Clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Kyung-Hun Lee, Kyoung-Bun Lee, Tae-Yong Kim, Sae-Won Han, Do-Youn Oh, Seock-Ah Im, Tae-You Kim, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Ja-June Jang, Yung-Jue Bang

ABSTRACT

BACKGROUND: More knowledge about genetic and molecular features of cholangiocarcinoma is needed to develop effective therapeutic strategies. We investigated the clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma. METHODS: One hundred ninety-four patients with curatively resected intrahepatic cholangiocarcinoma were included in this study. Tumor tissue specimens were collected and analyzed for ROS1 gene rearrangement using fluorescence in situ hybridization (FISH) and ROS1 protein expression using immunohistochemistry (IHC). RESULTS: ROS1 immunohistochemistry was positive (moderate or strong staining) in 72 tumors (37.1 %). ROS1 protein expression was significantly correlated with well differentiated tumors, papillary or mucinous histology, oncocytic/hepatoid or intestinal type tumors, and periductal infiltrating or intraductal growing tumors (vs. mass-forming cholangiocarcinoma). ROS-expressing tumors were associated with better disease-free survival (30.1 months for ROS1 expression (+) tumors vs. 9.0 months for ROS1 (-) tumors, p = 0.006). Moreover, ROS1 expression was an independent predictor of better disease-free survival in a multivariate analysis (HR 0.607, 95 % CI 0.377-0.976; p = 0.039). Although break-apart FISH was successfully performed in 102 samples, a split pattern indicative of ROS1 gene rearrangement was not found in the examined samples. CONCLUSION: ROS1 protein expression was associated with well-differentiated histology and better survival in our patients with resected intrahepatic cholangiocarcinoma. ROS1 gene rearrangement by break-apart FISH was not found in the examined samples. More... »

PAGES

721

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-015-1737-4

DOI

http://dx.doi.org/10.1186/s12885-015-1737-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019526242

