Auto-immune thyroid dysfunction induced by tyrosine kinase inhibitors in a patient with recurrent chordoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Juliette Eroukhmanoff, Frederic Castinetti, Nicolas Penel, Sebastien Salas

ABSTRACT

BACKGROUND: While hypothyroidism has frequently been reported with the use of TKIs, the thyroid-stimulating hormone (TSH) suppressing effect of TKIs is rare, except for thyroiditis. We describe a case with progressive recurrent chordoma who initially became hyperthyroid in a context of autoimmunity under sorafenib treatment and later under imatinib treatment. CASE PRESENTATION: A 57-year-old man with lumbar chordoma began daily treatment of 800 mg sorafenib. He did not have any other medication or recent iodinated-contrast exposure and his family history was negative for thyroid and autoimmune disease. There was no history of neck pain, irradiation or trauma, recent fever or viral illness. Pre-treatment TSH was normal. After 18 weeks of treatment, the patient presented hyperthyroidism with positive anti-TSH receptor antibodies. More surprisingly, Graves' disease recurred during treatment with imatinib. CONCLUSION: The fact that Graves' disease occurred after two different TKIs suggests that it could be a rare but important class effect. Anti-TSH receptor antibodies should be systematically measured when TSH decreases in order to avoid the erroneous diagnosis of transient hyperthyroidism due to thyroiditis. More... »

PAGES

679

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-016-2705-3

DOI

http://dx.doi.org/10.1186/s12885-016-2705-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010473172

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27558389


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