.org/10.1016/s0065-230x(02)84004-0
    49 https://doi.org/10.1016/s0092-8674(00)81333-1
    50 https://doi.org/10.1016/s0092-8674(04)00336-8
    51 https://doi.org/10.1016/s0959-437x(98)80068-3
    52 https://doi.org/10.1093/carcin/21.11.1935
    53 https://doi.org/10.1126/science.275.5307.1787
    54 https://doi.org/10.1126/science.281.5382.1509
    55 https://doi.org/10.1126/scisignal.2002806
    56 https://doi.org/10.1128/mcb.5.8.1969
    57 https://doi.org/10.1136/jclinpath-2015-202985
    58 https://doi.org/10.1158/1055-9965.epi-07-2615
    59 https://doi.org/10.1158/1078-0432.ccr-0157-03
    60 https://doi.org/10.1158/1078-0432.ccr-07-0173
    61 https://doi.org/10.1158/1078-0432.ccr-09-2446
    62 https://doi.org/10.1159/000226915
    63 https://doi.org/10.1159/000227619
    64 https://doi.org/10.1371/journal.pone.0063854
    65 https://doi.org/10.1371/journal.pone.0087456
    66 https://doi.org/10.1371/journal.pone.0091811
    67 https://doi.org/10.1371/journal.pone.0139727
    68 https://doi.org/10.3816/ccc.2007.s.004
    69 https://doi.org/10.4161/cc.7.5.5492
    70 schema:datePublished 2016-12
    71 schema:datePublishedReg 2016-12-01
    72 schema:description BACKGROUND: The purpose of our research was to determine the prognostic impact and clinicopathological feature of c-MYC and β-catenin overexpression in colorectal cancer (CRC) patients. METHODS: Using immunohistochemistry (IHC), we measured the c-MYC and β-catenin expression in 367 consecutive CRC patients retrospectively (cohort 1). Also, c-MYC expression was measured by mRNA in situ hybridization. Moreover, to analyze regional heterogeneity, three sites of CRC including the primary, distant and lymph node metastasis were evaluated in 176 advanced CRC patients (cohort 2). RESULTS: In cohort 1, c-MYC protein and mRNA overexpression and ß-catenin nuclear expression were found in 201 (54.8 %), 241 (65.7 %) and 221 (60.2 %) of 367 patients, respectively, each of which was associated with improved prognosis (P = 0.011, P = 0.012 and P = 0.033, respectively). Moreover, co-expression of c-MYC and ß-catenin was significantly correlated with longer survival by univariate (P = 0.012) and multivariate (P = 0.048) studies. Overexpression of c-MYC protein was associated with mRNA overexpression (ρ, 0.479; P < 0.001) and nuclear ß-catenin expression (ρ, 0.282; P < 0.001). Expression of c-MYC and ß-catenin was heterogeneous depending on location in advanced CRC patients (cohort 2). Nevertheless, both c-MYC and ß-catenin expression in primary cancer were significantly correlated with improved survival in univariate (P = 0.001) and multivariate (P = 0.002) analyses. c-MYC and ß-catenin expression of lymph node or distant metastatic tumor was not significantly correlated with patients' prognosis (P > 0.05). CONCLUSIONS: Co-expression of c-MYC and ß-catenin was independently correlated with favorable prognosis in CRC patient. We concluded that the expression of c-MYC and ß-catenin might be useful predicting indicator of CRC patient's prognosis.
