A randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in the treatment of patients ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-02-08

AUTHORS

Antonio Avallone, Maria Carmela Piccirillo, Luigi Aloj, Guglielmo Nasti, Paolo Delrio, Francesco Izzo, Elena Di Gennaro, Fabiana Tatangelo, Vincenza Granata, Ernesta Cavalcanti, Piera Maiolino, Francesco Bianco, Pasquale Aprea, Mario De Bellis, Biagio Pecori, Gerardo Rosati, Chiara Carlomagno, Alessandro Bertolini, Ciro Gallo, Carmela Romano, Alessandra Leone, Corradina Caracò, Elisabetta de Lutio di Castelguidone, Gennaro Daniele, Orlando Catalano, Gerardo Botti, Antonella Petrillo, Giovanni M. Romano, Vincenzo R. Iaffaioli, Secondo Lastoria, Francesco Perrone, Alfredo Budillon

ABSTRACT

BACKGROUND: Despite the improvements in diagnosis and treatment, colorectal cancer (CRC) is the second cause of cancer deaths in both sexes. Therefore, research in this field remains of great interest. The approval of bevacizumab, a humanized anti-vascular endothelial growth factor (VEGF) monoclonal antibody, in combination with a fluoropyrimidine-based chemotherapy in the treatment of metastatic CRC has changed the oncology practice in this disease. However, the efficacy of bevacizumab-based treatment, has thus far been rather modest. Efforts are ongoing to understand the better way to combine bevacizumab and chemotherapy, and to identify valid predictive biomarkers of benefit to avoid unnecessary and costly therapy to nonresponder patients. The BRANCH study in high-risk locally advanced rectal cancer patients showed that varying bevacizumab schedule may impact on the feasibility and efficacy of chemo-radiotherapy. METHODS/DESIGN: OBELICS is a multicentre, open-label, randomised phase 3 trial comparing in mCRC patients two treatment arms (1:1): standard concomitant administration of bevacizumab with chemotherapy (mFOLFOX/OXXEL regimen) vs experimental sequential bevacizumab given 4 days before chemotherapy, as first or second treatment line. Primary end point is the objective response rate (ORR) measured according to RECIST criteria. A sample size of 230 patients was calculated allowing reliable assessment in all plausible first-second line case-mix conditions, with a 80% statistical power and 2-sided alpha error of 0.05. Secondary endpoints are progression free-survival (PFS), overall survival (OS), toxicity and quality of life. The evaluation of the potential predictive role of several circulating biomarkers (circulating endothelial cells and progenitors, VEGF and VEGF-R SNPs, cytokines, microRNAs, free circulating DNA) as well as the value of the early [(18)F]-Fluorodeoxyglucose positron emission tomography (FDG-PET) response, are the objectives of the traslational project. DISCUSSION: Overall this study could optimize bevacizumab scheduling in combination with chemotherapy in mCRC patients. Moreover, correlative studies could improve the knowledge of the mechanisms by which bevacizumab enhance chemotherapy effect and could identify early predictors of response. EudraCT Number: 2011-004997-27 TRIAL REGISTRATION: ClinicalTrials.gove number, NCT01718873. More... »

PAGES

69

References to SciGraph publications

Journal

TITLE

BMC Cancer

ISSUE

1

VOLUME

16

Author Affiliations

  • Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Clinical Trials Unit, Istituto Nazionale Tumori “Fondazione G. Pascale” – IRCCS, Napoli, Italy
  • Nuclear Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Colorectal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Hepatobiliary Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Pathology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Radiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Pharmacy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Gastrointestinal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Vascular Access Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Endoscopy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Radiotherapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
  • Medical Oncology Unit, San Carlo Hospital, Potenza, Italy
  • Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy
  • A.O. Valtellina e Valchiavenna, Sondrio, Italy
  • Medical Statistics Unit, Second University, Naples, Italy
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-016-2102-y

    DOI

    http://dx.doi.org/10.1186/s12885-016-2102-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048107871