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26475437


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholangiocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Array Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kyung-Hun", 
        "id": "sg:person.01007250706.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007250706.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Pathology, Seoul National University Hospital, 101 Daehak-ro, 110-744, Seoul, Jongno-gu, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kyoung-Bun", 
        "id": "sg:person.01204275617.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204275617.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Tae-Yong", 
        "id": "sg:person.012611557304.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012611557304.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Sae-Won", 
        "id": "sg:person.0626600563.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626600563.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Do-Youn", 
        "id": "sg:person.0726553273.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726553273.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Im", 
        "givenName": "Seock-Ah", 
        "id": "sg:person.01212754274.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212754274.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Tae-You", 
        "id": "sg:person.012010335604.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012010335604.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yi", 
        "givenName": "Nam-Joon", 
        "id": "sg:person.0654144447.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654144447.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kwang-Woong", 
        "id": "sg:person.01210315044.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210315044.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suh", 
        "givenName": "Kyung-Suk", 
        "id": "sg:person.01166661455.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166661455.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Pathology, Seoul National University Hospital, 101 Daehak-ro, 110-744, Seoul, Jongno-gu, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jang", 
        "givenName": "Ja-June", 
        "id": "sg:person.01102152417.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102152417.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bang", 
        "givenName": "Yung-Jue", 
        "id": "sg:person.01363602512.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363602512.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00534-009-0208-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001342152", 
          "https://doi.org/10.1007/s00534-009-0208-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-008-9778-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003285170", 
          "https://doi.org/10.1007/s00268-008-9778-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-008-9778-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003285170", 
          "https://doi.org/10.1007/s00268-008-9778-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2014.03.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006308721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-2851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008060273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2012.09.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008195393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.10207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010289727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2008.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012540856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.12379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014227256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.2014.1823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014947222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.2014.1823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014947222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/med.20206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016501306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/med.20206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016501306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3349/ymj.2013.54.3.650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019621694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.35.6345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019635065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3182960fa7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020741718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3182960fa7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020741718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3182960fa7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020741718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3182960fa7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020741718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0015640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024506107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-013-0894-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024575834", 
          "https://doi.org/10.1007/s00535-013-0894-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8278(02)00297-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024907720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2004.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025932620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00534-002-0732-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026602769", 
          "https://doi.org/10.1007/s00534-002-0732-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-012-2553-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029070344", 
          "https://doi.org/10.1245/s10434-012-2553-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.11.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030265584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-0985-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033481932", 
          "https://doi.org/10.1245/s10434-010-0985-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lungcan.2013.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034875564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrgastro.2011.131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037668976", 
          "https://doi.org/10.1038/nrgastro.2011.131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-13-0479-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038583288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040612411", 
          "https://doi.org/10.1038/nm.2658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040612411", 
          "https://doi.org/10.1038/nm.2658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.22212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041938462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-3351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042635752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1311707110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046417494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.27967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046940693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.08.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047865255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-009-9970-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048201518", 
          "https://doi.org/10.1007/s00268-009-9970-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-009-9970-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048201518", 
          "https://doi.org/10.1007/s00268-009-9970-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-009-9970-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048201518", 
          "https://doi.org/10.1007/s00268-009-9970-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1406766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051743411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1319583110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052209707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2013.192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053372599", 
          "https://doi.org/10.1038/modpathol.2013.192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4254/wjh.v2.i12.419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072403054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078725155", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: More knowledge about genetic and molecular features of cholangiocarcinoma is needed to develop effective therapeutic strategies. We investigated the clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma.\nMETHODS: One hundred ninety-four patients with curatively resected intrahepatic cholangiocarcinoma were included in this study. Tumor tissue specimens were collected and analyzed for ROS1 gene rearrangement using fluorescence in situ hybridization (FISH) and ROS1 protein expression using immunohistochemistry (IHC).\nRESULTS: ROS1 immunohistochemistry was positive (moderate or strong staining) in 72 tumors (37.1 %). ROS1 protein expression was significantly correlated with well differentiated tumors, papillary or mucinous histology, oncocytic/hepatoid or intestinal type tumors, and periductal infiltrating or intraductal growing tumors (vs. mass-forming cholangiocarcinoma). ROS-expressing tumors were associated with better disease-free survival (30.1 months for ROS1 expression (+) tumors vs. 9.0 months for ROS1 (-) tumors, p\u2009=\u20090.006). Moreover, ROS1 expression was an independent predictor of better disease-free survival in a multivariate analysis (HR 0.607, 95 % CI 0.377-0.976; p\u2009=\u20090.039). Although break-apart FISH was successfully performed in 102 samples, a split pattern indicative of ROS1 gene rearrangement was not found in the examined samples.\nCONCLUSION: ROS1 protein expression was associated with well-differentiated histology and better survival in our patients with resected intrahepatic cholangiocarcinoma. ROS1 gene rearrangement by break-apart FISH was not found in the examined samples.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12885-015-1737-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma", 
    "pagination": "721", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5d0935912167b9e0b843d90a514404e6e7105d4d7631a31188d30304160b0a2d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26475437"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12885-015-1737-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019526242"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12885-015-1737-4", 
      "https://app.dimensions.ai/details/publication/pub.1019526242"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12885-015-1737-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1737-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1737-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1737-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1737-4'


 

This table displays all metadata directly associated to this object as RDF triples.

