Cetuximab-induced aseptic meningitis: case report and review of a rare adverse event View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07-04

AUTHORS

Christophe Maritaz, Carole Metz, Nabil Baba-Hamed, Méryam Jardin-Szucs, Gaël Deplanque

ABSTRACT

BackgroundCetuximab is a commonly used antibody agent in the treatment of colorectal or head and neck cancer. Although it is generally well tolerated in most patients, cetuximab has been associated with some rare but serious adverse events. Aseptic meningitis is one such distinctly uncommon adverse drug reaction.Case presentationWe present the case of a middle-aged Caucasian patient, who presented with fever and headache within a few hours of starting cetuximab therapy and was diagnosed with cetuximab-induced aseptic meningitis after a complete workup.ConclusionTo our knowledge, this is the ninth case of cetuximab-induced aseptic meningitis reported in literature. Because of a nonspecific clinical presentation, this adverse drug reaction can be easily misdiagnosed. It is important to increase awareness of this potentially severe reaction among oncologists. More... »

PAGES

384

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-016-2434-7

DOI

http://dx.doi.org/10.1186/s12885-016-2434-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012929852

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27378078


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cetuximab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Head and Neck Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meningitis, Aseptic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy, Saint-Joseph Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.414363.7", 
          "name": [
            "Department of Pharmacy, Saint-Joseph Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maritaz", 
        "givenName": "Christophe", 
        "id": "sg:person.01126473305.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126473305.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy, Saint-Joseph Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.414363.7", 
          "name": [
            "Department of Pharmacy, Saint-Joseph Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Metz", 
        "givenName": "Carole", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Saint-Joseph Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.414363.7", 
          "name": [
            "Department of Oncology, Saint-Joseph Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baba-Hamed", 
        "givenName": "Nabil", 
        "id": "sg:person.0624575614.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624575614.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy, Saint-Joseph Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.414363.7", 
          "name": [
            "Department of Pharmacy, Saint-Joseph Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jardin-Szucs", 
        "givenName": "M\u00e9ryam", 
        "id": "sg:person.015553016141.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015553016141.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, University hospital of Lausanne, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.8515.9", 
          "name": [
            "Department of Oncology, University hospital of Lausanne, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deplanque", 
        "givenName": "Ga\u00ebl", 
        "id": "sg:person.01032513530.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032513530.10"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2016-07-04", 
    "datePublishedReg": "2016-07-04", 
    "description": "BackgroundCetuximab is a commonly used antibody agent in the treatment of colorectal or head and neck cancer. Although it is generally well tolerated in most patients, cetuximab has been associated with some rare but serious adverse events. Aseptic meningitis is one such distinctly uncommon adverse drug reaction.Case presentationWe present the case of a middle-aged Caucasian patient, who presented with fever and headache within a few hours of starting cetuximab therapy and was diagnosed with cetuximab-induced aseptic meningitis after a complete workup.ConclusionTo our knowledge, this is the ninth case of cetuximab-induced aseptic meningitis reported in literature. Because of a nonspecific clinical presentation, this adverse drug reaction can be easily misdiagnosed. It is important to increase awareness of this potentially severe reaction among oncologists.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12885-016-2434-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "keywords": [
      "adverse drug reactions", 
      "aseptic meningitis", 
      "adverse events", 
      "drug reactions", 
      "uncommon adverse drug reaction", 
      "serious adverse events", 
      "nonspecific clinical presentation", 
      "rare adverse events", 
      "treatment of colorectal", 
      "cetuximab therapy", 
      "most patients", 
      "antibody agents", 
      "clinical presentation", 
      "Case presentationWe", 
      "neck cancer", 
      "Caucasian patients", 
      "case report", 
      "complete workup", 
      "ninth case", 
      "severe reactions", 
      "meningitis", 
      "patients", 
      "BackgroundCetuximab", 
      "cetuximab", 
      "colorectal", 
      "headache", 
      "fever", 
      "oncologists", 
      "therapy", 
      "workup", 
      "cancer", 
      "ConclusionTo", 
      "treatment", 
      "cases", 
      "presentation", 
      "report", 
      "hours", 
      "events", 
      "review", 
      "agents", 
      "head", 
      "awareness", 
      "reaction", 
      "literature", 
      "knowledge"
    ], 
    "name": "Cetuximab-induced aseptic meningitis: case report and review of a rare adverse event", 
    "pagination": "384", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012929852"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12885-016-2434-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27378078"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12885-016-2434-7", 
      "https://app.dimensions.ai/details/publication/pub.1012929852"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_701.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12885-016-2434-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2434-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2434-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2434-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2434-7'


 

This table displays all metadata directly associated to this object as RDF triples.