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26857924


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies, Monoclonal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies, Monoclonal, Humanized", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bevacizumab", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease-Free Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorouracil", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leucovorin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organoplatinum Compounds", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factor A", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/grid.508451.d", 
              "name": [
                "Multidisciplinary Treatment Unit, Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
                "Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Avallone", 
            "givenName": "Antonio", 
            "id": "sg:person.0661315002.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661315002.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Trials Unit, Istituto Nazionale Tumori \u201cFondazione G. Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/grid.508451.d", 
              "name": [
                "Clinical Trials Unit, Istituto Nazionale Tumori \u201cFondazione G. Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Piccirillo", 
            "givenName": "Maria Carmela", 
            "id": "sg:person.01105103631.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105103631.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuclear Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Nuclear Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aloj", 
            "givenName": "Luigi", 
            "id": "sg:person.01303125011.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303125011.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nasti", 
            "givenName": "Guglielmo", 
            "id": "sg:person.01114021120.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114021120.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Colorectal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Colorectal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Delrio", 
            "givenName": "Paolo", 
            "id": "sg:person.01011326540.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011326540.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hepatobiliary Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Hepatobiliary Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Izzo", 
            "givenName": "Francesco", 
            "id": "sg:person.01142627311.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142627311.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Di Gennaro", 
            "givenName": "Elena", 
            "id": "sg:person.01064371172.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064371172.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pathology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Pathology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tatangelo", 
            "givenName": "Fabiana", 
            "id": "sg:person.01050257615.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050257615.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Radiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Radiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Granata", 
            "givenName": "Vincenza", 
            "id": "sg:person.01323473164.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323473164.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cavalcanti", 
            "givenName": "Ernesta", 
            "id": "sg:person.0743654734.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743654734.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pharmacy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Pharmacy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maiolino", 
            "givenName": "Piera", 
            "id": "sg:person.0643620367.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643620367.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gastrointestinal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Gastrointestinal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bianco", 
            "givenName": "Francesco", 
            "id": "sg:person.01156605421.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156605421.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vascular Access Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Vascular Access Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aprea", 
            "givenName": "Pasquale", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Endoscopy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Endoscopy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "De Bellis", 
            "givenName": "Mario", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Radiotherapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Radiotherapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pecori", 
            "givenName": "Biagio", 
            "id": "sg:person.01255242716.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255242716.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Oncology Unit, San Carlo Hospital, Potenza, Italy", 
              "id": "http://www.grid.ac/institutes/grid.416325.7", 
              "name": [
                "Medical Oncology Unit, San Carlo Hospital, Potenza, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rosati", 
            "givenName": "Gerardo", 
            "id": "sg:person.01362033743.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362033743.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy", 
              "id": "http://www.grid.ac/institutes/grid.4691.a", 
              "name": [
                "Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carlomagno", 
            "givenName": "Chiara", 
            "id": "sg:person.0756634300.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756634300.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "A.O. Valtellina e Valchiavenna, Sondrio, Italy", 
              "id": "http://www.grid.ac/institutes/grid.476844.d", 
              "name": [
                "A.O. Valtellina e Valchiavenna, Sondrio, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bertolini", 
            "givenName": "Alessandro", 
            "id": "sg:person.0636427656.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636427656.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Statistics Unit, Second University, Naples, Italy", 
              "id": "http://www.grid.ac/institutes/grid.9841.4", 
              "name": [
                "Medical Statistics Unit, Second University, Naples, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gallo", 
            "givenName": "Ciro", 
            "id": "sg:person.01371653100.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371653100.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Romano", 
            "givenName": "Carmela", 
            "id": "sg:person.01122010300.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122010300.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leone", 