335 TRIPLES      21 PREDICATES      82 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12885-015-1737-4 schema:about N08bb189b1712464e81869f65ce413456
2 N254fb24e3c7545be874f2b99f2dd49c5
3 N3ee2fb5a7d7f4b678695bd5a4fbe8a0f
4 N3ff07101c8c14e548696ca4ac7f7d721
5 N46ba25b68b8e4eff99200e91922e8aa5
6 N5c212184fa73427aac9c14a305d8324c
7 N5ec614528f07449fba8531cc1fc55f2a
8 N800152a3be39482b8150504a37a38d6f
9 N8e42f48c3d2e4e6b978e75001bb4b8f0
10 Na2907c5326884ee6bfc561ca8f7efbd9
11 Nb590d6539a65435cbddadb2c8f5fdec3
12 Nb7c6cf77c79f46398b997191eaf0c04e
13 Nc1367d141a08462b87f82d6f1acd0970
14 Nc4994cfc502a420eae5f8fdfaa3b319f
15 Nc7f049da31514493885935987f99c1bf
16 Nc94bbe2d495444908a22da4d5a85ee6a
17 Nd922206d84df4444a8325e6f96767630
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author N9976c48b538a431daa502e1ecde72485
21 schema:citation sg:pub.10.1007/s00268-008-9778-3
22 sg:pub.10.1007/s00268-009-9970-0
23 sg:pub.10.1007/s00534-002-0732-8
24 sg:pub.10.1007/s00534-009-0208-1
25 sg:pub.10.1007/s00535-013-0894-y
26 sg:pub.10.1038/modpathol.2013.192
27 sg:pub.10.1038/nm.2658
28 sg:pub.10.1038/nrgastro.2011.131
29 sg:pub.10.1245/s10434-010-0985-4
30 sg:pub.10.1245/s10434-012-2553-6
31 https://app.dimensions.ai/details/publication/pub.1078725155
32 https://doi.org/10.1002/cncr.27967
33 https://doi.org/10.1002/gcc.10207
34 https://doi.org/10.1002/gcc.22212
35 https://doi.org/10.1002/med.20206
36 https://doi.org/10.1016/j.bbcan.2008.07.006
37 https://doi.org/10.1016/j.cell.2007.11.025
38 https://doi.org/10.1016/j.cell.2012.08.024
39 https://doi.org/10.1016/j.cgh.2012.09.009
40 https://doi.org/10.1016/j.humpath.2014.03.014
41 https://doi.org/10.1016/j.lungcan.2013.11.019
42 https://doi.org/10.1016/j.surg.2004.10.008
43 https://doi.org/10.1016/s0168-8278(02)00297-0
44 https://doi.org/10.1056/nejmoa1406766
45 https://doi.org/10.1073/pnas.1311707110
46 https://doi.org/10.1073/pnas.1319583110
47 https://doi.org/10.1097/pas.0b013e3182960fa7
48 https://doi.org/10.1111/his.12379
49 https://doi.org/10.1158/1078-0432.ccr-11-3351
50 https://doi.org/10.1158/1078-0432.ccr-12-2851
51 https://doi.org/10.1158/1541-7786.mcr-13-0479-t
52 https://doi.org/10.1200/jco.2011.35.6345
53 https://doi.org/10.1371/journal.pone.0015640
54 https://doi.org/10.3349/ymj.2013.54.3.650
55 https://doi.org/10.3892/ijmm.2014.1823
56 https://doi.org/10.4254/wjh.v2.i12.419
57 schema:datePublished 2015-12
58 schema:datePublishedReg 2015-12-01
59 schema:description BACKGROUND: More knowledge about genetic and molecular features of cholangiocarcinoma is needed to develop effective therapeutic strategies. We investigated the clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma. METHODS: One hundred ninety-four patients with curatively resected intrahepatic cholangiocarcinoma were included in this study. Tumor tissue specimens were collected and analyzed for ROS1 gene rearrangement using fluorescence in situ hybridization (FISH) and ROS1 protein expression using immunohistochemistry (IHC). RESULTS: ROS1 immunohistochemistry was positive (moderate or strong staining) in 72 tumors (37.1 %). ROS1 protein expression was significantly correlated with well differentiated tumors, papillary or mucinous histology, oncocytic/hepatoid or intestinal type tumors, and periductal infiltrating or intraductal growing tumors (vs. mass-forming cholangiocarcinoma). ROS-expressing tumors were associated with better disease-free survival (30.1 months for ROS1 expression (+) tumors vs. 9.0 months for ROS1 (-) tumors, p = 0.006). Moreover, ROS1 expression was an independent predictor of better disease-free survival in a multivariate analysis (HR 0.607, 95 % CI 0.377-0.976; p = 0.039). Although break-apart FISH was successfully performed in 102 samples, a split pattern indicative of ROS1 gene rearrangement was not found in the examined samples. CONCLUSION: ROS1 protein expression was associated with well-differentiated histology and better survival in our patients with resected intrahepatic cholangiocarcinoma. ROS1 gene rearrangement by break-apart FISH was not found in the examined samples.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N925ccb9ec0f442589e4410638970927f
64 Nb65b9b353a974371bf39ffdbbd0a30da
65 sg:journal.1024632
66 schema:name Clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma
67 schema:pagination 721
68 schema:productId N37e1a83ade294ed7a3eb6a2d8dc5f27a
69 N5035863d848f42e4a5b6ac10a6ab168c
70 N86a426d3f4574c059f31b48acd3f5143
71 Naf08ee3bd87b4871b635d1436440a51b
72 Nb19040c82711405ebe2a4d4205a0666b
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019526242