    73 schema:genre research_article
    74 schema:inLanguage en
    75 schema:isAccessibleForFree true
    76 schema:isPartOf Nb1fbadd647d64b69a4abb5df59f50908
    77 Nc801f84c558c4f9db80a4179cc115820
    78 sg:journal.1024632
    79 schema:name Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ß-catenin
    80 schema:pagination 730
    81 schema:productId N207fc2c499a94e9ca07dcd20cd9db19e
    82 N31c7a6f13d4240a7b11683e7f0b929ac
    83 N3466ec996ab14098b9f8c4ca9e16001b
    84 N68e80c3e1acb48e2ab3b19796050fee8
    85 Nba2fb9281ffc4a6680b836ac359953fb
    86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025304106
    87 https://doi.org/10.1186/s12885-016-2770-7
    88 schema:sdDatePublished 2019-04-11T12:27
    89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    90 schema:sdPublisher Nfdc45963094a458c85409b3e2bcd3589
    91 schema:url https://link.springer.com/10.1186%2Fs12885-016-2770-7
    92 sgo:license sg:explorer/license/
    93 sgo:sdDataset articles
    94 rdf:type schema:ScholarlyArticle
    95 N0013e6fe495646a293f3e230afc593b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name beta Catenin
    97 rdf:type schema:DefinedTerm
    98 N0142f36f2de74160af21bbb41c3181b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Humans
    100 rdf:type schema:DefinedTerm
    101 N18eab6b0dcda4ccb8b896e2f24295b39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Prognosis
    103 rdf:type schema:DefinedTerm
    104 N1d51a1c763c44b40bea808644552b853 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Retrospective Studies
    106 rdf:type schema:DefinedTerm
    107 N1efa0dd3fa5c4dd58638fd518c3cc1b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Tissue Array Analysis
    109 rdf:type schema:DefinedTerm
    110 N207fc2c499a94e9ca07dcd20cd9db19e schema:name nlm_unique_id
    111 schema:value 100967800
    112 rdf:type schema:PropertyValue
    113 N2d9e4c1196c54faeb045b48b5b9268c8 rdf:first sg:person.01155463454.13
    114 rdf:rest N862e96e3c1594e42b1d2e7e2f1e7596e
    115 N31c7a6f13d4240a7b11683e7f0b929ac schema:name readcube_id
    116 schema:value 788ca23b36b93030edaf9f69a308ed9f812d37c3751b43a5a8f2596e1ecf0e56
    117 rdf:type schema:PropertyValue
    118 N3466ec996ab14098b9f8c4ca9e16001b schema:name dimensions_id
    119 schema:value pub.1025304106
    120 rdf:type schema:PropertyValue
    121 N3f6221e23c124954b221cf994d43f294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Female
    123 rdf:type schema:DefinedTerm
    124 N540963a2dcfb4f5ea6fcad8ad1369c51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Up-Regulation
    126 rdf:type schema:DefinedTerm
    127 N5b88d1a334bf42758f8d482d70d40b49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Male
    129 rdf:type schema:DefinedTerm
    130 N5ba878ce167f463da3581c927be068bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Cell Nucleus
    132 rdf:type schema:DefinedTerm
    133 N5d4281a8f83b4bed80b732d7bbc7b08b rdf:first sg:person.01174003730.11
    134 rdf:rest Nfd3d6c864ba14aef917ed9bbc712c1f7
    135 N68e80c3e1acb48e2ab3b19796050fee8 schema:name doi
    136 schema:value 10.1186/s12885-016-2770-7
    137 rdf:type schema:PropertyValue
    138 N7255b2e2c98c447584c773c5f7e96b89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Colorectal Neoplasms
    140 rdf:type schema:DefinedTerm
    141 N7924d6667966480b9d3f23b08e4c80ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Middle Aged
    143 rdf:type schema:DefinedTerm
    144 N7ee8667bbf5549109db2f8d47ef4afcc rdf:first sg:person.014357233714.08
    145 rdf:rest rdf:nil
    146 N862e96e3c1594e42b1d2e7e2f1e7596e rdf:first sg:person.01355515405.70
    147 rdf:rest Nbc689d3b2eb34a89af4661a3f14607bc
    148 N899819b432af43a481656ee56bb185e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Survival Analysis
    150 rdf:type schema:DefinedTerm
    151 Na6869543d9cb42c2b00b2b41c18dd6e4 rdf:first sg:person.01041235054.55
    152 rdf:rest Nd6bf30a61d2748f2be9e2d6930a398f5
    153 Nb1fbadd647d64b69a4abb5df59f50908 schema:issueNumber 1
    154 rdf:type schema:PublicationIssue
    155 Nb4c41d1129e54ecdb819a57ae3ea9a4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Biomarkers, Tumor
    157 rdf:type schema:DefinedTerm
    158 Nb6915ecad1d348fcb16a9f05455b2f0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Gene Expression Regulation, Neoplastic
    160 rdf:type schema:DefinedTerm
    161 Nba2fb9281ffc4a6680b836ac359953fb schema:name pubmed_id
    162 schema:value 27619912
    163 rdf:type schema:PropertyValue
    164 Nbc689d3b2eb34a89af4661a3f14607bc rdf:first sg:person.0747637353.34
    165 rdf:rest N5d4281a8f83b4bed80b732d7bbc7b08b
    166 Nc801f84c558c4f9db80a4179cc115820 schema:volumeNumber 16
    167 rdf:type schema:PublicationVolume
    168 Nc85e71b5dbd547698f1512cfbcbca0d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Neoplasm Metastasis
    170 rdf:type schema:DefinedTerm
    171 Nd6bf30a61d2748f2be9e2d6930a398f5 rdf:first sg:person.01116610554.13
    172 rdf:rest N2d9e4c1196c54faeb045b48b5b9268c8
    173 Ne1162fb20b6e43ec90b197ace5bb0cd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Lymph Nodes
    175 rdf:type schema:DefinedTerm
    176 Nf06cc513be9f49fa8cfdb778f9bedf9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Proto-Oncogene Proteins c-myc
    178 rdf:type schema:DefinedTerm