            "givenName": "Alessandra", 
            "id": "sg:person.0711721676.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711721676.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuclear Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Nuclear Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carac\u00f2", 
            "givenName": "Corradina", 
            "id": "sg:person.016323715554.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016323715554.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Radiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Radiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "di Castelguidone", 
            "givenName": "Elisabetta de Lutio", 
            "id": "sg:person.012344624375.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012344624375.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Trials Unit, Istituto Nazionale Tumori \u201cFondazione G. Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/grid.508451.d", 
              "name": [
                "Clinical Trials Unit, Istituto Nazionale Tumori \u201cFondazione G. Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Daniele", 
            "givenName": "Gennaro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Radiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Radiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Catalano", 
            "givenName": "Orlando", 
            "id": "sg:person.01320101124.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320101124.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pathology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Pathology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Botti", 
            "givenName": "Gerardo", 
            "id": "sg:person.01142725140.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142725140.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Radiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Radiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petrillo", 
            "givenName": "Antonella", 
            "id": "sg:person.013437140303.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013437140303.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gastrointestinal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Gastrointestinal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Romano", 
            "givenName": "Giovanni M.", 
            "id": "sg:person.01120030046.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120030046.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iaffaioli", 
            "givenName": "Vincenzo R.", 
            "id": "sg:person.0743307600.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743307600.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuclear Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Nuclear Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lastoria", 
            "givenName": "Secondo", 
            "id": "sg:person.01127232427.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127232427.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Trials Unit, Istituto Nazionale Tumori \u201cFondazione G. Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/grid.508451.d", 
              "name": [
                "Clinical Trials Unit, Istituto Nazionale Tumori \u201cFondazione G. Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perrone", 
            "givenName": "Francesco", 
            "id": "sg:person.0577451344.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577451344.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori \u201cFondazione Giovanni Pascale\u201d \u2013 IRCCS, Napoli, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Budillon", 
            "givenName": "Alfredo", 
            "id": "sg:person.012066563720.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012066563720.91"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00259-012-2229-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043454565", 
              "https://doi.org/10.1007/s00259-012-2229-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2011.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007551781", 
              "https://doi.org/10.1038/bjc.2011.85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048606358", 
              "https://doi.org/10.1038/nature04483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030167380", 
              "https://doi.org/10.1038/nrclinonc.2009.110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040662289", 
              "https://doi.org/10.1038/nrc1971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0449-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016026190", 
              "https://doi.org/10.1186/s13059-014-0449-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003700365", 
              "https://doi.org/10.1038/nm988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035726640", 
              "https://doi.org/10.1038/nm.3870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602952", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051787522", 
              "https://doi.org/10.1038/sj.bjc.6602952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2011.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046506493", 
              "https://doi.org/10.1038/nrclinonc.2011.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002125905", 
              "https://doi.org/10.1038/nrclinonc.2009.63"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-02-08", 
        "datePublishedReg": "2016-02-08", 
        "description": "BACKGROUND: Despite the improvements in diagnosis and treatment, colorectal cancer (CRC) is the second cause of cancer deaths in both sexes. Therefore, research in this field remains of great interest. The approval of bevacizumab, a humanized anti-vascular endothelial growth factor (VEGF) monoclonal antibody, in combination with a fluoropyrimidine-based chemotherapy in the treatment of metastatic CRC has changed the oncology practice in this disease. However, the efficacy of bevacizumab-based treatment, has thus far been rather modest. Efforts are ongoing to understand the better way to combine bevacizumab and chemotherapy, and to identify valid predictive biomarkers of benefit to avoid unnecessary and costly therapy to nonresponder patients. The BRANCH study in high-risk locally advanced rectal cancer patients showed that varying bevacizumab schedule may impact on the feasibility and efficacy of chemo-radiotherapy.\nMETHODS/DESIGN: OBELICS is a multicentre, open-label, randomised phase 3 trial comparing in mCRC patients two treatment arms (1:1): standard concomitant administration of bevacizumab with chemotherapy (mFOLFOX/OXXEL regimen) vs experimental sequential bevacizumab given 4 days before chemotherapy, as first or second treatment line. Primary end point is the objective response rate (ORR) measured according to RECIST criteria. A sample size of 230 patients was calculated allowing reliable assessment in all plausible first-second line case-mix conditions, with a 80% statistical power and 2-sided alpha error of 0.05. Secondary endpoints are progression free-survival (PFS), overall survival (OS), toxicity and quality of life. The evaluation of the potential predictive role of several circulating biomarkers (circulating endothelial cells and progenitors, VEGF and VEGF-R SNPs, cytokines, microRNAs, free circulating DNA) as well as the value of the early [(18)F]-Fluorodeoxyglucose positron emission tomography (FDG-PET) response, are the objectives of the traslational project.\nDISCUSSION: Overall this study could optimize bevacizumab scheduling in combination with chemotherapy in mCRC patients. Moreover, correlative studies could improve the knowledge of the mechanisms by which bevacizumab enhance chemotherapy effect and could identify early predictors of response. EudraCT Number: 2011-004997-27 TRIAL REGISTRATION: ClinicalTrials.gove number, NCT01718873.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12885-016-2102-y", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1024632", 