74 https://doi.org/10.1186/s12885-015-1737-4
75 schema:sdDatePublished 2019-04-11T01:07
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N9c398d9ceb3447aaadc44e83038b89d4
78 schema:url http://link.springer.com/10.1186%2Fs12885-015-1737-4
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N08bb189b1712464e81869f65ce413456 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Liver
84 rdf:type schema:DefinedTerm
85 N1a184259222348089055fc907bd0b824 rdf:first sg:person.01102152417.00
86 rdf:rest Nc06ff2d9089e41699f412f5533cd04ca
87 N1a6a9d3df19e4fa386c9ead83eb61f0a rdf:first sg:person.01212754274.50
88 rdf:rest Nf99a897f50bb4f61b54e7e79f1f42066
89 N1d11d5f3744f4a78b6a9292ecfadbfaf rdf:first sg:person.01204275617.31
90 rdf:rest N83c00f1ef5754f4cb7764486801f519f
91 N254fb24e3c7545be874f2b99f2dd49c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name In Situ Hybridization, Fluorescence
93 rdf:type schema:DefinedTerm
94 N37e1a83ade294ed7a3eb6a2d8dc5f27a schema:name nlm_unique_id
95 schema:value 100967800
96 rdf:type schema:PropertyValue
97 N3ee2fb5a7d7f4b678695bd5a4fbe8a0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Aged, 80 and over
99 rdf:type schema:DefinedTerm
100 N3ff07101c8c14e548696ca4ac7f7d721 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Protein-Tyrosine Kinases
102 rdf:type schema:DefinedTerm
103 N4198db69b8e4413a983a7a7610ada361 rdf:first sg:person.0726553273.50
104 rdf:rest N1a6a9d3df19e4fa386c9ead83eb61f0a
105 N46ba25b68b8e4eff99200e91922e8aa5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Female
107 rdf:type schema:DefinedTerm
108 N5035863d848f42e4a5b6ac10a6ab168c schema:name readcube_id
109 schema:value 5d0935912167b9e0b843d90a514404e6e7105d4d7631a31188d30304160b0a2d
110 rdf:type schema:PropertyValue
111 N5c212184fa73427aac9c14a305d8324c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Disease-Free Survival
113 rdf:type schema:DefinedTerm
114 N5ec614528f07449fba8531cc1fc55f2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Immunohistochemistry
116 rdf:type schema:DefinedTerm
117 N800152a3be39482b8150504a37a38d6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Humans
119 rdf:type schema:DefinedTerm
120 N83c00f1ef5754f4cb7764486801f519f rdf:first sg:person.012611557304.53
121 rdf:rest N8a4e88144654423a81181b065d2643f4
122 N86a426d3f4574c059f31b48acd3f5143 schema:name dimensions_id
123 schema:value pub.1019526242
124 rdf:type schema:PropertyValue
125 N8a4e88144654423a81181b065d2643f4 rdf:first sg:person.0626600563.08
126 rdf:rest N4198db69b8e4413a983a7a7610ada361
127 N8c299ff34f4b49dbb60b4ff97631b4ec rdf:first sg:person.01166661455.74
128 rdf:rest N1a184259222348089055fc907bd0b824
129 N8e42f48c3d2e4e6b978e75001bb4b8f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Male
131 rdf:type schema:DefinedTerm
132 N925ccb9ec0f442589e4410638970927f schema:volumeNumber 15
133 rdf:type schema:PublicationVolume
134 N9976c48b538a431daa502e1ecde72485 rdf:first sg:person.01007250706.46
135 rdf:rest N1d11d5f3744f4a78b6a9292ecfadbfaf
136 N9c398d9ceb3447aaadc44e83038b89d4 schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 Na2907c5326884ee6bfc561ca8f7efbd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Tissue Array Analysis
140 rdf:type schema:DefinedTerm
141 Naf08ee3bd87b4871b635d1436440a51b schema:name pubmed_id
142 schema:value 26475437
143 rdf:type schema:PropertyValue
144 Nb19040c82711405ebe2a4d4205a0666b schema:name doi
145 schema:value 10.1186/s12885-015-1737-4
146 rdf:type schema:PropertyValue
147 Nb590d6539a65435cbddadb2c8f5fdec3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Middle Aged
149 rdf:type schema:DefinedTerm
150 Nb65b9b353a974371bf39ffdbbd0a30da schema:issueNumber 1
151 rdf:type schema:PublicationIssue
152 Nb7c6cf77c79f46398b997191eaf0c04e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Aged
154 rdf:type schema:DefinedTerm
155 Nc06ff2d9089e41699f412f5533cd04ca rdf:first sg:person.01363602512.42
156 rdf:rest rdf:nil
157 Nc1367d141a08462b87f82d6f1acd0970 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Prognosis
159 rdf:type schema:DefinedTerm
160 Nc4994cfc502a420eae5f8fdfaa3b319f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Adult
162 rdf:type schema:DefinedTerm
163 Nc7f049da31514493885935987f99c1bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Proto-Oncogene Proteins
165 rdf:type schema:DefinedTerm
166 Nc916b2c0077a4227bf63a4366781b40c rdf:first sg:person.01210315044.45
167 rdf:rest N8c299ff34f4b49dbb60b4ff97631b4ec
168 Nc94bbe2d495444908a22da4d5a85ee6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Gene Expression Regulation, Neoplastic