    179 Nfd3d6c864ba14aef917ed9bbc712c1f7 rdf:first sg:person.016630576674.47
    180 rdf:rest N7ee8667bbf5549109db2f8d47ef4afcc
    181 Nfdc45963094a458c85409b3e2bcd3589 schema:name Springer Nature - SN SciGraph project
    182 rdf:type schema:Organization
    183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    184 schema:name Medical and Health Sciences
    185 rdf:type schema:DefinedTerm
    186 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    187 schema:name Oncology and Carcinogenesis
    188 rdf:type schema:DefinedTerm
    189 sg:journal.1024632 schema:issn 1471-2407
    190 schema:name BMC Cancer
    191 rdf:type schema:Periodical
    192 sg:person.01041235054.55 schema:affiliation https://www.grid.ac/institutes/grid.412480.b
    193 schema:familyName Lee
    194 schema:givenName Kyu Sang
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041235054.55
    196 rdf:type schema:Person
    197 sg:person.01116610554.13 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
    198 schema:familyName Kwak
    199 schema:givenName Yoonjin
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116610554.13
    201 rdf:type schema:Person
    202 sg:person.01155463454.13 schema:affiliation https://www.grid.ac/institutes/grid.411631.0
    203 schema:familyName Nam
    204 schema:givenName Kyung Han
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155463454.13
    206 rdf:type schema:Person
    207 sg:person.01174003730.11 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
    208 schema:familyName Choe
    209 schema:givenName Gheeyoung
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174003730.11
    211 rdf:type schema:Person
    212 sg:person.01355515405.70 schema:affiliation https://www.grid.ac/institutes/grid.412480.b
    213 schema:familyName Kim
    214 schema:givenName Duck-Woo
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355515405.70
    216 rdf:type schema:Person
    217 sg:person.014357233714.08 schema:affiliation https://www.grid.ac/institutes/grid.412480.b
    218 schema:familyName Lee
    219 schema:givenName Hye Seung
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357233714.08
    221 rdf:type schema:Person
    222 sg:person.016630576674.47 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
    223 schema:familyName Kim
    224 schema:givenName Woo Ho
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016630576674.47
    226 rdf:type schema:Person
    227 sg:person.0747637353.34 schema:affiliation https://www.grid.ac/institutes/grid.412480.b
    228 schema:familyName Kang
    229 schema:givenName Sung-Bum
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747637353.34
    231 rdf:type schema:Person
    232 sg:pub.10.1007/s00280-011-1586-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1024916517
    233 https://doi.org/10.1007/s00280-011-1586-z
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1007/s12032-010-9436-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025837979
    236 https://doi.org/10.1007/s12032-010-9436-0
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/18884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037595361
    239 https://doi.org/10.1038/18884
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/359235a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044710385
    242 https://doi.org/10.1038/359235a0
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/bjc.2014.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016777244
    245 https://doi.org/10.1038/bjc.2014.218
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/modpathol.2008.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047673312
    248 https://doi.org/10.1038/modpathol.2008.177
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/modpathol.2009.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020674161
    251 https://doi.org/10.1038/modpathol.2009.113
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nature08822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010635813
    254 https://doi.org/10.1038/nature08822
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nm.3174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047655881
    257 https://doi.org/10.1038/nm.3174
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/nm.3967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014438312
    260 https://doi.org/10.1038/nm.3967
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/sj.bjc.6604560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002488471
    263 https://doi.org/10.1038/sj.bjc.6604560
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/sj.bjc.6605229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030221685
    266 https://doi.org/10.1038/sj.bjc.6605229
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/sj.onc.1202746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050186337
    269 https://doi.org/10.1038/sj.onc.1202746
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1186/s12885-015-1150-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1040426709
    272 https://doi.org/10.1186/s12885-015-1150-z
    273 rdf:type schema:CreativeWork
    274 https://app.dimensions.ai/details/publication/pub.1074963966 schema:CreativeWork
    275 https://app.dimensions.ai/details/publication/pub.1078151698 schema:CreativeWork