            "issn": [
              "1471-2407"
            ], 
            "name": "BMC Cancer", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "keywords": [
          "objective response rate", 
          "colorectal cancer", 
          "overall survival", 
          "humanized anti-vascular endothelial growth factor monoclonal antibody", 
          "anti-vascular endothelial growth factor monoclonal antibody", 
          "Fluorodeoxyglucose Positron Emission Tomography Response", 
          "positron emission tomography response", 
          "advanced rectal cancer patients", 
          "randomized phase 3 study", 
          "bevacizumab-based treatment", 
          "metastatic colorectal cancer", 
          "primary end point", 
          "combination of bevacizumab", 
          "phase 3 trial", 
          "phase 3 study", 
          "rectal cancer patients", 
          "approval of bevacizumab", 
          "fluoropyrimidine-based chemotherapy", 
          "treatment of patients", 
          "potential predictive role", 
          "valid predictive biomarkers", 
          "second treatment line", 
          "quality of life", 
          "two-treatment arm", 
          "nonresponder patients", 
          "Secondary endpoints", 
          "mCRC patients", 
          "RECIST criteria", 
          "treatment arms", 
          "concomitant administration", 
          "tomography response", 
          "cancer death", 
          "predictive biomarkers", 
          "cancer patients", 
          "trial registration", 
          "oncology practice", 
          "costly therapies", 
          "bevacizumab", 
          "chemotherapy effect", 
          "early predictor", 
          "chemotherapy", 
          "patients", 
          "response rate", 
          "alpha error", 
          "predictive role", 
          "second cause", 
          "end point", 
          "monoclonal antibodies", 
          "treatment lines", 
          "correlative studies", 
          "treatment", 
          "biomarkers", 
          "efficacy", 
          "branch study", 
          "sample size", 
          "multicentre", 
          "reliable assessment", 
          "therapy", 
          "statistical power", 
          "cancer", 
          "study", 
          "disease", 
          "diagnosis", 
          "administration", 
          "trials", 
          "progression", 
          "endpoint", 
          "response", 
          "antibodies", 
          "death", 
          "survival", 
          "sex", 
          "predictors", 
          "cause", 
          "toxicity", 
          "approval", 
          "days", 
          "combination", 
          "arm", 
          "assessment", 
          "schedule", 
          "criteria", 
          "evaluation", 
          "life", 
          "role", 
          "benefits", 
          "rate", 
          "effect", 
          "best way", 
          "improvement", 
          "objective", 
          "mechanism", 
          "practice", 
          "quality", 
          "registration", 
          "lines", 
          "feasibility", 
          "number", 
          "knowledge", 
          "great interest", 
          "efforts", 
          "values", 
          "research", 
          "conditions", 
          "size", 
          "point", 
          "interest", 
          "way", 
          "project", 
          "error", 
          "field", 
          "power", 
          "optimization", 
          "scheduling", 
          "endothelial growth factor (VEGF) monoclonal antibody", 
          "growth factor (VEGF) monoclonal antibody", 
          "factor (VEGF) monoclonal antibody", 
          "bevacizumab schedule", 
          "OBELICS", 
          "mCRC patients two treatment arms", 
          "patients two treatment arms", 
          "standard concomitant administration", 
          "experimental sequential bevacizumab", 
          "sequential bevacizumab", 
          "plausible first-second line case-mix conditions", 
          "first-second line case-mix conditions", 
          "line case-mix conditions", 
          "case-mix conditions", 
          "emission tomography (FDG-PET) response", 
          "traslational project", 
          "bevacizumab scheduling", 
          "bevacizumab enhance chemotherapy effect", 
          "enhance chemotherapy effect", 
          "NCT01718873", 
          "FOLFOX/OXXEL", 
          "OXXEL", 
          "metastatic colorectal cancer-OBELICS", 
          "colorectal cancer-OBELICS", 
          "cancer-OBELICS"
        ], 
        "name": "A randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in the treatment of patients with metastatic colorectal cancer-OBELICS (Optimization of BEvacizumab scheduLIng within Chemotherapy Scheme)", 
        "pagination": "69", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1048107871"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12885-016-2102-y"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26857924"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12885-016-2102-y", 
          "https://app.dimensions.ai/details/publication/pub.1048107871"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_715.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12885-016-2102-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2102-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2102-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2102-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-016-2102-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    568 TRIPLES      22 PREDICATES      193 URIs      174 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12885-016-2102-y schema:about N089bb9b5ea8844d6a6247d4ac231bedf
    2 N152dc52cb87742c791dc185f1cfb0f4b
    3 N1d62246983214d70a490da8a06c1c956
    4 N2ec33f8f34d846c59e746cf76abbd60d
    5 N42a62a7099e94a21b462ed7ad7f1ba52
    6 N510b0322cd564fc5925cd04d9fafabe2
    7 N51503903160f4e7aba26e3cfc7ecc698
    8 N5ca499624d024d05ae6622d3f06ab600
    9 N5ecbf8bb1efc486aaa6679b9c5afbb04
    10 N7699c7e7bc704937a3838cd6b38b813f
    11 N81573a64bfe14efdb2480a69310f0f67
    12 N916be4ec20a54d18bcf974a6b72ca3c0
    13 N9da2a8e1ff4a483d8ed18f2eb2f9a630