178 TRIPLES      21 PREDICATES      81 URIs      73 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12885-016-2434-7 schema:about N0a4a647d311a4ade8f95faa14f6f6dad
2 N0a61772a64844c13b3e32b8c138b4d77
3 N1c3713d82f294be2ba35d6906fdc3ca6
4 N47e800ac321d4256bccd4f609ecaf52e
5 N55cbabb838b24b79be1b4c49bcb65403
6 N64bd334e8ecb446c8138222429f5c789
7 N65aff49d709e473980bd80e79184bfef
8 Nae8f0d6a23764822b486af1c9e9d7cf1
9 Nc5195186517e486685a7f575d16b0fdb
10 Ne33e4ee47fc5479fa0fa6a6b913fd238
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author N6277493abc7e455abd6555d9550f8520
14 schema:datePublished 2016-07-04
15 schema:datePublishedReg 2016-07-04
16 schema:description BackgroundCetuximab is a commonly used antibody agent in the treatment of colorectal or head and neck cancer. Although it is generally well tolerated in most patients, cetuximab has been associated with some rare but serious adverse events. Aseptic meningitis is one such distinctly uncommon adverse drug reaction.Case presentationWe present the case of a middle-aged Caucasian patient, who presented with fever and headache within a few hours of starting cetuximab therapy and was diagnosed with cetuximab-induced aseptic meningitis after a complete workup.ConclusionTo our knowledge, this is the ninth case of cetuximab-induced aseptic meningitis reported in literature. Because of a nonspecific clinical presentation, this adverse drug reaction can be easily misdiagnosed. It is important to increase awareness of this potentially severe reaction among oncologists.
17 schema:genre article
18 schema:inLanguage en
19 schema:isAccessibleForFree true
20 schema:isPartOf N0a780510cb474a4ca2dfe40d8577f8e5
21 N0fbd51423ac441eaa0f6dc04e25e6035
22 sg:journal.1024632
23 schema:keywords BackgroundCetuximab
24 Case presentationWe
25 Caucasian patients
26 ConclusionTo
27 adverse drug reactions
28 adverse events
29 agents
30 antibody agents
31 aseptic meningitis
32 awareness
33 cancer
34 case report
35 cases
36 cetuximab
37 cetuximab therapy
38 clinical presentation
39 colorectal
40 complete workup
41 drug reactions
42 events
43 fever
44 head
45 headache
46 hours
47 knowledge
48 literature
49 meningitis
50 most patients
51 neck cancer
52 ninth case
53 nonspecific clinical presentation
54 oncologists
55 patients
56 presentation
57 rare adverse events
58 reaction
59 report
60 review
61 serious adverse events
62 severe reactions
63 therapy
64 treatment
65 treatment of colorectal
66 uncommon adverse drug reaction
67 workup
68 schema:name Cetuximab-induced aseptic meningitis: case report and review of a rare adverse event
69 schema:pagination 384
70 schema:productId Nb0eca736ec2a4e218b1f5cae3b06b67a
71 Nbdeacf802590461fac130917f3b8aac8
72 Necb9e0e4d65845d5b83d95ce93335a89
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012929852
74 https://doi.org/10.1186/s12885-016-2434-7
75 schema:sdDatePublished 2022-05-20T07:32
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N2da44f8b020d4bc6b0c70dc568e1de6d
78 schema:url https://doi.org/10.1186/s12885-016-2434-7
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N0a4a647d311a4ade8f95faa14f6f6dad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Treatment Outcome
84 rdf:type schema:DefinedTerm
85 N0a61772a64844c13b3e32b8c138b4d77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Anti-Bacterial Agents
87 rdf:type schema:DefinedTerm
88 N0a780510cb474a4ca2dfe40d8577f8e5 schema:volumeNumber 16
89 rdf:type schema:PublicationVolume
90 N0fbd51423ac441eaa0f6dc04e25e6035 schema:issueNumber 1
91 rdf:type schema:PublicationIssue
92 N179a6a63a5e849bf810ac46a67c0c10f rdf:first sg:person.01032513530.10
93 rdf:rest rdf:nil
94 N1c3713d82f294be2ba35d6906fdc3ca6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Aged
96 rdf:type schema:DefinedTerm