    276 https://app.dimensions.ai/details/publication/pub.1078647596 schema:CreativeWork
    277 https://app.dimensions.ai/details/publication/pub.1079695334 schema:CreativeWork
    278 https://app.dimensions.ai/details/publication/pub.1083347766 schema:CreativeWork
    279 https://app.dimensions.ai/details/publication/pub.1083350376 schema:CreativeWork
    280 https://doi.org/10.1002/(sici)1521-1878(199912)22:1<1021::aid-bies6>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1024295171
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.bbrc.2004.10.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045857189
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.cell.2012.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020496443
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.ejca.2005.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042909945
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.gene.2011.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032274769
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.stem.2009.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023129201
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.stem.2011.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005993914
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/s0065-230x(02)84004-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019234201
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/s0092-8674(00)81333-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014745301
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/s0092-8674(04)00336-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026878090
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/s0959-437x(98)80068-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033092559
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1093/carcin/21.11.1935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008043541
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1126/science.275.5307.1787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002102308
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1126/science.281.5382.1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042662127
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1126/scisignal.2002806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062682480
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1128/mcb.5.8.1969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028674790
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1136/jclinpath-2015-202985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050498560
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1158/1055-9965.epi-07-2615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026075620
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1158/1078-0432.ccr-0157-03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030074112
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1158/1078-0432.ccr-07-0173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038951372
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1158/1078-0432.ccr-09-2446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016545848
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1159/000226915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001636012
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1159/000227619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043534078
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1371/journal.pone.0063854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028670326
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1371/journal.pone.0087456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006765073
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1371/journal.pone.0091811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048291217
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1371/journal.pone.0139727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012627133
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.3816/ccc.2007.s.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013770759
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.4161/cc.7.5.5492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299868
    337 rdf:type schema:CreativeWork
    338 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
    339 schema:name Department of Pathology, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea
    340 Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro (Yongon-dong), 110-799, Jongno-gu, Seoul, Republic of Korea
    341 rdf:type schema:Organization
    342 https://www.grid.ac/institutes/grid.411631.0 schema:alternateName Inje University Haeundae Paik Hospital
    343 schema:name Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, 612-896, Busan, Republic of Korea
    344 rdf:type schema:Organization
    345 https://www.grid.ac/institutes/grid.412480.b schema:alternateName Seoul National University Bundang Hospital
    346 schema:name Department of Pathology, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea
    347 Department of Surgery, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea
    348 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...