    14 Na56c6d77731c4aac9009d77c4828868a
    15 Naa61769cbfb14045869faa54a4956f2c
    16 Naf0e16a1d2b14e34afebef8e5f9a3cf7
    17 Nfb1dd7b04b594d26adca3df07e08e72a
    18 anzsrc-for:11
    19 anzsrc-for:1112
    20 schema:author Nc70040c4219e4118b991ed8574fda8a8
    21 schema:citation sg:pub.10.1007/s00259-012-2229-2
    22 sg:pub.10.1038/bjc.2011.85
    23 sg:pub.10.1038/nature04483
    24 sg:pub.10.1038/nm.3870
    25 sg:pub.10.1038/nm988
    26 sg:pub.10.1038/nrc1971
    27 sg:pub.10.1038/nrclinonc.2009.110
    28 sg:pub.10.1038/nrclinonc.2009.63
    29 sg:pub.10.1038/nrclinonc.2011.83
    30 sg:pub.10.1038/sj.bjc.6602952
    31 sg:pub.10.1186/s13059-014-0449-4
    32 schema:datePublished 2016-02-08
    33 schema:datePublishedReg 2016-02-08
    34 schema:description BACKGROUND: Despite the improvements in diagnosis and treatment, colorectal cancer (CRC) is the second cause of cancer deaths in both sexes. Therefore, research in this field remains of great interest. The approval of bevacizumab, a humanized anti-vascular endothelial growth factor (VEGF) monoclonal antibody, in combination with a fluoropyrimidine-based chemotherapy in the treatment of metastatic CRC has changed the oncology practice in this disease. However, the efficacy of bevacizumab-based treatment, has thus far been rather modest. Efforts are ongoing to understand the better way to combine bevacizumab and chemotherapy, and to identify valid predictive biomarkers of benefit to avoid unnecessary and costly therapy to nonresponder patients. The BRANCH study in high-risk locally advanced rectal cancer patients showed that varying bevacizumab schedule may impact on the feasibility and efficacy of chemo-radiotherapy. METHODS/DESIGN: OBELICS is a multicentre, open-label, randomised phase 3 trial comparing in mCRC patients two treatment arms (1:1): standard concomitant administration of bevacizumab with chemotherapy (mFOLFOX/OXXEL regimen) vs experimental sequential bevacizumab given 4 days before chemotherapy, as first or second treatment line. Primary end point is the objective response rate (ORR) measured according to RECIST criteria. A sample size of 230 patients was calculated allowing reliable assessment in all plausible first-second line case-mix conditions, with a 80% statistical power and 2-sided alpha error of 0.05. Secondary endpoints are progression free-survival (PFS), overall survival (OS), toxicity and quality of life. The evaluation of the potential predictive role of several circulating biomarkers (circulating endothelial cells and progenitors, VEGF and VEGF-R SNPs, cytokines, microRNAs, free circulating DNA) as well as the value of the early [(18)F]-Fluorodeoxyglucose positron emission tomography (FDG-PET) response, are the objectives of the traslational project. DISCUSSION: Overall this study could optimize bevacizumab scheduling in combination with chemotherapy in mCRC patients. Moreover, correlative studies could improve the knowledge of the mechanisms by which bevacizumab enhance chemotherapy effect and could identify early predictors of response. EudraCT Number: 2011-004997-27 TRIAL REGISTRATION: ClinicalTrials.gove number, NCT01718873.
    35 schema:genre article
    36 schema:inLanguage en
    37 schema:isAccessibleForFree true
    38 schema:isPartOf N83bb5c0964e6400fa8c2be788a71a217
    39 Na4c99959c5594b3d9237f54f47f28223
    40 sg:journal.1024632
    41 schema:keywords FOLFOX/OXXEL
    42 Fluorodeoxyglucose Positron Emission Tomography Response
    43 NCT01718873
    44 OBELICS
    45 OXXEL
    46 RECIST criteria
    47 Secondary endpoints
    48 administration
    49 advanced rectal cancer patients
    50 alpha error
    51 anti-vascular endothelial growth factor monoclonal antibody
    52 antibodies
    53 approval
    54 approval of bevacizumab
    55 arm
    56 assessment
    57 benefits
    58 best way
    59 bevacizumab
    60 bevacizumab enhance chemotherapy effect
    61 bevacizumab schedule
    62 bevacizumab scheduling
    63 bevacizumab-based treatment
    64 biomarkers
    65 branch study
    66 cancer
    67 cancer death
    68 cancer patients
    69 cancer-OBELICS
    70 case-mix conditions
    71 cause
    72 chemotherapy
    73 chemotherapy effect
    74 colorectal cancer
    75 colorectal cancer-OBELICS
    76 combination
    77 combination of bevacizumab
    78 concomitant administration
    79 conditions
    80 correlative studies
    81 costly therapies
    82 criteria
    83 days
    84 death
    85 diagnosis
    86 disease
    87 early predictor
    88 effect
    89 efficacy
    90 efforts
    91 emission tomography (FDG-PET) response
    92 end point
    93 endothelial growth factor (VEGF) monoclonal antibody
    94 endpoint
    95 enhance chemotherapy effect
    96 error
    97 evaluation
    98 experimental sequential bevacizumab
    99 factor (VEGF) monoclonal antibody
    100 feasibility
    101 field
    102 first-second line case-mix conditions
    103 fluoropyrimidine-based chemotherapy
    104 great interest
    105 growth factor (VEGF) monoclonal antibody
    106 humanized anti-vascular endothelial growth factor monoclonal antibody
    107 improvement
    108 interest
    109 knowledge
    110 life
    111 line case-mix conditions
    112 lines
    113 mCRC patients
    114 mCRC patients two treatment arms
    115 mechanism
    116 metastatic colorectal cancer
    117 metastatic colorectal cancer-OBELICS
    118 monoclonal antibodies
    119 multicentre
    120 nonresponder patients
    121 number
    122 objective
    123 objective response rate
    124 oncology practice
    125 optimization
    126 overall survival
    127 patients
    128 patients two treatment arms
    129 phase 3 study
    130 phase 3 trial
    131 plausible first-second line case-mix conditions
    132 point
    133 positron emission tomography response
    134 potential predictive role
    135 power
    136 practice
    137 predictive biomarkers
    138 predictive role
    139 predictors
    140 primary end point
    141 progression
    142 project
    143 quality
    144 quality of life
    145 randomized phase 3 study
    146 rate
    147 rectal cancer patients
    148 registration
    149 reliable assessment
    150 research
    151 response
    152 response rate
    153 role
    154 sample size
    155 schedule
    156 scheduling
    157 second cause
    158 second treatment line
    159 sequential bevacizumab
    160 sex
    161 size
    162 standard concomitant administration
    163 statistical power
    164 study
    165 survival
    166 therapy
    167 tomography response
    168 toxicity
    169 traslational project
    170 treatment
    171 treatment arms
    172 treatment lines
    173 treatment of patients
    174 trial registration
    175 trials
    176 two-treatment arm
    177 valid predictive biomarkers
    178 values
    179 way
    180 schema:name A randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in the treatment of patients with metastatic colorectal cancer-OBELICS (Optimization of BEvacizumab scheduLIng within Chemotherapy Scheme)
    181 schema:pagination 69
    182 schema:productId N3d7867badb45485a963bb626bf23e748
    183 N5fda8a4b940a40968f286f9d9d3d2820
