The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis View Full Text


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Article Info

DATE

2015-07-04

AUTHORS

Kyung Ho Pak, Ara Jo, Hye Ji Choi, Younghee Choi, Hyunki Kim, Jae-Ho Cheong

ABSTRACT

BACKGROUND: Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD) has been controversial in gastric cancer. The purpose of this study was to investigate the differences of clinicopathologic characteristics with respect to I-LVD and P-LVD in gastric cancer. METHODS: Samples of I-LVD and P-LVD from 66 patients who had undergone radical gastrectomy for gastric cancer were assessed after staining with D2-40, an immunostaining marker for lymphatic endothelium. The mean number of lymphatic vessels in three hotspots was calculated in intratumoral and peritumoral areas. RESULTS: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics. I-LVD was positively correlated with diffuse gastric cancer subtype, tumor stage, lymphovascular invasion, tumor node metastasis stage, and overall survival (P < 0.05). P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05). CONCLUSIONS: We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion. However, both LVDs contributed to gastric cancer progression and prognosis. More... »

PAGES

498

References to SciGraph publications

  • 2012-12-14. High density of peritumoral lymphatic vessels measured by D2-40/podoplanin and LYVE-1 expression in gastric cancer patients: an excellent prognostic indicator or a false friend? in GASTRIC CANCER
  • 2006-01-06. Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma in MODERN PATHOLOGY
  • 2008-02-29. Lymph vascular invasion in invasive mammary carcinomas identified by the endothelial lymphatic marker D2-40 is associated with other indicators of poor prognosis in BMC CANCER
  • 2002-04-01. Monoclonal Antibody D2-40, a New Marker of Lymphatic Endothelium, Reacts with Kaposi's Sarcoma and a Subset of Angiosarcomas in MODERN PATHOLOGY
  • 2011-01-28. Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2009-09-24. Increased Intratumoral Lymphatic Vessel Density Correlates with Lymph Node Metastasis in Early Gastric Carcinoma in ANNALS OF SURGICAL ONCOLOGY
  • 2005-08-30. Lymphatic invasion using D2-40 monoclonal antibody and its relationship to lymph node micrometastasis in pN0 gastric cancer in BRITISH JOURNAL OF CANCER
  • 2010-06-17. Different significance between intratumoral and peritumoral lymphatic vessel density in gastric cancer: a retrospective study of 123 cases in BMC CANCER
  • 2005-07-01. Comparison of the diagnostic accuracy of lymphatic endothelium markers: Bayesian approach in MODERN PATHOLOGY
  • 2006-02-22. Increased density and diameter of lymphatic microvessels correlate with lymph node metastasis in early stage invasive colorectal carcinoma in VIRCHOWS ARCHIV
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    http://scigraph.springernature.com/pub.10.1186/s12885-015-1501-9

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    http://dx.doi.org/10.1186/s12885-015-1501-9

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26141595


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