97 N2da44f8b020d4bc6b0c70dc568e1de6d schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 N47e800ac321d4256bccd4f609ecaf52e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Humans
101 rdf:type schema:DefinedTerm
102 N55cbabb838b24b79be1b4c49bcb65403 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Meningitis, Aseptic
104 rdf:type schema:DefinedTerm
105 N6277493abc7e455abd6555d9550f8520 rdf:first sg:person.01126473305.27
106 rdf:rest Na792010e3a644a6a9a2c32f04a85b8e8
107 N64bd334e8ecb446c8138222429f5c789 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Head and Neck Neoplasms
109 rdf:type schema:DefinedTerm
110 N65aff49d709e473980bd80e79184bfef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Carcinoma, Squamous Cell
112 rdf:type schema:DefinedTerm
113 N69348828bd00437c94def2ce8f53739d schema:affiliation grid-institutes:grid.414363.7
114 schema:familyName Metz
115 schema:givenName Carole
116 rdf:type schema:Person
117 Na792010e3a644a6a9a2c32f04a85b8e8 rdf:first N69348828bd00437c94def2ce8f53739d
118 rdf:rest Necd89462ad484d1e924ce97d0ef239fd
119 Nac789992a26a40a69d4dc0f148974213 rdf:first sg:person.015553016141.69
120 rdf:rest N179a6a63a5e849bf810ac46a67c0c10f
121 Nae8f0d6a23764822b486af1c9e9d7cf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Cetuximab
123 rdf:type schema:DefinedTerm
124 Nb0eca736ec2a4e218b1f5cae3b06b67a schema:name pubmed_id
125 schema:value 27378078
126 rdf:type schema:PropertyValue
127 Nbdeacf802590461fac130917f3b8aac8 schema:name doi
128 schema:value 10.1186/s12885-016-2434-7
129 rdf:type schema:PropertyValue
130 Nc5195186517e486685a7f575d16b0fdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Female
132 rdf:type schema:DefinedTerm
133 Ne33e4ee47fc5479fa0fa6a6b913fd238 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Administration, Intravenous
135 rdf:type schema:DefinedTerm
136 Necb9e0e4d65845d5b83d95ce93335a89 schema:name dimensions_id
137 schema:value pub.1012929852
138 rdf:type schema:PropertyValue
139 Necd89462ad484d1e924ce97d0ef239fd rdf:first sg:person.0624575614.78
140 rdf:rest Nac789992a26a40a69d4dc0f148974213
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
145 schema:name Clinical Sciences
146 rdf:type schema:DefinedTerm
147 sg:journal.1024632 schema:issn 1471-2407
148 schema:name BMC Cancer
149 schema:publisher Springer Nature
150 rdf:type schema:Periodical
151 sg:person.01032513530.10 schema:affiliation grid-institutes:grid.8515.9
152 schema:familyName Deplanque
153 schema:givenName Gaël
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032513530.10
155 rdf:type schema:Person
156 sg:person.01126473305.27 schema:affiliation grid-institutes:grid.414363.7
157 schema:familyName Maritaz
158 schema:givenName Christophe
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126473305.27
160 rdf:type schema:Person
161 sg:person.015553016141.69 schema:affiliation grid-institutes:grid.414363.7
162 schema:familyName Jardin-Szucs
163 schema:givenName Méryam
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015553016141.69
165 rdf:type schema:Person
166 sg:person.0624575614.78 schema:affiliation grid-institutes:grid.414363.7
167 schema:familyName Baba-Hamed
168 schema:givenName Nabil
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624575614.78
170 rdf:type schema:Person
171 grid-institutes:grid.414363.7 schema:alternateName Department of Oncology, Saint-Joseph Hospital, Paris, France
172 Department of Pharmacy, Saint-Joseph Hospital, Paris, France
173 schema:name Department of Oncology, Saint-Joseph Hospital, Paris, France
174 Department of Pharmacy, Saint-Joseph Hospital, Paris, France
175 rdf:type schema:Organization
176 grid-institutes:grid.8515.9 schema:alternateName Department of Oncology, University hospital of Lausanne, Lausanne, Switzerland
177 schema:name Department of Oncology, University hospital of Lausanne, Lausanne, Switzerland
178 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...