    184 Nee0f51a735824596ba93c11eb95d67dc
    185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048107871
    186 https://doi.org/10.1186/s12885-016-2102-y
    187 schema:sdDatePublished 2021-12-01T19:38
    188 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    189 schema:sdPublisher N332ee752880e482da9709711cc3b1602
    190 schema:url https://doi.org/10.1186/s12885-016-2102-y
    191 sgo:license sg:explorer/license/
    192 sgo:sdDataset articles
    193 rdf:type schema:ScholarlyArticle
    194 N0298aa3a07a74b06b2b3bcd2cecafb7f rdf:first sg:person.012066563720.91
    195 rdf:rest rdf:nil
    196 N03b44ee4ead5432cbf1003e197007d0a rdf:first sg:person.01105103631.43
    197 rdf:rest N1378a1821b004bb4a91c59bdaf346cc6
    198 N089bb9b5ea8844d6a6247d4ac231bedf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Antibodies, Monoclonal
    200 rdf:type schema:DefinedTerm
    201 N0a1161470b91450cb0a54251b1c5e023 schema:affiliation grid-institutes:None
    202 schema:familyName De Bellis
    203 schema:givenName Mario
    204 rdf:type schema:Person
    205 N1131c2d13d394a2aa7938a25567e1233 rdf:first sg:person.01323473164.78
    206 rdf:rest Nd3e3a925de5f4346aac092bbdd704317
    207 N1378a1821b004bb4a91c59bdaf346cc6 rdf:first sg:person.01303125011.15
    208 rdf:rest N53808b92bf0a40ad9e2460a216e4a688
    209 N152dc52cb87742c791dc185f1cfb0f4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Humans
    211 rdf:type schema:DefinedTerm
    212 N1c5a162ef0894fdc95f0d812458a8ab2 rdf:first sg:person.01156605421.09
    213 rdf:rest N9d990c8ed25241dd99b82ff4bafc419a
    214 N1d62246983214d70a490da8a06c1c956 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Colorectal Neoplasms
    216 rdf:type schema:DefinedTerm
    217 N1e93fcd3fef94c04847d9d322925184f schema:affiliation grid-institutes:grid.508451.d
    218 schema:familyName Daniele
    219 schema:givenName Gennaro
    220 rdf:type schema:Person
    221 N2590a2034506429893696efaed86b5c0 rdf:first sg:person.0711721676.92
    222 rdf:rest N797b886e52484091bad63e7e20f48d9f
    223 N2c0e2313a2c847fc98447e9bf6bc6983 rdf:first sg:person.0756634300.40
    224 rdf:rest N45c4a49d0e314bd7bb59222157278612
    225 N2c8d71a372e4459786b7052e073dae0d schema:affiliation grid-institutes:None
    226 schema:familyName Aprea
    227 schema:givenName Pasquale
    228 rdf:type schema:Person
    229 N2dbaa0490a7b4bbfb5f4fd783d7b5a9e rdf:first sg:person.0577451344.32
    230 rdf:rest N0298aa3a07a74b06b2b3bcd2cecafb7f
    231 N2ec33f8f34d846c59e746cf76abbd60d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Adult
    233 rdf:type schema:DefinedTerm
    234 N332ee752880e482da9709711cc3b1602 schema:name Springer Nature - SN SciGraph project
    235 rdf:type schema:Organization
    236 N3d7867badb45485a963bb626bf23e748 schema:name dimensions_id
    237 schema:value pub.1048107871
    238 rdf:type schema:PropertyValue
    239 N3edfa28cb8f042128be2e16eb1d88988 rdf:first sg:person.01120030046.58
    240 rdf:rest N696e53439daa460087fd5cd542b5b193
    241 N42a62a7099e94a21b462ed7ad7f1ba52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name Organoplatinum Compounds
    243 rdf:type schema:DefinedTerm
    244 N45c4a49d0e314bd7bb59222157278612 rdf:first sg:person.0636427656.94
    245 rdf:rest N5f5ce6ebf59a4567901d2f205608f6c3
    246 N510b0322cd564fc5925cd04d9fafabe2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    247 schema:name Middle Aged
    248 rdf:type schema:DefinedTerm
    249 N51503903160f4e7aba26e3cfc7ecc698 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    250 schema:name Vascular Endothelial Growth Factor A
    251 rdf:type schema:DefinedTerm
    252 N53808b92bf0a40ad9e2460a216e4a688 rdf:first sg:person.01114021120.52
    253 rdf:rest N7c71e5db3ee2418196dc43f6c6f6b85f
    254 N5ca499624d024d05ae6622d3f06ab600 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    255 schema:name Bevacizumab
    256 rdf:type schema:DefinedTerm
    257 N5ecbf8bb1efc486aaa6679b9c5afbb04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    258 schema:name Leucovorin
    259 rdf:type schema:DefinedTerm
    260 N5f5ce6ebf59a4567901d2f205608f6c3 rdf:first sg:person.01371653100.87
    261 rdf:rest Ne4d6a00186e14b7c95df139afbfa89f1
    262 N5fda8a4b940a40968f286f9d9d3d2820 schema:name doi
    263 schema:value 10.1186/s12885-016-2102-y
    264 rdf:type schema:PropertyValue
    265 N66cfd3eb8f3849d8857a31dd50497667 rdf:first sg:person.01255242716.34
    266 rdf:rest Nc9b1f917fc564cdc890b81733016cd80
    267 N696e53439daa460087fd5cd542b5b193 rdf:first sg:person.0743307600.35
    268 rdf:rest Nec961a3d9e4c475aa61a87c54dcf40b5
    269 N7699c7e7bc704937a3838cd6b38b813f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    270 schema:name Prognosis
    271 rdf:type schema:DefinedTerm
    272 N797b886e52484091bad63e7e20f48d9f rdf:first sg:person.016323715554.17
    273 rdf:rest N89e23b3fff50437dbc19facedcd9d00a
    274 N7c71e5db3ee2418196dc43f6c6f6b85f rdf:first sg:person.01011326540.29
    275 rdf:rest Nae2a19d7533943b5a7f5d0d1a9002699
    276 N7f9aab93552346e2b3f1534496c13475 rdf:first sg:person.0643620367.94
    277 rdf:rest N1c5a162ef0894fdc95f0d812458a8ab2
    278 N81573a64bfe14efdb2480a69310f0f67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    279 schema:name Male
    280 rdf:type schema:DefinedTerm
    281 N83bb5c0964e6400fa8c2be788a71a217 schema:volumeNumber 16
    282 rdf:type schema:PublicationVolume
    283 N89e23b3fff50437dbc19facedcd9d00a rdf:first sg:person.012344624375.62
    284 rdf:rest Nac7dd1711c934a4e88405ca7a9abb1b7
    285 N8d91690c816a4ebb81f2188c25369230 rdf:first sg:person.01142725140.44
    286 rdf:rest Nab5da13e03b64e64920be5280310abfa
    287 N916be4ec20a54d18bcf974a6b72ca3c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    288 schema:name Fluorouracil
    289 rdf:type schema:DefinedTerm
    290 N9895356bddfd4a4c9ffcc0f6701c9383 rdf:first sg:person.01050257615.88
    291 rdf:rest N1131c2d13d394a2aa7938a25567e1233
    292 N9d990c8ed25241dd99b82ff4bafc419a rdf:first N2c8d71a372e4459786b7052e073dae0d
    293 rdf:rest Nc0474a816d154075b3be4b5eb735c1c4
    294 N9da2a8e1ff4a483d8ed18f2eb2f9a630 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    295 schema:name Antibodies, Monoclonal, Humanized
    296 rdf:type schema:DefinedTerm
    297 Na4c99959c5594b3d9237f54f47f28223 schema:issueNumber 1
    298 rdf:type schema:PublicationIssue
    299 Na56c6d77731c4aac9009d77c4828868a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    300 schema:name Disease-Free Survival
    301 rdf:type schema:DefinedTerm
    302 Naa61769cbfb14045869faa54a4956f2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    303 schema:name Antineoplastic Combined Chemotherapy Protocols
    304 rdf:type schema:DefinedTerm
    305 Naa6fc5006fd2472f954b6b4b75bb1aa6 rdf:first sg:person.01320101124.28
    306 rdf:rest N8d91690c816a4ebb81f2188c25369230
    307 Nab5da13e03b64e64920be5280310abfa rdf:first sg:person.013437140303.22
    308 rdf:rest N3edfa28cb8f042128be2e16eb1d88988
    309 Nac7dd1711c934a4e88405ca7a9abb1b7 rdf:first N1e93fcd3fef94c04847d9d322925184f
    310 rdf:rest Naa6fc5006fd2472f954b6b4b75bb1aa6