170 rdf:type schema:DefinedTerm
171 Nd922206d84df4444a8325e6f96767630 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Cholangiocarcinoma
173 rdf:type schema:DefinedTerm
174 Ndff6d472864d45049574adaa33e7c3c7 rdf:first sg:person.0654144447.73
175 rdf:rest Nc916b2c0077a4227bf63a4366781b40c
176 Nf99a897f50bb4f61b54e7e79f1f42066 rdf:first sg:person.012010335604.34
177 rdf:rest Ndff6d472864d45049574adaa33e7c3c7
178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
179 schema:name Medical and Health Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
182 schema:name Oncology and Carcinogenesis
183 rdf:type schema:DefinedTerm
184 sg:journal.1024632 schema:issn 1471-2407
185 schema:name BMC Cancer
186 rdf:type schema:Periodical
187 sg:person.01007250706.46 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
188 schema:familyName Lee
189 schema:givenName Kyung-Hun
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007250706.46
191 rdf:type schema:Person
192 sg:person.01102152417.00 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
193 schema:familyName Jang
194 schema:givenName Ja-June
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102152417.00
196 rdf:type schema:Person
197 sg:person.01166661455.74 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
198 schema:familyName Suh
199 schema:givenName Kyung-Suk
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166661455.74
201 rdf:type schema:Person
202 sg:person.012010335604.34 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
203 schema:familyName Kim
204 schema:givenName Tae-You
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012010335604.34
206 rdf:type schema:Person
207 sg:person.01204275617.31 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
208 schema:familyName Lee
209 schema:givenName Kyoung-Bun
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204275617.31
211 rdf:type schema:Person
212 sg:person.01210315044.45 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
213 schema:familyName Lee
214 schema:givenName Kwang-Woong
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210315044.45
216 rdf:type schema:Person
217 sg:person.01212754274.50 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
218 schema:familyName Im
219 schema:givenName Seock-Ah
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212754274.50
221 rdf:type schema:Person
222 sg:person.012611557304.53 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
223 schema:familyName Kim
224 schema:givenName Tae-Yong
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012611557304.53
226 rdf:type schema:Person
227 sg:person.01363602512.42 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
228 schema:familyName Bang
229 schema:givenName Yung-Jue
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363602512.42
231 rdf:type schema:Person
232 sg:person.0626600563.08 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
233 schema:familyName Han
234 schema:givenName Sae-Won
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626600563.08
236 rdf:type schema:Person
237 sg:person.0654144447.73 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
238 schema:familyName Yi
239 schema:givenName Nam-Joon
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654144447.73
241 rdf:type schema:Person
242 sg:person.0726553273.50 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
243 schema:familyName Oh
244 schema:givenName Do-Youn
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726553273.50
246 rdf:type schema:Person
247 sg:pub.10.1007/s00268-008-9778-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003285170
248 https://doi.org/10.1007/s00268-008-9778-3
249 rdf:type schema:CreativeWork
250 sg:pub.10.1007/s00268-009-9970-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048201518
251 https://doi.org/10.1007/s00268-009-9970-0
252 rdf:type schema:CreativeWork
253 sg:pub.10.1007/s00534-002-0732-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026602769
254 https://doi.org/10.1007/s00534-002-0732-8
255 rdf:type schema:CreativeWork
256 sg:pub.10.1007/s00534-009-0208-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001342152
257 https://doi.org/10.1007/s00534-009-0208-1
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s00535-013-0894-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1024575834
260 https://doi.org/10.1007/s00535-013-0894-y
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/modpathol.2013.192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053372599
263 https://doi.org/10.1038/modpathol.2013.192
