Ontology type: schema:ScholarlyArticle Open Access: True
2015-12
AUTHORSC. Raynaud, L. Greillier, J. Mazieres, I. Monnet, B. Mastroianni, G. Robinet, G. Fraboulet, A. Dixmier, H. Berard, R. Lamy, J. Letreut, H. Lena, G. Oliviero, S. Botta, A. Vergnenegre, I. Borget, C. Chouaid
ABSTRACTBACKGROUND: Malignant pleural mesothelioma (MPM) is a rare disease with poor prognosis in spite of significant improvement in survival, due to new chemotherapy regimens. We describe here patients' profiles and management in daily practice in France. METHODS: Observational retrospective study. Data were collected from medical files. All patients with histologically proven MPM diagnosed from January 2005 to December 2008 were included in the participating sites. RESULTS: Four hundred and six patients were included in 37 sites: mean age 68.9 ± 9.8 years, male predominance (sex ratio 3.27), latency of the disease 45.7 years, epithelioïd type 83 %. Diagnosis was made using thoracoscopy in 80.8 % of patients. Radical surgery was performed in 6.2 % of cases. Chemotherapy was administered to 74.6 % of patients. First line regimens consisted mainly of platinum + pemetrexed (91 %) or pemetrexed alone (7 %). Objective response rate was 17.2 % and another 41.6 % of patients experienced disease stabilization. Half of these patients underwent second line chemotherapy (platinium + pemetrexed 31.6 %, pemetrexed alone 24.6 %), resulting in a 6 % response rate. Third-line chemotherapy (56 patients) yielded disease control in 5.4 % of cases. CONCLUSIONS: The management of MPM in France is usually in accordance with guidelines. Response rates are somewhat lower than those described in clinical trials. More... »
PAGES857
http://scigraph.springernature.com/pub.10.1186/s12885-015-1881-x
DOIhttp://dx.doi.org/10.1186/s12885-015-1881-x
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26546402
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"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2Fs12885-015-1881-x"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1881-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1881-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1881-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1881-x'
This table displays all metadata directly associated to this object as RDF triples.
366 TRIPLES
21 PREDICATES
74 URIs
34 LITERALS
22 BLANK NODES