    311 Nae2a19d7533943b5a7f5d0d1a9002699 rdf:first sg:person.01142627311.57
    312 rdf:rest Nd0a45f77129f402db7a6a5064f3ba86d
    313 Naf0e16a1d2b14e34afebef8e5f9a3cf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    314 schema:name Aged
    315 rdf:type schema:DefinedTerm
    316 Nc0474a816d154075b3be4b5eb735c1c4 rdf:first N0a1161470b91450cb0a54251b1c5e023
    317 rdf:rest N66cfd3eb8f3849d8857a31dd50497667
    318 Nc70040c4219e4118b991ed8574fda8a8 rdf:first sg:person.0661315002.90
    319 rdf:rest N03b44ee4ead5432cbf1003e197007d0a
    320 Nc9b1f917fc564cdc890b81733016cd80 rdf:first sg:person.01362033743.92
    321 rdf:rest N2c0e2313a2c847fc98447e9bf6bc6983
    322 Nd0a45f77129f402db7a6a5064f3ba86d rdf:first sg:person.01064371172.74
    323 rdf:rest N9895356bddfd4a4c9ffcc0f6701c9383
    324 Nd3e3a925de5f4346aac092bbdd704317 rdf:first sg:person.0743654734.22
    325 rdf:rest N7f9aab93552346e2b3f1534496c13475
    326 Ne4d6a00186e14b7c95df139afbfa89f1 rdf:first sg:person.01122010300.11
    327 rdf:rest N2590a2034506429893696efaed86b5c0
    328 Nec961a3d9e4c475aa61a87c54dcf40b5 rdf:first sg:person.01127232427.46
    329 rdf:rest N2dbaa0490a7b4bbfb5f4fd783d7b5a9e
    330 Nee0f51a735824596ba93c11eb95d67dc schema:name pubmed_id
    331 schema:value 26857924
    332 rdf:type schema:PropertyValue
    333 Nfb1dd7b04b594d26adca3df07e08e72a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    334 schema:name Female
    335 rdf:type schema:DefinedTerm
    336 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    337 schema:name Medical and Health Sciences
    338 rdf:type schema:DefinedTerm
    339 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    340 schema:name Oncology and Carcinogenesis
    341 rdf:type schema:DefinedTerm
    342 sg:journal.1024632 schema:issn 1471-2407
    343 schema:name BMC Cancer
    344 schema:publisher Springer Nature
    345 rdf:type schema:Periodical
    346 sg:person.01011326540.29 schema:affiliation grid-institutes:None
    347 schema:familyName Delrio
    348 schema:givenName Paolo
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011326540.29
    350 rdf:type schema:Person
    351 sg:person.01050257615.88 schema:affiliation grid-institutes:None
    352 schema:familyName Tatangelo
    353 schema:givenName Fabiana
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050257615.88
    355 rdf:type schema:Person
    356 sg:person.01064371172.74 schema:affiliation grid-institutes:None
    357 schema:familyName Di Gennaro
    358 schema:givenName Elena
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064371172.74
    360 rdf:type schema:Person
    361 sg:person.01105103631.43 schema:affiliation grid-institutes:grid.508451.d
    362 schema:familyName Piccirillo
    363 schema:givenName Maria Carmela
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105103631.43
    365 rdf:type schema:Person
    366 sg:person.01114021120.52 schema:affiliation grid-institutes:None
    367 schema:familyName Nasti
    368 schema:givenName Guglielmo
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114021120.52
    370 rdf:type schema:Person
    371 sg:person.01120030046.58 schema:affiliation grid-institutes:None
    372 schema:familyName Romano
    373 schema:givenName Giovanni M.
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120030046.58
    375 rdf:type schema:Person
    376 sg:person.01122010300.11 schema:affiliation grid-institutes:None
    377 schema:familyName Romano
    378 schema:givenName Carmela
    379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122010300.11
    380 rdf:type schema:Person
    381 sg:person.01127232427.46 schema:affiliation grid-institutes:None
    382 schema:familyName Lastoria
    383 schema:givenName Secondo
    384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127232427.46
    385 rdf:type schema:Person
    386 sg:person.01142627311.57 schema:affiliation grid-institutes:None
    387 schema:familyName Izzo
    388 schema:givenName Francesco
    389 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142627311.57
    390 rdf:type schema:Person
    391 sg:person.01142725140.44 schema:affiliation grid-institutes:None
    392 schema:familyName Botti
    393 schema:givenName Gerardo
    394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142725140.44
    395 rdf:type schema:Person
    396 sg:person.01156605421.09 schema:affiliation grid-institutes:None
    397 schema:familyName Bianco
    398 schema:givenName Francesco
    399 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156605421.09
    400 rdf:type schema:Person
    401 sg:person.012066563720.91 schema:affiliation grid-institutes:None
    402 schema:familyName Budillon
    403 schema:givenName Alfredo
    404 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012066563720.91
    405 rdf:type schema:Person
    406 sg:person.012344624375.62 schema:affiliation grid-institutes:None
    407 schema:familyName di Castelguidone
    408 schema:givenName Elisabetta de Lutio
    409 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012344624375.62
    410 rdf:type schema:Person
    411 sg:person.01255242716.34 schema:affiliation grid-institutes:None
    412 schema:familyName Pecori
    413 schema:givenName Biagio
    414 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255242716.34
    415 rdf:type schema:Person
    416 sg:person.01303125011.15 schema:affiliation grid-institutes:None
    417 schema:familyName Aloj
    418 schema:givenName Luigi
    419 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303125011.15
    420 rdf:type schema:Person
    421 sg:person.01320101124.28 schema:affiliation grid-institutes:None
    422 schema:familyName Catalano
    423 schema:givenName Orlando
    424 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320101124.28
    425 rdf:type schema:Person
    426 sg:person.01323473164.78 schema:affiliation grid-institutes:None
    427 schema:familyName Granata
    428 schema:givenName Vincenza
    429 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323473164.78
    430 rdf:type schema:Person
    431 sg:person.013437140303.22 schema:affiliation grid-institutes:None
    432 schema:familyName Petrillo
    433 schema:givenName Antonella
    434 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013437140303.22
    435 rdf:type schema:Person
    436 sg:person.01362033743.92 schema:affiliation grid-institutes:grid.416325.7
    437 schema:familyName Rosati
    438 schema:givenName Gerardo
    439 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362033743.92
    440 rdf:type schema:Person
    441 sg:person.01371653100.87 schema:affiliation grid-institutes:grid.9841.4
    442 schema:familyName Gallo
    443 schema:givenName Ciro
    444 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371653100.87
    445 rdf:type schema:Person
    446 sg:person.016323715554.17 schema:affiliation grid-institutes:None
    447 schema:familyName Caracò
    448 schema:givenName Corradina
    449 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016323715554.17
    450 rdf:type schema:Person
    451 sg:person.0577451344.32 schema:affiliation grid-institutes:grid.508451.d
    452 schema:familyName Perrone
    453 schema:givenName Francesco