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nm.2658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040612411
266 https://doi.org/10.1038/nm.2658
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nrgastro.2011.131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037668976
269 https://doi.org/10.1038/nrgastro.2011.131
270 rdf:type schema:CreativeWork
271 sg:pub.10.1245/s10434-010-0985-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033481932
272 https://doi.org/10.1245/s10434-010-0985-4
273 rdf:type schema:CreativeWork
274 sg:pub.10.1245/s10434-012-2553-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029070344
275 https://doi.org/10.1245/s10434-012-2553-6
276 rdf:type schema:CreativeWork
277 https://app.dimensions.ai/details/publication/pub.1078725155 schema:CreativeWork
278 https://doi.org/10.1002/cncr.27967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046940693
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/gcc.10207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010289727
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1002/gcc.22212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041938462
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1002/med.20206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016501306
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.bbcan.2008.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012540856
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.cell.2007.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030265584
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.cell.2012.08.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047865255
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.cgh.2012.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008195393
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.humpath.2014.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006308721
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.lungcan.2013.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034875564
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.surg.2004.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025932620
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s0168-8278(02)00297-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024907720
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1056/nejmoa1406766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051743411
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1073/pnas.1311707110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046417494
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1073/pnas.1319583110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052209707
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1097/pas.0b013e3182960fa7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020741718
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1111/his.12379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014227256
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1158/1078-0432.ccr-11-3351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042635752
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1158/1078-0432.ccr-12-2851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008060273
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1158/1541-7786.mcr-13-0479-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1038583288
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1200/jco.2011.35.6345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019635065
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1371/journal.pone.0015640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024506107
321 rdf:type schema:CreativeWork
322 https://doi.org/10.3349/ymj.2013.54.3.650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019621694
323 rdf:type schema:CreativeWork
324 https://doi.org/10.3892/ijmm.2014.1823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014947222
325 rdf:type schema:CreativeWork
326 https://doi.org/10.4254/wjh.v2.i12.419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072403054
327 rdf:type schema:CreativeWork
328 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
329 schema:name Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
330 Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.412484.f schema:alternateName Seoul National University Hospital
333 schema:name Department of Pathology, Seoul National University Hospital, 101 Daehak-ro, 110-744, Seoul, Jongno-gu, South Korea
334 Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea
335 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...