    454 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577451344.32
    455 rdf:type schema:Person
    456 sg:person.0636427656.94 schema:affiliation grid-institutes:grid.476844.d
    457 schema:familyName Bertolini
    458 schema:givenName Alessandro
    459 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636427656.94
    460 rdf:type schema:Person
    461 sg:person.0643620367.94 schema:affiliation grid-institutes:None
    462 schema:familyName Maiolino
    463 schema:givenName Piera
    464 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643620367.94
    465 rdf:type schema:Person
    466 sg:person.0661315002.90 schema:affiliation grid-institutes:grid.508451.d
    467 schema:familyName Avallone
    468 schema:givenName Antonio
    469 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661315002.90
    470 rdf:type schema:Person
    471 sg:person.0711721676.92 schema:affiliation grid-institutes:None
    472 schema:familyName Leone
    473 schema:givenName Alessandra
    474 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711721676.92
    475 rdf:type schema:Person
    476 sg:person.0743307600.35 schema:affiliation grid-institutes:None
    477 schema:familyName Iaffaioli
    478 schema:givenName Vincenzo R.
    479 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743307600.35
    480 rdf:type schema:Person
    481 sg:person.0743654734.22 schema:affiliation grid-institutes:None
    482 schema:familyName Cavalcanti
    483 schema:givenName Ernesta
    484 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743654734.22
    485 rdf:type schema:Person
    486 sg:person.0756634300.40 schema:affiliation grid-institutes:grid.4691.a
    487 schema:familyName Carlomagno
    488 schema:givenName Chiara
    489 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756634300.40
    490 rdf:type schema:Person
    491 sg:pub.10.1007/s00259-012-2229-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043454565
    492 https://doi.org/10.1007/s00259-012-2229-2
    493 rdf:type schema:CreativeWork
    494 sg:pub.10.1038/bjc.2011.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007551781
    495 https://doi.org/10.1038/bjc.2011.85
    496 rdf:type schema:CreativeWork
    497 sg:pub.10.1038/nature04483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048606358
    498 https://doi.org/10.1038/nature04483
    499 rdf:type schema:CreativeWork
    500 sg:pub.10.1038/nm.3870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035726640
    501 https://doi.org/10.1038/nm.3870
    502 rdf:type schema:CreativeWork
    503 sg:pub.10.1038/nm988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003700365
    504 https://doi.org/10.1038/nm988
    505 rdf:type schema:CreativeWork
    506 sg:pub.10.1038/nrc1971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040662289
    507 https://doi.org/10.1038/nrc1971
    508 rdf:type schema:CreativeWork
    509 sg:pub.10.1038/nrclinonc.2009.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030167380
    510 https://doi.org/10.1038/nrclinonc.2009.110
    511 rdf:type schema:CreativeWork
    512 sg:pub.10.1038/nrclinonc.2009.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002125905
    513 https://doi.org/10.1038/nrclinonc.2009.63
    514 rdf:type schema:CreativeWork
    515 sg:pub.10.1038/nrclinonc.2011.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046506493
    516 https://doi.org/10.1038/nrclinonc.2011.83
    517 rdf:type schema:CreativeWork
    518 sg:pub.10.1038/sj.bjc.6602952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051787522
    519 https://doi.org/10.1038/sj.bjc.6602952
    520 rdf:type schema:CreativeWork
    521 sg:pub.10.1186/s13059-014-0449-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016026190
    522 https://doi.org/10.1186/s13059-014-0449-4
    523 rdf:type schema:CreativeWork
    524 grid-institutes:None schema:alternateName Colorectal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    525 Endoscopy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    526 Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    527 Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    528 Gastrointestinal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    529 Hepatobiliary Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    530 Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    531 Nuclear Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    532 Pathology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    533 Pharmacy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    534 Radiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    535 Radiotherapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    536 Vascular Access Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    537 schema:name Colorectal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    538 Endoscopy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    539 Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    540 Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    541 Gastrointestinal Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    542 Hepatobiliary Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    543 Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    544 Nuclear Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    545 Pathology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    546 Pharmacy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    547 Radiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    548 Radiotherapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    549 Vascular Access Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    550 rdf:type schema:Organization
    551 grid-institutes:grid.416325.7 schema:alternateName Medical Oncology Unit, San Carlo Hospital, Potenza, Italy
    552 schema:name Medical Oncology Unit, San Carlo Hospital, Potenza, Italy
    553 rdf:type schema:Organization
    554 grid-institutes:grid.4691.a schema:alternateName Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy
    555 schema:name Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy
    556 rdf:type schema:Organization
    557 grid-institutes:grid.476844.d schema:alternateName A.O. Valtellina e Valchiavenna, Sondrio, Italy
    558 schema:name A.O. Valtellina e Valchiavenna, Sondrio, Italy
    559 rdf:type schema:Organization
    560 grid-institutes:grid.508451.d schema:alternateName Clinical Trials Unit, Istituto Nazionale Tumori “Fondazione G. Pascale” – IRCCS, Napoli, Italy
    561 Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    562 schema:name Clinical Trials Unit, Istituto Nazionale Tumori “Fondazione G. Pascale” – IRCCS, Napoli, Italy
    563 Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    564 Multidisciplinary Treatment Unit, Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – IRCCS, Napoli, Italy
    565 rdf:type schema:Organization
    566 grid-institutes:grid.9841.4 schema:alternateName Medical Statistics Unit, Second University, Naples, Italy
    567 schema:name Medical Statistics Unit, Second University, Naples, Italy
    568 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...